ATE126209T1 - Sulfonylhydrazine und deren verwendung als antineoplastische und als antitrypanosomale mittel. - Google Patents

Sulfonylhydrazine und deren verwendung als antineoplastische und als antitrypanosomale mittel.

Info

Publication number
ATE126209T1
ATE126209T1 AT90114747T AT90114747T ATE126209T1 AT E126209 T1 ATE126209 T1 AT E126209T1 AT 90114747 T AT90114747 T AT 90114747T AT 90114747 T AT90114747 T AT 90114747T AT E126209 T1 ATE126209 T1 AT E126209T1
Authority
AT
Austria
Prior art keywords
sulfonylhydrazines
aryl
alkyl
antineoplastic
agents
Prior art date
Application number
AT90114747T
Other languages
English (en)
Inventor
Alan C Sartorelli
Alan A Divo
Krishnamurthy Shyam
Philip G Penketh
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Application granted granted Critical
Publication of ATE126209T1 publication Critical patent/ATE126209T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT90114747T 1989-09-06 1990-08-01 Sulfonylhydrazine und deren verwendung als antineoplastische und als antitrypanosomale mittel. ATE126209T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/403,533 US5101072A (en) 1989-09-06 1989-09-06 Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents

Publications (1)

Publication Number Publication Date
ATE126209T1 true ATE126209T1 (de) 1995-08-15

Family

ID=23596136

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90114747T ATE126209T1 (de) 1989-09-06 1990-08-01 Sulfonylhydrazine und deren verwendung als antineoplastische und als antitrypanosomale mittel.

Country Status (9)

Country Link
US (1) US5101072A (de)
EP (1) EP0416286B1 (de)
JP (1) JPH03167168A (de)
AT (1) ATE126209T1 (de)
CA (1) CA2024523A1 (de)
DE (1) DE69021466T2 (de)
DK (1) DK0416286T3 (de)
ES (1) ES2076998T3 (de)
GR (1) GR3018021T3 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256820A (en) * 1991-11-08 1993-10-26 Yale University 1-alkyl-2-acyl-1,2-disulfonylhydrazines
US5637619A (en) * 1995-07-05 1997-06-10 Yale University Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines
US6040338A (en) * 1997-11-03 2000-03-21 Yale University N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents
US20020142941A1 (en) * 2001-03-30 2002-10-03 Pro Duct Health, Inc. Intraductal treatment targeting methylated promoters in breast cancer
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US6855695B2 (en) * 2003-06-13 2005-02-15 Vion Pharmaceuticals, Inc. Water-soluble SHPs as novel alkylating agents
EP1804816B1 (de) * 2004-03-26 2011-12-21 Vion Pharmaceuticals, Inc. Kombinationstherapie mit kloretazin(tm)
US7405317B2 (en) * 2004-09-21 2008-07-29 Vion Pharmaceuticals Inc. Phosphate-bearing prodrugs of sulfonyl hydrazines as hypoxia-selective antineoplastic agents
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
EP1808173A1 (de) * 2006-01-12 2007-07-18 Matthias Dormeyer Verwendung von Krebsmitteln, die in das Zentralnervensystem eindringen, zur Behandlung protozoale Erkrankungen
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
EP2398500B1 (de) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Arzneiabgabesystem auf glutathion-basis
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1069637B (de) * 1960-04-28 Farbenfabriken Bayer Aktiengesellschaft Leverkusen Bayerwerk Verfahren zur Herstellung von Hydraziden aliphatischer Sulfosäuren
US4209632A (en) * 1974-06-05 1980-06-24 Uniroyal, Inc. Sulfonyl carbazates
US4175200A (en) * 1975-04-11 1979-11-20 Uniroyal, Inc. N,N-Disubstituted sulfonyl hydrazines
US4684747A (en) * 1984-12-20 1987-08-04 Yale University N,N'-bis(sulfonyl)hydrazines having antineoplastic activity
US4849563A (en) * 1986-01-21 1989-07-18 Yale University Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity

Also Published As

Publication number Publication date
CA2024523A1 (en) 1991-03-07
JPH03167168A (ja) 1991-07-19
US5101072A (en) 1992-03-31
DE69021466D1 (de) 1995-09-14
EP0416286B1 (de) 1995-08-09
ES2076998T3 (es) 1995-11-16
DE69021466T2 (de) 1996-02-29
DK0416286T3 (da) 1995-12-11
GR3018021T3 (en) 1996-02-29
EP0416286A1 (de) 1991-03-13

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee