ATE1648T1 - Verfahren zur magnetischen abtrennung von zellen und dgl. und dabei zu verwendende mikrosphaeren. - Google Patents

Verfahren zur magnetischen abtrennung von zellen und dgl. und dabei zu verwendende mikrosphaeren.

Info

Publication number
ATE1648T1
ATE1648T1 AT80300546T AT80300546T ATE1648T1 AT E1648 T1 ATE1648 T1 AT E1648T1 AT 80300546 T AT80300546 T AT 80300546T AT 80300546 T AT80300546 T AT 80300546T AT E1648 T1 ATE1648 T1 AT E1648T1
Authority
AT
Austria
Prior art keywords
microspheres
protein
cells
magnetic separation
prepared
Prior art date
Application number
AT80300546T
Other languages
English (en)
Inventor
Kenneth Jon Widder
Andrew Erwin Senyei
Original Assignee
Kendrew Biosystems, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21774226&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE1648(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kendrew Biosystems, Inc. filed Critical Kendrew Biosystems, Inc.
Application granted granted Critical
Publication of ATE1648T1 publication Critical patent/ATE1648T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16051—Methods of production or purification of viral material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/305—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
    • G01N2333/31—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/76—Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/30—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/84—Polymer coating, e.g. gelatin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/828—Protein A

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Hard Magnetic Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AT80300546T 1979-02-28 1980-02-25 Verfahren zur magnetischen abtrennung von zellen und dgl. und dabei zu verwendende mikrosphaeren. ATE1648T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/015,895 US4230685A (en) 1979-02-28 1979-02-28 Method of magnetic separation of cells and the like, and microspheres for use therein
EP80300546A EP0016552B2 (de) 1979-02-28 1980-02-25 Verfahren zur magnetischen Abtrennung von Zellen und dgl. und dabei zu verwendende Mikrosphären

Publications (1)

Publication Number Publication Date
ATE1648T1 true ATE1648T1 (de) 1982-10-15

Family

ID=21774226

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80300546T ATE1648T1 (de) 1979-02-28 1980-02-25 Verfahren zur magnetischen abtrennung von zellen und dgl. und dabei zu verwendende mikrosphaeren.

Country Status (11)

Country Link
US (1) US4230685A (de)
EP (1) EP0016552B2 (de)
JP (1) JPS55143440A (de)
AT (1) ATE1648T1 (de)
CA (1) CA1127571A (de)
DE (1) DE3060928D1 (de)
DK (1) DK154840C (de)
IE (1) IE49266B1 (de)
IL (1) IL59464A (de)
NZ (1) NZ192959A (de)
ZA (1) ZA801062B (de)

Families Citing this family (201)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) * 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US4430318A (en) 1978-11-29 1984-02-07 The United States Of America As Represented By The Department Of Health And Human Services Immunoassay utilizing 125 I Protein A
US4560484A (en) * 1980-04-25 1985-12-24 Purdue Research Foundation Method and apparatus for magnetically separating particles from a liquid
SE8201972L (sv) * 1982-03-29 1983-09-30 Gambro Lundia Ab Magnetiskt paverkbara kristalliserade kolhydrat sferer eller partiklar att anvendas tillsammans med bioadsorberande material
US4469787A (en) * 1982-05-14 1984-09-04 Mallinckrodt Inc. Immunoassay involving soluble complex of second antibody and labeled binding protein
US4471058A (en) * 1982-07-26 1984-09-11 Board Of Trustees Operating Michigan State University Method for the detection and/or determination of a polyvalent antigen using at least two different monoclonal antibodies
US4493825A (en) * 1982-10-05 1985-01-15 Iowa State University Research Foundation Purified and antigenically selective vaccines for domestic animals
US4695393A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4695392A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4628037A (en) * 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
US4526681A (en) * 1983-10-31 1985-07-02 Purdue Research Foundation Magnetic separation method utilizing a colloid of magnetic particles
SE8401125L (sv) * 1984-03-01 1985-09-02 Ulf Schroder Sett vid diagnostisering in vitro och diagnostiskt medel
US4704366A (en) * 1984-06-22 1987-11-03 Bio-Rad Laboratories, Inc. Process for binding IgG to protein A
GB8427436D0 (en) * 1984-10-30 1984-12-05 Lepetit Spa Receptor assay
DE3444939A1 (de) * 1984-12-08 1986-06-12 Bayer Ag, 5090 Leverkusen Magnetische microspheres
US4663029A (en) * 1985-04-08 1987-05-05 Massachusetts Institute Of Technology Method and apparatus for continuous magnetic separation
US4666595A (en) * 1985-09-16 1987-05-19 Coulter Electronics, Inc. Apparatus for acoustically removing particles from a magnetic separation matrix
US4710472A (en) * 1985-09-25 1987-12-01 The United States Of America As Represented By The Secretary Of The Navy Magnetic separation device
JP2588181B2 (ja) * 1985-10-04 1997-03-05 ニコメド イマギング アクスイェ セルスカプ 磁性・ポリマ−粒子
US5512332A (en) * 1985-10-04 1996-04-30 Immunivest Corporation Process of making resuspendable coated magnetic particles
US4795698A (en) * 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US4752563A (en) * 1985-11-19 1988-06-21 Coulter Corporation Monoclonal antibody for recovery of leukocytes in human peripheral blood and method of recovery employing said monoclonal antibody
US5076950A (en) * 1985-12-20 1991-12-31 Syntex (U.S.A.) Inc. Magnetic composition for particle separation
AU7358187A (en) * 1986-04-11 1987-11-09 Murex Corp. Colorimetric ratioing immunoassay
US4770183A (en) * 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
US5069216A (en) * 1986-07-03 1991-12-03 Advanced Magnetics Inc. Silanized biodegradable super paramagnetic metal oxides as contrast agents for imaging the gastrointestinal tract
US4951675A (en) * 1986-07-03 1990-08-28 Advanced Magnetics, Incorporated Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging
US5219554A (en) 1986-07-03 1993-06-15 Advanced Magnetics, Inc. Hydrated biodegradable superparamagnetic metal oxides
CA1326435C (en) * 1987-03-13 1994-01-25 Wallace H. Coulter Method and apparatus for rapid mixing of small volumes for enhancing biological reactions
US5238812A (en) * 1987-03-13 1993-08-24 Coulter Corporation Method and apparatus for rapid mixing of small volumes for enhancing biological reactions
US5136095A (en) * 1987-05-19 1992-08-04 Syntex (U.S.A.) Inc. Reversible agglutination mediators
US4812401A (en) * 1987-05-19 1989-03-14 Syntex (U.S.A.) Inc. Reversible agglutination mediators for separating cells from whole blood
US6013531A (en) * 1987-10-26 2000-01-11 Dade International Inc. Method to use fluorescent magnetic polymer particles as markers in an immunoassay
WO1989004373A1 (en) * 1987-10-26 1989-05-18 Baxter International Inc. Process for producing magnetically responsive polymer particles and application thereof
FR2624613B1 (fr) * 1987-12-15 1994-08-26 Toledano Jacques Support microspherique de detection immuno-enzymatique, fluorescente, cheminumilescente ou radio-active de substances microdosees dans les milieux biologiques
AU2613988A (en) * 1988-01-04 1989-08-01 E.I. Du Pont De Nemours And Company Multiple stage affinity process for isolation of specific cells from a cell mixture
DE3806431A1 (de) * 1988-02-29 1989-09-07 Boehringer Mannheim Gmbh Verfahren zur herstellung einer festphasenmatrix
US5268306A (en) * 1988-02-29 1993-12-07 Boehringer Mannheim Gmbh Preparation of a solid phase matrix containing a bound specific binding pair
AU2985289A (en) * 1988-03-18 1989-09-21 Idetek Inc. Sulfa drug screening for domestic animals
US5593897A (en) * 1988-04-04 1997-01-14 Northwestern University Binding of immune complexes by modified forms of C-reactive protein
US5256532A (en) * 1988-05-02 1993-10-26 Zynaxis Technologies, Inc. Methods, reagents and test kits for determination of subpopulations of biological entities
US5385822A (en) * 1988-05-02 1995-01-31 Zynaxis, Inc. Methods for detection and quantification of cell subsets within subpopulations of a mixed cell population
AU2612688A (en) * 1988-06-03 1990-01-05 E.I. Du Pont De Nemours And Company Procedure for designing efficient affinity cell separation processes
US5108933A (en) * 1988-09-16 1992-04-28 Immunicon Corporation Manipulation of colloids for facilitating magnetic separations
US5536475A (en) * 1988-10-11 1996-07-16 Baxter International Inc. Apparatus for magnetic cell separation
US6020210A (en) * 1988-12-28 2000-02-01 Miltenvi Biotech Gmbh Methods and materials for high gradient magnetic separation of biological materials
WO1990007380A2 (en) * 1988-12-28 1990-07-12 Stefan Miltenyi Methods and materials for high gradient magnetic separation of biological materials
US5385707A (en) * 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
US5698271A (en) * 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
US5139933A (en) * 1989-09-26 1992-08-18 Vicam, L.P. Assay method for detecting listeria
AU6847890A (en) * 1990-01-19 1991-07-25 Promega Corporation Immunospecific and bioluminescent assay of cellular atp
US5378624A (en) * 1990-04-23 1995-01-03 Cellpro, Incorporated Methods for removing ligands from a particle surface
CA2090126C (en) * 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
US5204451A (en) * 1990-08-13 1993-04-20 Baxter International Inc. Activating hydroxyl groups of polymeric carriers using 4-fluorobenzenesulfonyl chloride for binding biologically active ligands
US5541072A (en) * 1994-04-18 1996-07-30 Immunivest Corporation Method for magnetic separation featuring magnetic particles in a multi-phase system
US5200084A (en) * 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US6013532A (en) * 1990-09-26 2000-01-11 Immunivest Corporation Methods for magnetic immobilization and manipulation of cells
US5484584A (en) * 1990-10-02 1996-01-16 Board Of Regents, The University Of Texas System Therapeutic and diagnostic use of modified polymeric microcapsules
US5491068A (en) * 1991-02-14 1996-02-13 Vicam, L.P. Assay method for detecting the presence of bacteria
US5186827A (en) * 1991-03-25 1993-02-16 Immunicon Corporation Apparatus for magnetic separation featuring external magnetic means
US5646001A (en) * 1991-03-25 1997-07-08 Immunivest Corporation Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof
US5795470A (en) * 1991-03-25 1998-08-18 Immunivest Corporation Magnetic separation apparatus
US5466574A (en) * 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
US5589575A (en) * 1992-07-23 1996-12-31 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture Purification of hapten-carrier generated antibodies
WO1994007138A1 (en) 1992-09-14 1994-03-31 Fodstad Oystein Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
US5916539A (en) * 1993-03-02 1999-06-29 Silica Gel Ges. M.B.H. Superparamagnetic particles, process for producing the same and their use
DE4309333A1 (de) * 1993-03-17 1994-09-22 Silica Gel Gmbh Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben
EP0672458A3 (de) * 1994-03-04 1996-02-28 Cleveland Clinic Foundation Verfahren und Vorrichtung zur magnetischen Zytometrie.
NO180658C (no) 1994-03-10 1997-05-21 Oeystein Fodstad Fremgangsmåte og anordning for deteksjon av spesifikke målceller i spesialiserte eller blandede cellepopulasjoner og opplösninger som inneholder blandede cellepopulasjoner
US5646263A (en) * 1994-09-19 1997-07-08 Promega Corporation High efficiency method for isolating target substances using a multisample separation device
US5693784A (en) * 1994-09-19 1997-12-02 Promega Corporation Methods for creating agglomerates from colloidal particles
US5567326A (en) * 1994-09-19 1996-10-22 Promega Corporation Multisample magnetic separation device
EP0778899A4 (de) * 1994-09-20 2001-08-29 Miltenyi Biotech Inc Anreicherung von fötalen zellen aus maternalem blut
FI944937A0 (fi) † 1994-10-20 1994-10-20 Labsystems Oy Separeringsanordning
US6500343B2 (en) 1995-02-21 2002-12-31 Iqbal W. Siddiqi Method for mixing and separation employing magnetic particles
EP0810905B1 (de) 1995-02-21 1998-11-04 Iqbal W. Dr. Siddiqi Apparat und verfahren zum mischen und trennen durch verwendung von magnetischen teilchen
US6884357B2 (en) 1995-02-21 2005-04-26 Iqbal Waheed Siddiqi Apparatus and method for processing magnetic particles
US5705059A (en) * 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
DE19516323C2 (de) * 1995-04-27 1997-02-27 Dirk Dipl Chem Guenther Verfahren zur Herstellung von magnetisierbaren Dispersionen und deren Verwendung
US5655546A (en) * 1995-06-07 1997-08-12 Halpern; Alan A. Method for cartilage repair
US5639669A (en) * 1995-06-07 1997-06-17 Ledley; Robert Separation of fetal cells from maternal blood
DE19528029B4 (de) 1995-07-31 2008-01-10 Chemagen Biopolymer-Technologie Aktiengesellschaft Magnetische Polymerpartikel auf der Basis von Polyvinylalkohol, Verfahren für ihre Herstellung und Verwendung
IL116163A0 (en) * 1995-11-28 1996-01-31 Univ Ramot Detection of specific entities in a sample
GB9524393D0 (en) * 1995-11-29 1996-01-31 Mini Agriculture & Fisheries Extraction and labelling of materials
US6297062B1 (en) * 1996-03-07 2001-10-02 Bio-Magnetics Ltd. Separation by magnetic particles
NO961031D0 (no) 1996-03-13 1996-03-13 Det Norske Radiumshospital Tum Fremgangsmåte til å drepe uönskede målceller
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US5795784A (en) 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
FR2758884B1 (fr) 1997-01-30 1999-04-02 Bio Merieux Procede pour isoler, notamment detecter ou quantifier un analyte dans un milieu
ATE251306T1 (de) * 1997-03-25 2003-10-15 Immunivest Corp Gerät und methoden zum einfnag und zur analyse von partikel-einheiten
ES2260809T3 (es) * 1997-07-01 2006-11-01 Vlp Watertown Limited Partnership Metodo para la determinacion del sexo de una progenie mamifera.
US6103468A (en) * 1997-10-07 2000-08-15 Labatt Brewing Company Limited Rapid two-stage polymerase chain reaction method for detection of lactic acid bacteria in beer
CA2320418C (en) * 1998-02-12 2008-06-17 Leon W.M.M. Terstappen Methods and reagents for the rapid and efficient isolation of circulating cancer cells
ES2279600T3 (es) * 1998-03-12 2007-08-16 Miltenyi Biotec Gmbh Sistema de microcolumna para separacion magnetica.
WO1999058977A1 (en) 1998-05-11 1999-11-18 Miltenyi Biotec Gmbh Method of direct selection of antigen-specific t cells
US6361749B1 (en) 1998-08-18 2002-03-26 Immunivest Corporation Apparatus and methods for magnetic separation
US7071005B1 (en) * 1998-08-24 2006-07-04 Centrus International, Inc. Method and device for concentrating selected groups of microorganisms
CN1320060A (zh) * 1998-08-24 2001-10-31 露斯·F·埃登 浓集所选微生物群的方法和装置
US5973138A (en) 1998-10-30 1999-10-26 Becton Dickinson And Company Method for purification and manipulation of nucleic acids using paramagnetic particles
US6153411A (en) * 1998-10-30 2000-11-28 American Water Works Company, Inc. Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
US6291249B1 (en) * 1999-03-02 2001-09-18 Qualigen, Inc. Method using an apparatus for separation of biological fluids
US6828157B1 (en) 1999-05-04 2004-12-07 Dan A. Pankowsky Products and methods for single parameter and multiparameter phenotyping of cells
ES2275511T3 (es) * 1999-05-04 2007-06-16 Dan A. Pankowsky Productos y procedimientos para el fenotipado de celulas de tipo de parametro unico o multiple.
US6682940B2 (en) 1999-05-04 2004-01-27 Dan A. Pankowsky Products and methods for single parameter and multiparameter phenotyping of cells
US6303316B1 (en) 1999-07-02 2001-10-16 Conceptual Mind Works, Inc. Organic semiconductor recognition complex and system
US6623982B1 (en) * 1999-07-12 2003-09-23 Immunivest Corporation Increased separation efficiency via controlled aggregation of magnetic nanoparticles
GB9922971D0 (en) * 1999-09-29 1999-12-01 Secr Defence Reaction system
US6841393B2 (en) 1999-10-19 2005-01-11 Kimberly-Clark Worldwide, Inc. Selective removal of contaminants from a surface using colored particles and articles having magnets
US6503761B1 (en) * 1999-10-19 2003-01-07 Kimberly-Clark Worldwide, Inc. Selective removal of contaminants from a surface using articles having magnets
WO2001078087A2 (en) * 2000-04-06 2001-10-18 Luminex Corporation Magnetically-responsive microspheres
US7169618B2 (en) 2000-06-28 2007-01-30 Skold Technology Magnetic particles and methods of producing coated magnetic particles
US20030207271A1 (en) * 2000-06-30 2003-11-06 Holwitt Eric A. Methods and compositions for biological sensors
US6649419B1 (en) 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
US20020164659A1 (en) * 2000-11-30 2002-11-07 Rao Galla Chandra Analytical methods and compositions
US20030022203A1 (en) * 2001-04-23 2003-01-30 Rajan Kumar Cellular Arrays
GB0110476D0 (en) * 2001-04-30 2001-06-20 Secr Defence Reagent delivery system
US7169577B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US7285412B2 (en) * 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
US7169578B2 (en) 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US20030049836A1 (en) * 2001-08-15 2003-03-13 Phi-Wilson Janette T. Cell separation system
US7863012B2 (en) * 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
US20030099954A1 (en) * 2001-11-26 2003-05-29 Stefan Miltenyi Apparatus and method for modification of magnetically immobilized biomolecules
US20030119057A1 (en) * 2001-12-20 2003-06-26 Board Of Regents Forming and modifying dielectrically-engineered microparticles
US7018849B2 (en) * 2002-01-15 2006-03-28 Piasio Roger N Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughtout
DE10224352A1 (de) * 2002-06-01 2003-12-11 Mueller Schulte Detlef Thermosensitive Polymerträger mit veränderbarer physikalischer Struktur für die biochemische Analytik, Diagnostik und Therapie
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
CN1230531C (zh) * 2002-12-09 2005-12-07 清华大学 从样品中分离细胞粒子的方法
CN1223680C (zh) * 2002-12-10 2005-10-19 清华大学 扩增靶细胞或病毒的核酸的方法
US20040142384A1 (en) * 2003-01-16 2004-07-22 Cohen Barb Ariel Magnetic separator
US20040157219A1 (en) * 2003-02-06 2004-08-12 Jianrong Lou Chemical treatment of biological samples for nucleic acid extraction and kits therefor
US7601491B2 (en) * 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
WO2004097417A1 (en) * 2003-05-02 2004-11-11 Canon Kabushiki Kaisha Structured construct and producing method therefor
US20050277204A1 (en) * 2003-08-12 2005-12-15 Massachusetts Institute Of Technology Sample preparation methods and devices
MXPA06001646A (es) * 2003-08-12 2006-05-12 Massachusetts Inst Technology Metodos y dispositivos para la preparacion de muestras.
DE10350248A1 (de) * 2003-10-28 2005-06-16 Magnamedics Gmbh Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik
WO2005065267A2 (en) * 2003-12-24 2005-07-21 Massachusetts Institute Of Technology Magnetophoretic cell clarification
CN100507548C (zh) 2003-12-30 2009-07-01 3M创新有限公司 检测目标生物分析物的系统及方法
US20050181353A1 (en) * 2004-02-17 2005-08-18 Rao Galla C. Stabilization of cells and biological specimens for analysis
US20060024824A1 (en) * 2004-07-16 2006-02-02 Steven Woodside Magnetic cell separation method
CA2839092C (en) * 2004-08-03 2018-04-03 Becton, Dickinson And Company Use of magnetic material to direct isolation of compounds and fractionation of multipart samples
DE102005002343A1 (de) * 2005-01-18 2006-07-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur spezifischen oder unspezifischen Separation von Zellen und/oder Viren aus flüssigen Medien und dessen Verwendung
US7989065B2 (en) * 2005-05-20 2011-08-02 Seradyn, Inc. Magnetically-responsive microparticles with improved response times
WO2006123686A1 (ja) * 2005-05-20 2006-11-23 Jsr Corporation 担体ポリマー粒子およびその製造方法ならびに特異捕捉用磁性粒子およびその製造方法
US7901950B2 (en) * 2005-08-12 2011-03-08 Veridex, Llc Method for assessing disease states by profile analysis of isolated circulating endothelial cells
EP1945271B1 (de) 2005-10-24 2019-10-16 Magsense Life Sciences, INC. Verfahren zur herstellung von polymerbeschichteten mikropartikeln
US7763453B2 (en) * 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US9056291B2 (en) 2005-11-30 2015-06-16 Micronics, Inc. Microfluidic reactor system
GB0606822D0 (en) 2006-04-05 2006-05-17 Alaska Food Diagnostics Assay System
US8870446B2 (en) 2006-06-21 2014-10-28 Spinomix S.A. Device and method for manipulating and mixing magnetic particles in a liquid medium
US8585279B2 (en) * 2006-06-21 2013-11-19 Spinomix S.A. Device and method for manipulating and mixing magnetic particles in a liquid medium
WO2008007270A2 (en) 2006-06-21 2008-01-17 Spinomix S.A. A method for manipulating magnetic particles in a liquid medium
US8999732B2 (en) * 2006-06-21 2015-04-07 Spinomix, S.A. Method for manipulating magnetic particles in a liquid medium
US7862813B2 (en) 2006-07-29 2011-01-04 Bjork Jr Robert Lamar Bi-specific monoclonal antibody (specific for both CD3 and CD11b) therapeutic drug
CN101795744A (zh) * 2007-09-11 2010-08-04 阿尔利克斯公司 用于分选物体的结合方法和仪器
US12529164B2 (en) 2007-09-14 2026-01-20 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
CA3187687A1 (en) 2007-09-14 2009-03-19 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
ATE528077T1 (de) 2007-12-07 2011-10-15 Miltenyi Biotec Gmbh Zentrifuge zur trennung einer probe in mindestens zwei komponenten
CA2711564A1 (en) * 2008-01-07 2009-07-16 Luminex Corporation Immunomagnetic capture and imaging of biological targets
WO2009091643A1 (en) * 2008-01-07 2009-07-23 Luminex Corporation Isolation and enumeration of cells from a complex sample matrix
US20100018674A1 (en) * 2008-07-22 2010-01-28 Donald John Enzinna Reservoir with moveable partition for quick recovery
EP2359164A4 (de) * 2008-12-10 2012-05-30 Abqmr Inc Kernmagnetresonanzgerät, verfahren und zugehörige technologie
CA2772020A1 (en) 2009-08-31 2011-03-03 Mbio Diagnostics, Inc. Integrated sample preparation and analyte detection
EP2311564A1 (de) 2009-10-05 2011-04-20 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Mikrofluidisches System mit Kammer und Mitteln zum Erzeugen von sich ändernden Magnetfeldern
US8747677B2 (en) 2010-04-09 2014-06-10 Luminex Corporation Magnetic separation device
US9476812B2 (en) 2010-04-21 2016-10-25 Dna Electronics, Inc. Methods for isolating a target analyte from a heterogeneous sample
US8841104B2 (en) 2010-04-21 2014-09-23 Nanomr, Inc. Methods for isolating a target analyte from a heterogeneous sample
US9428547B2 (en) 2010-04-21 2016-08-30 Dna Electronics, Inc. Compositions for isolating a target analyte from a heterogeneous sample
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
EP2390661B1 (de) 2010-05-02 2015-06-24 Miltenyi Biotec GmbH Verankerungs-/Erfassungsmittel zum Auswählen oder Analysieren einer CHO-Zelle entsprechend einem Produkt, das von der CHO-Zelle sezerniert wird
WO2012019108A1 (en) 2010-08-05 2012-02-09 Abbott Point Of Care Inc. Magnetic immunosensor with trench configuration and method of use
WO2012019109A1 (en) 2010-08-05 2012-02-09 Abbott Point Of Care Inc. Oscillating immunoassay method and device
US9233370B2 (en) 2010-08-05 2016-01-12 Abbott Point Of Care Inc. Magnetic immunosensor and method of use
CN103118785B (zh) 2010-08-05 2015-11-25 雅培医护站股份有限公司 使用易感磁微珠捕获的免疫测定方法和装置
CN103154740B (zh) 2010-10-14 2016-08-03 维里德克斯有限责任公司 使用多特异性捕获和混合物检测试剂检测胰腺患者中的循环肿瘤细胞的方法和试剂盒
SG190009A1 (en) * 2010-11-24 2013-06-28 Univ Nanyang Tech Method for encapsulating particles
ES2621347T3 (es) 2010-12-27 2017-07-03 Abbott Molecular Inc. Cuantificación de muestras de títulos altos por PCR digital
EP2597153B1 (de) 2011-11-25 2016-10-05 Miltenyi Biotec GmbH Zelltrennverfahren
CA2869681A1 (en) 2011-12-23 2013-06-27 Advanced Technologies And Regenerative Medicine, Llc Detection of human umbilical cord tissue-derived cells
WO2013101741A1 (en) 2011-12-30 2013-07-04 Abbott Molecular, Inc. Channels with cross-sectional thermal gradients
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
CN103212377B (zh) * 2013-04-19 2014-09-24 哈尔滨益材新材料有限公司 一种琼脂糖免疫磁性微球的制备方法及其应用
EP3097187B1 (de) 2014-01-21 2018-07-04 Stemcell Technologies Inc. Verfahren zur trennung von zielentitäten aus einer probe mittels einer zusammensetzung aus monospezifischen tetrameren, an eine oberfläche gekoppelten antikörperkomplexen
US9568404B2 (en) 2014-05-16 2017-02-14 Junyu Mai Method and apparatus for biomolecule analysis
EP2955521A1 (de) 2014-06-11 2015-12-16 Centre Hospitalier Universitaire Vaudois (CHUV) Verfahren zur Trennung von Zellen
JP6716683B2 (ja) 2015-05-01 2020-07-01 バイオレジェンド，インコーポレイテッド 安定なナノ磁性粒子分散
US20180291364A1 (en) 2015-05-08 2018-10-11 Biomagnetic Solutions Llc. Apparatus and method for immunomagnetic cell separation
EP3295171A1 (de) 2015-05-12 2018-03-21 INSERM - Institut National de la Santé et de la Recherche Médicale Verfahren und kits zur markierung, zum nachweis und zur isolierung von foxp3+-regulierenden t-zellen, isolierten populationen von foxp3+-regulierenden t-zellen und verwendungen davon
US20180251810A1 (en) 2015-09-11 2018-09-06 Bacteria Detection Ltd Methods for isolating microbial cells from a blood sample
CA3005070A1 (en) 2015-11-11 2017-05-18 Serimmune Inc. Methods and compositions for assessing antibody specificities
JP6639906B2 (ja) * 2015-12-25 2020-02-05 東ソー株式会社 生物試料検出方法
US20190127697A1 (en) 2016-04-30 2019-05-02 BioLegend, Inc. Compositions and methods for performing magnetibuoyant separations
CN112135789B (zh) 2018-05-08 2023-09-08 生物磁性解决方案有限责任公司 从柔性一次性袋中分离细胞的刚性腔室
CN114397464B (zh) * 2022-03-24 2022-06-10 天津德祥生物技术有限公司 一种红细胞膜碎片与载体的偶联复合物、其偶联方法和应用
EP4548100A1 (de) 2022-06-29 2025-05-07 Abbott Laboratories Magnetische pflegepunktsysteme und assays zur bestimmung von gfap in biologischen proben

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3937668A (en) * 1970-07-15 1976-02-10 Ilse Zolle Method for incorporating substances into protein microspheres
DE2322533C2 (de) * 1972-11-06 1986-08-28 Pharmacia AB, Uppsala Verfahren zum Binden von Immunoglobulin und Hilfsmittel zur Durchführung des Verfahrens
DE2322562C2 (de) * 1972-11-06 1984-03-29 Pharmacia AB, Uppsala Verfahren zur Bestimmung von Antigenen in einer Probe
CA1039649A (en) * 1973-08-30 1978-10-03 General Electric Company Method of forming multilayer immunologically complexed films
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4018886A (en) * 1975-07-01 1977-04-19 General Electric Company Diagnostic method and device employing protein-coated magnetic particles
FR2334106A1 (fr) * 1975-12-02 1977-07-01 Pasteur Institut Gel magnetique convenant pour dosages immunoenzymatiques
GB1575805A (en) * 1976-03-12 1980-10-01 Technicon Instr Automatic diagnostic apparatus

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US4230685A (en) 1980-10-28
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IL59464A (en) 1983-09-30
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