ATE121950T1 - Verfahren zur einführung von sauerstoff-17 in gewebe zur bildformung in einem magnetischen resonanzbildformungssystem. - Google Patents

Verfahren zur einführung von sauerstoff-17 in gewebe zur bildformung in einem magnetischen resonanzbildformungssystem.

Info

Publication number
ATE121950T1
ATE121950T1 AT89909463T AT89909463T ATE121950T1 AT E121950 T1 ATE121950 T1 AT E121950T1 AT 89909463 T AT89909463 T AT 89909463T AT 89909463 T AT89909463 T AT 89909463T AT E121950 T1 ATE121950 T1 AT E121950T1
Authority
AT
Austria
Prior art keywords
imaging
image forming
tissue
agent
magnetic resonance
Prior art date
Application number
AT89909463T
Other languages
English (en)
Inventor
Pradeep Gupte
Toshiyuki Arai
Sigmund E Lasker
Original Assignee
Pradeep Gupte
Toshiyuki Arai
Sigmund E Lasker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pradeep Gupte, Toshiyuki Arai, Sigmund E Lasker filed Critical Pradeep Gupte
Application granted granted Critical
Publication of ATE121950T1 publication Critical patent/ATE121950T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AT89909463T 1988-08-19 1989-08-16 Verfahren zur einführung von sauerstoff-17 in gewebe zur bildformung in einem magnetischen resonanzbildformungssystem. ATE121950T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/234,339 US4996041A (en) 1988-08-19 1988-08-19 Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system

Publications (1)

Publication Number Publication Date
ATE121950T1 true ATE121950T1 (de) 1995-05-15

Family

ID=22880951

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89909463T ATE121950T1 (de) 1988-08-19 1989-08-16 Verfahren zur einführung von sauerstoff-17 in gewebe zur bildformung in einem magnetischen resonanzbildformungssystem.

Country Status (9)

Country Link
US (1) US4996041A (de)
EP (1) EP0386199B1 (de)
JP (1) JP2655004B2 (de)
AT (1) ATE121950T1 (de)
AU (1) AU4066589A (de)
CA (1) CA1336165C (de)
DE (1) DE68922485T2 (de)
IL (1) IL91368A (de)
WO (1) WO1990001953A1 (de)

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US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6001335A (en) * 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
GB9005080D0 (en) * 1990-03-07 1990-05-02 Univ Nottingham Labelled markers
EP0526503B1 (de) * 1990-04-10 1997-06-04 Imarx Pharmaceutical Corp. Polymere und ihre verwendung als kontrastmittel bei der bilderzeugung mit magnetischer resonanz
US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5304325A (en) * 1991-11-13 1994-04-19 Hemagen/Pfc Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use
EP0591544A4 (en) * 1992-03-26 1996-03-27 Toshiyuki Arai Reagent for nuclear magnetic resonance
WO1996003073A1 (en) * 1992-04-14 1996-02-08 Lasker Sigmund E Process for visualizing tissue metabolism using oxygen-17
US5339814A (en) * 1992-04-14 1994-08-23 Lasker Sigmund E Process for visualizing tissue metabolism using oxygen-17
JPH0625014A (ja) * 1992-07-13 1994-02-01 Toshiyuki Arai 核磁気共鳴剤
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
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US5665382A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US6280383B1 (en) * 1993-03-01 2001-08-28 Fonar Corporation Magnetic resonance imaging
US5433196A (en) * 1993-06-02 1995-07-18 The Board Of Trustees Of The University Of Illinois Oxygen-17 NMR spectroscopy and imaging in the human
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
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US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US6123919A (en) * 1994-04-08 2000-09-26 The Trustees Of Princeton University Magnetic resonance imaging using hyperpolarized noble gases
US5736121A (en) * 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) * 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
ES2189974T3 (es) * 1996-09-11 2003-07-16 Imarx Pharmaceutical Corp Procedimientos mejorados para la obtencion de imagenes de diagnostico usando un agente de contraste y un vasodilatador.
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6143276A (en) * 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6537246B1 (en) * 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US20050019266A1 (en) * 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
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US6284222B1 (en) 1998-11-03 2001-09-04 Medi--Physics, Inc. Hyperpolarized helium-3 microbubble gas entrapment methods
AU4686899A (en) 1999-02-23 2000-09-14 Medi-Physics, Inc. Portable system for monitoring the polarization level of a hyperpolarized gas during transport
US6648130B1 (en) * 1999-08-11 2003-11-18 Medi-Physics, Inc. Hyperpolarized gas transport and storage devices and associated transport and storage methods using permanent magnets
JP2003526437A (ja) * 2000-03-13 2003-09-09 メディ−フィジックス・インコーポレイテッド ガス状過分極１２９Ｘｅの直接注射を使用する診断処置並びに関連するシステムおよび生成物
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
US7407778B2 (en) * 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
ATE437884T1 (de) * 2003-05-29 2009-08-15 Jay W Pettegrew Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungen
JP5019883B2 (ja) 2004-01-16 2012-09-05 カーネギー メロン ユニバーシティ 核磁気共鳴技術のための細胞標識
WO2006108047A2 (en) * 2005-04-05 2006-10-12 Biopure Corporation Oxygenated polymerized hemoglobin solutions and their uses for tissue visualization
US7410634B2 (en) * 2005-10-17 2008-08-12 Rockland Technimed Ltd. Tissue metabolic stress monitoring
WO2007120911A2 (en) * 2006-04-14 2007-10-25 Carnegie Mellon University Cellular labeling and quantification for nuclear magnetic resonance techniques
WO2008054509A2 (en) * 2006-04-14 2008-05-08 Celsense, Inc. Methods for assessing cell labeling
CA2693678C (en) * 2007-07-10 2017-02-14 Carnegie Mellon University Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques
JP5751708B2 (ja) * 2008-05-02 2015-07-22 セルセンス， インコーポレイテッド 核磁気共鳴技法および他の用途のためのエマルジョンを生成するための組成物ならびに方法
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US4775522A (en) * 1983-03-04 1988-10-04 Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center NMR compositions for indirectly detecting a dissolved gas in an animal
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Also Published As

Publication number Publication date
DE68922485T2 (de) 1996-01-18
EP0386199B1 (de) 1995-05-03
EP0386199A4 (en) 1990-11-07
JPH03500896A (ja) 1991-02-28
JP2655004B2 (ja) 1997-09-17
CA1336165C (en) 1995-07-04
AU4066589A (en) 1990-03-23
IL91368A0 (en) 1990-04-29
IL91368A (en) 1995-05-26
DE68922485D1 (de) 1995-06-08
EP0386199A1 (de) 1990-09-12
WO1990001953A1 (en) 1990-03-08
US4996041A (en) 1991-02-26

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