ATE199543T1 - Bibphenylamid-derivate als 5-ht1d-antagonisten - Google Patents

Bibphenylamid-derivate als 5-ht1d-antagonisten

Info

Publication number
ATE199543T1
ATE199543T1 AT95929872T AT95929872T ATE199543T1 AT E199543 T1 ATE199543 T1 AT E199543T1 AT 95929872 T AT95929872 T AT 95929872T AT 95929872 T AT95929872 T AT 95929872T AT E199543 T1 ATE199543 T1 AT E199543T1
Authority
AT
Austria
Prior art keywords
6alkyl
independently hydrogen
6alkoxy
pct
hydroxyc1
Prior art date
Application number
AT95929872T
Other languages
English (en)
Inventor
Laramie Mary Gaster
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE199543T1 publication Critical patent/ATE199543T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Lubricants (AREA)
AT95929872T 1994-08-23 1995-08-14 Bibphenylamid-derivate als 5-ht1d-antagonisten ATE199543T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9416972A GB9416972D0 (en) 1994-08-23 1994-08-23 Carbon side chain/indole/indolene
PCT/EP1995/003226 WO1996006079A1 (en) 1994-08-23 1995-08-14 Biphenylamide derivatives as 5ht1d antagonists

Publications (1)

Publication Number Publication Date
ATE199543T1 true ATE199543T1 (de) 2001-03-15

Family

ID=10760239

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95929872T ATE199543T1 (de) 1994-08-23 1995-08-14 Bibphenylamid-derivate als 5-ht1d-antagonisten

Country Status (7)

Country Link
US (1) US5817833A (de)
EP (1) EP0777650B1 (de)
JP (1) JPH10504315A (de)
AT (1) ATE199543T1 (de)
DE (1) DE69520279T2 (de)
GB (1) GB9416972D0 (de)
WO (1) WO1996006079A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9421003D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds
GB9507203D0 (en) * 1995-04-07 1995-05-31 Smithkline Beecham Plc Novel compounds
JPH11511156A (ja) * 1995-08-11 1999-09-28 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ビフェニル（チオ）アミドおよびビフェニルエタン（チオ）オン誘導体、その製造方法ならびに５−ｈｔ▲下１ｄ▼ 受容体拮抗薬としてのその使用
JP2000502051A (ja) * 1995-11-22 2000-02-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５ｈｔ▲下１ｄ▼レセプターアンタゴニストとしての三環系スピロ化合物
GB9707830D0 (en) * 1997-04-18 1997-06-04 Smithkline Beecham Plc Novel compounds
AU2001256733A1 (en) 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
DE10059418A1 (de) * 2000-11-30 2002-06-20 Aventis Pharma Gmbh Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
TW593278B (en) 2001-01-23 2004-06-21 Wyeth Corp 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
US7271180B2 (en) * 2001-01-23 2007-09-18 Wyeth 1-Aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
TW200403223A (en) 2002-02-15 2004-03-01 Glaxo Group Ltd Novel compounds
RU2720237C2 (ru) 2013-11-18 2020-04-28 Форма Терапеутикс, Инк. Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет
ES2860695T3 (es) 2013-11-18 2021-10-05 Forma Therapeutics Inc Composiciones de tetrahidroquinolina como inhibidores de bromodominio BET
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470203A (en) * 1964-02-01 1969-09-30 Merck & Co Inc Intermediates for preparing 1-aroylindole-3-alkanoic acids
GB1306230A (de) * 1969-05-27 1973-02-07
US3860609A (en) * 1969-05-27 1975-01-14 Novo Terapeutisk Labor As 3-aminoalkyloxyindoles
US4059583A (en) * 1975-11-13 1977-11-22 Mcneil Laboratories, Incorporated Substituted indoles
US5481005A (en) * 1990-07-31 1996-01-02 Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
GB9119920D0 (en) * 1991-09-18 1991-10-30 Glaxo Group Ltd Chemical compounds
GB9119932D0 (en) * 1991-09-18 1991-10-30 Glaxo Group Ltd Chemical compounds
DE69417427T2 (de) * 1993-09-03 1999-11-25 Smithkline Beecham Plc Indol- und indolin-derivate als 5ht1d rezeptor antagonisten

Also Published As

Publication number Publication date
DE69520279T2 (de) 2001-10-31
US5817833A (en) 1998-10-06
JPH10504315A (ja) 1998-04-28
DE69520279D1 (de) 2001-04-12
EP0777650A1 (de) 1997-06-11
EP0777650B1 (de) 2001-03-07
GB9416972D0 (en) 1994-10-12
WO1996006079A1 (en) 1996-02-29

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Legal Events

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