FI102970B1 - Uusi ihmiskudostyyppinen plasminogeeni aktivaattori muunnelma - Google Patents

Uusi ihmiskudostyyppinen plasminogeeni aktivaattori muunnelma

Info

Publication number
FI102970B1
FI102970B1 FI902239A FI902239A FI102970B1 FI 102970 B1 FI102970 B1 FI 102970B1 FI 902239 A FI902239 A FI 902239A FI 902239 A FI902239 A FI 902239A FI 102970 B1 FI102970 B1 FI 102970B1
Authority
FI
Finland
Prior art keywords
plasminogen activator
human tissue
novel human
type plasminogen
activator variant
Prior art date
Application number
FI902239A
Other languages
English (en)
Swedish (sv)
Other versions
FI902239A0 (fi
FI102970B (fi
Inventor
Adair J Hotchkiss
John V O'connor
Michael W Spellman
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of FI902239A0 publication Critical patent/FI902239A0/fi
Application granted granted Critical
Publication of FI102970B1 publication Critical patent/FI102970B1/fi
Publication of FI102970B publication Critical patent/FI102970B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI902239A 1987-11-06 1990-05-04 Menetelmä ihmisen kudostyyppisen plasminogeeniaktivaattorimuunnelman v almistamiseksi FI102970B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11809887A 1987-11-06 1987-11-06
PCT/US1988/003901 WO1989004368A1 (en) 1987-11-06 1988-11-02 Novel human tissue-type plasminogen activator variant

Publications (3)

Publication Number Publication Date
FI902239A0 FI902239A0 (fi) 1990-05-04
FI102970B1 true FI102970B1 (fi) 1999-03-31
FI102970B FI102970B (fi) 1999-03-31

Family

ID=22376492

Family Applications (1)

Application Number Title Priority Date Filing Date
FI902239A FI102970B (fi) 1987-11-06 1990-05-04 Menetelmä ihmisen kudostyyppisen plasminogeeniaktivaattorimuunnelman v almistamiseksi

Country Status (18)

Country Link
EP (2) EP0754753A1 (fi)
JP (1) JPH03500843A (fi)
KR (1) KR920009521B1 (fi)
AT (1) ATE151812T1 (fi)
AU (2) AU2804989A (fi)
CA (1) CA1341609C (fi)
DD (1) DD286613A5 (fi)
DE (1) DE3855874T2 (fi)
DK (1) DK175482B1 (fi)
FI (1) FI102970B (fi)
HU (1) HU215230B (fi)
IL (1) IL88247A0 (fi)
NO (1) NO307612B1 (fi)
NZ (1) NZ226829A (fi)
PH (1) PH30064A (fi)
PT (1) PT88938B (fi)
WO (1) WO1989004368A1 (fi)
ZA (1) ZA888250B (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246850A (en) * 1990-07-31 1993-09-21 Genentech, Inc. DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
DK0542869T3 (da) * 1990-07-31 1996-02-05 Genentech Inc Vævsplasminogenaktivatorvarianter med nedsat udskillelse
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
ATE155816T1 (de) 1992-06-03 1997-08-15 Genentech Inc Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
DK0827751T3 (da) * 1996-09-06 2003-03-31 Chemo Sero Therapeut Res Inst Medicinsk præparat indeholdende vævsplasminogenaktivator og nicotinamid
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001786A1 (en) * 1982-10-28 1984-05-10 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
EP0293394B2 (en) * 1986-01-31 2003-10-29 Genetics Institute, LLC Novel thrombolytic proteins
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
ZA887556B (en) * 1987-10-09 1989-07-26 Monsanto Co Modified tissue plasminogen activator

Also Published As

Publication number Publication date
KR890701733A (ko) 1989-12-21
PT88938B (pt) 1993-05-31
ATE151812T1 (de) 1997-05-15
DE3855874D1 (de) 1997-05-22
FI902239A0 (fi) 1990-05-04
WO1989004368A1 (en) 1989-05-18
ZA888250B (en) 1990-07-25
IL88247A0 (en) 1989-06-30
AU2131792A (en) 1992-11-19
KR920009521B1 (ko) 1992-10-17
DK112290D0 (da) 1990-05-04
PT88938A (pt) 1989-11-30
AU658909B2 (en) 1995-05-04
HUT54209A (en) 1991-01-28
DD286613A5 (de) 1991-01-31
CA1341609C (en) 2011-02-01
DE3855874T2 (de) 1997-09-11
EP0387290B1 (en) 1997-04-16
AU2804989A (en) 1989-06-01
EP0754753A1 (en) 1997-01-22
DK112290A (da) 1990-07-06
NO901995D0 (no) 1990-05-04
HU890157D0 (en) 1990-12-28
JPH03500843A (ja) 1991-02-28
NO307612B1 (no) 2000-05-02
DK175482B1 (da) 2004-11-08
EP0387290A1 (en) 1990-09-19
HU215230B (hu) 2000-03-28
PH30064A (en) 1996-11-08
NZ226829A (en) 1991-06-25
NO901995L (no) 1990-07-05
FI102970B (fi) 1999-03-31

Similar Documents

Publication Publication Date Title
DE3751842D1 (de) Modifizierter, menschlicher Gewebeplasminogenaktivator und seine Herstellung
IL80659A0 (en) Modified tissue plasminogen activators,their preparation and pharmaceutical compositions containing them
FI102970B1 (fi) Uusi ihmiskudostyyppinen plasminogeeni aktivaattori muunnelma
NO883963D0 (no) Modifiserte plasminogen-aktivatorer.
ATE119940T1 (de) Gewebs-plasminogen-aktivator-derivat.

Legal Events

Date Code Title Description
FG Patent granted

Owner name: GENENTECH, INC.

MA Patent expired