ATE195507T1 - Verfahren zur kondensation von peptidsegmenten - Google Patents
Verfahren zur kondensation von peptidsegmentenInfo
- Publication number
- ATE195507T1 ATE195507T1 AT95915464T AT95915464T ATE195507T1 AT E195507 T1 ATE195507 T1 AT E195507T1 AT 95915464 T AT95915464 T AT 95915464T AT 95915464 T AT95915464 T AT 95915464T AT E195507 T1 ATE195507 T1 AT E195507T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide segments
- organic solvent
- condensing peptide
- ubiquitous
- polypeptides
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003849 aromatic solvent Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/023—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution using racemisation inhibiting agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/222,767 US5502165A (en) | 1994-04-04 | 1994-04-04 | Process for peptide segment condensation |
| PCT/US1995/003952 WO1995027727A2 (en) | 1994-04-04 | 1995-03-31 | Process for peptide segment condensation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE195507T1 true ATE195507T1 (de) | 2000-09-15 |
Family
ID=22833593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95915464T ATE195507T1 (de) | 1994-04-04 | 1995-03-31 | Verfahren zur kondensation von peptidsegmenten |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5502165A (de) |
| EP (1) | EP0755374B1 (de) |
| JP (1) | JPH09511743A (de) |
| AT (1) | ATE195507T1 (de) |
| AU (1) | AU690255B2 (de) |
| CA (1) | CA2186605A1 (de) |
| DE (1) | DE69518409T2 (de) |
| WO (1) | WO1995027727A2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5502165A (en) * | 1994-04-04 | 1996-03-26 | Merck & Co., Inc. | Process for peptide segment condensation |
| US7049059B2 (en) * | 2000-12-01 | 2006-05-23 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression |
| ES2670854T3 (es) * | 2012-10-10 | 2018-06-01 | Piramal Enterprises Limited | Un proceso mejorado para la preparación de perindoprilo intermedio |
| WO2014147124A1 (en) | 2013-03-21 | 2014-09-25 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
| MX365465B (es) | 2013-03-21 | 2019-06-04 | Sanofi Aventis Deutschland | Sintesis de productos peptidicos que contienen imida ciclica. |
| EP4201951B1 (de) * | 2021-12-21 | 2023-11-22 | Bachem Holding AG | Verfahren zur peptidsynthese |
| WO2025070753A1 (ja) * | 2023-09-28 | 2025-04-03 | 中外製薬株式会社 | 混合酸無水物法を用いたペプチド化合物の製造方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU466760B2 (en) * | 1972-03-14 | 1975-11-06 | Takeda Chemical Industries Ltd. | Process for producing peptide |
| DD160415A1 (de) * | 1981-05-04 | 1983-07-27 | Rudolf Doelling | Verfahren zur herstellung von peptiden |
| DE3542442A1 (de) * | 1985-11-30 | 1987-06-04 | Hoechst Ag | Verfahren zur herstellung von peptiden unter der verwendung von perchloraten |
| JP2585530B2 (ja) * | 1986-04-23 | 1997-02-26 | 株式会社日立製作所 | 半導体集積回路装置 |
| JPH0634745B2 (ja) * | 1986-05-07 | 1994-05-11 | 味の素株式会社 | Ｎ−保護ペプチドの酵素的合成法 |
| DE4016596A1 (de) * | 1990-05-23 | 1991-11-28 | Hoechst Ag | Ein neues kupplungsreagenz fuer die peptidsynthese |
| US5693805A (en) * | 1993-03-12 | 1997-12-02 | Merck & Co., Inc. | Process to derivatives of piperizinylcamphorsulfonyl oxytocin antagonists |
| AU1170995A (en) * | 1994-03-14 | 1995-10-03 | Merck & Co., Inc. | Pyridil ethylation of lactams |
| AU7836594A (en) * | 1994-03-14 | 1995-10-03 | Merck & Co., Inc. | Pyridyl ethylation of lactam derivatives |
| US5502165A (en) * | 1994-04-04 | 1996-03-26 | Merck & Co., Inc. | Process for peptide segment condensation |
-
1994
- 1994-04-04 US US08/222,767 patent/US5502165A/en not_active Expired - Fee Related
-
1995
- 1995-03-31 US US08/721,989 patent/US5773575A/en not_active Expired - Fee Related
- 1995-03-31 AT AT95915464T patent/ATE195507T1/de not_active IP Right Cessation
- 1995-03-31 WO PCT/US1995/003952 patent/WO1995027727A2/en not_active Ceased
- 1995-03-31 DE DE69518409T patent/DE69518409T2/de not_active Expired - Fee Related
- 1995-03-31 EP EP95915464A patent/EP0755374B1/de not_active Expired - Lifetime
- 1995-03-31 JP JP7526374A patent/JPH09511743A/ja not_active Withdrawn
- 1995-03-31 AU AU22337/95A patent/AU690255B2/en not_active Ceased
- 1995-03-31 CA CA002186605A patent/CA2186605A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2186605A1 (en) | 1995-10-19 |
| EP0755374A1 (de) | 1997-01-29 |
| AU690255B2 (en) | 1998-04-23 |
| WO1995027727A2 (en) | 1995-10-19 |
| AU2233795A (en) | 1995-10-30 |
| US5502165A (en) | 1996-03-26 |
| WO1995027727A3 (en) | 1996-10-03 |
| DE69518409D1 (de) | 2000-09-21 |
| EP0755374B1 (de) | 2000-08-16 |
| DE69518409T2 (de) | 2001-02-15 |
| JPH09511743A (ja) | 1997-11-25 |
| EP0755374A4 (de) | 1998-09-16 |
| US5773575A (en) | 1998-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |