ATE198621T1 - Herstellung und verwendung von transgenen mäusen mit fehlender expression von cd28 - Google Patents
Herstellung und verwendung von transgenen mäusen mit fehlender expression von cd28Info
- Publication number
- ATE198621T1 ATE198621T1 AT94917481T AT94917481T ATE198621T1 AT E198621 T1 ATE198621 T1 AT E198621T1 AT 94917481 T AT94917481 T AT 94917481T AT 94917481 T AT94917481 T AT 94917481T AT E198621 T1 ATE198621 T1 AT E198621T1
- Authority
- AT
- Austria
- Prior art keywords
- expression
- preparation
- transgenic mice
- mice defective
- defective
- Prior art date
Links
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 title 1
- 241000699660 Mus musculus Species 0.000 title 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 title 1
- 230000002950 deficient Effects 0.000 title 1
- 238000011830 transgenic mouse model Methods 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 3
- 108010029485 Protein Isoforms Proteins 0.000 abstract 2
- 102000001708 Protein Isoforms Human genes 0.000 abstract 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 abstract 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 abstract 1
- 108700019146 Transgenes Proteins 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70589—CD45
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0325—Animal model for autoimmune diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0381—Animal model for diseases of the hematopoietic system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biodiversity & Conservation Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Packaging For Recording Disks (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6776793A | 1993-05-26 | 1993-05-26 | |
PCT/US1994/005913 WO1994028123A1 (en) | 1993-05-26 | 1994-05-25 | Mammals lacking expression of cd28 transgenic |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE198621T1 true ATE198621T1 (de) | 2001-01-15 |
Family
ID=22078279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94917481T ATE198621T1 (de) | 1993-05-26 | 1994-05-25 | Herstellung und verwendung von transgenen mäusen mit fehlender expression von cd28 |
Country Status (9)
Country | Link |
---|---|
US (3) | US6664107B1 (de) |
EP (1) | EP0701607B1 (de) |
AT (1) | ATE198621T1 (de) |
AU (1) | AU685811B2 (de) |
DE (1) | DE69426564T2 (de) |
ES (1) | ES2155474T3 (de) |
GR (1) | GR3035603T3 (de) |
PT (1) | PT701607E (de) |
WO (1) | WO1994028123A1 (de) |
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US5777093A (en) * | 1995-05-16 | 1998-07-07 | Ramot-University Authority For Applied Research & Industrial Development Ltd. | cDNAs associated with ataxia-telangiectasia |
US5858661A (en) * | 1995-05-16 | 1999-01-12 | Ramot-University Authority For Applied Research And Industrial Development | Ataxia-telangiectasia gene and its genomic organization |
US5728807A (en) * | 1995-05-16 | 1998-03-17 | Ramot-University Authority For Applied Research And Industrial Development, Ltd. | Mutated proteins associated with ataxia-telangiectasia |
US6140309A (en) * | 1996-03-12 | 2000-10-31 | University Of South Florida | Vasoactive effects and free radical generation by β-amyloid peptides |
US20060021070A1 (en) * | 1996-04-01 | 2006-01-26 | University of Massachusetts, a Public Institution of Higher Education of the Commonwealth of MA | Production of chimeric bovine or porcine animals using cultured inner cell mass |
US7223849B1 (en) | 1996-07-01 | 2007-05-29 | Genesense Technologies Inc. | Oligonucleotides from the untranslated regions of housekeeping genes and methods of using same to modulate cell growth |
US5919656A (en) | 1996-11-15 | 1999-07-06 | Amgen Canada Inc. | Genes encoding telomerase protein 1 |
US7390891B1 (en) | 1996-11-15 | 2008-06-24 | Amgen Inc. | Polynucleotides encoding a telomerase component TP2 |
US6436669B1 (en) * | 1996-11-15 | 2002-08-20 | Sumitomo Pharmaceuticals Company, Limited | Semaphorin genes (I) |
US6046158A (en) * | 1996-12-20 | 2000-04-04 | Board Of Regents The University Of Texas Systems | Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof |
US7071171B1 (en) | 1996-12-20 | 2006-07-04 | Board Of Regents The University Of Texas System | Unique dendritic cell-associated c-type lectins, dectin-1 and dectin-2 compositions and uses thereof |
US5817912A (en) * | 1997-01-16 | 1998-10-06 | B.M.R.A. Corporation B.V. | Transgenic mice with disrupted NPY Y1 receptor genes |
EP1009753B1 (de) | 1997-08-21 | 2005-04-20 | Quark Biotech, Inc. | Hypoxie-regulierte gene |
US7973156B2 (en) | 1997-08-21 | 2011-07-05 | Quark Pharmaceuticals Inc. | Hypoxia-regulated genes |
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US6787318B1 (en) | 1999-06-01 | 2004-09-07 | Roskamp Research Institute, Llc | Assay for evaluating the therapeutic effectiveness of agents in reducing Alzheimer's disease pathology |
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US9422360B2 (en) * | 2011-12-19 | 2016-08-23 | Zhonghao Chenguang Research Institute Of Chemical Industry Company Limited | Porcine CD28 receptor, gene for encoding same, and application of same |
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Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2235992A (en) | 1991-06-14 | 1993-01-12 | Genpharm International, Inc. | Transgenic immunodeficient non-human animals |
AU2661692A (en) | 1991-09-19 | 1993-04-27 | President And Fellows Of Harvard College | Transgenic mhc class i and class ii antigen-deficient mammals |
-
1994
- 1994-02-02 US US08/191,225 patent/US6664107B1/en not_active Expired - Fee Related
- 1994-05-25 AU AU69187/94A patent/AU685811B2/en not_active Ceased
- 1994-05-25 PT PT94917481T patent/PT701607E/pt unknown
- 1994-05-25 AT AT94917481T patent/ATE198621T1/de not_active IP Right Cessation
- 1994-05-25 ES ES94917481T patent/ES2155474T3/es not_active Expired - Lifetime
- 1994-05-25 WO PCT/US1994/005913 patent/WO1994028123A1/en active IP Right Grant
- 1994-05-25 DE DE69426564T patent/DE69426564T2/de not_active Expired - Fee Related
- 1994-05-25 EP EP94917481A patent/EP0701607B1/de not_active Expired - Lifetime
-
1995
- 1995-05-26 US US08/451,691 patent/US5557032A/en not_active Expired - Fee Related
- 1995-09-14 US US08/528,363 patent/US5616491A/en not_active Expired - Lifetime
-
2001
- 2001-03-20 GR GR20010400449T patent/GR3035603T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2155474T3 (es) | 2001-05-16 |
WO1994028123A1 (en) | 1994-12-08 |
EP0701607A1 (de) | 1996-03-20 |
AU685811B2 (en) | 1998-01-29 |
US6664107B1 (en) | 2003-12-16 |
DE69426564D1 (de) | 2001-02-15 |
GR3035603T3 (en) | 2001-06-29 |
PT701607E (pt) | 2001-05-31 |
DE69426564T2 (de) | 2001-05-31 |
US5616491A (en) | 1997-04-01 |
US5557032A (en) | 1996-09-17 |
EP0701607B1 (de) | 2001-01-10 |
AU6918794A (en) | 1994-12-20 |
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Legal Events
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UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |