ATE210656T1 - Heterocyclische ether-derivate zur verstärkung der cognitiven funktionen - Google Patents
Heterocyclische ether-derivate zur verstärkung der cognitiven funktionenInfo
- Publication number
- ATE210656T1 ATE210656T1 AT93923826T AT93923826T ATE210656T1 AT E210656 T1 ATE210656 T1 AT E210656T1 AT 93923826 T AT93923826 T AT 93923826T AT 93923826 T AT93923826 T AT 93923826T AT E210656 T1 ATE210656 T1 AT E210656T1
- Authority
- AT
- Austria
- Prior art keywords
- heterocyclic ether
- ether derivatives
- cognitive functions
- enhance cognitive
- cholinergic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95900592A | 1992-10-09 | 1992-10-09 | |
PCT/US1993/009662 WO1994008992A1 (en) | 1992-10-09 | 1993-10-08 | Heterocyclic ether compounds that enhance cognitive function |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE210656T1 true ATE210656T1 (de) | 2001-12-15 |
Family
ID=25501548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93923826T ATE210656T1 (de) | 1992-10-09 | 1993-10-08 | Heterocyclische ether-derivate zur verstärkung der cognitiven funktionen |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0663912B1 (de) |
JP (1) | JP3098035B2 (de) |
KR (1) | KR100311546B1 (de) |
AT (1) | ATE210656T1 (de) |
AU (1) | AU687017B2 (de) |
CA (1) | CA2136075C (de) |
DE (1) | DE69331329T2 (de) |
DK (1) | DK0663912T3 (de) |
ES (1) | ES2169727T3 (de) |
IL (1) | IL107184A (de) |
PT (1) | PT663912E (de) |
WO (1) | WO1994008992A1 (de) |
Families Citing this family (73)
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US5948793A (en) * | 1992-10-09 | 1999-09-07 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release |
US5852041A (en) * | 1993-04-07 | 1998-12-22 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acethylcholine receptors |
US5605908A (en) * | 1994-10-24 | 1997-02-25 | Eli Lilly And Company | Heterocyclic compounds and their use |
US5998404A (en) * | 1994-10-24 | 1999-12-07 | Eli Lilly And Company | Heterocyclic compounds and their use |
US5585388A (en) * | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
IL118279A (en) * | 1995-06-07 | 2006-10-05 | Abbott Lab | Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission |
WO1997017955A1 (en) * | 1995-11-13 | 1997-05-22 | Eli Lilly And Company | Method for treating anxiety |
US5794887A (en) | 1995-11-17 | 1998-08-18 | Komerath; Narayanan M. | Stagnation point vortex controller |
US6979695B2 (en) | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
US6437138B1 (en) | 1996-06-06 | 2002-08-20 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
ES2189003T3 (es) * | 1996-12-10 | 2003-07-01 | Abbott Lab | Enantiomeros 3-piridilo y su utilizacion como analgesicos. |
US6133253A (en) * | 1996-12-10 | 2000-10-17 | Abbott Laboratories | 3-Pyridyl enantiomers and their use as analgesics |
CA2287223A1 (en) * | 1997-04-26 | 1998-11-05 | Tomohiro Toyoda | 2-azabicyclo compounds |
US7214686B2 (en) | 1997-06-30 | 2007-05-08 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
US6525065B1 (en) | 1997-06-30 | 2003-02-25 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
US6624173B1 (en) | 1997-06-30 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions for treating and/or preventing CNS disorders |
EP1034174B1 (de) | 1997-11-05 | 2003-08-13 | Neurosearch A/S | Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren |
EP1047690B1 (de) * | 1997-12-19 | 2004-03-24 | Abbott Laboratories | Heterozyklische ether- und thioether-verbindungen, verwendbar zur steuerung von chemischer synaptischer transmission |
ES2199561T3 (es) * | 1998-04-02 | 2004-02-16 | Targacept, Inc. | Derivados de azatriciclo(3.3.1.1)decano y composiciones farmaceuticas que los contienen. |
KR20010052171A (ko) | 1998-04-02 | 2001-06-25 | 알. 제이. 레이놀즈 터베코 컴퍼니 | 의약 조성물 및 그 사용방법 |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
US6432975B1 (en) | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
US20010031771A1 (en) | 1999-05-24 | 2001-10-18 | Gary Maurice Dull | Pharmaceutical compositions and methods for use |
US6544976B1 (en) | 1999-07-09 | 2003-04-08 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods |
CA2381252A1 (en) * | 1999-09-14 | 2001-03-22 | Abbott Laboratories | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
US6890935B2 (en) | 1999-11-01 | 2005-05-10 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
US6812314B2 (en) | 2001-10-17 | 2004-11-02 | University Of Florida | Thermally responsive polymer materials and uses thereof |
PL374384A1 (en) | 2001-12-14 | 2005-10-17 | Targacept, Inc. | Methods and compositions for treatment of central nervous system disorders |
AU2003245753B2 (en) | 2002-07-05 | 2009-12-24 | Targacept, Inc. | N-aryl diazaspiracyclic compounds and methods of preparation and use thereof |
WO2004009775A2 (en) | 2002-07-19 | 2004-01-29 | Targacept, Inc. | Methods and compositions relating to chimeric nicotinic receptor subunits |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
US7098331B2 (en) | 2003-03-05 | 2006-08-29 | Targacept, Inc. | Arylvinylazacycloalkane compounds and methods of preparation and use thereof |
AU2004282201A1 (en) | 2003-10-15 | 2005-04-28 | Targacept, Inc. | Azabicycyclic compounds for relieving pain and treating central nervous system disorders |
AR049401A1 (es) | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
EP1802258A4 (de) | 2004-09-13 | 2015-09-23 | Chrono Therapeutics Inc | Biosynchrone transdermale arzneiabgabe |
JP2008513482A (ja) | 2004-09-20 | 2008-05-01 | ターガセプト,インコーポレイテッド | ニコチン性コリン作動性受容体活性を有するアザスピロアルケンおよびアザピロアルカン |
US7459469B2 (en) | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
UA88792C2 (ru) | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
DE602006017235D1 (de) | 2005-08-22 | 2010-11-11 | Targacept Inc | Heteroarylsubstituierte diazatricycloalkane, verfahren zu deren herstellung und deren anwendung |
GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
TWI389889B (zh) | 2006-05-09 | 2013-03-21 | Targacept Inc | (2s)-(4e)-n-甲基-5-〔3-(5-異丙氧基吡啶)基〕-4-戊烯-2-胺之新穎多晶型 |
CN101528698A (zh) | 2006-05-09 | 2009-09-09 | 阿斯利康公司 | (2s)-(4e)-n-甲基-5-[3-(5-异丙氧基吡啶)基]-4-戊烯-2-胺的盐形式 |
TWI405763B (zh) | 2006-11-02 | 2013-08-21 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
JP2010511014A (ja) * | 2006-11-29 | 2010-04-08 | ビーエーエスエフ ソシエタス・ヨーロピア | 害虫を駆除するためのピリジン化合物 |
US20100028447A1 (en) | 2007-01-22 | 2010-02-04 | Targacept, Inc. | Intranasal, Buccal, And Sublingual Administration Of Metanicotine Analogs |
TW200845977A (en) | 2007-03-30 | 2008-12-01 | Targacept Inc | Sub-type selective azabicycloalkane derivatives |
GB2448224B (en) | 2007-04-02 | 2010-09-01 | Parkinson S Inst | Solid orally administered pharmaceutical composition for the reduction of side-effects of a dopaminergic agent |
SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
US8114891B2 (en) | 2007-10-01 | 2012-02-14 | Comentis, Inc. | 4-substituted quinuclidine derivatives, methods of production, pharmaceutical uses thereof |
KR20110091501A (ko) * | 2008-10-14 | 2011-08-11 | 싸이코제닉스 아이엔씨. | 니코틴성 아세틸콜린 수용체 리간드 및 이들의 용도 |
TW201024283A (en) | 2008-12-01 | 2010-07-01 | Targacept Inc | Synthesis and novel salt forms of (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine |
EP3279195B1 (de) | 2008-12-01 | 2020-07-01 | Oyster Point Pharma, Inc. | Synthese und neuartige salzformen von (r)-5-((e)-2-pyrrolidin-3-ylvinyl)pyrimidin |
US9145396B2 (en) | 2008-12-01 | 2015-09-29 | Targacept, Inc. | Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine |
WO2010080757A2 (en) | 2009-01-07 | 2010-07-15 | Astrazeneca Ab | Combinations with an alpha-4beta-2 nicotinic agonist |
TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
JP2013512922A (ja) | 2009-12-07 | 2013-04-18 | ターガセプト,インコーポレイテッド | 神経型ニコチン性アセチルコリン受容体リガンドとしての3,6−ジアザビシクロ[3.1.1]ヘプタン |
WO2011146009A1 (en) | 2010-05-20 | 2011-11-24 | Targacept Inc. | New process for the preparation of aryl substituted olefinic amines |
PL2576496T3 (pl) | 2010-05-27 | 2017-08-31 | Catalyst Biosciences, Inc. | Niekompetycyjni antagoniści receptorów nikotynowych |
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WO2012129262A1 (en) | 2011-03-23 | 2012-09-27 | Targacept, Inc. | Treatment of attention deficit/hyperactivity disease |
TW201311698A (zh) | 2011-08-22 | 2013-03-16 | Targacept Inc | 作為神經元菸鹼乙醯膽鹼受體配位體之1,4-二氮雜雙環[3.2.2]壬烷 |
US9303017B2 (en) | 2011-11-11 | 2016-04-05 | Georgetown University | 2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof |
TW201617342A (zh) | 2014-07-11 | 2016-05-16 | 阿法馬根公司 | 調節α7活性之啶類 |
US10213586B2 (en) | 2015-01-28 | 2019-02-26 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
US9724340B2 (en) | 2015-07-31 | 2017-08-08 | Attenua, Inc. | Antitussive compositions and methods |
CN105418477B (zh) * | 2015-12-22 | 2018-12-21 | 爱斯特(成都)生物制药股份有限公司 | 降低雷迪帕韦中间体中非对映异构体杂质含量的方法 |
WO2018129304A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
AU2019279884A1 (en) | 2018-05-29 | 2020-12-10 | Morningside Venture Investments Limited | Drug delivery methods and systems |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA848275B (en) * | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
CA1307790C (en) * | 1987-08-04 | 1992-09-22 | Ian Anthony Cliffe | Ethers |
YU84791A (sh) * | 1990-05-19 | 1994-06-10 | Boehringer Ingelheim Kg. | Biciklicni 1-aza-cikloalkalni |
-
1993
- 1993-10-04 IL IL10718493A patent/IL107184A/xx not_active IP Right Cessation
- 1993-10-08 CA CA002136075A patent/CA2136075C/en not_active Expired - Fee Related
- 1993-10-08 EP EP93923826A patent/EP0663912B1/de not_active Expired - Lifetime
- 1993-10-08 DE DE69331329T patent/DE69331329T2/de not_active Expired - Lifetime
- 1993-10-08 PT PT93923826T patent/PT663912E/pt unknown
- 1993-10-08 ES ES93923826T patent/ES2169727T3/es not_active Expired - Lifetime
- 1993-10-08 AU AU53557/94A patent/AU687017B2/en not_active Ceased
- 1993-10-08 WO PCT/US1993/009662 patent/WO1994008992A1/en active IP Right Grant
- 1993-10-08 AT AT93923826T patent/ATE210656T1/de active
- 1993-10-08 JP JP06510167A patent/JP3098035B2/ja not_active Expired - Fee Related
- 1993-10-08 DK DK93923826T patent/DK0663912T3/da active
- 1993-10-08 KR KR1019940704340A patent/KR100311546B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1994008992A1 (en) | 1994-04-28 |
EP0663912A4 (de) | 1995-02-17 |
CA2136075A1 (en) | 1994-04-28 |
IL107184A0 (en) | 1994-01-25 |
EP0663912B1 (de) | 2001-12-12 |
DE69331329D1 (de) | 2002-01-24 |
EP0663912A1 (de) | 1995-07-26 |
AU687017B2 (en) | 1998-02-19 |
KR950701920A (ko) | 1995-05-17 |
PT663912E (pt) | 2002-06-28 |
CA2136075C (en) | 2004-12-14 |
DK0663912T3 (da) | 2002-04-15 |
AU5355794A (en) | 1994-05-09 |
JPH08502481A (ja) | 1996-03-19 |
JP3098035B2 (ja) | 2000-10-10 |
IL107184A (en) | 1997-08-14 |
KR100311546B1 (ko) | 2005-12-06 |
DE69331329T2 (de) | 2002-08-08 |
ES2169727T3 (es) | 2002-07-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |