ATE201398T1 - Propenon-derivate - Google Patents
Propenon-derivateInfo
- Publication number
- ATE201398T1 ATE201398T1 AT95900905T AT95900905T ATE201398T1 AT E201398 T1 ATE201398 T1 AT E201398T1 AT 95900905 T AT95900905 T AT 95900905T AT 95900905 T AT95900905 T AT 95900905T AT E201398 T1 ATE201398 T1 AT E201398T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- lower alkyl
- represents hydrogen
- halogen
- represent
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000003435 aroyl group Chemical group 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 1
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28809193 | 1993-11-17 | ||
| PCT/JP1994/001934 WO1995014003A1 (en) | 1993-11-17 | 1994-11-16 | Propenone derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE201398T1 true ATE201398T1 (de) | 2001-06-15 |
Family
ID=17725678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95900905T ATE201398T1 (de) | 1993-11-17 | 1994-11-16 | Propenon-derivate |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0680950B1 (de) |
| JP (1) | JP3272727B2 (de) |
| AT (1) | ATE201398T1 (de) |
| CA (1) | CA2153905A1 (de) |
| DE (1) | DE69427283T2 (de) |
| ES (1) | ES2159618T3 (de) |
| WO (1) | WO1995014003A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5952355A (en) * | 1993-11-17 | 1999-09-14 | Kyowa Hakko Kogyo Co., Ltd. | Propenone derivatives |
| WO1996035665A1 (en) * | 1995-05-10 | 1996-11-14 | Kyowa Hakko Kogyo Co., Ltd. | Propenone derivatives |
| BR9607708A (pt) * | 1995-12-01 | 1998-01-13 | Kyowa Hakko Kogyo Kk | Derivado de propenona |
| US6150395A (en) * | 1997-05-30 | 2000-11-21 | The Regents Of The University Of California | Indole-3-carbinol (I3C) derivatives and methods |
| US7528165B2 (en) | 2001-12-13 | 2009-05-05 | National Health Research Institutes | Indole compounds |
| US7632955B2 (en) * | 2001-12-13 | 2009-12-15 | National Health Research Institutes | Indole compounds |
| FR2854399B1 (fr) * | 2003-04-30 | 2006-11-17 | Aventis Pharma Sa | 1-aryl-3-(indol-5-yl)-prop-2-en-1-ones, compositions les contenant et utilisation |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7456289B2 (en) | 2004-12-31 | 2008-11-25 | National Health Research Institutes | Anti-tumor compounds |
| PT1984333E (pt) * | 2006-02-03 | 2012-07-16 | Bionomics Ltd | Benzofuranos, benzotiofenos, benzoselenofenos e indóis substituídos e sua utilização como inibidores da polimerização da tubulina |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| TWI429628B (zh) | 2010-03-29 | 2014-03-11 | Univ Taipei Medical | 吲哚基或吲哚啉基羥肟酸化合物 |
| CN110526854B (zh) * | 2019-07-26 | 2023-12-15 | 宁夏医科大学 | 一种ɑ,β-不饱和酮衍生物、制备方法及作为药物的用途 |
| KR20220046766A (ko) * | 2020-10-08 | 2022-04-15 | 연세대학교 산학협력단 | 암의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2230349A1 (en) * | 1973-05-23 | 1974-12-20 | Delalande Sa | 1-Phenyl-2-methyl-5-methoxy indoles - with e.g. sedative, cardiac analeptic, vasodilator, antihypertensive, analgesic, and antiinflammatory activities |
| US5196446A (en) * | 1990-04-16 | 1993-03-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Certain indole compounds which inhibit EGF receptor tyrosine kinase |
| EP0527181A4 (en) * | 1990-04-16 | 1993-04-07 | Rorer International (Holdings) | Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase |
-
1994
- 1994-11-16 ES ES95900905T patent/ES2159618T3/es not_active Expired - Lifetime
- 1994-11-16 AT AT95900905T patent/ATE201398T1/de not_active IP Right Cessation
- 1994-11-16 CA CA002153905A patent/CA2153905A1/en not_active Abandoned
- 1994-11-16 DE DE69427283T patent/DE69427283T2/de not_active Expired - Fee Related
- 1994-11-16 JP JP51434395A patent/JP3272727B2/ja not_active Expired - Fee Related
- 1994-11-16 EP EP95900905A patent/EP0680950B1/de not_active Expired - Lifetime
- 1994-11-16 WO PCT/JP1994/001934 patent/WO1995014003A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69427283T2 (de) | 2001-09-13 |
| WO1995014003A1 (en) | 1995-05-26 |
| JP3272727B2 (ja) | 2002-04-08 |
| ES2159618T3 (es) | 2001-10-16 |
| EP0680950A4 (de) | 1996-02-28 |
| DE69427283D1 (de) | 2001-06-28 |
| EP0680950B1 (de) | 2001-05-23 |
| EP0680950A1 (de) | 1995-11-08 |
| CA2153905A1 (en) | 1995-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |