ATE128449T1 - Durch komplexmittel beschleunigte katalytische asymmetrische dihydroxylierung. - Google Patents

Durch komplexmittel beschleunigte katalytische asymmetrische dihydroxylierung.

Info

Publication number
ATE128449T1
ATE128449T1 AT89901900T AT89901900T ATE128449T1 AT E128449 T1 ATE128449 T1 AT E128449T1 AT 89901900 T AT89901900 T AT 89901900T AT 89901900 T AT89901900 T AT 89901900T AT E128449 T1 ATE128449 T1 AT E128449T1
Authority
AT
Austria
Prior art keywords
olefin
osmium
combined
derivative
chiral ligand
Prior art date
Application number
AT89901900T
Other languages
English (en)
Inventor
Istvan E Marko
K Barry Sharpless
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/159,068 external-priority patent/US4871855A/en
Priority claimed from US07/250,378 external-priority patent/US4965364A/en
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE128449T1 publication Critical patent/ATE128449T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/20—Dihydroxylic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/48—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/26—Polyhydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT89901900T 1988-01-11 1989-01-10 Durch komplexmittel beschleunigte katalytische asymmetrische dihydroxylierung. ATE128449T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14269288A 1988-01-11 1988-01-11
US07/159,068 US4871855A (en) 1988-01-11 1988-02-23 Ligand-accelerated catalytic asymmetric dihydroxylation using dihydroquinidine and dihydroquinidine esters as ligands
US07/250,378 US4965364A (en) 1988-02-23 1988-09-28 Ligand-accelerated catalytic asymmetric dihydroxylation

Publications (1)

Publication Number Publication Date
ATE128449T1 true ATE128449T1 (de) 1995-10-15

Family

ID=27385846

Family Applications (2)

Application Number Title Priority Date Filing Date
AT95200458T ATE178578T1 (de) 1988-01-11 1989-01-10 Durch einen komplexbilder beschleunigte asymmetrische katalytische dihydroxylierung
AT89901900T ATE128449T1 (de) 1988-01-11 1989-01-10 Durch komplexmittel beschleunigte katalytische asymmetrische dihydroxylierung.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT95200458T ATE178578T1 (de) 1988-01-11 1989-01-10 Durch einen komplexbilder beschleunigte asymmetrische katalytische dihydroxylierung

Country Status (6)

Country Link
EP (2) EP0395729B1 (de)
JP (2) JP3153540B2 (de)
AT (2) ATE178578T1 (de)
CA (1) CA1338314C (de)
DE (2) DE68928969T2 (de)
WO (1) WO1989006225A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260461A (en) * 1988-01-11 1993-11-09 Massachusetts Institute Of Technology Ligands for ADH: cinchona alkaloids and moderately sized organic substituents linked through a planar aromatic spacer group
US5516929A (en) * 1988-01-11 1996-05-14 Massachusetts Institute Of Technology Method for catalytic asymmetric dihydroxylation of olefins using heterocyclic chiral ligands
US5227543A (en) * 1988-01-11 1993-07-13 Massachusetts Institute Of Technology Facilitation of turnover in the ADH by additives which catalyze the hydrolysis of the OS(VI) glycolate esters
US5126494A (en) * 1988-01-11 1992-06-30 Massachusetts Institute Of Technology Methods for catalytic asymmetric dihydroxylation of olefins
JP3550397B2 (ja) * 1991-05-13 2004-08-04 マサチユセツツ・インスチチユート・オブ・テクノロジイ 複素環式キラル配位子およびオレフィン類の接触非対称性ジヒドロキシル化方法
US5491237A (en) * 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
US6559309B2 (en) 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
AU5710198A (en) * 1996-12-18 1998-07-15 Scripps Research Institute, The Catalytic asymmetric amidohydroxylation of olefins with n-halo carboxamides
WO2000063173A1 (en) * 1999-04-14 2000-10-26 F. Hoffmann-La Roche Ag Process for the preparation of substituted piperidines
DE19920039A1 (de) * 1999-04-25 2000-10-26 Bayer Ag Verfahren zur asymmetrischen Dihydroxylierung von Olefinen mittels Osmium-Katalysatoren
WO2011159177A1 (en) 2010-06-18 2011-12-22 Industrial Research Limited Improved aminohydroxylation of alkenes
US9120732B2 (en) 2010-12-31 2015-09-01 California Institute Of Technology Catalytic anti-markovnikov oxidation and hydration of olefins
CN102531911B (zh) * 2011-12-22 2016-02-17 浙江工业大学 手性二环类化合物及其不对称合成方法
EP3759063A1 (de) 2018-02-26 2021-01-06 Bischof, Steven M. Normale alpha-olefinsynthese unter verwendung einer dehydroformylierung oder dehydroxymethylierung
US11123723B2 (en) 2018-02-26 2021-09-21 The Regents Of The University Of California Oxidative dehydroxymethylation of alcohols to produce olefins
EP3546447A1 (de) * 2018-03-29 2019-10-02 Heidelberg Pharma GmbH Synthese von (2s,3r,4r)-4,5-dihydroxyisoleucin und derivaten

Also Published As

Publication number Publication date
CA1338314C (en) 1996-05-07
DE68924418D1 (de) 1995-11-02
DE68924418T2 (de) 1996-03-28
WO1989006225A1 (en) 1989-07-13
JP2001192383A (ja) 2001-07-17
EP0658532B1 (de) 1999-04-07
EP0395729B1 (de) 1995-09-27
JPH03503885A (ja) 1991-08-29
DE68928969D1 (de) 1999-05-12
DE68928969T2 (de) 1999-12-16
JP3153540B2 (ja) 2001-04-09
EP0658532A1 (de) 1995-06-21
ATE178578T1 (de) 1999-04-15
EP0395729A1 (de) 1990-11-07

Similar Documents

Publication Publication Date Title
ATE128449T1 (de) Durch komplexmittel beschleunigte katalytische asymmetrische dihydroxylierung.
WO1991016322A3 (en) Heterocyclic chiral ligands and method for catalytic asymmetric dihydroxylation of olefins
KR900700247A (ko) 서어보 모우터에 의해 구동되는 기계작동부의 충돌검출방법
DE3685970T2 (de) Verfahren zum herstellen eines halbleiterbauelements.
NL930125I2 (nl) Werkwijze voor de bereiding van een alkeenderivaatvan een aminozuur, alsmede werkwijze voor de bereiding van een farmaceutisch preparaat dat deze verbinding bevat, en het gevormde farmaceutische preparaat.
DE3579840D1 (de) Verfahren zum herstellen von kohlenstoffasern durch wachsen in der gasphase.
DE69233299D1 (de) Liganden für asymmetrische dihydroxylierung: mehrere cinchona alkaloid einheiten gebunden an einen zentralen heterozyklischen kern
NL7605756A (nl) Stuurbooraanbrengmiddel voor gatzaagstelsel.
DE3576329D1 (de) Verfahren zur herstellung von 18f-markierten organischen verbindungen durch nukleophilen austausch.
BR7600323A (pt) Broca de perfuracao profunda aperfeicoada
DE3671583D1 (de) Verfahren zum herstellen eines halbleiter-speicherbauelementes.
ATA253275A (de) Verfahren zum schweissen von niederlegierten stahlen hoher harte
CA2087035A1 (en) Heterocyclic chiral ligands and method for catalytic asymmetric dihydroxylation of olefins
DE69422795D1 (de) Verfahren zur herstellung von 9-amino camptothecin
NL7514304A (nl) Werkwijze voor het vormen van een corrosiebesten- dige oxydebeschermlaag op staalsoorten, in het bijzonder aan martensietveroudering onderhevige staalsoorten.
DE3681033D1 (de) Katalytisches verfahren zur herstellung von fluoraomatischen verbindungen mittels n-sek-alkylpyridiniumsalze.
DE3577845D1 (de) Organische quaternaere ammoniumverbindungen und verfahren zu deren herstellung.
IT8019316A0 (it) Processi e apparati di post-trattamento, specialmente per impianti per la produzione di urea e ammonio nitrato.
DE68918484D1 (de) Blockiervorrichtung für den Lenksäulenschaft eines Kraftfahrzeuges.
NL7507800A (nl) Prilwerkwijze, alsmede geprild materiaal.
Wiley The chemistry of actinospectacin. I. Actinamine
DE69109466D1 (de) Verfahren zum selbsttägigen abruf von bearbeitungsbedingungen für eine elektroerosionsmaschine.
DE3675778D1 (de) (2-amino-4-aryl-thiazol-5-yl)aethanol, und deren derivate mit diuretischer aktivitaet und verfahren zu deren herstellung.
AT344716B (de) Verfahren zur herstellung von 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-on-2,2-dioxid und seinen salzen
ATE223394T1 (de) Verahren zur selektiven acylierung von 10- deacetylbaccatin-iii in der c-10 position

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties