ATE206114T1 - Benzensulfonamidderivate als bradykinin antagonisten - Google Patents
Benzensulfonamidderivate als bradykinin antagonistenInfo
- Publication number
- ATE206114T1 ATE206114T1 AT96920901T AT96920901T ATE206114T1 AT E206114 T1 ATE206114 T1 AT E206114T1 AT 96920901 T AT96920901 T AT 96920901T AT 96920901 T AT96920901 T AT 96920901T AT E206114 T1 ATE206114 T1 AT E206114T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- nr4r5
- sec
- different
- date
- Prior art date
Links
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 150000008331 benzenesulfonamides Chemical class 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 101800004538 Bradykinin Proteins 0.000 abstract 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
- 102100035792 Kininogen-1 Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9506703A FR2735128B1 (fr) | 1995-06-07 | 1995-06-07 | Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique. |
| PCT/FR1996/000845 WO1996040639A1 (fr) | 1995-06-07 | 1996-06-05 | Derives de benzenesulfonamide comme antagonistes de la bradykinine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE206114T1 true ATE206114T1 (de) | 2001-10-15 |
Family
ID=9479700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96920901T ATE206114T1 (de) | 1995-06-07 | 1996-06-05 | Benzensulfonamidderivate als bradykinin antagonisten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5968951A (de) |
| EP (1) | EP0773932B1 (de) |
| JP (1) | JPH10504840A (de) |
| AT (1) | ATE206114T1 (de) |
| DE (1) | DE69615498T2 (de) |
| DK (1) | DK0773932T3 (de) |
| ES (1) | ES2164896T3 (de) |
| FR (1) | FR2735128B1 (de) |
| PT (1) | PT773932E (de) |
| WO (1) | WO1996040639A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19609827A1 (de) * | 1996-03-13 | 1997-09-18 | Hoechst Ag | Aminoalkyl- und Acylaminoalkylether, Verfahren zu deren Herstellung und ihre Verwendung als Bradykinin-Rezeptorantagonisten |
| FR2751650B1 (fr) * | 1996-07-24 | 1998-10-09 | Fournier Ind & Sante | Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique |
| DE19712960A1 (de) * | 1997-03-27 | 1998-10-01 | Hoechst Ag | Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten |
| FR2765222B1 (fr) | 1997-06-27 | 1999-12-31 | Fournier Ind & Sante | Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique |
| FR2790260B1 (fr) | 1999-02-26 | 2001-05-04 | Fournier Ind & Sante | Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique |
| US7105172B1 (en) | 1999-11-18 | 2006-09-12 | Bolla John D | Treatment of rosacea |
| US6699486B1 (en) | 1999-11-18 | 2004-03-02 | Bolla Corporation | Treatment or prevention of photoaging and skin cancer |
| FR2819254B1 (fr) * | 2001-01-08 | 2003-04-18 | Fournier Lab Sa | Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques |
| FR2822827B1 (fr) * | 2001-03-28 | 2003-05-16 | Sanofi Synthelabo | Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant |
| EP1914236A1 (de) | 2002-04-10 | 2008-04-23 | Ortho-McNeil Pharmaceutical, Inc. | Neue Heteroaryl-Alkylamid-Derivate als Bradykininrezeptormodulatoren |
| EP1501807A1 (de) * | 2002-05-03 | 2005-02-02 | Elan Pharmaceuticals, Inc. | Sulfonylchinoxalonacetamid-derivate als bradykininantagonisten |
| ITMI20021247A1 (it) * | 2002-06-07 | 2003-12-09 | Menarini Ricerche Spa | Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche |
| FR2840897B1 (fr) | 2002-06-14 | 2004-09-10 | Fournier Lab Sa | Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique |
| US20050020591A1 (en) * | 2002-12-13 | 2005-01-27 | Dai-Shi Su | 2-Quinoxalinone derivatives as bradykinin antagonists and novel compounds |
| DK1606288T3 (da) | 2003-03-25 | 2009-10-05 | Fournier Lab Sa | Benzensulfonamidderivater, fremgangsmåde til fremstilling deraf og deres anvendelse til behandling af smerte |
| WO2008144247A1 (en) * | 2007-05-14 | 2008-11-27 | Tyco Healthcare Group Lp | Antimicrobial materials and coatings |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2533821A1 (de) * | 1975-07-29 | 1977-02-17 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| DE3632329A1 (de) * | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
| US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| US5212182A (en) * | 1990-10-03 | 1993-05-18 | American Home Products Corpooration | Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics |
| AU686115B2 (en) * | 1992-11-02 | 1998-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation |
| AU680870B2 (en) * | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
-
1995
- 1995-06-07 FR FR9506703A patent/FR2735128B1/fr not_active Expired - Fee Related
-
1996
- 1996-06-05 AT AT96920901T patent/ATE206114T1/de not_active IP Right Cessation
- 1996-06-05 WO PCT/FR1996/000845 patent/WO1996040639A1/fr not_active Ceased
- 1996-06-05 PT PT96920901T patent/PT773932E/pt unknown
- 1996-06-05 ES ES96920901T patent/ES2164896T3/es not_active Expired - Lifetime
- 1996-06-05 DE DE69615498T patent/DE69615498T2/de not_active Expired - Fee Related
- 1996-06-05 DK DK96920901T patent/DK0773932T3/da active
- 1996-06-05 JP JP9500190A patent/JPH10504840A/ja not_active Ceased
- 1996-06-05 EP EP96920901A patent/EP0773932B1/de not_active Expired - Lifetime
- 1996-06-05 US US08/776,544 patent/US5968951A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5968951A (en) | 1999-10-19 |
| DE69615498T2 (de) | 2002-05-16 |
| JPH10504840A (ja) | 1998-05-12 |
| DK0773932T3 (da) | 2002-01-14 |
| EP0773932A1 (de) | 1997-05-21 |
| EP0773932B1 (de) | 2001-09-26 |
| WO1996040639A1 (fr) | 1996-12-19 |
| FR2735128B1 (fr) | 1997-07-25 |
| DE69615498D1 (de) | 2001-10-31 |
| ES2164896T3 (es) | 2002-03-01 |
| FR2735128A1 (fr) | 1996-12-13 |
| PT773932E (pt) | 2002-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |