ATE121950T1 - Verfahren zur einführung von sauerstoff-17 in gewebe zur bildformung in einem magnetischen resonanzbildformungssystem. - Google Patents
Verfahren zur einführung von sauerstoff-17 in gewebe zur bildformung in einem magnetischen resonanzbildformungssystem.Info
- Publication number
- ATE121950T1 ATE121950T1 AT89909463T AT89909463T ATE121950T1 AT E121950 T1 ATE121950 T1 AT E121950T1 AT 89909463 T AT89909463 T AT 89909463T AT 89909463 T AT89909463 T AT 89909463T AT E121950 T1 ATE121950 T1 AT E121950T1
- Authority
- AT
- Austria
- Prior art keywords
- imaging
- image forming
- tissue
- agent
- magnetic resonance
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/234,339 US4996041A (en) | 1988-08-19 | 1988-08-19 | Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE121950T1 true ATE121950T1 (de) | 1995-05-15 |
Family
ID=22880951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89909463T ATE121950T1 (de) | 1988-08-19 | 1989-08-16 | Verfahren zur einführung von sauerstoff-17 in gewebe zur bildformung in einem magnetischen resonanzbildformungssystem. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4996041A (de) |
EP (1) | EP0386199B1 (de) |
JP (1) | JP2655004B2 (de) |
AT (1) | ATE121950T1 (de) |
AU (1) | AU4066589A (de) |
CA (1) | CA1336165C (de) |
DE (1) | DE68922485T2 (de) |
IL (1) | IL91368A (de) |
WO (1) | WO1990001953A1 (de) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991007990A1 (en) * | 1989-11-24 | 1991-06-13 | Toshiyuki Arai | Nuclear magnetic resonance agent, detection thereof, and tomography using said agent |
US6146657A (en) * | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US5922304A (en) * | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US5305757A (en) * | 1989-12-22 | 1994-04-26 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
US6001335A (en) * | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
US5733572A (en) * | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
US20020150539A1 (en) * | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
US5585112A (en) * | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US5705187A (en) * | 1989-12-22 | 1998-01-06 | Imarx Pharmaceutical Corp. | Compositions of lipids and stabilizing materials |
US5656211A (en) * | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
US5773024A (en) * | 1989-12-22 | 1998-06-30 | Imarx Pharmaceutical Corp. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US5776429A (en) * | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
US6088613A (en) * | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
GB9005080D0 (en) * | 1990-03-07 | 1990-05-02 | Univ Nottingham | Labelled markers |
EP0526503B1 (de) * | 1990-04-10 | 1997-06-04 | Imarx Pharmaceutical Corp. | Polymere und ihre verwendung als kontrastmittel bei der bilderzeugung mit magnetischer resonanz |
US5368840A (en) * | 1990-04-10 | 1994-11-29 | Imarx Pharmaceutical Corp. | Natural polymers as contrast media for magnetic resonance imaging |
US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
US5874062A (en) * | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
US5304325A (en) * | 1991-11-13 | 1994-04-19 | Hemagen/Pfc | Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use |
WO1993018796A1 (en) * | 1992-03-26 | 1993-09-30 | Toshiyuki Arai | Reagent for nuclear magnetic resonance |
WO1996003073A1 (en) * | 1992-04-14 | 1996-02-08 | Lasker Sigmund E | Process for visualizing tissue metabolism using oxygen-17 |
US5339814A (en) * | 1992-04-14 | 1994-08-23 | Lasker Sigmund E | Process for visualizing tissue metabolism using oxygen-17 |
JPH0625014A (ja) * | 1992-07-13 | 1994-02-01 | Toshiyuki Arai | 核磁気共鳴剤 |
US6753006B1 (en) | 1993-02-22 | 2004-06-22 | American Bioscience, Inc. | Paclitaxel-containing formulations |
US5650156A (en) * | 1993-02-22 | 1997-07-22 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of nutriceuticals and compositions useful therefor |
US5362478A (en) * | 1993-03-26 | 1994-11-08 | Vivorx Pharmaceuticals, Inc. | Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell |
US5665382A (en) * | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of pharmaceutically active agents for in vivo delivery |
US6280383B1 (en) * | 1993-03-01 | 2001-08-28 | Fonar Corporation | Magnetic resonance imaging |
US5433196A (en) * | 1993-06-02 | 1995-07-18 | The Board Of Trustees Of The University Of Illinois | Oxygen-17 NMR spectroscopy and imaging in the human |
US5716597A (en) * | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
IL106066A (en) * | 1993-06-18 | 1997-04-15 | British Tech Group | Method of measuring the 17o content and distribution in a body |
US7083572B2 (en) * | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
US5545396A (en) * | 1994-04-08 | 1996-08-13 | The Research Foundation Of State University Of New York | Magnetic resonance imaging using hyperpolarized noble gases |
US6123919A (en) * | 1994-04-08 | 2000-09-26 | The Trustees Of Princeton University | Magnetic resonance imaging using hyperpolarized noble gases |
US5736121A (en) * | 1994-05-23 | 1998-04-07 | Imarx Pharmaceutical Corp. | Stabilized homogenous suspensions as computed tomography contrast agents |
US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
US5830430A (en) * | 1995-02-21 | 1998-11-03 | Imarx Pharmaceutical Corp. | Cationic lipids and the use thereof |
US6139819A (en) * | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
US6521211B1 (en) * | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
US6033645A (en) * | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
CA2252617A1 (en) | 1996-05-01 | 1997-11-06 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
DK1323434T3 (da) * | 1996-09-11 | 2007-11-12 | Bristol Myers Squibb Medical I | Fremgangsmåde til diagnostisk billeddannelse af nyreregioner under anvendelse af et kontrastmiddel og en vasodilator |
US5846517A (en) * | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
US6143276A (en) * | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
US6090800A (en) * | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
US6537246B1 (en) * | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
US20050019266A1 (en) * | 1997-05-06 | 2005-01-27 | Unger Evan C. | Novel targeted compositions for diagnostic and therapeutic use |
US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
US6123923A (en) * | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
JP2002518651A (ja) * | 1998-06-17 | 2002-06-25 | メディ‐フィジクス,インコーポレイテッド | 過分極ガス輸送装置及びその輸送方法 |
US6284222B1 (en) | 1998-11-03 | 2001-09-04 | Medi--Physics, Inc. | Hyperpolarized helium-3 microbubble gas entrapment methods |
WO2000050914A1 (en) | 1999-02-23 | 2000-08-31 | Medi-Physics, Inc. | Portable system for monitoring the polarization level of a hyperpolarized gas during transport |
US6648130B1 (en) * | 1999-08-11 | 2003-11-18 | Medi-Physics, Inc. | Hyperpolarized gas transport and storage devices and associated transport and storage methods using permanent magnets |
CA2401308A1 (en) * | 2000-03-13 | 2001-09-20 | Klaus D. Hagspiel | Diagnostic procedures using direct injection of gaseous hyperpolarized 129xe and associated systems and products |
US7407778B2 (en) * | 2002-02-07 | 2008-08-05 | Pettegrew Jay W | Compounds, compositions and methods for treating neuropsychiatric disorders |
US7700074B2 (en) * | 2002-02-07 | 2010-04-20 | Pettegrew Jay W | Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism |
US20060257842A1 (en) * | 2003-05-29 | 2006-11-16 | Pettegrew Jay W | Cryopreservation media and molecules |
ATE437884T1 (de) * | 2003-05-29 | 2009-08-15 | Jay W Pettegrew | Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungen |
CA2560544C (en) | 2004-01-16 | 2015-05-19 | Carnegie Mellon University | Cellular labeling for nuclear magnetic resonance techniques |
WO2006108047A2 (en) * | 2005-04-05 | 2006-10-12 | Biopure Corporation | Oxygenated polymerized hemoglobin solutions and their uses for tissue visualization |
US7410634B2 (en) * | 2005-10-17 | 2008-08-12 | Rockland Technimed Ltd. | Tissue metabolic stress monitoring |
AU2007314614A1 (en) * | 2006-04-14 | 2008-05-08 | Celsense, Inc. | Methods for assessing cell labeling |
EP2010646A2 (de) * | 2006-04-14 | 2009-01-07 | Carnegie Mellon University | Zellbeschriftung und -quantifizierung für nukleare magnetresonanzverfahren |
JP5645658B2 (ja) * | 2007-07-10 | 2014-12-24 | カーネギー メロン ユニバーシティー | 核磁気共鳴技術のための細胞標識を製造するための組成物及び方法 |
AU2009241762B2 (en) * | 2008-05-02 | 2015-07-16 | Celsense Inc. | Compositions and methods for producing emulsions for nuclear magnetic resonance techniques and other applications |
WO2013043236A1 (en) * | 2011-09-22 | 2013-03-28 | Rockland Technimed, Ltd. | Compositions and methods useful for realtime in situ physiological molecular imaging of oxygen metabolism |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775522A (en) * | 1983-03-04 | 1988-10-04 | Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center | NMR compositions for indirectly detecting a dissolved gas in an animal |
US4586511A (en) * | 1983-03-04 | 1986-05-06 | Children's Hospital Medical Center | Methods and compositions for detecting and imaging a gas in an animal by nuclear magnetic resonance |
DE3785054T2 (de) * | 1986-01-24 | 1993-07-08 | Childrens Hosp Medical Center | Stabile emulsionen von stark fluorierten, organischen verbindungen. |
-
1988
- 1988-08-19 US US07/234,339 patent/US4996041A/en not_active Expired - Lifetime
-
1989
- 1989-08-16 DE DE68922485T patent/DE68922485T2/de not_active Expired - Lifetime
- 1989-08-16 WO PCT/US1989/003503 patent/WO1990001953A1/en active IP Right Grant
- 1989-08-16 EP EP89909463A patent/EP0386199B1/de not_active Expired - Lifetime
- 1989-08-16 AU AU40665/89A patent/AU4066589A/en not_active Abandoned
- 1989-08-16 JP JP1508876A patent/JP2655004B2/ja not_active Expired - Lifetime
- 1989-08-16 AT AT89909463T patent/ATE121950T1/de not_active IP Right Cessation
- 1989-08-18 CA CA000608686A patent/CA1336165C/en not_active Expired - Fee Related
- 1989-08-20 IL IL9136889A patent/IL91368A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE68922485D1 (de) | 1995-06-08 |
EP0386199A1 (de) | 1990-09-12 |
WO1990001953A1 (en) | 1990-03-08 |
IL91368A (en) | 1995-05-26 |
EP0386199A4 (en) | 1990-11-07 |
US4996041A (en) | 1991-02-26 |
AU4066589A (en) | 1990-03-23 |
CA1336165C (en) | 1995-07-04 |
IL91368A0 (en) | 1990-04-29 |
JPH03500896A (ja) | 1991-02-28 |
JP2655004B2 (ja) | 1997-09-17 |
EP0386199B1 (de) | 1995-05-03 |
DE68922485T2 (de) | 1996-01-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |