ATE137757T1 - Gem-diphosphonsäuren, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

Gem-diphosphonsäuren, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
ATE137757T1
ATE137757T1 AT90915106T AT90915106T ATE137757T1 AT E137757 T1 ATE137757 T1 AT E137757T1 AT 90915106 T AT90915106 T AT 90915106T AT 90915106 T AT90915106 T AT 90915106T AT E137757 T1 ATE137757 T1 AT E137757T1
Authority
AT
Austria
Prior art keywords
alkyl
chain
pct
phenyl
hydrogen
Prior art date
Application number
AT90915106T
Other languages
English (en)
Inventor
Sergio Tognella
Valeria Livi
Ernesto Menta
Silvano Spinelli
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Application granted granted Critical
Publication of ATE137757T1 publication Critical patent/ATE137757T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564—Three-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT90915106T 1989-10-12 1990-10-11 Gem-diphosphonsäuren, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel ATE137757T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22004A IT1241674B (it) 1989-10-12 1989-10-12 Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono.

Publications (1)

Publication Number Publication Date
ATE137757T1 true ATE137757T1 (de) 1996-05-15

Family

ID=11190055

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90915106T ATE137757T1 (de) 1989-10-12 1990-10-11 Gem-diphosphonsäuren, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Country Status (14)

Country Link
US (1) US5300671A (de)
EP (1) EP0593437B1 (de)
JP (1) JPH05500949A (de)
KR (1) KR927003610A (de)
AT (1) ATE137757T1 (de)
AU (1) AU639495B2 (de)
CA (1) CA2067191A1 (de)
DE (1) DE69026964T2 (de)
ES (1) ES2090143T3 (de)
FI (1) FI921562A7 (de)
HU (1) HUT61027A (de)
IT (1) IT1241674B (de)
WO (1) WO1991005791A1 (de)
ZA (1) ZA908131B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0496520A1 (de) * 1991-01-22 1992-07-29 Merck & Co. Inc. Knochenaktive Verbindungen
US5183815A (en) * 1991-01-22 1993-02-02 Merck & Co., Inc. Bone acting agents
IT1246778B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono
IT1246777B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Aminoacil derivati di acidi gem-difosfonici,un processo per la loro preparazione e composizioni farmaceutiche che li contengono
IT1284070B1 (it) * 1996-06-26 1998-05-08 Boehringer Mannheim Italia Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che
IT1290444B1 (it) * 1997-03-27 1998-12-03 Boehringer Mannheim Italia Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale
EP1115396A4 (de) * 1998-09-25 2002-05-22 Sunol Molecular Corp Pharmazeutisch aktive verbindungen und deren verwendungsmethoden
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
EP1865967A4 (de) * 2005-04-08 2011-02-09 Chimerix Inc Verbindungen, zusammensetzungen und verfahren zur behandlung viraler infektionen und anderer erkrankungen
JP2008535862A (ja) 2005-04-08 2008-09-04 キメリクス，インコーポレイテッド ポックスウイルス感染の治療のための化合物、組成物および方法
AU2009206673B2 (en) * 2008-01-25 2015-04-23 Chimerix, Inc. Methods of treating viral infections
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
WO2011017253A1 (en) 2009-08-03 2011-02-10 Chimerix, Inc. Composition and methods of treating viral infections and viral induced tumors
EP3216789A1 (de) 2010-02-12 2017-09-13 Chimerix, Inc. Verfahren zur behandlung von vireninfektionen
CA2797601A1 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
US11246905B2 (en) 2016-08-15 2022-02-15 President And Fellows Of Harvard College Treating infections using IdsD from Proteus mirabilis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3425812A1 (de) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
FI921562L (fi) 1992-04-08
IT8922004A0 (it) 1989-10-12
JPH05500949A (ja) 1993-02-25
WO1991005791A1 (en) 1991-05-02
DE69026964T2 (de) 1996-10-24
HU9201215D0 (en) 1992-07-28
EP0593437A1 (de) 1994-04-27
FI921562A0 (fi) 1992-04-08
EP0593437B1 (de) 1996-05-08
AU639495B2 (en) 1993-07-29
FI921562A7 (fi) 1992-04-08
DE69026964D1 (de) 1996-06-13
IT8922004A1 (it) 1991-04-12
US5300671A (en) 1994-04-05
IT1241674B (it) 1994-01-27
KR927003610A (ko) 1992-12-18
HUT61027A (en) 1992-11-30
ES2090143T3 (es) 1996-10-16
AU6510890A (en) 1991-05-16
CA2067191A1 (en) 1991-04-13
ZA908131B (en) 1991-07-31

Similar Documents

Publication Publication Date Title
ATE137757T1 (de) Gem-diphosphonsäuren, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
ATE49766T1 (de) Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel.
ATE63124T1 (de) Prodrugverbindungen, verfahren zu deren herstellung und diese enthaltende zubereitungen mit verzoegerter freisetzung.
DE69317413D1 (de) Basische derivate von glutaminsäure und asparaginsäure als gastrin oder cholecystokinin antagonisten
BG101402A (en) Apoliprotein-b synthesis inhibitors
ZA835577B (en) Anorexigenic trifluoromethylphenyltetrahydropyridines,a process for their preparation and pharmaceutical compositions containing them
DE3369980D1 (en) Disubstituted proline derivatives, process for their preparation and their use
SE7714660L (sv) Aminosockerderivat, sett for framstellning derav samt anvendning derav som lekemedel
DE3676179D1 (de) N-enthaltende heterozyklische verbindungen, verfahren zu deren herstellung und diese enthaltende arzneimittel.
ES8702341A1 (es) Un procedimiento para la produccion de un derivado de dia- midas de n-acilaminoacidos
GB9215844D0 (en) Novel compounds
PH20421A (en) Derivatives of piperidinedione for protecting the myocardium presenting an anti-arrythmic activity and pharmaceutical compositions containing them
ZA912618B (en) 3-aminochroman derivatives,process for preparing these and pharmaceutical compositions containing them
IL65347A0 (en) N-substituted amido-amino acids,process for their preparation and pharmaceutical compositions comprising them
FR2713644B1 (fr) Nouveaux analogues de l'éburnane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
ATE59637T1 (de) Neue basisch substituierte pyridinverbindungen, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung.
ZA842686B (en) Disubstituted polymethylene imines,processes for the preparation thereof and pharmaceutical compositions containing them
DE59305351D1 (de) Neue acyclische amidingruppen-haltige diphosphonsäurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
ATE25523T1 (de) Bicyclische phenolether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel.
FR2658518B1 (fr) N-phenyl n-alcoxycarbonylalkyle glycinamides, leur preparation et les medicaments les contenant.
ES2097320T3 (es) Derivados nitrosocarbamoilados del acido gemdifosfonico, procedimiento para la preparacion de los mismos y composiciones farmaceuticas que los contienen.
MY101827A (en) 2-[n-substitutedguanidino]-4-heteroarylthiazole antiulcer agents
DK0599732T3 (da) 1-phenylbicyklo 2.2.2 octanderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem.
NO921406L (no) Gem-difosfonsyrer, fremgangsmaate ved deres fremstilling og farmasoeytiske sammensetninger som inneholder dem
ES2036561T3 (es) Un procedimiento para preparar un grupo de compuestos que son acidos 4-hidroxi-4-(alquenil sustituido)ciclohexanocarboxilicos.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee