NO307612B1 - Fremgangsmåte for fremstilling av en vevstypeplasminogen- aktivatorvariant - Google Patents

Fremgangsmåte for fremstilling av en vevstypeplasminogen- aktivatorvariant

Info

Publication number
NO307612B1
NO307612B1 NO901995A NO901995A NO307612B1 NO 307612 B1 NO307612 B1 NO 307612B1 NO 901995 A NO901995 A NO 901995A NO 901995 A NO901995 A NO 901995A NO 307612 B1 NO307612 B1 NO 307612B1
Authority
NO
Norway
Prior art keywords
plasminogen activator
type plasminogen
preparing
tissue type
activator variant
Prior art date
Application number
NO901995A
Other languages
English (en)
Other versions
NO901995D0 (no
NO901995L (no
Inventor
Adair J Hotchkiss
John V O'connor
Michael W Spellman
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of NO901995D0 publication Critical patent/NO901995D0/no
Publication of NO901995L publication Critical patent/NO901995L/no
Publication of NO307612B1 publication Critical patent/NO307612B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NO901995A 1987-11-06 1990-05-04 Fremgangsmåte for fremstilling av en vevstypeplasminogen- aktivatorvariant NO307612B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11809887A 1987-11-06 1987-11-06
PCT/US1988/003901 WO1989004368A1 (en) 1987-11-06 1988-11-02 Novel human tissue-type plasminogen activator variant

Publications (3)

Publication Number Publication Date
NO901995D0 NO901995D0 (no) 1990-05-04
NO901995L NO901995L (no) 1990-07-05
NO307612B1 true NO307612B1 (no) 2000-05-02

Family

ID=22376492

Family Applications (1)

Application Number Title Priority Date Filing Date
NO901995A NO307612B1 (no) 1987-11-06 1990-05-04 Fremgangsmåte for fremstilling av en vevstypeplasminogen- aktivatorvariant

Country Status (18)

Country Link
EP (2) EP0387290B1 (no)
JP (1) JPH03500843A (no)
KR (1) KR920009521B1 (no)
AT (1) ATE151812T1 (no)
AU (2) AU2804989A (no)
CA (1) CA1341609C (no)
DD (1) DD286613A5 (no)
DE (1) DE3855874T2 (no)
DK (1) DK175482B1 (no)
FI (1) FI102970B1 (no)
HU (1) HU215230B (no)
IL (1) IL88247A0 (no)
NO (1) NO307612B1 (no)
NZ (1) NZ226829A (no)
PH (1) PH30064A (no)
PT (1) PT88938B (no)
WO (1) WO1989004368A1 (no)
ZA (1) ZA888250B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246850A (en) * 1990-07-31 1993-09-21 Genentech, Inc. DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
DE69113049T2 (de) * 1990-07-31 1996-04-04 Genentech Inc Varianten des gewebeplasminogenaktivators mit vermindertem abbau.
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
DK0643772T3 (da) 1992-06-03 1998-02-02 Genentech Inc Glycosyleringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber
US6139838A (en) * 1996-09-06 2000-10-31 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Tissue plasminogen activator medicinal composition
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125254A1 (en) * 1982-10-28 1984-11-21 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
WO1987004722A1 (en) * 1986-01-31 1987-08-13 Genetics Institute, Inc. Novel thrombolytic proteins
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
ATE103332T1 (de) * 1987-10-09 1994-04-15 Monsanto Co Modifizierter gewebeplasminogenaktivator.

Also Published As

Publication number Publication date
KR920009521B1 (ko) 1992-10-17
FI102970B (fi) 1999-03-31
NO901995D0 (no) 1990-05-04
CA1341609C (en) 2011-02-01
AU658909B2 (en) 1995-05-04
HU890157D0 (en) 1990-12-28
DK112290A (da) 1990-07-06
DE3855874D1 (de) 1997-05-22
NO901995L (no) 1990-07-05
FI102970B1 (fi) 1999-03-31
DK175482B1 (da) 2004-11-08
KR890701733A (ko) 1989-12-21
PH30064A (en) 1996-11-08
DE3855874T2 (de) 1997-09-11
DD286613A5 (de) 1991-01-31
AU2804989A (en) 1989-06-01
EP0387290B1 (en) 1997-04-16
EP0387290A1 (en) 1990-09-19
NZ226829A (en) 1991-06-25
EP0754753A1 (en) 1997-01-22
PT88938A (pt) 1989-11-30
ZA888250B (en) 1990-07-25
IL88247A0 (en) 1989-06-30
PT88938B (pt) 1993-05-31
JPH03500843A (ja) 1991-02-28
AU2131792A (en) 1992-11-19
HUT54209A (en) 1991-01-28
FI902239A0 (fi) 1990-05-04
ATE151812T1 (de) 1997-05-15
DK112290D0 (da) 1990-05-04
WO1989004368A1 (en) 1989-05-18
HU215230B (hu) 2000-03-28

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Legal Events

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