ATE196907T1 - Tris(isonitril)kupfer(i)sulfate zur herstellung von radionukleidkomplexen - Google Patents

Tris(isonitril)kupfer(i)sulfate zur herstellung von radionukleidkomplexen

Info

Publication number
ATE196907T1
ATE196907T1 AT94923912T AT94923912T ATE196907T1 AT E196907 T1 ATE196907 T1 AT E196907T1 AT 94923912 T AT94923912 T AT 94923912T AT 94923912 T AT94923912 T AT 94923912T AT E196907 T1 ATE196907 T1 AT E196907T1
Authority
AT
Austria
Prior art keywords
isonitrile
complexes
tris
copper
radionuclace
Prior art date
Application number
AT94923912T
Other languages
English (en)
Inventor
David Scott Edwards
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Application granted granted Critical
Publication of ATE196907T1 publication Critical patent/ATE196907T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic System without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
AT94923912T 1993-08-03 1994-07-29 Tris(isonitril)kupfer(i)sulfate zur herstellung von radionukleidkomplexen ATE196907T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/098,442 US5420321A (en) 1993-08-03 1993-08-03 Tris(isonitrile)copper(i) sulfates for preparing radionuclide complexes
PCT/US1994/007457 WO1995004114A1 (en) 1993-08-03 1994-07-29 Tris(isonitrile)copper(i) sulfates for preparing radionuclide complexes

Publications (1)

Publication Number Publication Date
ATE196907T1 true ATE196907T1 (de) 2000-10-15

Family

ID=22269298

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94923912T ATE196907T1 (de) 1993-08-03 1994-07-29 Tris(isonitril)kupfer(i)sulfate zur herstellung von radionukleidkomplexen

Country Status (22)

Country Link
US (2) US5420321A (de)
EP (1) EP0713513B1 (de)
JP (1) JPH09500899A (de)
KR (1) KR100322359B1 (de)
CN (1) CN1046857C (de)
AT (1) ATE196907T1 (de)
AU (1) AU682382B2 (de)
BR (1) BR9407347A (de)
CA (1) CA2168775C (de)
DE (1) DE69426118T2 (de)
DK (1) DK0713513T3 (de)
ES (1) ES2153425T3 (de)
FI (1) FI960496A (de)
HU (1) HU221858B1 (de)
IL (1) IL110462A (de)
NO (1) NO307566B1 (de)
NZ (1) NZ269642A (de)
PL (1) PL180320B1 (de)
PT (1) PT713513E (de)
TW (1) TW253887B (de)
WO (1) WO1995004114A1 (de)
ZA (1) ZA945706B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420321A (en) * 1993-08-03 1995-05-30 The Du Pont Merck Pharmaceutical Company Tris(isonitrile)copper(i) sulfates for preparing radionuclide complexes
CA2420645A1 (en) 2000-09-25 2002-04-04 The Procter & Gamble Company Metal complexes for use in medical and therapeutic applications
GB0031592D0 (en) * 2000-12-28 2001-02-07 Nycomed Amersham Plc Stabilised radiopharmaceutical compositions
CN1136921C (zh) * 2001-04-27 2004-02-04 北京师范大学 一种心肌显像剂及其制备方法
WO2005014510A2 (en) * 2003-08-08 2005-02-17 Washington University In St. Louis AUTOMATED SEPARATION, PURIFICATION AND LABELING SYSTEMS FOR 60CU, 61Cu and 64Cu RADIONUCLIDES AND RECOVERY THEREOF
WO2006085941A1 (en) * 2004-06-17 2006-08-17 Anazaohealth Corporation Copper-complex isonitrile positron emission tomography (pet) imaging agent and method
US7229603B2 (en) * 2004-06-17 2007-06-12 Anazaohealth Corporation Stablilized and lyophilized radiopharmaceutical agents

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3117938A (en) * 1959-12-23 1964-01-14 Du Pont Cuprous chloride-benzonitrile catalyst for preparing acetylene reaction products
US4452774A (en) * 1982-04-30 1984-06-05 President And Fellows Of Harvard College Isonitrile radionuclide complexes for labelling and imaging agents
AU4311085A (en) * 1984-06-01 1985-12-05 E.I. Du Pont De Nemours And Company Copper salt and ligand containing composition
US4826961A (en) * 1984-11-28 1989-05-02 President And Fellows Of Harvard College Method for preparing radiopharmaceutical complexes
US4707544A (en) * 1984-11-28 1987-11-17 President And Fellows Of Harvard College Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents
US4894445A (en) * 1985-08-05 1990-01-16 E. I. Du Pont De Nemours And Company Metal-isonitrile adducts for preparing radionuclide complexes
US5324824A (en) * 1985-08-05 1994-06-28 The Dupont Merck Pharmaceutical Co. Metal-isonitrile adducts for preparing radionuclide complexes
US4872561A (en) * 1985-08-30 1989-10-10 Massachusetts Institute Of Technology Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes
US4735793A (en) * 1985-08-30 1988-04-05 Massachusetts Institute Of Technology Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes
CA1305160C (en) * 1985-12-23 1992-07-14 Paul Louis Bergstein Ether isonitriles and radiolabeled complexes thereof
GB8714072D0 (en) * 1987-06-16 1987-07-22 Cloke F G N Bis(-arene)complexes of yttrium(o)& gadolinium(o)
US4885100A (en) * 1987-09-11 1989-12-05 E. I. Du Pont De Nemours And Company Tris(isonitrile)copper(I) adducts for preparing radionuclide complexes
US5008418A (en) * 1987-09-11 1991-04-16 E. I. Du Pont De Nemours And Company Tris(isonitrile)copper(I) adducts for preparing radionuclide complexes
US5407653A (en) * 1991-06-26 1995-04-18 Brigham And Women's Hospital Evaluation of the multidrug resistance phenotype
US5210270A (en) * 1991-11-25 1993-05-11 Institute Of Nuclear Energy Research Method for synthesis and 99m C labelling of 2-alkoxyisobutylisonitrile
US5420321A (en) * 1993-08-03 1995-05-30 The Du Pont Merck Pharmaceutical Company Tris(isonitrile)copper(i) sulfates for preparing radionuclide complexes

Also Published As

Publication number Publication date
CN1046857C (zh) 1999-12-01
NO960448D0 (no) 1996-02-02
DE69426118T2 (de) 2001-05-23
DK0713513T3 (da) 2001-01-29
DE69426118D1 (de) 2000-11-16
PL180320B1 (pl) 2001-01-31
NZ269642A (en) 1997-06-24
IL110462A0 (en) 1994-10-21
IL110462A (en) 2000-02-29
BR9407347A (pt) 1996-10-08
HUT74727A (en) 1997-02-28
AU682382B2 (en) 1997-10-02
KR100322359B1 (ko) 2002-06-24
EP0713513B1 (de) 2000-10-11
CA2168775C (en) 2000-07-11
CA2168775A1 (en) 1995-02-09
ZA945706B (en) 1996-02-01
EP0713513A1 (de) 1996-05-29
AU7396794A (en) 1995-02-28
TW253887B (de) 1995-08-11
KR960704001A (ko) 1996-08-31
US5693324A (en) 1997-12-02
JPH09500899A (ja) 1997-01-28
NO960448L (no) 1996-02-02
HU221858B1 (hu) 2003-02-28
NO307566B1 (no) 2000-04-25
PT713513E (pt) 2001-03-30
FI960496A0 (fi) 1996-02-02
ES2153425T3 (es) 2001-03-01
WO1995004114A1 (en) 1995-02-09
FI960496A (fi) 1996-04-02
PL312794A1 (en) 1996-05-13
CN1131962A (zh) 1996-09-25
EP0713513A4 (de) 1999-05-19
US5420321A (en) 1995-05-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee