DE60123105D1 - Verfahren zur Herstellung von 4'-O-substituierten 4'-Demethyl-1 desoxypodophyllotoxinderivaten und geometrischen Isomeren davon ,und Antikrebspräparat, das diese enthält - Google Patents

Verfahren zur Herstellung von 4'-O-substituierten 4'-Demethyl-1 desoxypodophyllotoxinderivaten und geometrischen Isomeren davon ,und Antikrebspräparat, das diese enthält

Info

Publication number
DE60123105D1
DE60123105D1 DE60123105T DE60123105T DE60123105D1 DE 60123105 D1 DE60123105 D1 DE 60123105D1 DE 60123105 T DE60123105 T DE 60123105T DE 60123105 T DE60123105 T DE 60123105T DE 60123105 D1 DE60123105 D1 DE 60123105D1
Authority
DE
Germany
Prior art keywords
demethyl
substituted
deoxypodophyllotoxin
same
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60123105T
Other languages
English (en)
Other versions
DE60123105T2 (de
Inventor
Song-Bae Kim
Byung-Zun Ahn
Yong Kim
Young-Jae You
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR10-2001-0040806A external-priority patent/KR100433679B1/ko
Application filed by Individual filed Critical Individual
Publication of DE60123105D1 publication Critical patent/DE60123105D1/de
Application granted granted Critical
Publication of DE60123105T2 publication Critical patent/DE60123105T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60123105T 2000-11-20 2001-11-19 Verfahren zur Herstellung von 4'-O-substituierten 4'-Demethyl-1 desoxypodophyllotoxinderivaten und geometrischen Isomeren davon ,und Antikrebspräparat, das diese enthält Expired - Fee Related DE60123105T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR20000069004 2000-11-20
KR2000069004 2000-11-20
KR10-2001-0040806A KR100433679B1 (ko) 2000-11-20 2001-07-09 신규의 4'-데메틸-4'-ｏ-치환-1-데옥시포도필로톡신유도체 및 그의 기하 이성체, 그의 제조방법 및 그를포함하는 항암제
KR2001040806 2001-07-09
PCT/KR2001/001972 WO2002040489A1 (en) 2000-11-20 2001-11-19 Novel 4'-demethyl-4'-o-substituted-1-deoxypodophyllotoxin derivative and geometric isomer thereof, process for the preparation thereof and anti-cancer composition comprising the same

Publications (2)

Publication Number Publication Date
DE60123105D1 true DE60123105D1 (de) 2006-10-26
DE60123105T2 DE60123105T2 (de) 2007-04-26

Family

ID=26638551

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60123105T Expired - Fee Related DE60123105T2 (de) 2000-11-20 2001-11-19 Verfahren zur Herstellung von 4'-O-substituierten 4'-Demethyl-1 desoxypodophyllotoxinderivaten und geometrischen Isomeren davon ,und Antikrebspräparat, das diese enthält

Country Status (10)

Country Link
US (1) US6894075B2 (de)
EP (1) EP1335922B1 (de)
JP (1) JP4024148B2 (de)
CN (1) CN1256336C (de)
AT (1) ATE339423T1 (de)
AU (1) AU2002222695A1 (de)
DE (1) DE60123105T2 (de)
DK (1) DK1335922T3 (de)
ES (1) ES2271120T3 (de)
WO (1) WO2002040489A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102168D0 (sv) 2001-06-19 2001-06-19 Karolinska Innovations Ab New use and new compounds
MX2013000250A (es) 2010-07-02 2013-10-28 Angiochem Inc Polipeptidos cortos y que contienen d-aminoacido para conjugados terapeuticos y usos de los mismos.
CN102070645B (zh) * 2011-01-07 2015-04-22 兰州大学 一种脱氧鬼臼毒素类化合物及其制备与应用
CN102260273B (zh) * 2011-05-13 2015-04-22 兰州大学 脱氧鬼臼与5-氟尿嘧啶的拼合物及其制备与用途
CN103214495A (zh) * 2013-03-29 2013-07-24 西南交通大学 抗癌用4’-去甲基-4’-氧-环丁甲酰基-去氧鬼臼毒及其制备方法
KR102378151B1 (ko) * 2020-05-11 2022-03-24 주식회사 제이앤씨사이언스 베타-아포피크로포도필린의 신규한 유도체

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH454169A (de) * 1964-08-12 1968-04-15 Sandoz Ag Verfahren zur Herstellung von neuen Podophyllotoxin-Derivaten
IL119749A (en) * 1995-12-04 2001-03-19 Nippon Kayaku Kk Process for producing etoposide
US6051721A (en) * 1997-10-02 2000-04-18 The Board Of Regents Of The University Of Nebraska Ring E-modified analogues of(-)-podophyllotoxin and etoposide and a method for their synthesis

Also Published As

Publication number Publication date
EP1335922A1 (de) 2003-08-20
ATE339423T1 (de) 2006-10-15
CN1474822A (zh) 2004-02-11
JP4024148B2 (ja) 2007-12-19
ES2271120T3 (es) 2007-04-16
US20040044058A1 (en) 2004-03-04
EP1335922B1 (de) 2006-09-13
DE60123105T2 (de) 2007-04-26
EP1335922A4 (de) 2004-08-11
JP2004513949A (ja) 2004-05-13
DK1335922T3 (da) 2007-01-15
CN1256336C (zh) 2006-05-17
WO2002040489A1 (en) 2002-05-23
US6894075B2 (en) 2005-05-17
AU2002222695A1 (en) 2002-05-27

Similar Documents

Publication Publication Date Title
EE200000318A (et) Uudsed ühendid
SE9901875D0 (sv) Novel compounds
DE60021381D1 (de) Chinonverbindungen zur behandlung von krankheiten
DE69229339D1 (de) Kristallines tiagabinehydrochlorid-monohydrat, seine herstellung und verwendung
DE60239842D1 (de) Verfahren zur Herstellung von 10,11-dihydro-10-oxo-5h-dibenzoÄb,fÜazepin-5-carboxamid
DE60123105D1 (de) Verfahren zur Herstellung von 4'-O-substituierten 4'-Demethyl-1 desoxypodophyllotoxinderivaten und geometrischen Isomeren davon ,und Antikrebspräparat, das diese enthält
DE10085452T1 (de) Verfahren zur Herstellung von 1,1,1,2-Tetrafluorethan
DE59907526D1 (de) Verfahren zur Herstellung von 3-Cyano-3,5,5-trimethyl-cyclohexanon
ATE393624T1 (de) Verwendung von sesquiterpene enthaltenden zusammenstellungen zur behandlung von krebs
DE59200298D1 (de) Verfahren zur Herstellung von 2,4-Dichlorfluorbenzol.
DE60222806D1 (de) Verfahren zur herstellung von (1,4,5)-oxadiazepinderivaten
DE69205601D1 (de) Verfahren zur Herstellung von 3-Cyano-3,5,5-trimethylcyclohexanon.
DE69009394D1 (de) Verfahren zur Herstellung von 3-Cyano-3,5,5-trimethyl-1-cyclohexanon.
ATE299851T1 (de) Verfahren zur herstellung von zwischenprodukten
DE60104789D1 (de) Verfahren zur Herstellung von 2,4,5-Trialkylbenzaldehyden
DE60004931D1 (de) Kontinuierliches Verfahren zur Herstellung von 3,5,5-Trimethylcyclohexa-3-en-1-on(beta-Isophoron)
BR0017091A (pt) Uso de um composto, composição perfumante ou produto perfumado, composição aromatizante ou produto aromatizado, e, processo para conferir, aperfeiçoar, aumentar ou modificar as propriedades aromatizantes do tipo mandarina ou tangerina de uma composição aromatizante ou de um produto aromatizado
DE59802620D1 (de) Verfahren zur Herstellung von trans-(R,R)-Actinol
ID27733A (id) Metoksiminofenilasetamida
ATE265418T1 (de) Neue substituierte 3-phenoxy- und 3- phenylalkyloxy-2-phenyl-propylamine
DE60230097D1 (de) Verfahren zur herstellung von 1,5-diaminonaphthalinen
DE69018028D1 (de) Verfahren zur Herstellung von 2-substituierten-1,4-Naphtochinonen.
DE59900401D1 (de) Verfahren zur Herstellung von 1,3-Dimethyl-imidazolium-4-carboxylat
DE69802329D1 (de) Verfahren zur Herstellung von 3,4 disubstituirten Dinitroanilinen
DE60143350D1 (de) Verfahren zur herstellung von 1,3-dialkyl-2-imidazolidinon-derivaten

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee