ATE125361T1 - Verfahren zur bestimmung des immunregulatorischen zustands des immunsystems mononuklearer leukozyten. - Google Patents

Verfahren zur bestimmung des immunregulatorischen zustands des immunsystems mononuklearer leukozyten.

Info

Publication number
ATE125361T1
ATE125361T1 AT87905531T AT87905531T ATE125361T1 AT E125361 T1 ATE125361 T1 AT E125361T1 AT 87905531 T AT87905531 T AT 87905531T AT 87905531 T AT87905531 T AT 87905531T AT E125361 T1 ATE125361 T1 AT E125361T1
Authority
AT
Austria
Prior art keywords
mononuclear
cells
subclasses
immune system
activation
Prior art date
Application number
AT87905531T
Other languages
English (en)
Inventor
Jeffrey E Anderson
Original Assignee
Jeffrey E Anderson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jeffrey E Anderson filed Critical Jeffrey E Anderson
Application granted granted Critical
Publication of ATE125361T1 publication Critical patent/ATE125361T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • AIDS & HIV (AREA)
  • Physiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT87905531T 1986-08-12 1987-08-12 Verfahren zur bestimmung des immunregulatorischen zustands des immunsystems mononuklearer leukozyten. ATE125361T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89575486A 1986-08-12 1986-08-12

Publications (1)

Publication Number Publication Date
ATE125361T1 true ATE125361T1 (de) 1995-08-15

Family

ID=25405027

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87905531T ATE125361T1 (de) 1986-08-12 1987-08-12 Verfahren zur bestimmung des immunregulatorischen zustands des immunsystems mononuklearer leukozyten.

Country Status (7)

Country Link
US (3) US5445939A (de)
EP (1) EP0319543B1 (de)
JP (1) JP2769156B2 (de)
AT (1) ATE125361T1 (de)
CA (1) CA1296622C (de)
DE (1) DE3751422T2 (de)
WO (1) WO1988001385A1 (de)

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CA1296622C (en) * 1986-08-12 1992-03-03 Jeffrey E. Anderson Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system
AT392481B (de) * 1989-04-18 1991-04-10 Keplinger Klaus Verfahren zum nachweis fuer die anwesenheit von aids-viren im menschlichen organismus
CA2011099A1 (en) * 1989-04-19 1990-10-19 Stephen C. Wardlaw Determination of lymphocyte reactivity to specific antigens in blood
SE9501782D0 (sv) * 1995-05-12 1995-05-12 Landstinget I Oestergoetland Method of predicting the therapeutic response of a drug against a malignant tumour
US5846758A (en) * 1995-11-30 1998-12-08 His Excellency Ghassan I. Shaker Method for diagnosing autoimmune diseases
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5774482A (en) * 1996-04-30 1998-06-30 Sun Microsystems, Inc. Apparatus and method for processing errors associated with data transfers in a computer
US6014904A (en) * 1996-05-09 2000-01-18 Becton, Dickinson And Company Method for classifying multi-parameter data
US6429025B1 (en) 1996-06-28 2002-08-06 Caliper Technologies Corp. High-throughput screening assay systems in microscale fluidic devices
US20060000722A1 (en) * 1996-06-28 2006-01-05 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
US7514232B2 (en) 1996-12-06 2009-04-07 Becton, Dickinson And Company Method for detecting T cell response to specific antigens in whole blood
US6285377B1 (en) * 1997-06-26 2001-09-04 Bayer Corporation Method and apparatus for generating a smooth normalized star diagram
AU8653598A (en) * 1997-08-01 1999-02-22 Derek Nigel John Hart Method for counting dendritic cells
US6132685A (en) 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
WO2000011476A1 (en) * 1998-08-25 2000-03-02 The Immune Response Corporation Methods for evaluating immune function
CN1140801C (zh) * 2000-03-01 2004-03-03 胡军 检测血液中淋巴细胞对特定抗原反应性的方法
EP1295243A4 (de) 2000-05-11 2010-09-01 Becton Dickinson Co System zur Identifizierung von Clustern in Streudiagrammen unter Verwendung von geglättetn Polygonen mit optimalen Grenzflächen
EP1752160A3 (de) 2001-04-06 2007-05-30 Mannkind Corporation Epitop-Sequenzen
WO2003008537A2 (en) 2001-04-06 2003-01-30 Mannkind Corporation Epitope sequences
US7658926B2 (en) * 2001-09-14 2010-02-09 Opexa Pharmaceuticals, Inc. Autologous T-cell vaccines materials and methods
AU2003226067A1 (en) * 2002-04-11 2003-10-27 Cyclex, Inc. Method for monitoring the immune response and predicting clinical outcomes in transplant recipients
AU2003258090B2 (en) * 2002-08-08 2010-07-22 Baylor College Of Medicine Isolation and identification of T cells
US20040180354A1 (en) * 2002-09-06 2004-09-16 Simard John J.L. Epitope sequences
CA2594224A1 (en) * 2004-12-29 2006-07-06 Mannkind Corporation Methods to elicit, enhance and sustain immune responses against mhc class i-restricted epitopes, for prophylactic or therapeutic purposes
JP4649231B2 (ja) * 2005-02-28 2011-03-09 株式会社カネカ フローサイトメータ、細胞の解析方法、細胞解析プログラム、蛍光検出器の感度設定方法および陽性率判定法における基準ゲート設定方法
DK2016414T3 (en) * 2006-05-05 2015-12-07 Opexa Therapeutics T-cell vaccine
US20090062237A1 (en) * 2007-06-15 2009-03-05 Mayo Foundation For Medical Education And Research Evaluating immune competence
EP2437887B1 (de) 2009-06-04 2016-05-11 Lockheed Martin Corporation Mikrofluidischer chip für dna analyse von mehrfachen proben
CA2814720C (en) 2010-10-15 2016-12-13 Lockheed Martin Corporation Micro fluidic optic design
JP6047870B2 (ja) 2011-10-14 2016-12-21 ソニー株式会社 ３ｄデータ解析のための装置、方法及びプログラムと、微小粒子解析システム
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US10458976B2 (en) 2014-04-08 2019-10-29 Satish Deshpande Early warning of changes in health and robustness using narrowly forward scattered light to track ease of morphological changes of blood cells
US20150285738A1 (en) * 2014-04-08 2015-10-08 Satish Deshpande Early warning of changes in health and robustness using narrowly forward scattered light to track ease of morphological changes of blood cells
JP6367351B2 (ja) * 2014-10-22 2018-08-08 株式会社日立ハイテクノロジーズ 細胞計測機構及びそれを有する細胞培養装置並びに細胞計測方法
TW201939514A (zh) 2018-03-16 2019-10-01 日商弘泰生物科技股份有限公司 免疫實體之有效率的分群
JP6796737B1 (ja) * 2020-06-02 2020-12-09 振武 曽 多項目自動血球計数装置

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US4381295A (en) * 1979-04-26 1983-04-26 Ortho Pharmaceutical Corporation Monoclonal antibody to human helper T cells and methods of preparing same
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
US4520110A (en) * 1981-10-06 1985-05-28 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor
US4492752A (en) * 1982-09-03 1985-01-08 Ortho Diagnostics Systems Inc. Method for discriminating between unstained and absorbing dye stained cells
US4607007A (en) * 1983-04-07 1986-08-19 Becton, Dickinson And Company Differentiation of natural killer cell subpopulations of cells
US4599304A (en) * 1983-10-07 1986-07-08 Becton, Dickinson And Company Method for monitoring activated cell subpopulations
US4701408A (en) * 1984-01-30 1987-10-20 Smithkline Beckman Corporation Monoclonal antibody to activated macrophages
US4677061A (en) * 1984-10-19 1987-06-30 Genetic Systems Corporation T-cell lymphocyte subset monitoring of immunologic disease
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US4778750A (en) * 1986-02-19 1988-10-18 Imreg, Inc. Diagnostic methods for immune function
CA1296622C (en) * 1986-08-12 1992-03-03 Jeffrey E. Anderson Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system
EP0325489B1 (de) * 1988-01-21 1994-01-19 Becton, Dickinson and Company Leu-23: Monoclonaler Antikörper zur Überwachung von Leukozyten-Aktivierung

Also Published As

Publication number Publication date
DE3751422D1 (de) 1995-08-24
EP0319543A1 (de) 1989-06-14
DE3751422T2 (de) 1995-12-14
US5656446A (en) 1997-08-12
CA1296622C (en) 1992-03-03
US5843689A (en) 1998-12-01
US5445939A (en) 1995-08-29
WO1988001385A1 (en) 1988-02-25
EP0319543B1 (de) 1995-07-19
AU7851187A (en) 1988-03-08
JPH02500297A (ja) 1990-02-01
EP0319543A4 (de) 1990-01-08
JP2769156B2 (ja) 1998-06-25
AU615880B2 (en) 1991-10-17

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