ATE178328T1 - Loracarbef isopropanolat und umwandlungsverfahren vom isopropanolat in loracarbef monohydrat - Google Patents
Loracarbef isopropanolat und umwandlungsverfahren vom isopropanolat in loracarbef monohydratInfo
- Publication number
- ATE178328T1 ATE178328T1 AT94303942T AT94303942T ATE178328T1 AT E178328 T1 ATE178328 T1 AT E178328T1 AT 94303942 T AT94303942 T AT 94303942T AT 94303942 T AT94303942 T AT 94303942T AT E178328 T1 ATE178328 T1 AT E178328T1
- Authority
- AT
- Austria
- Prior art keywords
- loracarbef
- isopropanolate
- conversion process
- monohydrate
- crystalline
- Prior art date
Links
- GPYKKBAAPVOCIW-HSASPSRMSA-N (6r,7s)-7-[[(2r)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate Chemical compound O.C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CC[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 GPYKKBAAPVOCIW-HSASPSRMSA-N 0.000 title abstract 3
- 229960001977 loracarbef Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- OGHBATFHNDZKSO-UHFFFAOYSA-N propan-2-olate Chemical compound CC(C)[O-] OGHBATFHNDZKSO-UHFFFAOYSA-N 0.000 title 2
- 238000006243 chemical reaction Methods 0.000 title 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 150000004682 monohydrates Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/072,204 US5399686A (en) | 1993-06-04 | 1993-06-04 | Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE178328T1 true ATE178328T1 (de) | 1999-04-15 |
Family
ID=22106211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94303942T ATE178328T1 (de) | 1993-06-04 | 1994-06-01 | Loracarbef isopropanolat und umwandlungsverfahren vom isopropanolat in loracarbef monohydrat |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5399686A (de) |
| EP (1) | EP0627429B1 (de) |
| JP (1) | JP3442861B2 (de) |
| KR (1) | KR100308746B1 (de) |
| AT (1) | ATE178328T1 (de) |
| BR (1) | BR9402148A (de) |
| CA (1) | CA2124999C (de) |
| DE (1) | DE69417472T2 (de) |
| DK (1) | DK0627429T3 (de) |
| ES (1) | ES2129106T3 (de) |
| FI (1) | FI108133B (de) |
| GR (1) | GR3030211T3 (de) |
| HU (1) | HUT67911A (de) |
| IL (1) | IL109869A (de) |
| SI (1) | SI0627429T1 (de) |
| TW (1) | TW492968B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399686A (en) * | 1993-06-04 | 1995-03-21 | Eli Lilly And Company | Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate |
| US5550231A (en) * | 1993-06-15 | 1996-08-27 | Eli Lilly And Company | Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof |
| US5580977A (en) * | 1995-03-01 | 1996-12-03 | Eli Lilly And Company | Process for preparing loracarbef monohydrate |
| GB9717629D0 (en) | 1997-08-21 | 1997-10-22 | Johnson Matthey Plc | Removal of residual organic solvents |
| KR100519650B1 (ko) * | 1999-02-05 | 2005-10-07 | 제일모직주식회사 | 점도가 균일한 폴리아믹산의 제조방법 |
| WO2004046142A1 (en) * | 2002-11-21 | 2004-06-03 | Ranbaxy Laboratories Limited | Monohydrate solvates of loracarbef |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3502663A (en) * | 1969-04-21 | 1970-03-24 | Lilly Co Eli | Crystalline cephalosporin,method for its manufacture |
| US3531481A (en) * | 1969-04-21 | 1970-09-29 | Lilly Co Eli | Method for manufacture of crystalline cephalosporin |
| US4775751A (en) * | 1985-06-03 | 1988-10-04 | Eli Lilly & Company | Process for cephalexin hydrochloride alcoholates |
| DD273634A5 (de) * | 1987-10-06 | 1989-11-22 | ����@�����@�����@����k�� | Verfahren zur herstellung eines kristallinen monohydrats eines 1-carbacephalosporins |
| CA2002596A1 (en) * | 1988-11-14 | 1990-05-14 | Thomas M. Eckrich | Hydrates of b-lactam antibiotic |
| US4977257A (en) * | 1988-11-14 | 1990-12-11 | Eli Lilly And Company | DMF solvates of a β-lactam antibiotic |
| US5352782A (en) * | 1993-06-04 | 1994-10-04 | Eli Lilly And Company | Process for preparing crystalline β-lactam monohydrate |
| US5399686A (en) * | 1993-06-04 | 1995-03-21 | Eli Lilly And Company | Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate |
-
1993
- 1993-06-04 US US08/072,204 patent/US5399686A/en not_active Expired - Lifetime
-
1994
- 1994-06-01 ES ES94303942T patent/ES2129106T3/es not_active Expired - Lifetime
- 1994-06-01 DK DK94303942T patent/DK0627429T3/da active
- 1994-06-01 EP EP94303942A patent/EP0627429B1/de not_active Expired - Lifetime
- 1994-06-01 AT AT94303942T patent/ATE178328T1/de not_active IP Right Cessation
- 1994-06-01 TW TW083105010A patent/TW492968B/zh not_active IP Right Cessation
- 1994-06-01 SI SI9430256T patent/SI0627429T1/xx not_active IP Right Cessation
- 1994-06-01 DE DE69417472T patent/DE69417472T2/de not_active Expired - Fee Related
- 1994-06-01 BR BR9402148A patent/BR9402148A/pt not_active Application Discontinuation
- 1994-06-02 IL IL109869A patent/IL109869A/en not_active IP Right Cessation
- 1994-06-02 KR KR1019940012342A patent/KR100308746B1/ko not_active IP Right Cessation
- 1994-06-02 CA CA002124999A patent/CA2124999C/en not_active Expired - Fee Related
- 1994-06-03 FI FI942631A patent/FI108133B/fi not_active IP Right Cessation
- 1994-06-03 JP JP12229794A patent/JP3442861B2/ja not_active Expired - Fee Related
- 1994-06-03 HU HU9401673A patent/HUT67911A/hu unknown
- 1994-12-01 US US08/347,759 patent/US5672700A/en not_active Expired - Fee Related
-
1999
- 1999-05-13 GR GR990401296T patent/GR3030211T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2124999A1 (en) | 1994-12-05 |
| BR9402148A (pt) | 1994-12-27 |
| FI942631A (fi) | 1994-12-05 |
| IL109869A0 (en) | 1994-10-07 |
| DK0627429T3 (da) | 1999-10-11 |
| SI0627429T1 (en) | 1999-10-31 |
| EP0627429B1 (de) | 1999-03-31 |
| DE69417472D1 (de) | 1999-05-06 |
| DE69417472T2 (de) | 1999-08-19 |
| KR950000703A (ko) | 1995-01-03 |
| FI108133B (fi) | 2001-11-30 |
| CA2124999C (en) | 2004-08-10 |
| ES2129106T3 (es) | 1999-06-01 |
| JPH06345762A (ja) | 1994-12-20 |
| IL109869A (en) | 1998-06-15 |
| KR100308746B1 (ko) | 2001-11-30 |
| US5672700A (en) | 1997-09-30 |
| EP0627429A1 (de) | 1994-12-07 |
| TW492968B (en) | 2002-07-01 |
| GR3030211T3 (en) | 1999-08-31 |
| US5399686A (en) | 1995-03-21 |
| FI942631A0 (fi) | 1994-06-03 |
| HU9401673D0 (en) | 1994-09-28 |
| HUT67911A (en) | 1995-05-29 |
| JP3442861B2 (ja) | 2003-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |