ATE21031T1 - Medizinische zusammensetzungen, die als aktives bestandteil substituierte 1,4-benzochinone enthalten. - Google Patents

Medizinische zusammensetzungen, die als aktives bestandteil substituierte 1,4-benzochinone enthalten.

Info

Publication number
ATE21031T1
ATE21031T1 AT80304729T AT80304729T ATE21031T1 AT E21031 T1 ATE21031 T1 AT E21031T1 AT 80304729 T AT80304729 T AT 80304729T AT 80304729 T AT80304729 T AT 80304729T AT E21031 T1 ATE21031 T1 AT E21031T1
Authority
AT
Austria
Prior art keywords
benzochinone
active ingredient
compositions containing
medicinal compositions
containing substituted
Prior art date
Application number
AT80304729T
Other languages
German (de)
English (en)
Inventor
Isuke Imada
Akinobu Nagaoka
Minoru Hirata
Tetsuya Okutani
Giichi Goto
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE21031T1 publication Critical patent/ATE21031T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C07C46/08—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring with molecular oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
AT80304729T 1979-12-30 1980-12-29 Medizinische zusammensetzungen, die als aktives bestandteil substituierte 1,4-benzochinone enthalten. ATE21031T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17112579A JPS5697223A (en) 1979-12-30 1979-12-30 Tissue metabolism activator
EP80304729A EP0031727B1 (en) 1979-12-30 1980-12-29 Medicinal compositions comprising as an active ingredient substituted 1,4-benzoquinones

Publications (1)

Publication Number Publication Date
ATE21031T1 true ATE21031T1 (de) 1986-08-15

Family

ID=15917438

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80304729T ATE21031T1 (de) 1979-12-30 1980-12-29 Medizinische zusammensetzungen, die als aktives bestandteil substituierte 1,4-benzochinone enthalten.

Country Status (9)

Country Link
US (1) US4436753A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0031727B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5697223A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE21031T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3049039A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK64089A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1144075B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY8700652A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG84688G (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3069496D1 (de) * 1979-06-28 1984-11-29 Takeda Chemical Industries Ltd 2,3-dialkoxy-1,4-quinone derivatives; method of producing 1,4-quinone derivatives
JPS58174313A (ja) * 1982-04-06 1983-10-13 Takeda Chem Ind Ltd 動物組織の線維化抑制剤
US4808339A (en) * 1982-04-13 1989-02-28 Takeda Chemical Industries, Ltd. Benzoquinone derivatives
JPS58177934A (ja) * 1982-04-13 1983-10-18 Takeda Chem Ind Ltd ベンゾキノン誘導体
JPS59204167A (ja) * 1983-05-02 1984-11-19 Takeda Chem Ind Ltd ヒドロキノン誘導体およびその製法
JPS60130515A (ja) * 1983-12-15 1985-07-12 Shiratori Seiyaku Kk 血中２，３−ジホスホグリセリン酸上昇剤
JPS60255749A (ja) * 1984-05-31 1985-12-17 Univ Nagoya キノン誘導体
MX9203040A (es) * 1984-08-01 1992-07-31 Takeda Chemical Industries Ltd Derivados de quinona y composicion farmaceutica que los contiene.
EP0201196B1 (en) * 1985-04-08 1991-07-03 Takeda Chemical Industries, Ltd. Benzoquinone derivatives, their production and use
JP2503571B2 (ja) * 1988-02-26 1996-06-05 武田薬品工業株式会社 脳循環代謝改善剤
JPH08768B2 (ja) * 1989-08-24 1996-01-10 武田薬品工業株式会社 神経成長因子分泌誘導剤
RU1822549C (ru) * 1989-12-06 1996-08-20 Тихоокеанский институт биоорганической химии ДВО АН СССР Полигидрокси-1,4-нафтохиноны, обладающие свойством протектора миокарда при его ишемии и реперфузии
EP0560568A3 (en) * 1992-03-13 1994-06-29 Takeda Chemical Industries Ltd Hydroquinone derivatives and intermediates for production thereof
DK0643775T3 (da) * 1992-05-28 2004-09-06 Ct For Molecular Biology And M Quinonderivater til forbedring af cellebioenergi
EP0788793A1 (en) 1996-02-01 1997-08-13 Takeda Chemical Industries, Ltd. Idebenone for the treatment of dementia
AU8562998A (en) * 1997-08-12 1999-03-01 Takeda Chemical Industries Ltd. Idebenone-containing preparation for percutaneous administration
DE19932197A1 (de) 1999-07-09 2001-01-18 Neudecker Birgit Topisch anzuwendendes Mittel mit schützender und regenerativer Wirkung
US20050152857A1 (en) * 2004-01-08 2005-07-14 Pcr Technology Holdings, Lc Method and preparation for reducing sunburn cell formation in skin
US20050175559A1 (en) * 2004-02-10 2005-08-11 Pcr Technology Holdings, Lc Method and preparation for reducing skin hyperpigmentation
US20050197407A1 (en) * 2004-02-13 2005-09-08 Pcr Technology Holdings, Lc Method and preparation for reducing irritation and/or inflammatory reaction in human skin
CA2589252C (en) 2004-11-25 2012-12-04 Meiji Dairies Corporation Ameliorant for renal insufficiency
EP2564842A1 (en) 2005-06-01 2013-03-06 Edison Pharmaceuticals, Inc. Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
ES2823728T3 (es) * 2005-09-15 2021-05-10 Ptc Therapeutics Inc Variantes de cola de agentes terapéuticos con actividad redox para el tratamiento de enfermedades mitocondriales y otras afecciones y la modulación de biomarcadores de energía
AR053665A1 (es) * 2006-01-23 2007-05-16 Creactivar S A Uso de la mimosina o un derivado de la misma, en el tratamiento de las manifestaciones cutaneas de la psoriasis y de los desordenes cutaneos relacionados con esta y una composicion cosmetica o farmaceutica que la comprende
US9278085B2 (en) 2006-02-22 2016-03-08 Edison Pharmaceuticals, Inc. Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
EP3827815B1 (en) 2008-09-10 2023-09-06 PTC Therapeutics, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
US20100129431A1 (en) * 2008-11-24 2010-05-27 Alpharx Inc. Idebenone composition for the treatment of neurological disorders
WO2011079212A2 (en) * 2009-12-24 2011-06-30 LifeSpan Extension, LLC Methods and compositions for identifying, producing and using plant-derived products modulating cell function and aging
US10017445B2 (en) 2012-07-12 2018-07-10 Concert Pharmaceuticals, Inc. Deuterated idebenone
WO2017106803A1 (en) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5919930B2 (ja) * 1974-05-02 1984-05-09 武田薬品工業株式会社 キノン酸誘導体の製造法
JPS51128932A (en) * 1975-04-30 1976-11-10 Takeda Chem Ind Ltd Organic compounds
DE3069496D1 (de) * 1979-06-28 1984-11-29 Takeda Chemical Industries Ltd 2,3-dialkoxy-1,4-quinone derivatives; method of producing 1,4-quinone derivatives

Also Published As

Publication number Publication date
EP0031727A2 (en) 1981-07-08
MY8700652A (en) 1987-12-31
JPS5697223A (en) 1981-08-05
IT1144075B (it) 1986-10-29
IT8050468A0 (it) 1980-12-24
DE3049039A1 (de) 1981-09-10
SG84688G (en) 1989-04-14
EP0031727B1 (en) 1986-07-30
EP0031727A3 (en) 1981-07-22
JPH0112727B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-03-02
DE3071684D1 (en) 1986-09-04
US4436753A (en) 1984-03-13
HK64089A (en) 1989-08-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time