ATE151812T1 - Neue variante von menschlichem gewebeplasminogenaktivator - Google Patents

Neue variante von menschlichem gewebeplasminogenaktivator

Info

Publication number
ATE151812T1
ATE151812T1 AT89900085T AT89900085T ATE151812T1 AT E151812 T1 ATE151812 T1 AT E151812T1 AT 89900085 T AT89900085 T AT 89900085T AT 89900085 T AT89900085 T AT 89900085T AT E151812 T1 ATE151812 T1 AT E151812T1
Authority
AT
Austria
Prior art keywords
plasminogen activator
human tissue
tissue plasminogen
new variant
variant
Prior art date
Application number
AT89900085T
Other languages
English (en)
Inventor
Adair J Hotchkiss
John V O'connor
Michael W Spellman
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE151812T1 publication Critical patent/ATE151812T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT89900085T 1987-11-06 1988-11-02 Neue variante von menschlichem gewebeplasminogenaktivator ATE151812T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11809887A 1987-11-06 1987-11-06

Publications (1)

Publication Number Publication Date
ATE151812T1 true ATE151812T1 (de) 1997-05-15

Family

ID=22376492

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89900085T ATE151812T1 (de) 1987-11-06 1988-11-02 Neue variante von menschlichem gewebeplasminogenaktivator

Country Status (18)

Country Link
EP (2) EP0387290B1 (de)
JP (1) JPH03500843A (de)
KR (1) KR920009521B1 (de)
AT (1) ATE151812T1 (de)
AU (2) AU2804989A (de)
CA (1) CA1341609C (de)
DD (1) DD286613A5 (de)
DE (1) DE3855874T2 (de)
DK (1) DK175482B1 (de)
FI (1) FI102970B (de)
HU (1) HU215230B (de)
IL (1) IL88247A0 (de)
NO (1) NO307612B1 (de)
NZ (1) NZ226829A (de)
PH (1) PH30064A (de)
PT (1) PT88938B (de)
WO (1) WO1989004368A1 (de)
ZA (1) ZA888250B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3126381B2 (ja) * 1990-07-31 2001-01-22 ジェネンテク，インコーポレイテッド 減少されたクリアランスを有する組織プラスミノーゲンアクチベーター変異体
US5246850A (en) * 1990-07-31 1993-09-21 Genentech, Inc. DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
AU664469B2 (en) 1992-06-03 1995-11-16 Genentech Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
DK0827751T3 (da) * 1996-09-06 2003-03-31 Chemo Sero Therapeut Res Inst Medicinsk præparat indeholdende vævsplasminogenaktivator og nicotinamid
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125254A1 (de) * 1982-10-28 1984-11-21 Beecham Group Plc Enzymderivate und deren verwendung bei der behandlung von trombosen
JP2527454B2 (ja) * 1986-01-31 1996-08-21 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド 新しい血栓溶解タンパク質
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
DE3888619D1 (de) * 1987-10-09 1994-04-28 Monsanto Co Modifizierter Gewebeplasminogenaktivator.

Also Published As

Publication number Publication date
ZA888250B (en) 1990-07-25
HU890157D0 (en) 1990-12-28
EP0754753A1 (de) 1997-01-22
DK112290A (da) 1990-07-06
EP0387290B1 (de) 1997-04-16
CA1341609C (en) 2011-02-01
DD286613A5 (de) 1991-01-31
NO307612B1 (no) 2000-05-02
HUT54209A (en) 1991-01-28
EP0387290A1 (de) 1990-09-19
DE3855874T2 (de) 1997-09-11
DK112290D0 (da) 1990-05-04
IL88247A0 (en) 1989-06-30
NZ226829A (en) 1991-06-25
KR890701733A (ko) 1989-12-21
PT88938A (pt) 1989-11-30
NO901995D0 (no) 1990-05-04
AU2131792A (en) 1992-11-19
DK175482B1 (da) 2004-11-08
AU2804989A (en) 1989-06-01
HU215230B (hu) 2000-03-28
FI902239A0 (fi) 1990-05-04
JPH03500843A (ja) 1991-02-28
FI102970B1 (fi) 1999-03-31
PH30064A (en) 1996-11-08
FI102970B (fi) 1999-03-31
KR920009521B1 (ko) 1992-10-17
NO901995L (no) 1990-07-05
PT88938B (pt) 1993-05-31
DE3855874D1 (de) 1997-05-22
WO1989004368A1 (en) 1989-05-18
AU658909B2 (en) 1995-05-04

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time