ATE223926T1 - Verfahren zur herstellung von igf-1 und igfbp-3 mit richtiger faltung und disulfidbindungen - Google Patents
Verfahren zur herstellung von igf-1 und igfbp-3 mit richtiger faltung und disulfidbindungenInfo
- Publication number
- ATE223926T1 ATE223926T1 AT96916829T AT96916829T ATE223926T1 AT E223926 T1 ATE223926 T1 AT E223926T1 AT 96916829 T AT96916829 T AT 96916829T AT 96916829 T AT96916829 T AT 96916829T AT E223926 T1 ATE223926 T1 AT E223926T1
- Authority
- AT
- Austria
- Prior art keywords
- igfbp
- igf
- disulfide bonds
- proper folding
- cofolding
- Prior art date
Links
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 title abstract 6
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 6
- 102000004374 Insulin-like growth factor binding protein 3 Human genes 0.000 title abstract 6
- 108090000965 Insulin-like growth factor binding protein 3 Proteins 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4743—Insulin-like growth factor binding protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/482,271 US5789547A (en) | 1995-06-07 | 1995-06-07 | Method of producing insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) with correct folding and disulfide bonding |
PCT/US1996/008113 WO1996040736A1 (en) | 1995-06-07 | 1996-05-30 | Method of producing igf-i and igfbp-3 with correct folding and disulfide bonding |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE223926T1 true ATE223926T1 (de) | 2002-09-15 |
Family
ID=23915418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96916829T ATE223926T1 (de) | 1995-06-07 | 1996-05-30 | Verfahren zur herstellung von igf-1 und igfbp-3 mit richtiger faltung und disulfidbindungen |
Country Status (15)
Country | Link |
---|---|
US (1) | US5789547A (de) |
EP (1) | EP0832098B1 (de) |
JP (1) | JPH11507037A (de) |
KR (1) | KR19990022718A (de) |
CN (1) | CN1214689A (de) |
AT (1) | ATE223926T1 (de) |
AU (1) | AU703489B2 (de) |
CA (1) | CA2223495A1 (de) |
CZ (1) | CZ394397A3 (de) |
DE (1) | DE69623620T2 (de) |
DK (1) | DK0832098T3 (de) |
ES (1) | ES2179943T3 (de) |
NO (1) | NO975749L (de) |
PL (1) | PL323731A1 (de) |
WO (1) | WO1996040736A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6015786A (en) * | 1997-02-25 | 2000-01-18 | Celtrix Pharmaceuticals, Inc. | Method for increasing sex steroid levels using IGF or IGF/IGFBP-3 |
US6025368A (en) * | 1997-02-25 | 2000-02-15 | Celtrix Pharmaceuticals, Inc. | Method for treating the symptoms of chronic stress-related disorders using IGF |
US6514937B1 (en) | 1997-02-25 | 2003-02-04 | Celtrix Pharmaceuticals, Inc. | Method of treating psychological and metabolic disorders using IGF or IGF/IGFBP-3 |
US5914390A (en) * | 1997-05-12 | 1999-06-22 | Celtrix Pharmaceuticals, Inc. | Methods for increasing yields of recombinant proteins |
US6653098B1 (en) * | 1998-02-23 | 2003-11-25 | G. D. Searle & Co. | Method of producing mouse and human endostatin |
US6417330B1 (en) | 1998-06-01 | 2002-07-09 | Celtrix Pharmaceuticals, Inc. | Insulin-like growth factor binding protein variants |
US6436897B2 (en) | 1998-06-01 | 2002-08-20 | Celtrix Pharmaceuticals, Inc. | Pharmaceutical formulations for IGF/IGFBP |
EP1273655A4 (de) * | 2000-03-30 | 2004-08-04 | Takeda Chemical Industries Ltd | Verfahren zur herstellung eines rekombinanten proteins |
EP1399475A2 (de) * | 2001-06-07 | 2004-03-24 | F. Hoffmann-La Roche Ag | Mutanten igf-bindender proteine und verfahren zur produktion deren antagonisten |
ES2341270T3 (es) * | 2004-12-24 | 2010-06-17 | Insmed, Inc. | Complejos rhigf-i/rhigfbp-3 purificados y procedimientos de fabricacion de los mismos. |
US8518877B2 (en) | 2007-04-18 | 2013-08-27 | Premacure Ab | Method and product for treatment and/or prevention of complications of prematurity |
CN104011070A (zh) * | 2011-12-15 | 2014-08-27 | 爱德迪安(北京)生物技术有限公司 | 具有降血糖作用的化合物、组合物及其用途 |
EA202090705A1 (ru) | 2017-09-11 | 2020-06-11 | Шайр Хьюман Дженетик Терапиз, Инк. | Способы и композиции, предназначенные для лечения хронических заболеваний легких |
CN107991492A (zh) * | 2017-11-17 | 2018-05-04 | 广州赛莱拉干细胞科技股份有限公司 | 一种胰岛素样生长因子结合蛋白-3的定量检测试剂盒及其非诊断目的的检测方法 |
CN111876490B (zh) * | 2020-07-03 | 2022-07-15 | 扬州大学 | 一种提高猪生长速度的连锁分子标记、其检测方法及应用 |
IL301688A (en) | 2020-10-19 | 2023-05-01 | Oak Hill Bio Ltd | The compositions are suitable for use in newborns |
IL314331A (en) | 2022-01-19 | 2024-09-01 | Oak Hill Bio Ltd | Methods and compounds for reducing oxidation of IGF-1/IGFBP |
WO2023139250A1 (en) * | 2022-01-24 | 2023-07-27 | Oak Hill Bio Limited | Lot release assays for igf‐1/igfbp complexes |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
US4766205A (en) * | 1985-11-13 | 1988-08-23 | Beatrice Companies, Inc. | Method for isolation of recombinant polypeptides in biologically active forms |
US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
US5158875A (en) * | 1989-08-25 | 1992-10-27 | Amgen Inc. | Production of biologically active insulin-like growth factor i from high expression host cell systems |
US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
AU3812993A (en) * | 1992-03-24 | 1993-10-21 | Synergen, Inc. | Refolding and purification of insulin-like growth factor I |
SE9303784D0 (sv) * | 1993-11-16 | 1993-11-16 | Kabi Pharmacia Ab | Igf |
-
1995
- 1995-06-07 US US08/482,271 patent/US5789547A/en not_active Expired - Lifetime
-
1996
- 1996-05-30 ES ES96916829T patent/ES2179943T3/es not_active Expired - Lifetime
- 1996-05-30 AU AU59576/96A patent/AU703489B2/en not_active Ceased
- 1996-05-30 CA CA002223495A patent/CA2223495A1/en not_active Abandoned
- 1996-05-30 KR KR1019970709160A patent/KR19990022718A/ko not_active Application Discontinuation
- 1996-05-30 JP JP9500881A patent/JPH11507037A/ja not_active Ceased
- 1996-05-30 EP EP96916829A patent/EP0832098B1/de not_active Expired - Lifetime
- 1996-05-30 CN CN96195432A patent/CN1214689A/zh active Pending
- 1996-05-30 DK DK96916829T patent/DK0832098T3/da active
- 1996-05-30 DE DE69623620T patent/DE69623620T2/de not_active Expired - Fee Related
- 1996-05-30 WO PCT/US1996/008113 patent/WO1996040736A1/en not_active Application Discontinuation
- 1996-05-30 CZ CZ973943A patent/CZ394397A3/cs unknown
- 1996-05-30 PL PL96323731A patent/PL323731A1/xx unknown
- 1996-05-30 AT AT96916829T patent/ATE223926T1/de not_active IP Right Cessation
-
1997
- 1997-12-05 NO NO975749A patent/NO975749L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE69623620T2 (de) | 2003-08-07 |
DE69623620D1 (de) | 2002-10-17 |
EP0832098B1 (de) | 2002-09-11 |
EP0832098A1 (de) | 1998-04-01 |
EP0832098A4 (de) | 1999-09-15 |
ES2179943T3 (es) | 2003-02-01 |
NO975749L (no) | 1998-01-27 |
AU5957696A (en) | 1996-12-30 |
DK0832098T3 (da) | 2002-12-16 |
JPH11507037A (ja) | 1999-06-22 |
CN1214689A (zh) | 1999-04-21 |
WO1996040736A1 (en) | 1996-12-19 |
NO975749D0 (no) | 1997-12-05 |
KR19990022718A (ko) | 1999-03-25 |
CZ394397A3 (cs) | 1998-09-16 |
PL323731A1 (en) | 1998-04-14 |
AU703489B2 (en) | 1999-03-25 |
US5789547A (en) | 1998-08-04 |
CA2223495A1 (en) | 1996-12-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE223926T1 (de) | Verfahren zur herstellung von igf-1 und igfbp-3 mit richtiger faltung und disulfidbindungen | |
ES2058341T3 (es) | Subunidades de proteina portadoras de somatomedina humana y proceso para producirlas. | |
DE59305396D1 (de) | Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken | |
DK564989D0 (da) | Bindingsproteiner | |
PL323858A1 (en) | Compounds and peptides capable to bond to a receptor of erythropoetin | |
ATE329624T1 (de) | Technetium-99m markierte peptide zur bilderzeugung von thrombus | |
ATE352617T1 (de) | Lösliche polypeptidfraktionen des lag-3-proteins; verfahren zur herstellung; therapeutische zusamensetzung; antiidiotypischer antikörper | |
ATE181320T1 (de) | Verfahren zur herstellung von mischungen von n- acylierten aminosaeuren | |
IL92816A0 (en) | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides | |
ATE350053T1 (de) | Herstellung von humaninsulin | |
DE3676683D1 (de) | Mischung von derivaten von aminosaeuren, verfahren zur herstellung der mischung und verwendung der mischung zur mengenbestimmung der aminosaeuren. | |
DE69319012D1 (de) | Protein mit Knochenbildungs-Eigenschaften und Verfahren zu seiner Herstellung | |
WO1995032221A3 (en) | Autotaxin: motility stimulating protein useful in cancer diagnosis and therapy | |
DE69508532D1 (de) | Markierungsmaterial für Treibriemen und ein Verfahren zur Herstellung von Treibriemen mit diesem Markierungsmaterial | |
ATE177459T1 (de) | Verfahren zur kontinuierlichen herstellung von flüssigsiliconkautschuken | |
ATE212360T1 (de) | Polyethylenglycol-hirudin-konjugate, deren verfahren zur herstellung und verwendung für die heilung von thrombosen | |
ATE194167T1 (de) | Ein prozess für die herstellung von faktor ix biologischen ursprungs | |
DE59605774D1 (de) | Verfahren zur Herstellung von beta-Carotin-Präparaten mit hohem 9(Z)-Gehalt | |
ATE161269T1 (de) | Verfahren zur herstellung von peptiden und neue zwischenverbindungen dazu | |
ATE81013T1 (de) | Verfahren zur herstellung von faktor viii:cmangelplasma und ein so erhaltenes mangelplasma. | |
ATE190653T1 (de) | Verfahren zur herstellung von rekombinanten und synthetischen peptiden und deren verwendung | |
DE69423516D1 (de) | Verwendung von igf-bp zur rückfaltung von igf | |
PT959895E (pt) | Peptidos que reajem a anticorpos contra um peptido de consenso da familia de proteinas cs4-cfa/i | |
DE69608512D1 (de) | Verfahren zur Herstellung von benzylsubstituierten Rhodaninederivaten | |
ATE253839T1 (de) | Verfahren zur herstellung von molkenproteinaggregaten aus sauermolke |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0832098 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |