ATE120236T1 - T-pa-mutante gk1l. - Google Patents

T-pa-mutante gk1l.

Info

Publication number
ATE120236T1
ATE120236T1 AT90912217T AT90912217T ATE120236T1 AT E120236 T1 ATE120236 T1 AT E120236T1 AT 90912217 T AT90912217 T AT 90912217T AT 90912217 T AT90912217 T AT 90912217T AT E120236 T1 ATE120236 T1 AT E120236T1
Authority
AT
Austria
Prior art keywords
present
pct
domains
protein
date
Prior art date
Application number
AT90912217T
Other languages
German (de)
English (en)
Inventor
Ulrich Weidle
Anne Stern
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Application granted granted Critical
Publication of ATE120236T1 publication Critical patent/ATE120236T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
AT90912217T 1989-08-23 1990-08-22 T-pa-mutante gk1l. ATE120236T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3927865A DE3927865A1 (de) 1989-08-23 1989-08-23 T-pa-mutante gk1l

Publications (1)

Publication Number Publication Date
ATE120236T1 true ATE120236T1 (de) 1995-04-15

Family

ID=6387718

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90912217T ATE120236T1 (de) 1989-08-23 1990-08-22 T-pa-mutante gk1l.

Country Status (6)

Country Link
US (1) US5223422A (en22)
EP (1) EP0440763B1 (en22)
JP (1) JPH04500010A (en22)
AT (1) ATE120236T1 (en22)
DE (2) DE3927865A1 (en22)
WO (1) WO1991002798A2 (en22)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020802A1 (fr) * 2000-09-04 2002-03-14 Hunan Royal Biotech Lignee cellulaire exprimant un activateur de plasminogene tissulaire humain mutant, procede de recombinaison et procede de preparation de la proteine exprimee

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0231624B1 (en) * 1985-12-20 1993-01-27 The Upjohn Company Tissue plasminogen activator (tpa) analogs

Also Published As

Publication number Publication date
DE3927865A1 (de) 1991-02-28
WO1991002798A2 (de) 1991-03-07
US5223422A (en) 1993-06-29
JPH04500010A (ja) 1992-01-09
EP0440763A1 (de) 1991-08-14
DE59008764D1 (de) 1995-04-27
EP0440763B1 (de) 1995-03-22
JPH0571228B2 (en22) 1993-10-06
WO1991002798A3 (de) 1991-04-04

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Legal Events

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