DE69715231D1 - Methode zur identifizierung von verbindungen mit anxiolytischem potential - Google Patents

Methode zur identifizierung von verbindungen mit anxiolytischem potential

Info

Publication number
DE69715231D1
DE69715231D1 DE69715231T DE69715231T DE69715231D1 DE 69715231 D1 DE69715231 D1 DE 69715231D1 DE 69715231 T DE69715231 T DE 69715231T DE 69715231 T DE69715231 T DE 69715231T DE 69715231 D1 DE69715231 D1 DE 69715231D1
Authority
DE
Germany
Prior art keywords
identifying connections
anxiolytic potential
ligands
cloned
gabaa receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69715231T
Other languages
English (en)
Other versions
DE69715231T2 (de
Inventor
Helth Jensen
Holm Johansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of DE69715231D1 publication Critical patent/DE69715231D1/de
Application granted granted Critical
Publication of DE69715231T2 publication Critical patent/DE69715231T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Elimination Of Static Electricity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69715231T 1996-10-25 1997-10-27 Methode zur identifizierung von verbindungen mit anxiolytischem potential Expired - Lifetime DE69715231T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK118296 1996-10-25
PCT/DK1997/000475 WO1998019165A1 (en) 1996-10-25 1997-10-27 A method for the identification of compounds with anxiolytic potential

Publications (2)

Publication Number Publication Date
DE69715231D1 true DE69715231D1 (de) 2002-10-10
DE69715231T2 DE69715231T2 (de) 2003-05-22

Family

ID=8101912

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69715231T Expired - Lifetime DE69715231T2 (de) 1996-10-25 1997-10-27 Methode zur identifizierung von verbindungen mit anxiolytischem potential

Country Status (5)

Country Link
EP (1) EP0934528B1 (de)
JP (1) JP3868502B2 (de)
AT (1) ATE223576T1 (de)
DE (1) DE69715231T2 (de)
WO (1) WO1998019165A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6737242B1 (en) * 1999-05-07 2004-05-18 Neurogen Corporation Methods for screening GABA-modulatory compounds for specified pharmacological activities
JP2002544487A (ja) * 1999-05-07 2002-12-24 ニューロゲン コーポレイション 特定の薬理活性を有するｇａｂａ−修飾化合物のスクリーニング方法
CA2425124A1 (en) * 2000-10-05 2002-04-11 Hanns Mohler Selective anxiolytic therapeutic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166066A (en) * 1991-07-11 1992-11-24 The Upjohn Company Transformed cells comprising GABAA receptors
US5597920A (en) * 1992-04-30 1997-01-28 Neurogen Corporation Gabaa receptor subtypes and methods for screening drug compounds using imidazoquinoxalines and pyrrolopyrimidines to bind to gabaa receptor subtypes
WO1994013799A1 (en) * 1992-12-10 1994-06-23 Merck Sharp & Dohme Limited Stably transfected cell lines expressing gaba-a receptors
BR9608056A (pt) * 1995-04-21 1999-11-30 Neurosearch As Compostos de benzimidazol, composições farmacêuticas contendo os compostos e sua utilização.

Also Published As

Publication number Publication date
JP3868502B2 (ja) 2007-01-17
JP2001505661A (ja) 2001-04-24
ATE223576T1 (de) 2002-09-15
EP0934528B1 (de) 2002-09-04
WO1998019165A1 (en) 1998-05-07
EP0934528A1 (de) 1999-08-11
DE69715231T2 (de) 2003-05-22

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