ATE159933T1 - Phenylsubstituierte cycloalkyl- hydroxyharnstoffderivate als lipoxygenase-hemmer - Google Patents

Phenylsubstituierte cycloalkyl- hydroxyharnstoffderivate als lipoxygenase-hemmer

Info

Publication number
ATE159933T1
ATE159933T1 AT93905957T AT93905957T ATE159933T1 AT E159933 T1 ATE159933 T1 AT E159933T1 AT 93905957 T AT93905957 T AT 93905957T AT 93905957 T AT93905957 T AT 93905957T AT E159933 T1 ATE159933 T1 AT E159933T1
Authority
AT
Austria
Prior art keywords
alkyl
halosubstituted
phenylthio
phenoxy
phenyl
Prior art date
Application number
AT93905957T
Other languages
English (en)
Inventor
Kazunari Nakao
Akiyoshi Kawai
Rodney W Stevens
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE159933T1 publication Critical patent/ATE159933T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
AT93905957T 1992-04-17 1993-02-18 Phenylsubstituierte cycloalkyl- hydroxyharnstoffderivate als lipoxygenase-hemmer ATE159933T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4098150A JPH05294921A (ja) 1992-04-17 1992-04-17 新規なフェニル置換シクロアルキル尿素誘導体および組成物

Publications (1)

Publication Number Publication Date
ATE159933T1 true ATE159933T1 (de) 1997-11-15

Family

ID=14212150

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93905957T ATE159933T1 (de) 1992-04-17 1993-02-18 Phenylsubstituierte cycloalkyl- hydroxyharnstoffderivate als lipoxygenase-hemmer

Country Status (10)

Country Link
EP (1) EP0636119B1 (de)
JP (1) JPH05294921A (de)
AT (1) ATE159933T1 (de)
CA (1) CA2133218C (de)
DE (1) DE69315069T2 (de)
DK (1) DK0636119T3 (de)
ES (1) ES2108266T3 (de)
FI (1) FI944848A0 (de)
GR (1) GR3025692T3 (de)
WO (1) WO1993021149A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW448144B (en) * 1993-08-19 2001-08-01 Pfizer Phenoxyphenyl cyclopentenyl hydroxyureas
WO1995017379A1 (en) * 1993-12-22 1995-06-29 Pfizer Inc. Phenylthiophenyl cycloalkenyl hydroxyureas as lipoxygenase inhibitors
US6832204B1 (en) * 1999-12-27 2004-12-14 Ge-Harris Railway Electronics, Llc Train building planning method
JP2008503482A (ja) 2004-06-18 2008-02-07 ワイス ６−アルキル−５−アリールスルホニル−ジヒドロフェナントリジンの製造方法
EP2298734A3 (de) * 2005-06-03 2011-07-13 Abbott Laboratories Cyclobutylaminderivate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
DE69122759T2 (de) * 1990-07-25 1997-05-15 Abbott Lab Acetylenderivate mit lipoxygenase inhibitorischer wirkung
GB9025514D0 (en) * 1990-11-23 1991-01-09 Wellcome Found Anti-inflammatory compounds
JP3007138B2 (ja) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物
US5283361A (en) * 1991-04-23 1994-02-01 Eli Lilly And Company N-hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]ureas as lipoxygenase inhibitors
JP2989951B2 (ja) * 1991-10-25 1999-12-13 ファイザー製薬株式会社 新規なシクロアルキル尿素誘導体および組成物
US5187192A (en) * 1992-03-13 1993-02-16 Abbott Laboratories Cyclobutyl derivatives having lipoxygenase inhibitory activity

Also Published As

Publication number Publication date
DE69315069D1 (en) 1997-12-11
EP0636119B1 (de) 1997-11-05
CA2133218A1 (en) 1993-10-28
WO1993021149A1 (en) 1993-10-28
DE69315069T2 (de) 1998-02-26
EP0636119A1 (de) 1995-02-01
GR3025692T3 (en) 1998-03-31
FI944848A (fi) 1994-10-14
ES2108266T3 (es) 1997-12-16
DK0636119T3 (da) 1997-12-22
CA2133218C (en) 2002-07-09
JPH05294921A (ja) 1993-11-09
FI944848A0 (fi) 1994-10-14

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee