ATE223576T1 - Methode zur identifizierung von verbindungen mit anxiolytischem potential - Google Patents
Methode zur identifizierung von verbindungen mit anxiolytischem potentialInfo
- Publication number
- ATE223576T1 ATE223576T1 AT97909212T AT97909212T ATE223576T1 AT E223576 T1 ATE223576 T1 AT E223576T1 AT 97909212 T AT97909212 T AT 97909212T AT 97909212 T AT97909212 T AT 97909212T AT E223576 T1 ATE223576 T1 AT E223576T1
- Authority
- AT
- Austria
- Prior art keywords
- identifying compounds
- anxiolytic potential
- ligands
- cloned
- gabaa receptor
- Prior art date
Links
- 230000000949 anxiolytic effect Effects 0.000 title abstract 2
- 239000002249 anxiolytic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 2
- 108091008681 GABAA receptors Proteins 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 102000004300 GABA-A Receptors Human genes 0.000 abstract 1
- 108090000839 GABA-A Receptors Proteins 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Elimination Of Static Electricity (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK118296 | 1996-10-25 | ||
| PCT/DK1997/000475 WO1998019165A1 (en) | 1996-10-25 | 1997-10-27 | A method for the identification of compounds with anxiolytic potential |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE223576T1 true ATE223576T1 (de) | 2002-09-15 |
Family
ID=8101912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97909212T ATE223576T1 (de) | 1996-10-25 | 1997-10-27 | Methode zur identifizierung von verbindungen mit anxiolytischem potential |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0934528B1 (de) |
| JP (1) | JP3868502B2 (de) |
| AT (1) | ATE223576T1 (de) |
| DE (1) | DE69715231T2 (de) |
| WO (1) | WO1998019165A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6737242B1 (en) | 1999-05-07 | 2004-05-18 | Neurogen Corporation | Methods for screening GABA-modulatory compounds for specified pharmacological activities |
| AU4703200A (en) * | 1999-05-07 | 2000-11-21 | Neurogen Corporation | Methods for screening gaba-modulatory compounds for specified pharmacological activities |
| EP1337859A1 (de) * | 2000-10-05 | 2003-08-27 | Hanns Mohler | Selektive anxiolytika |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166066A (en) * | 1991-07-11 | 1992-11-24 | The Upjohn Company | Transformed cells comprising GABAA receptors |
| US5597920A (en) * | 1992-04-30 | 1997-01-28 | Neurogen Corporation | Gabaa receptor subtypes and methods for screening drug compounds using imidazoquinoxalines and pyrrolopyrimidines to bind to gabaa receptor subtypes |
| US5652100A (en) * | 1992-12-10 | 1997-07-29 | Merck Sharpe & Dohme Ltd. | Stably transfected rodent fibroblast cell lines expressing human GABA-A -receptors |
| KR100283363B1 (ko) * | 1995-04-21 | 2001-03-02 | 페더 벨링 | 벤즈이미다졸 화합물 및 감마-아미노부틸산 수용체 복합체의 조절인자로 그들의 용도 |
-
1997
- 1997-10-27 WO PCT/DK1997/000475 patent/WO1998019165A1/en not_active Ceased
- 1997-10-27 EP EP97909212A patent/EP0934528B1/de not_active Expired - Lifetime
- 1997-10-27 JP JP51993498A patent/JP3868502B2/ja not_active Expired - Fee Related
- 1997-10-27 DE DE69715231T patent/DE69715231T2/de not_active Expired - Lifetime
- 1997-10-27 AT AT97909212T patent/ATE223576T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69715231T2 (de) | 2003-05-22 |
| EP0934528A1 (de) | 1999-08-11 |
| JP2001505661A (ja) | 2001-04-24 |
| EP0934528B1 (de) | 2002-09-04 |
| WO1998019165A1 (en) | 1998-05-07 |
| JP3868502B2 (ja) | 2007-01-17 |
| DE69715231D1 (de) | 2002-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |