ATE215401T1 - Verfahren und vorrichtung zur herstellung von matrixen von proben - Google Patents

Verfahren und vorrichtung zur herstellung von matrixen von proben

Info

Publication number
ATE215401T1
ATE215401T1 AT98956385T AT98956385T ATE215401T1 AT E215401 T1 ATE215401 T1 AT E215401T1 AT 98956385 T AT98956385 T AT 98956385T AT 98956385 T AT98956385 T AT 98956385T AT E215401 T1 ATE215401 T1 AT E215401T1
Authority
AT
Austria
Prior art keywords
heads
assembly
producing
array
regions
Prior art date
Application number
AT98956385T
Other languages
English (en)
Inventor
Reid B Kowallis
Yefim M Raysberg
Original Assignee
Pe Corp Ny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pe Corp Ny filed Critical Pe Corp Ny
Application granted granted Critical
Publication of ATE215401T1 publication Critical patent/ATE215401T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0262—Drop counters; Drop formers using touch-off at substrate or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1037—Using surface tension, e.g. pins or wires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/115831—Condition or time responsive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/119163—Automated chemical analysis with aspirator of claimed structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Physics & Mathematics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT98956385T 1997-10-31 1998-10-30 Verfahren und vorrichtung zur herstellung von matrixen von proben ATE215401T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6526297P 1997-10-31 1997-10-31
PCT/US1998/023092 WO1999022867A1 (en) 1997-10-31 1998-10-30 Method and apparatus for making arrays

Publications (1)

Publication Number Publication Date
ATE215401T1 true ATE215401T1 (de) 2002-04-15

Family

ID=22061476

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98956385T ATE215401T1 (de) 1997-10-31 1998-10-30 Verfahren und vorrichtung zur herstellung von matrixen von proben

Country Status (8)

Country Link
US (1) US6228659B1 (de)
EP (1) EP1027159B1 (de)
JP (2) JP4564165B2 (de)
AT (1) ATE215401T1 (de)
AU (1) AU748226B2 (de)
CA (1) CA2307141C (de)
DE (1) DE69804653T2 (de)
WO (1) WO1999022867A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0955084B1 (de) 1998-04-27 2006-07-26 Corning Incorporated Verfahren zur Ablage von biologischen Proben mit hilfe eines nachgezogenen Kapillar-speichers
US6884626B1 (en) 1998-04-27 2005-04-26 Corning Incorporated Redrawn capillary imaging reservoir
US6762061B1 (en) * 1998-07-03 2004-07-13 Corning Incorporated Redrawn capillary imaging reservoir
GB2348002B (en) * 1999-07-20 2001-02-07 Genpak Ltd Microarrayer
US6423536B1 (en) * 1999-08-02 2002-07-23 Molecular Dynamics, Inc. Low volume chemical and biochemical reaction system
JP3723021B2 (ja) * 1999-09-30 2005-12-07 富士写真フイルム株式会社 マイクロアレイチップ製造装置
US6420180B1 (en) * 2000-01-26 2002-07-16 Agilent Technologies, Inc. Multiple pass deposition for chemical array fabrication
US6706538B1 (en) * 2000-02-29 2004-03-16 Boston Innovation Inc. Microvolume liquid dispensing array
JP3502803B2 (ja) * 2000-03-06 2004-03-02 日立ソフトウエアエンジニアリング株式会社 マイクロアレイ、マイクロアレイ作製方法及びマイクロアレイにおけるピン間スポット量誤差補正方法
US6447723B1 (en) 2000-03-13 2002-09-10 Packard Instrument Company, Inc. Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments
US6756232B1 (en) * 2000-03-20 2004-06-29 Perkinelmer Las, Inc. Method and apparatus for producing compact microarrays
US6878554B1 (en) 2000-03-20 2005-04-12 Perkinelmer Las, Inc. Method and apparatus for automatic pin detection in microarray spotting instruments
KR100340126B1 (ko) * 2000-03-24 2002-06-10 박한오 자동 생물학적 시료 미세배열 장치
DE10017105A1 (de) * 2000-04-06 2001-10-11 Basf Ag Verfahren und Vorrichtung zur Herstellung von Biopolymer-Feldern
US7521245B1 (en) 2000-06-05 2009-04-21 Perkinelmer Las, Inc. Method for washing and drying pins in microarray spotting instruments
DE10032811B4 (de) * 2000-06-30 2004-04-08 Epigenomics Ag Vorrichtung zur Herstellung von Oligomer-Arrays
US6613893B1 (en) * 2000-07-31 2003-09-02 Agilent Technologies Inc. Array fabrication
US6890760B1 (en) * 2000-07-31 2005-05-10 Agilent Technologies, Inc. Array fabrication
US7205400B2 (en) 2000-07-31 2007-04-17 Agilent Technologies, Inc. Array fabrication
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US6455352B1 (en) * 2000-09-01 2002-09-24 The University Of Chicago Pin array assembly and method of manufacture
US20020132368A1 (en) * 2000-12-18 2002-09-19 Ngk Insulators, Ltd. Method of forming detection spots on an analyte detection chip
KR100717819B1 (ko) * 2001-04-23 2007-05-11 (주)바이오니아 생물학적 시료의 미세 배열을 위한 스팟팅 장치
WO2003006164A1 (en) * 2001-07-11 2003-01-23 Universisty Of Southern California Dna probe synthesis on chip on demand by mems ejector array
US20030044320A1 (en) * 2001-08-31 2003-03-06 Shun Luo High throughput screening micro array platform
WO2003028868A2 (en) * 2001-10-03 2003-04-10 Kin Chiu Ng Apparatus and method for fabricating high density microarrays and applications thereof
US6936474B2 (en) * 2001-11-05 2005-08-30 Industrial Technology Research Institute Method and apparatus for manufacturing biochip
US6935727B2 (en) 2001-12-18 2005-08-30 Agilent Technologies, Inc. Pulse jet print head assembly having multiple reservoirs and methods for use in the manufacture of biopolymeric arrays
US7141368B2 (en) * 2002-01-30 2006-11-28 Agilent Technologies, Inc. Multi-directional deposition in array fabrication
US6789965B2 (en) * 2002-05-31 2004-09-14 Agilent Technologies, Inc. Dot printer with off-axis loading
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
US20040091941A1 (en) * 2002-08-13 2004-05-13 Ewing William R. Spotting pattern for placement of compounds in an array
US6913931B2 (en) * 2002-10-03 2005-07-05 3M Innovative Properties Company Devices, methods and systems for low volume microarray processing
US6881588B2 (en) * 2002-10-18 2005-04-19 Indiana University Research & Technology Corporation Fluid treatment device
US6911182B2 (en) * 2002-10-18 2005-06-28 Indiana University Research And Technology Corporation Device for placement of effluent
US20040151635A1 (en) * 2003-01-31 2004-08-05 Leproust Eric M. Array fabrication using deposited drop splat size
US6970240B2 (en) * 2003-03-10 2005-11-29 Applera Corporation Combination reader
US7534561B2 (en) * 2003-04-02 2009-05-19 Agilent Technologies, Inc. Nucleic acid array in situ fabrication methods and arrays produced using the same
US7767152B2 (en) 2003-08-11 2010-08-03 Sakura Finetek U.S.A., Inc. Reagent container and slide reaction retaining tray, and method of operation
US9518899B2 (en) 2003-08-11 2016-12-13 Sakura Finetek U.S.A., Inc. Automated reagent dispensing system and method of operation
US7744817B2 (en) 2003-08-11 2010-06-29 Sakura Finetek U.S.A., Inc. Manifold assembly
US20050233472A1 (en) * 2003-09-19 2005-10-20 Kao H P Spotting high density plate using a banded format
US20050226771A1 (en) * 2003-09-19 2005-10-13 Lehto Dennis A High speed microplate transfer
US20050221358A1 (en) * 2003-09-19 2005-10-06 Carrillo Albert L Pressure chamber clamp mechanism
US20070015289A1 (en) * 2003-09-19 2007-01-18 Kao H P Dispenser array spotting
US20050226779A1 (en) * 2003-09-19 2005-10-13 Oldham Mark F Vacuum assist for a microplate
EP1675682B1 (de) * 2003-10-24 2017-07-19 Aushon Biosystems, Inc. Vorrichtung und verfahren zur dosierung von flüssigen, halbfesten und festen proben
JP2007535681A (ja) * 2004-04-30 2007-12-06 バイオフォース・ナノサイエンシィズ・インコーポレーテッド 物質を表面上に堆積させるための方法と装置
WO2006039561A2 (en) * 2004-09-30 2006-04-13 University Of Southern California Silicon inertial sensors formed using mems
DE502005003509D1 (de) * 2004-11-19 2008-05-08 Ebm Papst St Georgen Gmbh & Co Anordnung mit einem luefter und einer pumpe
US7622079B2 (en) * 2005-03-22 2009-11-24 Applied Biosystems, Llc Dual nest microplate spotter
WO2007042964A1 (en) * 2005-10-07 2007-04-19 Koninklijke Philips Electronics N.V. A method and apparatus for printing a pattern of distinct dots of different reagent fluids using a printing head comprising a set of nozzles
US8459509B2 (en) 2006-05-25 2013-06-11 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
US7719170B1 (en) 2007-01-11 2010-05-18 University Of Southern California Self-focusing acoustic transducer with fresnel lens
US8900527B2 (en) * 2010-06-29 2014-12-02 Roche Molecular Systems Inc. Pipetting device with independently movable pipette units
DE102010037084A1 (de) * 2010-08-20 2012-02-23 LCTech GmbH Probenaufbereitungssystem sowie ein Verfahren zur Bearbeitung einer Probe
US8752732B2 (en) 2011-02-01 2014-06-17 Sakura Finetek U.S.A., Inc. Fluid dispensing system
US8580568B2 (en) 2011-09-21 2013-11-12 Sakura Finetek U.S.A., Inc. Traceability for automated staining system
US8932543B2 (en) 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
US20160266162A1 (en) * 2013-11-06 2016-09-15 Degree Of Freedom Scientific Machine Co., Ltd. Fully-automatic pipetting instrument and use thereof
US11364492B2 (en) 2016-03-31 2022-06-21 Hewlett-Packard Development Company, L.P. Monolithic carrier structure for digital dispensing
DE102017105600A1 (de) * 2017-03-16 2018-09-20 Bruker Daltonik Gmbh Trennung von Tropfenflüssigkeit und davon umschlossenem sedimentierten Material
US11090938B1 (en) 2020-05-15 2021-08-17 Funai Electric Co., Ltd. Multi-array ejection head and method of use

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3164304A (en) 1961-05-08 1965-01-05 Standard Thomson Corp Liquid dispensing apparatus for small quantities
US3329964A (en) 1965-06-24 1967-07-04 Xerox Corp Facsimile recording apparatus
US3334354A (en) 1966-03-17 1967-08-01 Xerox Corp Dotting ink recorder
US3568735A (en) 1968-06-26 1971-03-09 Cooke Eng Co Laboratory microtitration dispensing apparatus
US3843053A (en) 1973-03-29 1974-10-22 Kontes Glass Co Spotter for use in thin layer chromatography and method of forming drops therewith
US4023716A (en) 1976-04-20 1977-05-17 Justin Joel Shapiro Micro-dispensing liquid pipet
US4165646A (en) 1978-07-26 1979-08-28 Shapiro Justin J Adjustable micro-dispensing liquid pipet
US4351799A (en) 1981-07-15 1982-09-28 Gross Valery N Micrometering liquid sample dispenser
DE3407849A1 (de) 1984-02-29 1985-08-29 Alois 3201 Algermissen Höft Verfahren und einrichtung zum gleichzeitigen aufbringen einer vielzahl von fluessigkeitsproben auf einen objekttraeger
US4681742A (en) 1984-10-01 1987-07-21 Cetus Corporation Assay tray
US4952518A (en) 1984-10-01 1990-08-28 Cetus Corporation Automated assay machine and assay tray
US4731335A (en) * 1985-09-13 1988-03-15 Fisher Scientific Company Method for treating thin samples on a surface employing capillary flow
US5000921A (en) * 1986-10-24 1991-03-19 Hanaway Richard W Multiple pipette samples
US5011779A (en) 1988-01-21 1991-04-30 Long Island Jewish Medical Center Apparatus for rapid deposition of test samples on an absorbent support
GB8809611D0 (en) * 1988-04-22 1988-05-25 Darougar S Deposition apparatus
US5046539A (en) 1989-05-26 1991-09-10 The Rockefeller University Automatic fluid dispenser for multi-welled dish
US5262128A (en) * 1989-10-23 1993-11-16 The United States Of America As Represented By The Department Of Health And Human Services Array-type multiple cell injector
EP0478753B1 (de) 1990-04-06 1997-07-02 The Perkin-Elmer Corporation Automatisiertes labor für molekularbiologie
DE4024545A1 (de) * 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Verfahren und vorrichtung zum dosierten zufuehren einer biochemischen analysefluessigkeit auf ein target
US5525302A (en) * 1991-02-01 1996-06-11 Astle; Thomas W. Method and device for simultaneously transferring plural samples
US5226462A (en) * 1991-07-26 1993-07-13 Carl Richard A Introducing measured amounts of liquid into receptacles
ATE293011T1 (de) 1991-11-22 2005-04-15 Affymetrix Inc A Delaware Corp Kombinatorische strategien für die polymersynthese
US5508200A (en) 1992-10-19 1996-04-16 Tiffany; Thomas Method and apparatus for conducting multiple chemical assays
US5525515A (en) 1993-02-03 1996-06-11 Blattner; Frederick R. Process of handling liquids in an automated liquid handling apparatus
RU2041263C1 (ru) 1993-08-11 1995-08-09 Геннадий Моисеевич Ершов Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления
US5540889A (en) 1994-05-11 1996-07-30 Whitehead Institute For Biomedical Research Apparatus and method for a highly parallel pipetter
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5601980A (en) 1994-09-23 1997-02-11 Hewlett-Packard Company Manufacturing method and apparatus for biological probe arrays using vision-assisted micropipetting
JPH08233710A (ja) * 1995-02-24 1996-09-13 Hitachi Ltd 試料調製装置
US5551487A (en) 1995-03-10 1996-09-03 Hewlett-Packard Company Micro-dispenser for preparing assay plates
US5849598A (en) 1996-03-15 1998-12-15 Washington University Method for transferring micro quantities of liquid samples to discrete locations
US5958342A (en) * 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
US5770151A (en) 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
DE19628178C1 (de) * 1996-07-12 1997-09-18 Bruker Franzen Analytik Gmbh Verfahren zum Beladen von Probenträgern für Massenspektrometer
US5772966A (en) 1997-01-24 1998-06-30 Maracas; George N. Assay dispensing apparatus

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WO1999022867A1 (en) 1999-05-14
DE69804653D1 (de) 2002-05-08
DE69804653T2 (de) 2002-11-28
AU748226B2 (en) 2002-05-30
JP4564165B2 (ja) 2010-10-20
EP1027159B1 (de) 2002-04-03
JP2001522033A (ja) 2001-11-13
CA2307141C (en) 2004-01-27
JP2010139512A (ja) 2010-06-24
AU1292099A (en) 1999-05-24
EP1027159A1 (de) 2000-08-16
US6228659B1 (en) 2001-05-08
CA2307141A1 (en) 1999-05-14

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