ATE169627T1 - TETRAHYDROTHIENO, FURO AND PYRROLOPYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS PLALEET AGGREGATION INHIBITORS - Google Patents

TETRAHYDROTHIENO, FURO AND PYRROLOPYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS PLALEET AGGREGATION INHIBITORS

Info

Publication number
ATE169627T1
ATE169627T1 AT92308180T AT92308180T ATE169627T1 AT E169627 T1 ATE169627 T1 AT E169627T1 AT 92308180 T AT92308180 T AT 92308180T AT 92308180 T AT92308180 T AT 92308180T AT E169627 T1 ATE169627 T1 AT E169627T1
Authority
AT
Austria
Prior art keywords
substd
alkoxy
opt
dioxolen
alkanoyl
Prior art date
Application number
AT92308180T
Other languages
German (de)
Inventor
Hiroyuki Koike
Fumitoshi Asai
Atsuhiro Sugidachi
Tomio Kimura
Teruhiko Inoue
Shigeyoshi Nishino
Yasunori Tsuzaki
Original Assignee
Sankyo Co
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26471534&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE169627(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co, Ube Industries filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE169627T1 publication Critical patent/ATE169627T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

Hydropyridine derivs. of formula (I) and their tautomers and their salts are new. In (I), R1 = H, 1-4C alkyl, halo, 1-4C haloalkyl, OH, 1-4C alkoxy, 1-4C haloalkoxy, 1-4C alkylthio, 1-4C haloalkylthio, amino, 1-5C alkanoyl, 2-5C haloalkanoyl, COOH, 2-5C alkoxycarbonyl, carbamoyl, CN, NO2, 1-4C alkanesulphonyl, 1-4C haloalkanesulphonyl or sulphamoyl; R2 = 1-10C alkanoyl, 2-10C alkanoyl substd. by at least one A, 3-6C alkenoyl opt. substd. by at least one A, 4-8C cycloalkylcarbonyl opt. substd. by at least one A, benzoyl substd. by at least one B or 5,6-dihydro-1,4,2-dioxazin-3-yl; R3 = H, OH, 1-4C alkoxy opt. substd. by at least one C, aralkyloxy, 1-18C alkanoyl, 3-6C alkenoyl, 4-8C cycloalkylcarbonoxy, arylcarbonyloxy, phthalidyloxy, (5-methyl-2-oxo -1,3-dioxolen-4-yl) methoxy, (5-phenyl-2-oxo-1,3 -dioxolen-4-yl)-methoxy, NRaRb, aralkylamino, 1-18C alkanoylamino, 3-6C alkenoylamino, 4-8C cycloalkylcarbonylamino, arylcarbonylamino, 2-5C alkoxycarbonylamino, aralkyloxycarbonylamino, phthalidylamino, (5-methyl-2-oxo -1,3-dioxolen-4-yl) methylamino, (5-phenyl-2-oxo-1,3 -dioxolen-4-yl) methylamino or NO2; Ra,Rb = H or 1-4C alkyl opt. substd. by at least one C; Y = NH, O or S; n = 1-5; A = halo, OH, 1-4C alkoxy or CN; B = 1-4C alkyl, halo or 1-4C alkoxy; C = 1-4C alkoxy, 1-6C alkanoyloxy or arylcarbonyloxy; alkyl contain 1-4C; aryl have 6-10C in a carbocyclic ring opt. substd. by at least one D; D = as R' except H.
AT92308180T 1991-09-09 1992-09-09 TETRAHYDROTHIENO, FURO AND PYRROLOPYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS PLALEET AGGREGATION INHIBITORS ATE169627T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22787591 1991-09-09
JP13852992 1992-05-29

Publications (1)

Publication Number Publication Date
ATE169627T1 true ATE169627T1 (en) 1998-08-15

Family

ID=26471534

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92308180T ATE169627T1 (en) 1991-09-09 1992-09-09 TETRAHYDROTHIENO, FURO AND PYRROLOPYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS PLALEET AGGREGATION INHIBITORS

Country Status (24)

Country Link
US (2) US5288726A (en)
EP (1) EP0542411B1 (en)
JP (1) JP2683479B2 (en)
KR (1) KR0148023B1 (en)
CN (2) CN1041730C (en)
AT (1) ATE169627T1 (en)
AU (1) AU656798B2 (en)
CA (1) CA2077695C (en)
CZ (1) CZ287181B6 (en)
DE (2) DE122009000045I2 (en)
DK (1) DK0542411T3 (en)
ES (1) ES2122984T3 (en)
FI (1) FI101150B (en)
GR (1) GR3027650T3 (en)
HK (1) HK1011017A1 (en)
HU (2) HU218785B (en)
IL (1) IL103098A (en)
LU (1) LU91589I2 (en)
MX (1) MX9205160A (en)
NL (1) NL300397I2 (en)
NO (2) NO303733B1 (en)
NZ (1) NZ244260A (en)
PH (1) PH29921A (en)
TW (1) TW213461B (en)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3840662B2 (en) * 1994-10-07 2006-11-01 宇部興産株式会社 2-silyloxy-tetrahydrothienopyridines, salts thereof and process for producing the same
WO1997049397A1 (en) * 1996-06-26 1997-12-31 Sankyo Company, Limited Novel medicinal compositions of hydropyridines
NZ334389A (en) * 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
KR100567950B1 (en) 1998-02-27 2006-04-05 상꾜 가부시키가이샤 Cyclic amino compounds
US6509348B1 (en) * 1998-11-03 2003-01-21 Bristol-Myers Squibb Company Combination of an ADP-receptor blocking antiplatelet drug and a thromboxane A2 receptor antagonist and a method for inhibiting thrombus formation employing such combination
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
CN1147490C (en) 1999-01-19 2004-04-28 神经研究公司 Fused heterocyclic compounds and their use in the treatment of neurodegenerative diseases
RU2270695C2 (en) 1999-03-17 2006-02-27 Дайити Фармасьютикал Ко., Лтд. Pharmaceutical composition
US7099027B1 (en) * 1999-11-12 2006-08-29 Electronics For Imaging, Inc. Method and apparatus for distributing print jobs
ES2308633T3 (en) * 2000-07-06 2008-12-01 Daiichi Sankyo Company, Limited MALEATE ADDITION SALT OF HYDROPIRIDINE DERIVATIVES.
EP1350511B1 (en) * 2000-12-25 2008-09-10 Daiichi Sankyo Company, Limited Medicinal compositions containing aspirin
NZ547401A (en) * 2003-11-28 2008-06-30 Sankyo Co Cyclic amine derivative having heteroaryl ring
JP5557410B2 (en) * 2004-07-13 2014-07-23 第一三共株式会社 Preventive and therapeutic agent for thrombus and embolism by oral administration
US7205296B2 (en) * 2004-09-29 2007-04-17 Portola Pharmaceuticals, Inc. Substituted 2H-1,3-benzoxazin-4(3H)-ones
TWI318571B (en) * 2005-06-10 2009-12-21 Lilly Co Eli Formulation of a thienopyridine platelet aggregation inhibitor
CN101198329A (en) * 2005-06-17 2008-06-11 伊莱利利公司 Dosage regimen for prasugrel
TWI392681B (en) * 2006-04-06 2013-04-11 Daiichi Sankyo Co Ltd Prasugrel with high purity and a method for preparing its acid addition salt
WO2008060934A2 (en) * 2006-11-14 2008-05-22 Acusphere, Inc. Formulations of tetrahydropyridine antiplatelet agents for parenteral or oral administration
KR101442862B1 (en) 2006-12-07 2014-09-22 다이이찌 산쿄 가부시키가이샤 Solid medicinal preparation containing mannitol or lactose
BRPI0719529B8 (en) 2006-12-07 2021-05-25 Daiichi Sankyo Co Ltd method for producing a solid preparation
CA2671975C (en) 2006-12-07 2013-10-29 Daiichi Sankyo Company, Limited Film-coated preparation having improved stability
WO2008072532A1 (en) 2006-12-07 2008-06-19 Daiichi Sankyo Company, Limited Pharmaceutical composition having improved storage stability
CA2671979C (en) * 2006-12-07 2014-02-04 Daiichi Sankyo Company, Limited Pharmaceutical composition containing low-substituted hydroxypropyl cellulose
EP2123656B1 (en) * 2007-03-02 2014-06-11 Daiichi Sankyo Company, Limited Process for production of prasugrel hydrochloride having high purity
KR20150041173A (en) 2007-04-27 2015-04-15 사이덱스 파마슈티칼스, 인크. Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
CZ302135B6 (en) * 2007-07-09 2010-11-10 Zentiva, A. S. Process for preparing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]-pyridin-2-yl acetate (prasugrel)
US8669268B2 (en) * 2007-09-12 2014-03-11 Deuterx, Llc Deuterium-enriched prasugrel
US20100261908A1 (en) * 2007-11-09 2010-10-14 Dr. Reddy's Laboratories Ltd. Processes for the preparation of prasugrel , and its salts and polymorphs
HU230262B1 (en) * 2007-11-27 2015-11-30 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Process for the preparation of pharmaceutical intermediers
HU230261B1 (en) * 2007-11-27 2015-11-30 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Process for producing pharmaceutical intermediers
CN101177430A (en) * 2007-12-11 2008-05-14 鲁南制药集团股份有限公司 Hydrogenated pyridine derivative and method for preparing salt thereof
EP2257556A1 (en) 2008-02-06 2010-12-08 Helm AG Prasugrel salts with improved properties
CN101245073B (en) * 2008-03-21 2011-03-23 上海医药工业研究院 Medicine intermediate and preparation method thereof
CN101245072B (en) * 2008-03-21 2011-03-30 上海医药工业研究院 Intermediate for producing prasugrel and producing method thereof
CN101250192B (en) * 2008-03-24 2010-08-11 上海医药工业研究院 Method for preparing 5-(alpha-cyclopropyl carbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothiophene [3,2-c] pyridine
CN101250193B (en) * 2008-03-28 2010-09-08 上海医药工业研究院 Method for preparing 2-methoxy-5-(alpha-cyclopropyl carbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothiophene [3,2-c] pyridine
WO2009122440A1 (en) * 2008-03-31 2009-10-08 Torrent Pharmaceuticals Ltd. PROCESS FOR THE PREPARATION OF 2-ACETOXY-5-(α -CYCLOPRPYLCARBONYL -2-FLUOROBENZYL)-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE
WO2009129983A1 (en) * 2008-04-21 2009-10-29 Ratiopharm Gmbh Acid addition salts of prasugrel and pharmaceutical compositions comprising the same
PL2112155T3 (en) 2008-04-25 2011-03-31 Sandoz Ag Hydrogensulfate salt of 2-acetoxy-5-(a-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine and its preparation
US20090281136A1 (en) * 2008-05-08 2009-11-12 Sandeep Mhetre Prasugrel pharmaceutical formulations
WO2009140092A1 (en) 2008-05-13 2009-11-19 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US20130303477A1 (en) * 2008-05-13 2013-11-14 The Medicines Company Maintenance of Platelet Inhibition During Antiplatelet Therapy
US20120141468A1 (en) 2008-05-13 2012-06-07 Lisa Ruderman Chen Maintenance of platelet inhibition during antiplatelet therapy
US8759316B2 (en) * 2008-05-13 2014-06-24 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US9427448B2 (en) 2009-11-11 2016-08-30 The Medicines Company Methods of treating, reducing the incidence of, and/or preventing ischemic events
CN101591344B (en) * 2008-05-27 2012-12-05 连云港恒邦医药科技有限公司 Antithrombotic compound as well as preparation method and application thereof
CN101289454B (en) * 2008-06-10 2011-02-16 上海医药工业研究院 Method for preparing 2-oxygen-2,4,5,6,7,7alpha-hexahydro thieno [3,2-c]pyridine
KR20110045034A (en) 2008-08-02 2011-05-03 루난 파마슈티컬 그룹 코퍼레이션 Prasugrel hydrogen sulfate and pharmaceutical compositions and uses thereof
CN103936756B (en) * 2008-09-22 2017-09-19 广州赫尔氏药物开发有限公司 Compound with blood coagulation resisting function
CN101684124B (en) * 2008-09-22 2013-11-13 广州赫尔氏药物开发有限公司 Novel compound with blood coagulation resisting function
CN101402556B (en) * 2008-11-11 2014-01-29 上海现代制药股份有限公司 New compound 1-cyclopropyl-2-(2-fluorine phenyl)-2-hydroxyl ethanone, preparation method and application thereof
CN101402642B (en) * 2008-11-11 2013-01-09 上海现代制药股份有限公司 Novel environment friendly preparation method for prasugrel
CN101402643B (en) * 2008-11-11 2012-11-28 上海现代制药股份有限公司 Industrial production method for prasugrel
CZ2008748A3 (en) 2008-11-26 2010-06-02 Zentiva, A. S Process for preparing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7- tetrahydrothieno[3,2-c]pyridin-2-yl acetate (prasugrel)
WO2010070677A2 (en) * 2008-12-15 2010-06-24 Glenmark Generics Limited A process for the preparation of prasugrel and its pharmaceutically acceptable salts thereof
WO2010111951A1 (en) 2009-03-31 2010-10-07 上海医药工业研究院 Crystals of prasugrel hydrobromate
AU2010233089B2 (en) 2009-04-10 2016-05-26 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (MMP-1)
KR101743591B1 (en) 2009-05-13 2017-06-20 사이덱스 파마슈티칼스, 인크. Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
CN101885730B (en) * 2009-05-13 2012-07-04 连云港恒邦医药科技有限公司 Compound for resisting thrombus
DE102009036646A1 (en) 2009-08-07 2011-02-10 Ratiopharm Gmbh Prasugrel in non-crystalline form and pharmaceutical composition thereof
KR20110015254A (en) * 2009-08-07 2011-02-15 한미홀딩스 주식회사 Prasugrel disulfonate salts and crystals thereof
CN101993447A (en) 2009-08-26 2011-03-30 浙江华海药业股份有限公司 Method for synthesizing Prasugrel artificially
KR20110024057A (en) * 2009-09-01 2011-03-09 한미홀딩스 주식회사 Novel polymorphic prasugrel hydrogensulfate
WO2011036533A1 (en) 2009-09-23 2011-03-31 Glenmark Pharmaceuticals Limited Pharmaceutical composition comprising prasugrel and triflusal
WO2011042918A2 (en) * 2009-10-07 2011-04-14 Msn Laboratories Limited Novel and improved processes for the preparation of prasugrel, its intermediates and pharmaceutically acceptable salts
CN102040498B (en) * 2009-10-10 2014-01-29 台州市华南医化有限公司 Method for preparing cyclopropyl o-fluobenzyl ketone
CN102050828A (en) * 2009-10-28 2011-05-11 北京万全阳光医学技术有限公司 Prasugrel salt and preparation method thereof
EA028885B1 (en) 2009-11-11 2018-01-31 Чиези Фармачеутичи С.П.А. Methods of treating or preventing stent thrombosis and myocardial infarction (embodiments)
US10376532B2 (en) 2009-11-11 2019-08-13 Chiesi Farmaceutici, S.P.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
CZ2009763A3 (en) 2009-11-16 2011-05-25 Zentiva, K. S. Process for preparing extreme pure 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate known under unprotected name prasugrel and its novel pharmaceutically acceptable salts
CZ2009762A3 (en) 2009-11-16 2011-05-25 Zentiva, K. S. Novel salts of 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate known under unprotected name prasugrel and process of their preparation
CZ2009828A3 (en) 2009-12-09 2011-06-22 Zentiva, K.S. Process for preparing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride (prasugrelu hydrochloride in polymorphous B form
HU229031B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel and its intermediate
HU229035B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel
CN102120744B (en) 2010-02-02 2013-01-09 江苏威凯尔医药科技有限公司 Optical-activity 2-hydroxytetrahydrothienopyridine derivative, preparation method and application thereof in pharmacy
EP2360159A1 (en) 2010-02-11 2011-08-24 Ratiopharm GmbH Prasugrel in micronized, crystalline form and pharmaceutical compound of same
EP2545059A1 (en) * 2010-03-09 2013-01-16 Synthon BV A process for making prasugrel
CA2788764A1 (en) 2010-03-23 2011-09-29 Alembic Pharmaceuticals Limited A process for the preparation of prasugrel hcl salt
EP2377520A1 (en) 2010-03-24 2011-10-19 Ratiopharm GmbH Pharmaceutical compound of prasugrel
CN102212069A (en) * 2010-04-06 2011-10-12 刘桂坤 Cycloalkane derivative, preparation method thereof and application thereof in medicaments for cardiovascular and cerebrovascular diseases
KR20120052381A (en) 2010-04-08 2012-05-23 테바 파마슈티컬 인더스트리즈 리미티드 Crystalline forms of prasugrel salts
CN102212070B (en) * 2010-04-08 2014-11-26 上海医药工业研究院 Preparation method for 2-acetoxyl-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
CN101812069A (en) * 2010-04-10 2010-08-25 山东新华制药股份有限公司 Process for synthesizing prasugrel
CN102241690B (en) 2010-05-13 2015-08-12 天津药物研究院 Thienopyridine ester derivative, the Preparation Method And The Use of one class nitrile group-containing
CN101845052B (en) * 2010-06-11 2012-01-11 天津药物研究院 Nitrogen-containing heterocyclic ring thienopyridine ketone derivative, preparation method and application thereof
WO2012001486A1 (en) 2010-06-28 2012-01-05 Mayuka Labs Pvt. Ltd. An improved process for the preparation of prasugrel hydrochloride and its intermediates
CN101899056A (en) * 2010-08-02 2010-12-01 江苏万全特创医药生物技术有限公司 Prasugrel hydrobromide polymorph and preparation method thereof
JP5856177B2 (en) 2010-10-18 2016-02-09 セレニス セラピューティクス ホールディング エスアー Compounds, compositions and methods useful for cholesterol mobilization
AU2015227476B2 (en) * 2010-10-18 2017-03-23 Cerenis Therapeutics Holding Sa Compounds, compositions and methods useful for cholesterol mobilisation
HUP1000565A2 (en) 2010-10-22 2012-05-02 Egis Gyogyszergyar Nyrt Process for the preparation of pharmaceutically active compound and intermediers
CN102093385B (en) * 2010-12-30 2013-03-27 天津药物研究院 Schiff base compounds as well as preparation method and application of Schiff base compounds
CN102199163A (en) * 2011-04-01 2011-09-28 中国药科大学 2-hydroxy tetrahydrothiophene derivative, preparation method thereof and application thereof in pharmacy
CN102229616A (en) * 2011-05-06 2011-11-02 伍复健 Tetrahydrothieno pyridine derivative, and preparation method and purpose thereof
EP2736509B1 (en) 2011-07-28 2015-09-23 Laboratorios Lesvi, S.L. Process for preparing prasugrel
WO2013033178A1 (en) 2011-08-30 2013-03-07 University Of Utah Research Foundation Methods and compositions for treating nephrogenic diabetes insipidus
CN103102355A (en) * 2011-11-09 2013-05-15 丁克 Tetrahydrothienopyridine compound with optical activity
CZ2011872A3 (en) 2011-12-22 2013-07-03 Zentiva, K.S. Pharmaceutical formulation of prasugrel hydrobromide
CN103254211B (en) * 2012-02-17 2015-12-16 江苏威凯尔医药科技有限公司 A kind of method preparing dimension card Gray and derivative thereof
US8603537B2 (en) 2012-04-02 2013-12-10 Egis Pharmaceuticals Plc Prasugrel containing quickly released stable oral pharmaceutical compositions
ITMI20121494A1 (en) * 2012-09-07 2014-03-08 Erregierre Spa PRASUGREL CHLORIDRATE PRODUCTION PROCESS
CN103694250B (en) * 2012-09-28 2016-02-10 武汉启瑞药业有限公司 Thiophene pyridine derivatives and preparation method thereof and medicinal use
HU230649B1 (en) 2013-01-24 2017-05-29 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Improved process for producing pharmaceutical agent prasugrel and 2-(2-fluorophenyl)-1-cyclopropylethanone intermediate
CN103193792A (en) * 2013-03-13 2013-07-10 广东中科药物研究有限公司 New compound for treating ischemic cardiovascular and cerebrovascular diseases
CN104725396B (en) * 2013-12-18 2019-03-22 山东新时代药业有限公司 A kind of method that " a pot of porridge " method prepares prasugrel
CN103694252A (en) * 2014-01-14 2014-04-02 中国药科大学 Thienopyridine compound and anti-platelet aggregative activity thereof
DE102014108210A1 (en) 2014-06-11 2015-12-17 Dietrich Gulba rodenticide
EP2979693A1 (en) 2014-08-01 2016-02-03 Zaklady Farmaceutyczne Polpharma SA Pharmaceutical composition comprising prasugrel or pharmaceutically acceptable salt thereof and process for its preparation
CN105362266A (en) * 2014-08-28 2016-03-02 杭州雷索药业有限公司 Application of thienopyridines compounds or medically-acceptable salt of thienopyridines compounds in preparing medicine for treating or preventing epilepsy
CN105153192B (en) * 2014-09-02 2019-03-29 南京曼杰生物科技有限公司 Substituted tetrahydro thienopyridine derivative and its application
EP3156049A1 (en) 2015-10-15 2017-04-19 Alembic Pharmaceuticals Limited Pharmaceutical composition of prasugrel
EP3158993A1 (en) 2015-10-22 2017-04-26 Zaklady Farmaceutyczne Polpharma SA Process for preparing a tablet comprising prasugrel or pharmaceutically acceptable salt thereof
HU231079B1 (en) 2016-06-23 2020-06-29 Richter Gedeon Nyrt. Process for the preparation of high-purity prasugrel by the elimination of the bromopentyl impurity
WO2018073437A1 (en) 2016-10-21 2018-04-26 Laboratorios Lesvi, Sl Pharmaceutical formulations of prasugrel and processes for the preparation thereof
WO2018234565A1 (en) 2017-06-23 2018-12-27 Chiesi Farmaceutici S.P.A. Method of preventing of systemic-to-pulmonary-artery shunt thrombosis
CN114286823B (en) * 2020-08-03 2023-11-28 天地恒一制药股份有限公司 Optically active 2-hydroxy tetrahydrothiophene pyridine derivative and preparation method and application thereof
EP4070658A1 (en) 2021-04-06 2022-10-12 BIORoxx GmbH Use of anticoagulant active compounds as rodenticide

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2215948B1 (en) * 1973-02-01 1976-05-14 Centre Etd Ind Pharma
US4075215A (en) * 1973-02-01 1978-02-21 Centre D'etudes Pour L'industrie Pharmaceutique Thieno-pyridine derivatives
US4127580A (en) * 1975-02-07 1978-11-28 Parcor Process for the preparation of thieno-pyridine derivatives
FR2338703A1 (en) * 1976-01-22 1977-08-19 Parcor THIENO (3,2-C) PYRIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS
GB2038178B (en) * 1978-12-29 1983-03-09 Parcor Antithrombotic therapeutic compsition
US4464377A (en) * 1977-06-22 1984-08-07 BLANCHARD Jean Anti-thrombotic therapeutic compositions
FR2508459A1 (en) * 1981-06-30 1982-12-31 Sanofi Sa PROCESS FOR THE PREPARATION OF TETRAHYDRO-5,6,7,7A 4H THIENO (3,2-C) PYRIDINONE-2 DERIVATIVES
FR2530247B1 (en) * 1982-07-13 1986-05-16 Sanofi Sa NOVEL THIENO (3, 2-C) PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC APPLICATION
FR2576901B1 (en) * 1985-01-31 1987-03-20 Sanofi Sa NOVEL DERIVATIVES OF A- (OXO-2 HEXAHYDRO-2,4,5,6,7,7A THIENO (3,2-C) PYRIDYL-5) ACETIC PHENYL, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
IT1215251B (en) * 1985-03-14 1990-01-31 Ellem Ind Farmaceutica PHARMACEUTICALS THAT CONTAIN THEM. ANTI-AGGREGATING PLATE COMPOUNDS, PROCEDURE FOR THEIR PREPARATION AND COMPOSITIONS
FR2652579B1 (en) * 1989-10-02 1992-01-24 Sanofi Sa DERIVATIVES OF 2-HYDROXY THIOPHENE AND FURANNE CONDENSED WITH A NITROGEN CYCLE, ON THE PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION.
EP0439404B1 (en) * 1990-01-25 1995-10-25 Sanofi Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno [3,2-c] pyridine derivatives therefrom
FR2664596B1 (en) * 1990-07-10 1994-06-10 Sanofi Sa PROCESS FOR THE PREPARATION OF AN N-PHENYLACETIC DERIVATIVE OF TETRAHYDROTHIENO [3,2-C] PYRIDINE AND ITS SYNTHESIS INTERMEDIATE.
ES2097295T3 (en) * 1991-07-08 1997-04-01 Sanofi Sa PREPARATION OF 2- (2-TENYL) ETHYLAMINE AND SYNTHESIS OF ITS TENO DERIVATIVES (3,2-C) PIRIDINE.

Also Published As

Publication number Publication date
AU2284792A (en) 1993-03-18
ES2122984T3 (en) 1999-01-01
JPH0641139A (en) 1994-02-15
TW213461B (en) 1993-09-21
EP0542411B1 (en) 1998-08-12
NO923484D0 (en) 1992-09-08
CN1041730C (en) 1999-01-20
PH29921A (en) 1996-09-16
HU9202888D0 (en) 1992-11-30
FI924002A (en) 1993-03-10
DE122009000045I2 (en) 2010-07-08
NO2009017I1 (en) 2009-08-03
NO2009017I2 (en) 2011-10-17
NL300397I2 (en) 2009-12-01
HK1011017A1 (en) 1999-07-02
EP0542411A2 (en) 1993-05-19
AU656798B2 (en) 1995-02-16
DK0542411T3 (en) 1999-05-17
NZ244260A (en) 1994-07-26
JP2683479B2 (en) 1997-11-26
NO923484L (en) 1993-03-10
EP0542411A3 (en) 1993-07-21
CA2077695A1 (en) 1993-03-10
LU91589I2 (en) 2009-10-05
US5288726A (en) 1994-02-22
DE122009000045I1 (en) 2009-11-05
HU218785B (en) 2000-12-28
DE69226607T2 (en) 1999-04-22
HUT66195A (en) 1994-10-28
KR0148023B1 (en) 1998-08-17
DE69226607D1 (en) 1998-09-17
CZ287181B6 (en) 2000-10-11
GR3027650T3 (en) 1998-11-30
NL300397I1 (en) 2009-10-01
CA2077695C (en) 2002-08-20
IL103098A (en) 1996-05-14
FI924002A0 (en) 1992-09-07
CZ278492A3 (en) 1993-10-13
KR930006019A (en) 1993-04-20
US5436242A (en) 1995-07-25
NO303733B1 (en) 1998-08-24
IL103098A0 (en) 1993-02-21
FI101150B (en) 1998-04-30
MX9205160A (en) 1993-03-01
CN1074446A (en) 1993-07-21
CN1217186A (en) 1999-05-26
HU211876A9 (en) 1995-12-28
CN1107502C (en) 2003-05-07

Similar Documents

Publication Publication Date Title
ATE169627T1 (en) TETRAHYDROTHIENO, FURO AND PYRROLOPYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS PLALEET AGGREGATION INHIBITORS
IL117396A (en) Benzofuran derivatives and pharmaceutical compositions containing them
CY2111B1 (en) 7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic-acid derivatives metho for their preparation and for substituted mono- and bi-cyclic pyrrolidine intermediates and their antibacterial
NO964093L (en) Substituted quinoline-2-carboxylic acid amides, their preparation and their use as a drug, as well as intermediate
DE69221003D1 (en) Antibiotic carbapenem derivatives
GR3006971T3 (en)
DK40890D0 (en) SUBSTITUTED URINARY COMPOUNDS, THEIR PREPARATION AND USE
TW197420B (en)
ATE239023T1 (en) ANTIALLERGIC IMIDAZO(1,2-A)THIENO(2,3-D)AZEPINE DERIVATIVES
NZ224956A (en) Benzo-thieno-thiazine derivatives, pharmaceuticals and intermediates
AU6193196A (en) Substituted 4H-pyrans
HUP9902890A2 (en) Substituted pyrimidine derivatives and their pharmaceutical use
HUP9903604A2 (en) Heterocyclylmethylamino derivatives of cyclobutene-3,4-diones as potassium channel modulators, preparation and use thereof
HUT60742A (en) Method for producing imidqzo-benzodiazepine-2-(1h)-one derivatives and pharmaceutical preparatives containing them
HUP9903423A3 (en) 3-descladinose-2,3-anhydroerythromycin derivatives