ATE214287T1 - Verwendung von relaxin zur herstellung eines arzneimittels für die behandlung kardiovaskulären krankeiten. - Google Patents

Verwendung von relaxin zur herstellung eines arzneimittels für die behandlung kardiovaskulären krankeiten.

Info

Publication number
ATE214287T1
ATE214287T1 AT92918862T AT92918862T ATE214287T1 AT E214287 T1 ATE214287 T1 AT E214287T1 AT 92918862 T AT92918862 T AT 92918862T AT 92918862 T AT92918862 T AT 92918862T AT E214287 T1 ATE214287 T1 AT E214287T1
Authority
AT
Austria
Prior art keywords
relaxin
treatment
production
cardiovascular diseases
medicinal product
Prior art date
Application number
AT92918862T
Other languages
English (en)
Inventor
Michael Cronin
Phyllis L Osheroff
G Roger Thomas
David G Ward
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/747,080 external-priority patent/US5166191A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE214287T1 publication Critical patent/ATE214287T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
AT92918862T 1991-08-19 1992-08-18 Verwendung von relaxin zur herstellung eines arzneimittels für die behandlung kardiovaskulären krankeiten. ATE214287T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/747,080 US5166191A (en) 1991-08-19 1991-08-19 Use of relaxin in cardiovascular therapy
US07/902,637 US5478807A (en) 1991-08-19 1992-06-23 Use of relaxin in the treatment of bradycardia
PCT/US1992/006927 WO1993003755A2 (en) 1991-08-19 1992-08-18 Use of relaxin in cardiovascular therapy and in the treatment of neurodegenerative diseases

Publications (1)

Publication Number Publication Date
ATE214287T1 true ATE214287T1 (de) 2002-03-15

Family

ID=27114692

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92918862T ATE214287T1 (de) 1991-08-19 1992-08-18 Verwendung von relaxin zur herstellung eines arzneimittels für die behandlung kardiovaskulären krankeiten.

Country Status (11)

Country Link
US (1) US5478807A (de)
EP (1) EP0600010B1 (de)
JP (1) JP3747058B2 (de)
AT (1) ATE214287T1 (de)
AU (1) AU662923B2 (de)
CA (1) CA2114250C (de)
DE (1) DE69232485T2 (de)
DK (1) DK0600010T3 (de)
ES (1) ES2173868T3 (de)
NZ (1) NZ243970A (de)
WO (1) WO1993003755A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2145515A1 (en) * 1993-07-27 1995-02-09 Mario Bigazzi Use of relaxin as therapeutic or preventing agent
US7069634B1 (en) 1995-04-28 2006-07-04 Medtronic, Inc. Method for manufacturing a catheter
US5911997A (en) * 1995-06-07 1999-06-15 Connetics Corporation Relaxin-like factor and methods and uses thereof
US5811395A (en) * 1995-06-07 1998-09-22 Medical University Of South Carolina Relaxin analogs and derivatives methods and uses thereof
ATE228004T1 (de) 1995-08-15 2002-12-15 Connetics Corp Verwendung von relaxin zur stimulierung der angiogenese
US5612051A (en) * 1995-11-17 1997-03-18 Yue; Samuel K. Method of treating involuntary muscle dysfunction with relaxin hormone
US5846220A (en) 1996-04-30 1998-12-08 Medtronic, Inc. Therapeutic method for treatment of Alzheimer's disease
US7189222B2 (en) 1996-04-30 2007-03-13 Medtronic, Inc. Therapeutic method of treatment of alzheimer's disease
US6627746B1 (en) 1998-04-17 2003-09-30 Exelixis, Inc. Nucleic acids and proteins of C. elegans insulin-like genes and uses thereof
US6251863B1 (en) 1998-09-08 2001-06-26 Samuel K. Yue Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin
US6266554B1 (en) 1999-02-12 2001-07-24 Cardiac Pacemakers, Inc. System and method for classifying cardiac complexes
US6308095B1 (en) 1999-02-12 2001-10-23 Cardiac Pacemakers, Inc. System and method for arrhythmia discrimination
US6312388B1 (en) 1999-03-12 2001-11-06 Cardiac Pacemakers, Inc. Method and system for verifying the integrity of normal sinus rhythm templates
US6223078B1 (en) 1999-03-12 2001-04-24 Cardiac Pacemakers, Inc. Discrimination of supraventricular tachycardia and ventricular tachycardia events
US6449503B1 (en) * 1999-07-14 2002-09-10 Cardiac Pacemakers, Inc. Classification of supraventricular and ventricular cardiac rhythms using cross channel timing algorithm
US6684100B1 (en) 2000-10-31 2004-01-27 Cardiac Pacemakers, Inc. Curvature based method for selecting features from an electrophysiologic signals for purpose of complex identification and classification
DE10155843A1 (de) * 2000-11-16 2003-01-30 Immundiagnostik Ag Verfahren zur Prognose und Diagnose von Herzinsuffizienz
US20040006205A1 (en) * 2001-04-03 2004-01-08 Li Li Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US6526313B2 (en) 2001-06-05 2003-02-25 Cardiac Pacemakers, Inc. System and method for classifying cardiac depolarization complexes with multi-dimensional correlation
AUPR814401A0 (en) 2001-10-08 2001-11-01 Howard Florey Institute Of Experimental Physiology And Medicine Human 3 relaxin
US6950702B2 (en) 2002-07-15 2005-09-27 Cardiac Pacemakers, Inc. Use of curvature based features for beat detection
US7792571B2 (en) 2003-06-27 2010-09-07 Cardiac Pacemakers, Inc. Tachyarrhythmia detection and discrimination based on curvature parameters
US7878978B2 (en) * 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
JP5502274B2 (ja) * 2004-03-19 2014-05-28 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 動脈コンプライアンスを増加させるためのレラキシンの使用
US7430446B2 (en) 2005-01-20 2008-09-30 Cardiac Pacemakers, Inc. Methods and apparatuses for cardiac arrhythmia classification using morphology stability
CN101189019A (zh) * 2005-04-26 2008-05-28 卫材R&D管理有限公司 具有抗焦虑作用的肽及其筛选方法
US20060264367A1 (en) * 2005-05-21 2006-11-23 Howard Florey Institute Prevention of fibrosis following cardiac injury
US9314210B2 (en) 2005-06-13 2016-04-19 Cardiac Pacemakers, Inc. Method and apparatus for rate-dependent morphology-based cardiac arrhythmia classification
US8048419B2 (en) 2006-02-02 2011-11-01 Innovative Biotherapies, Inc. Extracorporeal cell-based therapeutic device and delivery system
AU2009246114B2 (en) 2008-05-16 2013-01-31 Corthera, Inc. Treating dyspnea associated with acute heart failure with relaxin
CA2728215A1 (en) 2008-06-18 2010-06-24 Innovative Biotherapies, Inc. Methods for enhanced propagation of cells
US9653006B2 (en) 2008-09-17 2017-05-16 Avery Dennison Corporation Activatable adhesive, labels, and related methods
KR101879190B1 (ko) 2009-09-17 2018-07-17 애버리 데니슨 코포레이션 활성화 가능 접착제, 라벨, 및 관련 방법
WO2024047130A1 (en) 2022-08-31 2024-03-07 Relaxera Pharmazeutische Gesellschaft mbH & Co. KG Immunosuppressive medicament and method of treatment

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656249A (en) * 1982-06-10 1987-04-07 Howard Florey Institute Of Experimental Physiology And Medicine Peptides with relaxin activity
IL69469A (en) * 1982-08-12 1991-06-10 Florey Howard Inst Polypeptide having human h1-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
AU562962B2 (en) * 1982-08-12 1987-06-25 Howard Florey Institute Of Experimental Physiology And Medicine Molecular cloning and characterisation of the gene sequence coding for human relaxin
DE3236264A1 (de) * 1982-09-30 1984-04-05 Serono Pharmazeutische Präparate GmbH, 7800 Freiburg Verfahren zur gewinnung von relaxin
DE3236267A1 (de) * 1982-09-30 1984-04-05 Serono Pharmazeutische Präparate GmbH, 7800 Freiburg Verfahren zur herstellung von relaxin und verfahren zur hochreinigung von relaxin
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
IL70414A (en) * 1982-12-13 1991-06-10 Florey Howard Inst Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
AU562713B2 (en) * 1982-12-13 1987-06-18 Howard Florey Institute Of Experimental Physiology And Medicine Cloning for human relaxin
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
WO1989007945A1 (en) * 1988-02-26 1989-09-08 Genentech, Inc. Human relaxin formulation
JP2857684B2 (ja) * 1989-05-04 1999-02-17 ジェネンテク，インコーポレイテッド ヒトリラキシンの単離のための方法および組成物
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy

Also Published As

Publication number Publication date
ES2173868T3 (es) 2002-11-01
EP0600010A1 (de) 1994-06-08
NZ243970A (en) 1997-06-24
DE69232485T2 (de) 2002-11-21
DE69232485D1 (de) 2002-04-18
WO1993003755A3 (en) 1993-04-01
CA2114250A1 (en) 1993-03-04
JPH06510045A (ja) 1994-11-10
US5478807A (en) 1995-12-26
DK0600010T3 (da) 2002-07-01
JP3747058B2 (ja) 2006-02-22
CA2114250C (en) 2007-10-16
WO1993003755A2 (en) 1993-03-04
AU2518692A (en) 1993-03-16
AU662923B2 (en) 1995-09-21
EP0600010B1 (de) 2002-03-13

Similar Documents

Publication Publication Date Title
ATE214287T1 (de) Verwendung von relaxin zur herstellung eines arzneimittels für die behandlung kardiovaskulären krankeiten.
ATE332702T1 (de) Verwendung von glu-trp dipeptiden zur herstellung eines arzneimittels zur behandlung von verschiedenen gefässneubildung-assozierten erkrankungen
DE69434431D1 (de) Methoden zur behandlung von muskelerkrankungen und muskelstörungen
ATE136030T1 (de) Azaheterocyclylmethyl-chromane als wirkstoffe zur behandlung von erkrankungen des zentralnervensystems
WO2002058684A3 (en) Combinations of drugs (e.g., chlorpromazine and pentamidine) for the treatment of neoplastic disorders
DE69602424D1 (de) Verwendung von carbazolverbindungen zur herstellung eines arzneimittels für die behandlung von kongestivem herzversagen
ATE206919T1 (de) Verwendung des wirkstoffs flupirtin zur herstellung eines arzneimittels zur bekämpfung von muskelverspannungen
ATE192923T1 (de) Verwendung von boswelliasäure zur behandlung von hirntumoren
DE69423577T2 (de) Verwendung von Oenothein B zur Herstellung eines Medikaments zur Behandlung der durch Hyperandrogenität bedingte Störungen.
DE69621786T2 (de) Aminotetralinderivat zur behandlung von herzkreislauferkrankung
DE68905657T2 (de) Verwendung von arginin-aspartat zur herstellung eines arzneimittels zur behandlung gewisser gedaechtnisstoerungen.
ATE235237T1 (de) Sertralin zur behandlung von post-myocard-infarkt-patienten
ATE234613T1 (de) Verwendung von comt inhibitoren zur herstellung eines arzneimittels zur vorbeugung von diabetischen vaskulären funktionsstörungen
DE69620786D1 (de) Verwendung von cholinesterase-inhibitoren für die herstellung eines medikaments zur behandlung von xerostomie
DE3873210T2 (de) Verwendung von benzylpyridin-derivaten zur herstellung eines arzneimittels zur behandlung der demenz.
DE69915848D1 (de) Verwendung von neohesperidin dc zur herstellung eines medikaments zur vorbeugung bzw. behandlung von krankheiten aufgrund erhoehter blutfettwerte
DE3578374D1 (de) Verwendung von chinolonen fuer die herstellung eines arzneimittels zur behandlung von herzerkrankungen.
DE3483944D1 (de) Verwendung von selektiv peripheren dopamin-antagonisten zur herstellung eines arzneimittels zur topischen behandlung von okularer hypertension.
DE69701258T2 (de) Verwendung von benzonaphtalene-derivaten zur herstellung eines arzneimittels zur behandlung von krankheiten des nervensystems
ATE320263T1 (de) Verwendung von menschliche protein c zur herstellung eines arzneimittels zur behandlung von heparininduzierter thrombozytopenie
DE69428797D1 (de) Verwendung von benzydamin zur behandlung von krankheitszuständen, die durch tnf verursacht werden
DE69427927T2 (de) Verwendung von Trimetazidin zur Herstellung von Medikamenten für die Behandlung von Gesundheitsstörungen, die durch die Nephrotoxizität von Cyclosporin A bedingt sind.
ATE56360T1 (de) Zusammensetzung zur herstellung eines arzneimittels zur therapeutischen behandlung von hauttrauma.
DE69223811T2 (de) Verwendung eines homöopathisches Erzeugnisses zur Herstellung eines Arzneimittels für die Behandlung von metabolischen Krankheiten
DE500713T1 (de) Derivate des 3,3,5-trimethylcyclohexylesters von 2-methylpropionsaeure, ihr herstellungsverfahren sowie diese enthaltende therapeutische kompositionen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0600010

Country of ref document: EP