ATE150747T1 - Indolderivate - Google Patents
IndolderivateInfo
- Publication number
- ATE150747T1 ATE150747T1 AT91108019T AT91108019T ATE150747T1 AT E150747 T1 ATE150747 T1 AT E150747T1 AT 91108019 T AT91108019 T AT 91108019T AT 91108019 T AT91108019 T AT 91108019T AT E150747 T1 ATE150747 T1 AT E150747T1
- Authority
- AT
- Austria
- Prior art keywords
- chem
- alkyl
- hydrogen
- alkylene
- lower alkylene
- Prior art date
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000002947 alkylene group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909011335A GB9011335D0 (en) | 1990-05-21 | 1990-05-21 | Indolebutyric acid derivatives and process for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE150747T1 true ATE150747T1 (de) | 1997-04-15 |
Family
ID=10676312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91108019T ATE150747T1 (de) | 1990-05-21 | 1991-05-17 | Indolderivate |
Country Status (18)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2120942C1 (ru) * | 1991-06-17 | 1998-10-27 | Фудзисава Фармасьютикал Ко., Лтд. | ПРОИЗВОДНЫЕ ИНДОЛИЗИНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИНГИБИРОВАНИЯ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ |
| US5334716A (en) * | 1991-06-17 | 1994-08-02 | Fujisawa Pharmaceutical Co., Ltd. | Heterocyclic derivatives |
| GB9115951D0 (en) * | 1991-07-24 | 1991-09-11 | Pfizer Ltd | Indoles |
| EP0603278A1 (en) * | 1991-09-11 | 1994-06-29 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives as 5-alpha-reductase inhibitor |
| GB9127531D0 (en) * | 1991-12-31 | 1992-02-19 | Fujisawa Pharmaceutical Co | Heterocyclic compound |
| GB9204024D0 (en) * | 1992-02-25 | 1992-04-08 | Fujisawa Pharmaceutical Co | Indole derivatives |
| GB9204365D0 (en) * | 1992-02-28 | 1992-04-08 | Pfizer Ltd | Indoles |
| EP0641211A1 (en) * | 1992-05-21 | 1995-03-08 | Endorecherche Inc. | INHIBITORS OF TESTOSTERONE 5$g(a)-REDUCTASE ACTIVITY |
| GB9302577D0 (en) * | 1993-02-10 | 1993-03-24 | Fujisawa Pharmaceutical Co | Indole derivatives |
| EP0648208A1 (en) * | 1993-04-05 | 1995-04-19 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives as testosterone 5 alpha-reductase inhibitors |
| GB9310092D0 (en) * | 1993-05-17 | 1993-06-30 | Fujisawa Pharmaceutical Co | Indole derivatives |
| IL109728A0 (en) * | 1993-05-28 | 1994-08-26 | Pfizer Res & Dev | Indoles |
| GB9317096D0 (en) * | 1993-08-17 | 1993-09-29 | Pfizer Ltd | Indoles |
| AU681021B2 (en) * | 1994-03-30 | 1997-08-14 | Zeria Pharmaceutical Co., Ltd. | Indole derivative and medicine containing the same |
| GB9409583D0 (en) * | 1994-05-13 | 1994-07-06 | Pfizer Ltd | Indoles |
| AU774929B2 (en) | 1998-03-31 | 2004-07-15 | Institutes For Pharmaceutical Discovery, Llc, The | Substituted indolealkanoic acids |
| WO2003020311A1 (fr) * | 2001-08-28 | 2003-03-13 | Fujisawa Pharmaceutical Co., Ltd. | Remedes contre les maladies de la peau |
| ATE406363T1 (de) | 2003-05-09 | 2008-09-15 | Hoffmann La Roche | Methylindole und methylpyrrolopyridine als alpha- 1-adrenerge agonisten |
| TW201329025A (zh) * | 2011-11-01 | 2013-07-16 | Astex Therapeutics Ltd | 醫藥化合物 |
| EP3774767A1 (en) * | 2018-04-05 | 2021-02-17 | Beth Israel Deaconess Medical Center, Inc. | Aryl hydrocarbon receptor modulators and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR7337M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1968-01-11 | 1969-10-13 | ||
| PH23498A (en) * | 1984-08-06 | 1989-08-16 | Sterling Drug Inc | 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof |
-
1990
- 1990-05-21 GB GB909011335A patent/GB9011335D0/en active Pending
-
1991
- 1991-05-07 ZA ZA913457A patent/ZA913457B/xx unknown
- 1991-05-13 IE IE164191A patent/IE911641A1/en unknown
- 1991-05-16 FI FI912375A patent/FI912375A7/fi not_active Application Discontinuation
- 1991-05-16 NO NO911938A patent/NO175475C/no unknown
- 1991-05-16 AU AU77116/91A patent/AU645560B2/en not_active Ceased
- 1991-05-17 EP EP91108019A patent/EP0458207B1/en not_active Expired - Lifetime
- 1991-05-17 DE DE69125308T patent/DE69125308T2/de not_active Expired - Fee Related
- 1991-05-17 CA CA002042905A patent/CA2042905A1/en not_active Abandoned
- 1991-05-17 DK DK91108019.0T patent/DK0458207T3/da active
- 1991-05-17 AT AT91108019T patent/ATE150747T1/de not_active IP Right Cessation
- 1991-05-20 CN CN91103461A patent/CN1030701C/zh not_active Expired - Fee Related
- 1991-05-20 HU HU911681A patent/HUT60471A/hu unknown
- 1991-05-20 PT PT97717A patent/PT97717B/pt not_active IP Right Cessation
- 1991-05-20 RU SU914895529A patent/RU2045518C1/ru active
- 1991-05-20 KR KR1019910008139A patent/KR910019975A/ko not_active Ceased
- 1991-05-21 JP JP3229864A patent/JPH0678307B2/ja not_active Expired - Fee Related
-
1995
- 1995-06-22 HU HU95P/P00391P patent/HU211637A9/hu unknown
-
1997
- 1997-03-27 GR GR970400551T patent/GR3022953T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI912375A7 (fi) | 1991-11-22 |
| CA2042905A1 (en) | 1991-11-22 |
| DE69125308T2 (de) | 1997-07-10 |
| NO911938D0 (no) | 1991-05-16 |
| PT97717A (pt) | 1992-02-28 |
| FI912375A0 (fi) | 1991-05-16 |
| ZA913457B (en) | 1992-02-26 |
| PT97717B (pt) | 1998-08-31 |
| JPH0678307B2 (ja) | 1994-10-05 |
| EP0458207A2 (en) | 1991-11-27 |
| HU211637A9 (en) | 1995-12-28 |
| HU911681D0 (en) | 1991-11-28 |
| RU2045518C1 (ru) | 1995-10-10 |
| GB9011335D0 (en) | 1990-07-11 |
| JPH04244061A (ja) | 1992-09-01 |
| AU7711691A (en) | 1991-11-21 |
| NO911938L (no) | 1991-11-22 |
| KR910019975A (ko) | 1991-12-19 |
| DK0458207T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-04-21 |
| DE69125308D1 (de) | 1997-04-30 |
| HUT60471A (en) | 1992-09-28 |
| NO175475B (no) | 1994-07-11 |
| AU645560B2 (en) | 1994-01-20 |
| CN1030701C (zh) | 1996-01-17 |
| GR3022953T3 (en) | 1997-06-30 |
| NO175475C (no) | 1994-10-19 |
| EP0458207A3 (en) | 1992-03-25 |
| CN1056685A (zh) | 1991-12-04 |
| EP0458207B1 (en) | 1997-03-26 |
| IE911641A1 (en) | 1991-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |