ATE160023T1 - Verfahren zur bestimmung eines analyts und seine verwendung zur bestimmung von anti-tsh- rezeptorautoantikörpern in einem patientenserum - Google Patents

Verfahren zur bestimmung eines analyts und seine verwendung zur bestimmung von anti-tsh- rezeptorautoantikörpern in einem patientenserum

Info

Publication number
ATE160023T1
ATE160023T1 AT94925460T AT94925460T ATE160023T1 AT E160023 T1 ATE160023 T1 AT E160023T1 AT 94925460 T AT94925460 T AT 94925460T AT 94925460 T AT94925460 T AT 94925460T AT E160023 T1 ATE160023 T1 AT E160023T1
Authority
AT
Austria
Prior art keywords
competitor
analyte
amount
bound
binder
Prior art date
Application number
AT94925460T
Other languages
English (en)
Inventor
Andreas Bergmann
Joachim Struck
Shaul Kornfeld
Original Assignee
Brahms Diagnostica Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brahms Diagnostica Gmbh filed Critical Brahms Diagnostica Gmbh
Application granted granted Critical
Publication of ATE160023T1 publication Critical patent/ATE160023T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT94925460T 1993-08-20 1994-08-18 Verfahren zur bestimmung eines analyts und seine verwendung zur bestimmung von anti-tsh- rezeptorautoantikörpern in einem patientenserum ATE160023T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4328070A DE4328070C1 (de) 1993-08-20 1993-08-20 Verfahren zur Bestimmung eines Analyten in einem Volumen einer flüssigen Probe sowie seine Anwendung zur Bestimmung von anti-TSH-Rezeptor-Autoantikörpern in einem Patientenserum

Publications (1)

Publication Number Publication Date
ATE160023T1 true ATE160023T1 (de) 1997-11-15

Family

ID=6495659

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94925460T ATE160023T1 (de) 1993-08-20 1994-08-18 Verfahren zur bestimmung eines analyts und seine verwendung zur bestimmung von anti-tsh- rezeptorautoantikörpern in einem patientenserum

Country Status (6)

Country Link
US (1) US5814461A (de)
EP (1) EP0724726B1 (de)
JP (1) JP2684244B2 (de)
AT (1) ATE160023T1 (de)
DE (2) DE4328070C1 (de)
WO (1) WO1995006258A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
EP0719858A3 (de) * 1994-12-27 1997-12-29 Tosoh Corporation Myeloma Zell-Linie die den rekombinanten menschlichen Rezeptor für das thyroid-stimulierenden Hormon exprimiert
DE19522171C1 (de) * 1995-06-19 1996-08-22 Brahms Diagnostica Gmbh Verfahren zur Bestimmung von Anti-TSH-Rezeptor-Autoantikörpern
DE19645729C1 (de) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19651093C2 (de) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays
DE19801319A1 (de) * 1998-01-15 1999-07-22 Brahms Diagnostica Gmbh Rezeptorbindungsassays zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenzien und Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays
GB9909661D0 (en) * 1998-06-06 1999-06-23 Rsr Ltd Assays for TSH receptor autoantibodies
GB9823397D0 (en) 1998-10-27 1998-12-23 Rsr Ltd Assays for thyroid autoantibodies
JP3649319B2 (ja) * 1999-01-25 2005-05-18 東洋紡績株式会社 レセプター結合能の測定方法および測定用試薬
DE19907094C1 (de) 1999-02-19 2000-04-13 Brahms Diagnostica Gmbh Verwendung von blockierenden Anti-TSH-Rezeptor-Antikörpern bei der Therapie von Hyperthyreosen sowie monoklonale Antikörper für eine solche Verwendung
US6852546B1 (en) 2000-03-30 2005-02-08 Diagnostic Hybrids, Inc. Diagnosis of autoimmune disease
US8293879B2 (en) 2000-03-30 2012-10-23 Diagnostic Hybrids, Inc. Methods of using chimeric receptors to identify autoimmune disease
CN1622958B (zh) 2001-08-23 2013-04-03 Rsr有限公司 促甲状腺素(tsh)受体的表位区域、其用途和针对该区域的抗体
DE10306992A1 (de) * 2003-02-19 2005-08-11 Klinikum der Universität München Großhadern-Innenstadt Verfahren zur quantitativen Messung von Liganden in der Probe gelöster Bindungsproteine
WO2009020142A1 (ja) * 2007-08-06 2009-02-12 Chugai Seiyaku Kabushiki Kaisha リガンド－レセプター結合阻害活性の測定方法
CN110187132A (zh) * 2019-05-14 2019-08-30 太原瑞盛生物科技有限公司 一种检测促甲状腺激素的分析方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3654090A (en) * 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies
US4447528A (en) * 1981-08-10 1984-05-08 Corning Glass Works Detecting intrinsic factor blocking site antibody
DE3377531D1 (en) * 1982-09-29 1988-09-01 Serono Diagnostics Ltd Immunoassay of antigens
GB8317124D0 (en) * 1983-06-23 1983-07-27 Ekins R P Free ligand assay
IL73938A (en) * 1984-01-02 1989-09-28 Boehringer Mannheim Gmbh Process and reagent for the determination of polyvalent antigen by incubation with three different receptors
DE3834766A1 (de) * 1988-10-12 1990-04-26 Boehringer Mannheim Gmbh Verfahren zur bestimmung einer spezifisch bindefaehigen substanz
US5196513A (en) * 1989-09-05 1993-03-23 Mayo Foundation For Medical Education And Research Synthetic peptides derived from the beta-subunit of human thyroid stimulating hormone
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
DE4120412C1 (de) * 1991-06-20 1993-01-07 Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin, De
US5578496A (en) * 1991-12-19 1996-11-26 Board Of Regents, Baylor College Of Medicine Detection of autoantibodies associated with the disease myasthenia gravis
DE4214922C2 (de) * 1992-05-06 1996-06-13 Brahms Diagnostica Gmbh Verfahren zur quantitativen Bestimmung des Anteils der freien Form eines Schilddrüsenhormon-Liganden in einer biologischen Flüssigkeit und Kit zur Durchführung eines solchen Verfahrens

Also Published As

Publication number Publication date
EP0724726A1 (de) 1996-08-07
WO1995006258A1 (en) 1995-03-02
EP0724726B1 (de) 1997-11-05
DE69406679D1 (de) 1997-12-11
JP2684244B2 (ja) 1997-12-03
JPH09500215A (ja) 1997-01-07
US5814461A (en) 1998-09-29
DE69406679T2 (de) 1998-03-05
DE4328070C1 (de) 1994-11-24

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