ATE158506T1 - Okulare hypotensive 2-dekarboxyl-2-aminoalkyl- prostaglandine - Google Patents

Okulare hypotensive 2-dekarboxyl-2-aminoalkyl- prostaglandine

Info

Publication number
ATE158506T1
ATE158506T1 AT92900219T AT92900219T ATE158506T1 AT E158506 T1 ATE158506 T1 AT E158506T1 AT 92900219 T AT92900219 T AT 92900219T AT 92900219 T AT92900219 T AT 92900219T AT E158506 T1 ATE158506 T1 AT E158506T1
Authority
AT
Austria
Prior art keywords
decarboxyl
aminoalkyl
prostaglandins
occular
hypotensive
Prior art date
Application number
AT92900219T
Other languages
English (en)
Inventor
Ming Fai Chan
David Frederick Woodward
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ATE158506T1 publication Critical patent/ATE158506T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Geophysics And Detection Of Objects (AREA)
  • Feedback Control In General (AREA)
  • Peptides Or Proteins (AREA)
AT92900219T 1990-11-09 1991-10-30 Okulare hypotensive 2-dekarboxyl-2-aminoalkyl- prostaglandine ATE158506T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/611,029 US5270049A (en) 1990-11-09 1990-11-09 2-decarboxyl-2-aminoalkyl-prostaglandins as ocular hypotensives

Publications (1)

Publication Number Publication Date
ATE158506T1 true ATE158506T1 (de) 1997-10-15

Family

ID=24447325

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92900219T ATE158506T1 (de) 1990-11-09 1991-10-30 Okulare hypotensive 2-dekarboxyl-2-aminoalkyl- prostaglandine

Country Status (15)

Country Link
US (1) US5270049A (de)
EP (1) EP0556296B1 (de)
JP (1) JP3488456B2 (de)
AT (1) ATE158506T1 (de)
AU (1) AU656752B2 (de)
BR (1) BR9107071A (de)
CA (1) CA2095430A1 (de)
DE (1) DE69127755T2 (de)
ES (1) ES2107522T3 (de)
HU (1) HUT70500A (de)
IE (1) IE913906A1 (de)
IL (1) IL99975A (de)
NZ (1) NZ240502A (de)
WO (1) WO1992008465A2 (de)
ZA (1) ZA918869B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288754A (en) * 1992-02-04 1994-02-22 Allergan, Inc. Polar C-1 esters of prostaglandins
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5688819A (en) * 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5972991A (en) 1992-09-21 1999-10-26 Allergan Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5834498A (en) * 1992-09-21 1998-11-10 Allergan Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5328933A (en) * 1992-10-28 1994-07-12 Allergan, Inc. Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
US6124353A (en) * 1992-11-12 2000-09-26 Allergan Sales, Inc. Method of treating ocular hypertension with 8-epi prostaglandins
US5545665A (en) * 1993-12-28 1996-08-13 Allergan Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
US5698733A (en) * 1994-09-30 1997-12-16 Alcon Laboratories, Inc. Use of 9-deoxy prostaglandin derivatives to treat glaucoma
US6169111B1 (en) 1995-06-07 2001-01-02 Alcon Laboratories, Inc. Conformationally rigid aryl prostaglandins for use in glaucoma therapy
US6066671A (en) 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
US6646001B2 (en) 1997-12-19 2003-11-11 Alcon Manufacturing, Ltd. Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
US6096783A (en) * 1998-12-15 2000-08-01 Alcon Laboratories, Inc. Cyclobutane prostaglandin analogues as ocular hypotensive agents
US6211226B1 (en) 1998-12-17 2001-04-03 Alcon Laboratories, Inc. 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
US6160013A (en) * 1998-12-17 2000-12-12 Alcon Laboratories, Inc. 14-aza prostaglandins for the treatment of glaucoma and ocular hypertension
US20090148527A1 (en) * 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
US9241918B2 (en) 2005-03-16 2016-01-26 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
US7851504B2 (en) 2005-03-16 2010-12-14 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4122282A (en) * 1975-12-29 1978-10-24 The Upjohn Company 2-Decarboxy-2-carboxyamino-methyl-PGFα compounds
US4599353A (en) * 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
EP0242580B1 (de) * 1986-03-13 1993-04-28 The Trustees Of Columbia University In The City Of New York Verwendung von A-, B- und C-Prostaglandinen und deren Derivaten zur Behandlung von Augen-Hypertension und Glaukom
US4883819A (en) * 1986-07-31 1989-11-28 The Trustees Of Columbia University In The City Of New York Use of A, B and C prostaglandins and derivatives thereof to treat ocular hypertension and glaucoma
US4824857A (en) * 1986-05-16 1989-04-25 Yasumasa Goh Use of prostaglandin D2 -active substances
US4952581A (en) * 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
ES2052735T3 (es) * 1987-09-18 1994-07-16 R Tech Ueno Ltd Un metodo para producir un agente hipotensor ocular.
US4927846A (en) * 1988-11-23 1990-05-22 Allergan, Inc. Intraocular pressure reducing 1,11-lactone prostaglandins
US4994274A (en) * 1989-07-27 1991-02-19 Allergan, Inc. Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using
US5011856A (en) * 1990-03-12 1991-04-30 Allergan, Inc. Use of prostaglandin F3 α as an ocular hypotensive agent
US5238961A (en) * 1990-06-14 1993-08-24 Allergan, Inc. Pgf 1-alcohols and their use as ocular hypotensives

Also Published As

Publication number Publication date
JP3488456B2 (ja) 2004-01-19
US5270049A (en) 1993-12-14
IL99975A0 (en) 1992-08-18
AU656752B2 (en) 1995-02-16
BR9107071A (pt) 1993-09-21
IL99975A (en) 1996-05-14
DE69127755T2 (de) 1998-04-30
IE913906A1 (en) 1992-05-20
WO1992008465A2 (en) 1992-05-29
DE69127755D1 (de) 1997-10-30
JPH06501482A (ja) 1994-02-17
EP0556296A1 (de) 1993-08-25
ZA918869B (en) 1992-07-29
HU9301327D0 (en) 1993-09-28
WO1992008465A3 (en) 1992-10-15
ES2107522T3 (es) 1997-12-01
NZ240502A (en) 1995-07-26
AU9041491A (en) 1992-06-11
EP0556296B1 (de) 1997-09-24
CA2095430A1 (en) 1992-05-10
HUT70500A (en) 1995-10-30

Similar Documents

Publication Publication Date Title
ATE158506T1 (de) Okulare hypotensive 2-dekarboxyl-2-aminoalkyl- prostaglandine
ES2138691T3 (es) Procedimiento para la obtencion de derivados de n-acil-5-fluorocitidina.
NO912630L (no) Fremgangsmaate for fremstilling av nye 2,6-dialkyl-4-silyl-fenoler som antiarteriosklerotiske midler
ES2134226T3 (es) Derivados de s-triazina como fotoestabilizadores.
ES2106700T3 (es) Procedimiento para la preparacion de derivados de la 4a,5,9,10,11,12-hexahidro-6h-benzofuro(3a,3,2-ef)(2)benzacepinas.
ES2174298T3 (es) Derivados de aminotiazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
FI98455B (fi) Menetelmä terapeuttisesti aktiivisten indolijohdannaisten valmistamiseksi
ES2079872T3 (es) Derivados hipotensores oculares de la 2-descarboxil-2-aciltioalquilprostaglandina.
FI892222A (fi) Peptidalkoholer med antikoagulantverkan.
ATE164763T1 (de) Okulare hypotensive homo-prostaglandinderivate
ES2060944T3 (es) Derivados de 2,5,6,7-tetranor-4,8-inter-m-fenileno de pgi2 (prostaglandina i2).
ES2072936T3 (es) Derivados de pradimicin-amida.
WO1992010473A3 (en) 2-decarboxyl-2-alkoxyalkyl prostaglandins as ocular hypotensives
GR1001309B (el) Μεθοδος παρασκευης παραγωγου ενωσεως της διχλωροανιλινης.
NO921317L (no) Antimetastatisk virkende midler
BE860603A (fr) Derives de l'oxadiazole-1,2,4 utilisables comme azureurs optiques

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties