ATE224909T1 - 1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine - Google Patents

1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine

Info

Publication number
ATE224909T1
ATE224909T1 AT97916633T AT97916633T ATE224909T1 AT E224909 T1 ATE224909 T1 AT E224909T1 AT 97916633 T AT97916633 T AT 97916633T AT 97916633 T AT97916633 T AT 97916633T AT E224909 T1 ATE224909 T1 AT E224909T1
Authority
AT
Austria
Prior art keywords
arabinofuranosyl
deoxy
thio
fluoro
beta
Prior art date
Application number
AT97916633T
Other languages
German (de)
English (en)
Inventor
Yuichi Yoshimura
Kenji Kitano
Shinji Miura
Haruhiko Machida
Mikari Watanabe
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of ATE224909T1 publication Critical patent/ATE224909T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT97916633T 1996-04-09 1997-04-09 1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine ATE224909T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP11196896 1996-04-09
JP21508296 1996-07-26
JP27863196 1996-09-30
PCT/JP1997/001206 WO1997038001A1 (en) 1996-04-09 1997-04-09 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINES

Publications (1)

Publication Number Publication Date
ATE224909T1 true ATE224909T1 (de) 2002-10-15

Family

ID=27312140

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97916633T ATE224909T1 (de) 1996-04-09 1997-04-09 1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine

Country Status (10)

Country Link
US (1) US6147058A (en:Method)
EP (1) EP0841344B1 (en:Method)
JP (1) JP3657008B2 (en:Method)
AT (1) ATE224909T1 (en:Method)
CA (1) CA2224155C (en:Method)
DE (1) DE69715774T2 (en:Method)
DK (1) DK0841344T3 (en:Method)
ES (1) ES2182061T3 (en:Method)
PT (1) PT841344E (en:Method)
WO (1) WO1997038001A1 (en:Method)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
WO1999043691A1 (en) 1998-02-25 1999-09-02 Emory University 2'-fluoronucleosides
AU2004274021B2 (en) * 2003-09-18 2009-08-13 Isis Pharmaceuticals, Inc. 4'-thionucleosides and oligomeric compounds
US7524831B2 (en) * 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
MX2012006872A (es) 2009-12-18 2012-09-12 Libramedicina Inc Proceso para preparar 1-o-acil-2-deoxi-2-fluoro-4-tio-beta-d-arabi nofuranosas sustituidas.
EP2388257A1 (en) 2010-05-20 2011-11-23 LibraMedicina, Inc. Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-ß-D-arabinofuranoses
WO2013146833A1 (ja) * 2012-03-28 2013-10-03 富士フイルム株式会社 １－（２－デオキシ－２－フルオロ－４－チオ－β－Ｄ－アラビノフラノシル）シトシンの塩
DK2883866T3 (da) 2012-08-13 2019-05-13 Fujifilm Corp MELLEMPRODUKT TIL SYNTESE AF 1-(2-DEOXY-2-FLUOR-4-THIO-beta-D- ARABINOFURANOSYL)CYTOSIN, MELLEMPRODUKT TIL SYNTESE AF THIONUKLEOSID OG FREMGANGSMÅDER TIL FREMSTILLING AF DISSE MELLEMPRODUKTER
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
JP6351107B2 (ja) * 2014-02-18 2018-07-04 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6175553B2 (ja) * 2014-02-18 2017-08-09 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) * 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
CN106661077B (zh) * 2015-04-03 2019-02-12 四川科伦博泰生物医药股份有限公司 4’-硫代核苷的新型化合物及其制备方法、药物组合物和应用
JP6450356B2 (ja) * 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
SG11201901815WA (en) * 2016-08-31 2019-04-29 Fujifilm Corp Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit
WO2018113592A1 (zh) 2016-12-22 2018-06-28 四川科伦博泰生物医药股份有限公司 4'-硫代-2'-氟代核苷磷酰胺化合物的固体形式及其制备方法和用途
CN110831604B (zh) * 2017-09-01 2023-05-02 四川科伦博泰生物医药股份有限公司 用于肿瘤治疗或预防的药物组合物、方法及其用途
TW201932120A (zh) * 2018-01-29 2019-08-16 日商富士軟片股份有限公司 用於具有異檸檬酸脫氫酶突變的腫瘤的藥物組成物與抗腫瘤劑及其應用
TW201932119A (zh) * 2018-01-29 2019-08-16 日商富士軟片股份有限公司 膽道癌用抗腫瘤劑和膽道癌的處理方法
TW202000207A (zh) * 2018-02-26 2020-01-01 日商富士軟片股份有限公司 膀胱癌用抗腫瘤劑及膀胱癌的處置方法
JP6974585B2 (ja) * 2018-03-13 2021-12-01 富士フイルム株式会社 抗腫瘍剤、抗腫瘍効果増強剤及び抗腫瘍用キット
CA3110224A1 (en) * 2018-09-25 2020-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
CN112770731A (zh) * 2018-11-28 2021-05-07 四川科伦博泰生物医药股份有限公司 以4’-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途
EP4004013A4 (en) * 2019-07-30 2023-08-09 Pinotbio, Inc. DINUCLEOTIDE COMPOUNDS FOR THE TREATMENT OF CANCER AND THEIR MEDICAL USES
WO2023008511A1 (ja) 2021-07-29 2023-02-02 富士フイルム株式会社 Ｂａｐ１およびｐｂｒｍ１の少なくとも１つの機能低下を有する腫瘍に対する医薬組成物および抗腫瘍剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE74701B1 (en) * 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
US5811408A (en) * 1994-07-12 1998-09-22 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
JPH0853490A (ja) * 1994-08-09 1996-02-27 Yamasa Shoyu Co Ltd ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド

Also Published As

Publication number Publication date
DE69715774D1 (de) 2002-10-31
CA2224155A1 (en) 1997-10-16
ES2182061T3 (es) 2003-03-01
JP3657008B2 (ja) 2005-06-08
US6147058A (en) 2000-11-14
CA2224155C (en) 2004-10-26
DK0841344T3 (da) 2002-12-23
EP0841344A4 (en:Method) 1998-05-13
EP0841344A1 (en) 1998-05-13
DE69715774T2 (de) 2003-05-15
EP0841344B1 (en) 2002-09-25
PT841344E (pt) 2003-02-28
WO1997038001A1 (en) 1997-10-16

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