ATE199160T1 - Hochaktive vip - antagonisten - Google Patents
Hochaktive vip - antagonistenInfo
- Publication number
- ATE199160T1 ATE199160T1 AT95909489T AT95909489T ATE199160T1 AT E199160 T1 ATE199160 T1 AT E199160T1 AT 95909489 T AT95909489 T AT 95909489T AT 95909489 T AT95909489 T AT 95909489T AT E199160 T1 ATE199160 T1 AT E199160T1
- Authority
- AT
- Austria
- Prior art keywords
- vip
- highly active
- relates
- vip antagonists
- peptides
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 abstract 5
- 102400000015 Vasoactive intestinal peptide Human genes 0.000 abstract 5
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 abstract 5
- 230000000694 effects Effects 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000032823 cell division Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000005062 synaptic transmission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/083—Neurotensin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/194,591 US5565424A (en) | 1994-02-07 | 1994-02-07 | Superactive VIP antagonists |
| PCT/US1995/001496 WO1995021194A1 (en) | 1994-02-07 | 1995-02-06 | Superactive vip antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199160T1 true ATE199160T1 (de) | 2001-02-15 |
Family
ID=22718168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95909489T ATE199160T1 (de) | 1994-02-07 | 1995-02-06 | Hochaktive vip - antagonisten |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5565424A (de) |
| EP (1) | EP0738280B1 (de) |
| JP (1) | JP3588119B2 (de) |
| AT (1) | ATE199160T1 (de) |
| AU (1) | AU697829B2 (de) |
| CA (1) | CA2182795C (de) |
| DE (1) | DE69520092T2 (de) |
| DK (1) | DK0738280T3 (de) |
| ES (1) | ES2155886T3 (de) |
| IL (1) | IL112557A (de) |
| WO (1) | WO1995021194A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US6492330B1 (en) * | 1996-08-16 | 2002-12-10 | National Institute Of Immunology | Antiangiogenic drugs |
| US6156725A (en) * | 1996-08-16 | 2000-12-05 | National Institute Of Immunology | Drug for the treatment of cancer |
| EP0835662B1 (de) * | 1996-10-08 | 2001-11-14 | National Institute of Immunology | Arzneimittel zur Behandlung von Krebs |
| US20020099003A1 (en) * | 1997-10-28 | 2002-07-25 | Wilson Leland F. | Treatment of female sexual dysfunction with vasoactive agents, particularly vasoactive intestinal polypeptide and agonists thereof |
| WO2000023096A2 (en) * | 1998-10-16 | 2000-04-27 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Combination therapy with vip antagonist |
| AU2000263935A1 (en) | 2000-02-18 | 2001-08-27 | Dabur Research Foundation | Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotherapy |
| EP1257576B1 (de) | 2000-02-18 | 2004-09-15 | Dabur Research Foundation | Vip-analoge |
| US6828304B1 (en) | 2000-07-31 | 2004-12-07 | Dabur Research Foundation | Peptides for treatment of cancer |
| WO2002010193A1 (en) * | 2000-07-31 | 2002-02-07 | Dabur Research Foundation | Lipid-peptide conjugates for treatment of cancer |
| US20060075968A1 (en) * | 2004-10-12 | 2006-04-13 | Applied Materials, Inc. | Leak detector and process gas monitor |
| EP2670422B1 (de) | 2011-02-02 | 2018-10-17 | Emory University | Antagonismus des vip-signalweges |
| US9458217B2 (en) * | 2013-12-05 | 2016-10-04 | Emory University | Methods of managing graft versus host disease |
| WO2017176932A1 (en) | 2016-04-08 | 2017-10-12 | Emory University | Methods of treating cancer and infectious diseases using cell based therapies |
| US11850263B2 (en) | 2017-11-10 | 2023-12-26 | Emory University | Nanoparticles conjugated with vasoactive intestinal peptide antagonists |
| US11471506B2 (en) | 2018-04-23 | 2022-10-18 | Emory University | VIP antagonists and uses in treating cancer |
| EP3880228A4 (de) * | 2018-11-15 | 2022-09-28 | Emory University | Zusammensetzungen und verwendungen von antagonisten von vasoaktivem intestinalem peptid (vip) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4734400A (en) * | 1984-10-09 | 1988-03-29 | Hoffmann-La Roche Inc. | Synthetic vasoactive intestinal peptide analogs |
| US4605641A (en) * | 1984-10-09 | 1986-08-12 | Hoffmann-La Roche Inc. | Synthetic vasoactive intestinal peptide analogs |
| US5196315A (en) * | 1990-05-01 | 1993-03-23 | The Johns Hopkins University | Human neuronal cell line |
| EP0463450B1 (de) * | 1990-06-26 | 1994-02-16 | Sanwa Kagaku Kenkyusho Co., Ltd. | VIP-Analogen und ihre Verwendung |
| US5217953A (en) * | 1990-11-30 | 1993-06-08 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Vasoactive intestinal peptide antagonist |
| US5273963A (en) * | 1991-03-29 | 1993-12-28 | The George Washington University | Compositions and methods for treating small cell and nonsmall cell lung cancers |
| IL99924A (en) * | 1991-10-31 | 1995-12-31 | Yeda Res & Dev | Derivatives of structurally modified vip and pharmaceutical compositions containing them |
-
1994
- 1994-02-07 US US08/194,591 patent/US5565424A/en not_active Expired - Lifetime
-
1995
- 1995-02-06 CA CA002182795A patent/CA2182795C/en not_active Expired - Fee Related
- 1995-02-06 DK DK95909489T patent/DK0738280T3/da active
- 1995-02-06 ES ES95909489T patent/ES2155886T3/es not_active Expired - Lifetime
- 1995-02-06 AT AT95909489T patent/ATE199160T1/de not_active IP Right Cessation
- 1995-02-06 WO PCT/US1995/001496 patent/WO1995021194A1/en not_active Ceased
- 1995-02-06 JP JP52080495A patent/JP3588119B2/ja not_active Expired - Fee Related
- 1995-02-06 IL IL11255795A patent/IL112557A/xx not_active IP Right Cessation
- 1995-02-06 DE DE69520092T patent/DE69520092T2/de not_active Expired - Fee Related
- 1995-02-06 AU AU17438/95A patent/AU697829B2/en not_active Ceased
- 1995-02-06 EP EP95909489A patent/EP0738280B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09511494A (ja) | 1997-11-18 |
| DE69520092D1 (de) | 2001-03-22 |
| US5565424A (en) | 1996-10-15 |
| ES2155886T3 (es) | 2001-06-01 |
| AU1743895A (en) | 1995-08-21 |
| CA2182795C (en) | 2007-11-06 |
| CA2182795A1 (en) | 1995-08-10 |
| EP0738280B1 (de) | 2001-02-14 |
| AU697829B2 (en) | 1998-10-15 |
| WO1995021194A1 (en) | 1995-08-10 |
| IL112557A (en) | 2000-02-17 |
| IL112557A0 (en) | 1995-05-26 |
| DE69520092T2 (de) | 2001-08-02 |
| DK0738280T3 (da) | 2001-09-17 |
| JP3588119B2 (ja) | 2004-11-10 |
| EP0738280A1 (de) | 1996-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE199160T1 (de) | Hochaktive vip - antagonisten | |
| DK1091975T3 (da) | Ny cyclosporin med forbedret aktivitetsprofil | |
| DZ2509A1 (fr) | Analogues peptidiques de la lh-rh leur utilisationet les compositions pharmaceutiques les contenant. | |
| HUP9903714A2 (hu) | GLP-1-származékok | |
| DE69732250D1 (de) | Zyklische peptide mit breitspektrum antimikrobieller aktivität | |
| FI880509A7 (fi) | LHRH:n nonapeptidi- ja dekapeptidianalogeja, jotka ovat käyttökelpoisia LHRH:n antagonisteina | |
| DK0994710T3 (da) | Farmaceutiske præparater til oral indgivelse omfattende en benzhydrylpiperazin og en cyclodextrin | |
| NL194828B (nl) | Somatostatinepeptiden, alsmede dergelijke somatostatinepeptiden bevattende farmaceutische preparaten. | |
| IL70944A (en) | Octapeptide vasopressin antagonists,their preparation and pharmaceutical compositions comprising them | |
| DE69939327D1 (de) | Funktionelle antagonisten von hedgehog-aktivität | |
| AU5186799A (en) | Peptides of il-2 and derivatives thereof and their use as therapeutic agents | |
| ATE398630T1 (de) | Zyklische conotoxin-peptide | |
| FI954986L (fi) | Uudet, suun kautta annettavat, syklosporiinia sisältävät farmaseuttiset valmisteet | |
| UA26845C2 (uk) | Похідhі пептидів, що є аhтагоhістами речовиhи р та hейрокіhіhу а | |
| WO2001005811A3 (de) | Zyklische peptidomimetische urokinaserezeptorantagonisten | |
| ITRM950273A0 (it) | Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni farmaceutiche. | |
| HRP20000400B1 (hr) | Transmukozni pripravci levosimendana | |
| FI991441L (fi) | Peptidiyhdisteitä erityisesti LHRH-antagonisteja | |
| NO992298L (no) | Konformasjonsbegrensede LH-RH analoger, anvendelse derav og farmas°ytiske sammensetninger inneholdende disse | |
| ATE283279T1 (de) | Therapeutische inhaltsstoffe | |
| BG102514A (en) | New lh-rh-antagonists of improved effect | |
| WO1999025732A3 (en) | Design of coiled-coil dimer derived antagonists of 4-helix bundle cytokine specific receptors | |
| EP0154544A3 (de) | Antagonisten von Des-Proline Vasopressin | |
| WO2002020437A3 (en) | Basic compounds containing tertiary amides with activity on tachykinin receptors, and pharmaceutical compositions containing them | |
| IE881484L (en) | Cyclic peptide compounds, vasopressin antagonists |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |