ES2097320T3 - Derivados nitrosocarbamoilados del acido gemdifosfonico, procedimiento para la preparacion de los mismos y composiciones farmaceuticas que los contienen. - Google Patents

Derivados nitrosocarbamoilados del acido gemdifosfonico, procedimiento para la preparacion de los mismos y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2097320T3
ES2097320T3 ES92907813T ES92907813T ES2097320T3 ES 2097320 T3 ES2097320 T3 ES 2097320T3 ES 92907813 T ES92907813 T ES 92907813T ES 92907813 T ES92907813 T ES 92907813T ES 2097320 T3 ES2097320 T3 ES 2097320T3
Authority
ES
Spain
Prior art keywords
nitrosocarbamoilated
gemdifosphonic
derivatives
procedure
contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92907813T
Other languages
English (en)
Inventor
Sergio Tognella
Valeria Livi
Ernesto Menta
Silvano Spinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics SpA
Original Assignee
Boehringer Mannheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia SpA filed Critical Boehringer Mannheim Italia SpA
Application granted granted Critical
Publication of ES2097320T3 publication Critical patent/ES2097320T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4

Abstract

SE DESCRIBEN ACIDOS DIFOSFONICOS DE FORMULA (I), DONDE R1 Y R2 SON HIDROGENO O ALQUILO C1-C4; A ES HIDROGENO, HALOGENO, HIDROXILO O ALQUILO C1-C12; B ES UN ENLACE COVALENTE, UNA CADENA ALQUILICA C1-C8 UN HETERO-ATOMO(O,S O N-CH3) QUE CONTIENE UNA CADENA ALQUILICA, UNA CADENA CICLOALQUILICA, UNA CADENA ALQUILICA SUSTITUIDA POR GRUPOS CICLOPENTILO O CICLOHEXILO; R3 ES HIDROGENO, ALQUILO C1-C9, CICLOALQUILO C3-C6, BENCILO, FENILO O P-METOXIBENCILO; R4 Y R5, JUNTOS CON EL GRUPO (ALFA), SON EL RESIDUO DE UN AMINO ACIDO D O L; Q ES CERO O 1. ESTOS COMPUESTOS SON UTILES COMO AGENTES ANTITUMORALES.
ES92907813T 1991-04-12 1992-04-03 Derivados nitrosocarbamoilados del acido gemdifosfonico, procedimiento para la preparacion de los mismos y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2097320T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911017A IT1246778B (it) 1991-04-12 1991-04-12 Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono

Publications (1)

Publication Number Publication Date
ES2097320T3 true ES2097320T3 (es) 1997-04-01

Family

ID=11359574

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92907813T Expired - Lifetime ES2097320T3 (es) 1991-04-12 1992-04-03 Derivados nitrosocarbamoilados del acido gemdifosfonico, procedimiento para la preparacion de los mismos y composiciones farmaceuticas que los contienen.

Country Status (9)

Country Link
US (1) US5442102A (es)
EP (1) EP0579656B1 (es)
JP (1) JPH06506451A (es)
AT (1) ATE145647T1 (es)
AU (1) AU1466592A (es)
DE (1) DE69215511T2 (es)
ES (1) ES2097320T3 (es)
IT (1) IT1246778B (es)
WO (1) WO1992018511A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1539185A4 (en) * 2002-05-02 2006-04-05 Osteoscreen Inc METHODS AND COMPOSITIONS FOR STIMULATING BONE GROWTH USING NITRIC OXIDE FREEZING BISPHOSPHONATE CONJUGATES
US20090312406A1 (en) * 2008-06-12 2009-12-17 Hsing-Pang Hsieh Coumarin compounds and their use for treating viral infection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2536075B1 (fr) * 1982-11-17 1985-07-05 Adir Nouveaux derives de la nitrosouree, leur procede de preparation et les compositions pharmaceutiques les renfermant
DE3425812A1 (de) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
IT1241674B (it) * 1989-10-12 1994-01-27 Boehringer Biochemia Srl Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono.
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof

Also Published As

Publication number Publication date
US5442102A (en) 1995-08-15
DE69215511T2 (de) 1997-04-17
ITMI911017A1 (it) 1992-10-12
ITMI911017A0 (it) 1991-04-12
IT1246778B (it) 1994-11-26
DE69215511D1 (de) 1997-01-09
WO1992018511A1 (en) 1992-10-29
EP0579656B1 (en) 1996-11-27
ATE145647T1 (de) 1996-12-15
EP0579656A1 (en) 1994-01-26
AU1466592A (en) 1992-11-17
JPH06506451A (ja) 1994-07-21

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