ATE119196T1 - Verfahren zur herstellung einer an faktor-viia angereicherten fraktion und ihre verwendung als arzneimittel. - Google Patents
Verfahren zur herstellung einer an faktor-viia angereicherten fraktion und ihre verwendung als arzneimittel.Info
- Publication number
- ATE119196T1 ATE119196T1 AT89401605T AT89401605T ATE119196T1 AT E119196 T1 ATE119196 T1 AT E119196T1 AT 89401605 T AT89401605 T AT 89401605T AT 89401605 T AT89401605 T AT 89401605T AT E119196 T1 ATE119196 T1 AT E119196T1
- Authority
- AT
- Austria
- Prior art keywords
- viia
- factor
- producing
- medicinal product
- enriched fraction
- Prior art date
Links
- 229940012414 factor viia Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 239000006096 absorbing agent Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 108010012557 prothrombin complex concentrates Proteins 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8807687A FR2632524B1 (fr) | 1988-06-09 | 1988-06-09 | Procede de preparation d'une fraction concentree en facteur viia et son application a titre de medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE119196T1 true ATE119196T1 (de) | 1995-03-15 |
Family
ID=9367108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89401605T ATE119196T1 (de) | 1988-06-09 | 1989-06-09 | Verfahren zur herstellung einer an faktor-viia angereicherten fraktion und ihre verwendung als arzneimittel. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0346241B1 (de) |
| JP (1) | JPH02504587A (de) |
| AT (1) | ATE119196T1 (de) |
| DE (1) | DE68921371T2 (de) |
| ES (1) | ES2070921T3 (de) |
| FR (1) | FR2632524B1 (de) |
| WO (1) | WO1989012097A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2965069B2 (ja) * | 1989-01-13 | 1999-10-18 | 吉富製薬株式会社 | 蛋白質含有組成物の製造方法 |
| FR2684999A1 (fr) * | 1991-12-16 | 1993-06-18 | Aquitaine Dev Transf Sanguine | Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag. |
| DE19538716A1 (de) * | 1995-10-18 | 1997-04-24 | Behringwerke Ag | Verfahren zur Quantifizierung von aktiviertem Gerinnungsfaktor VII (FVIIa) |
| DE19531637A1 (de) * | 1995-08-28 | 1997-03-06 | Immuno Ag | Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung |
| DE19538715A1 (de) | 1995-10-18 | 1997-04-30 | Behringwerke Ag | Verfahren zur Reinigung von Faktor VII und aktiviertem Faktor VII |
| FR2894831B1 (fr) | 2005-12-16 | 2008-02-15 | Lab Francais Du Fractionnement | Colle biologique exempte de thrombine et son utilisation comme medicament. |
| ES2257225B1 (es) * | 2006-02-17 | 2007-03-16 | Grifols, S.A | Preparacion terapeutica de fviia de muy alta pureza y metodo para su obtencion. |
| FR2901796A1 (fr) * | 2006-05-31 | 2007-12-07 | Lab Francais Du Fractionnement | Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait |
| FR2901707B1 (fr) * | 2006-05-31 | 2017-09-29 | Lab Francais Du Fractionnement | Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis |
| FR2904558B1 (fr) * | 2006-08-01 | 2008-10-17 | Lab Francais Du Fractionnement | "composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees" |
| FR2942231B1 (fr) | 2009-02-19 | 2015-03-20 | Lfb Biotechnologies | Acides nucleiques se liant specifiquement au facteur vii/viia humain, et utilisations |
| FR2946348B1 (fr) * | 2009-06-05 | 2011-08-05 | Lab Francais Du Fractionnement | Procede de preparation d'une composition de complexe prothrombique a haut degre de purete |
| AU2011343813B2 (en) | 2010-12-15 | 2015-05-21 | Takeda Pharmaceutical Company Limited | Eluate collection using conductivity gradient |
| EP2687595B1 (de) | 2012-07-19 | 2018-05-30 | Laboratoire Français du Fractionnement et des Biotechnologies | Verfahren zur Reinigung eines transgenen Faktor VII |
| PL2938351T3 (pl) | 2012-12-24 | 2020-03-31 | Coagulant Therapeutics Corporation | Krótko działające polipeptydy czynnika VII |
| FR3011250A1 (fr) | 2013-09-30 | 2015-04-03 | Lab Francais Du Fractionnement | Acides nucleiques se liant specifiquement au facteur ix/ixa humain, et utilisations |
| RU2559576C1 (ru) * | 2014-06-09 | 2015-08-10 | Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения РФ | Способ получения вирусбезопасного полного протромбинового комплекса |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4382083A (en) * | 1981-06-25 | 1983-05-03 | Baxter Travenol Laboratories, Inc. | Therapeutic method for treating blood-clotting defects with factor VIIa |
| US4470979A (en) * | 1982-09-17 | 1984-09-11 | Janssen Pharmaceutica N.V. | Chemical sterilization of insects with salicylanilides |
| US4470969A (en) * | 1983-12-02 | 1984-09-11 | Miles Laboratories, Inc. | Process for producing a concentrate of coagulation factors VII and VIIa |
| US4473553A (en) * | 1983-12-02 | 1984-09-25 | Miles Laboratories, Inc. | Process for producing a lipoprotein-poor concentrate of coagulation factors VII and VIIa |
| US4637932A (en) * | 1984-10-15 | 1987-01-20 | Miles Laboratories, Inc. | Process for producing a concentrate enriched in coagulation factors VII and VIIa |
-
1988
- 1988-06-09 FR FR8807687A patent/FR2632524B1/fr not_active Expired - Fee Related
-
1989
- 1989-06-09 EP EP89401605A patent/EP0346241B1/de not_active Expired - Lifetime
- 1989-06-09 DE DE68921371T patent/DE68921371T2/de not_active Expired - Fee Related
- 1989-06-09 AT AT89401605T patent/ATE119196T1/de not_active IP Right Cessation
- 1989-06-09 WO PCT/FR1989/000294 patent/WO1989012097A1/fr not_active Ceased
- 1989-06-09 ES ES89401605T patent/ES2070921T3/es not_active Expired - Lifetime
- 1989-06-09 JP JP1507004A patent/JPH02504587A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0346241A1 (de) | 1989-12-13 |
| JPH02504587A (ja) | 1990-12-27 |
| EP0346241B1 (de) | 1995-03-01 |
| DE68921371T2 (de) | 1996-01-04 |
| WO1989012097A1 (fr) | 1989-12-14 |
| ES2070921T3 (es) | 1995-06-16 |
| FR2632524A1 (fr) | 1989-12-15 |
| DE68921371D1 (de) | 1995-04-06 |
| FR2632524B1 (fr) | 1992-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |