ATE118220T1 - Kristallines menschliches proinsulin und verfahren zu dessen herstellung. - Google Patents

Kristallines menschliches proinsulin und verfahren zu dessen herstellung.

Info

Publication number
ATE118220T1
ATE118220T1 AT88303573T AT88303573T ATE118220T1 AT E118220 T1 ATE118220 T1 AT E118220T1 AT 88303573 T AT88303573 T AT 88303573T AT 88303573 T AT88303573 T AT 88303573T AT E118220 T1 ATE118220 T1 AT E118220T1
Authority
AT
Austria
Prior art keywords
production
human proinsulin
crystalline human
crystalline
proinsulin
Prior art date
Application number
AT88303573T
Other languages
English (en)
Inventor
Richard Lee Jackson
Eddie Herman Massey
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE118220T1 publication Critical patent/ATE118220T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT88303573T 1987-04-23 1988-04-20 Kristallines menschliches proinsulin und verfahren zu dessen herstellung. ATE118220T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/041,498 US4764592A (en) 1987-04-23 1987-04-23 Crystalline human proinsulin and process for its production

Publications (1)

Publication Number Publication Date
ATE118220T1 true ATE118220T1 (de) 1995-02-15

Family

ID=21916831

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88303573T ATE118220T1 (de) 1987-04-23 1988-04-20 Kristallines menschliches proinsulin und verfahren zu dessen herstellung.

Country Status (21)

Country Link
US (1) US4764592A (de)
EP (1) EP0288273B1 (de)
JP (1) JP2602529B2 (de)
KR (1) KR0126477B1 (de)
CN (1) CN1030988C (de)
AR (1) AR244242A1 (de)
AT (1) ATE118220T1 (de)
AU (1) AU609798B2 (de)
CA (1) CA1339045C (de)
DE (1) DE3852963T2 (de)
DK (1) DK210188A (de)
ES (1) ES2068826T3 (de)
GR (1) GR3015662T3 (de)
HU (1) HU202555B (de)
IE (1) IE65952B1 (de)
IL (1) IL86094A (de)
MX (1) MX166069B (de)
NZ (1) NZ224281A (de)
PH (1) PH24261A (de)
PT (1) PT87265B (de)
ZA (1) ZA882714B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH23446A (en) * 1986-10-20 1989-08-07 Novo Industri As Peptide preparations
ATE101620T1 (de) * 1988-06-23 1994-03-15 Hoechst Ag Mini-proinsulin, seine herstellung und verwendung.
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
DK168790D0 (de) * 1990-07-13 1990-07-13 Novo Nordisk As
US5504188A (en) * 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
MX2007000883A (es) * 2004-07-19 2007-04-02 Biocon Ltd Conjugados de insulina-oligomero, formulaciones y usos de los mismos.
US20090074882A1 (en) 2005-12-28 2009-03-19 Novo Nordisk A/S Insulin compositions and method of making a composition
BRPI0818004B8 (pt) 2007-10-16 2021-05-25 Biocon Ltd composição farmacêutica sólida administrável por via oral e o processo da mesma.
EP2569002B1 (de) * 2010-05-10 2016-10-26 Novo Nordisk A/S Verfahren zur herstellung von insulin-zink komlexen
JP6110312B2 (ja) * 2011-02-01 2017-04-05 ノヴォ ノルディスク アー／エス インスリンの精製
CN102219851B (zh) * 2011-05-09 2012-05-30 甘李药业有限公司 甘精胰岛素结晶的制备方法
CN109957001B (zh) * 2017-12-26 2022-11-18 甘李药业股份有限公司 甘赖脯胰岛素结晶的制备方法
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
CN114096269B (zh) 2019-07-12 2024-06-11 诺和诺德股份有限公司 高浓度胰岛素制剂
CN111304271A (zh) * 2020-02-28 2020-06-19 东莞市东阳光生物药研发有限公司 一种含脂肪酸侧链的胰岛素类似物的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE515508A (de) *
DE132863C (de) * 1901-07-11
US2143590A (en) * 1936-09-26 1939-01-10 Univ Alberta Insulin preparation and process of producing crystals of insulin
US2174862A (en) * 1938-12-30 1939-10-03 Frederick Stearns & Company Process of producing crystalline insulin
US2626228A (en) * 1945-05-17 1953-01-20 Novo Terapeutisk Labor As Method of producing crystalline insulin
US2663666A (en) * 1949-03-31 1953-12-22 Organon Process of preparing crystalline insulin from acid alcoholic extracts of pancreas glands
US2836542A (en) * 1952-02-13 1958-05-27 Novo Terapeutisk Labor As Process of production of crystalline insulin
DK78069C (da) * 1952-06-23 1954-09-06 Novo Terapeutisk Labor As Fremgangsmåde til fremstilling af krystallinsk insulin.
US3102077A (en) * 1953-08-19 1963-08-27 Christensen Henry Marinus Preparation of insulin containing 2.75 to 8 percent zinc content
GB786635A (en) * 1953-08-19 1957-11-20 Roskilde Medical Company Ltd R Method for the production of insulin with increased zinc content
US4430266A (en) * 1980-11-28 1984-02-07 Eli Lilly And Company Process for producing an insulin precursor
US4654324A (en) * 1981-08-27 1987-03-31 Eli Lilly And Company Human proinsulin pharmaceutical formulations
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
US4616078A (en) * 1985-04-08 1986-10-07 Eli Lilly And Company Process for purifying proinsulin-like materials

Also Published As

Publication number Publication date
EP0288273A3 (en) 1990-08-08
IL86094A0 (en) 1988-09-30
PT87265A (pt) 1988-05-01
DK210188D0 (da) 1988-04-18
ZA882714B (en) 1989-12-27
US4764592A (en) 1988-08-16
CN88102311A (zh) 1988-11-09
MX166069B (es) 1992-12-17
IE65952B1 (en) 1995-11-29
AU1474788A (en) 1988-11-10
DE3852963D1 (de) 1995-03-23
EP0288273A2 (de) 1988-10-26
CA1339045C (en) 1997-04-01
JPS63280100A (ja) 1988-11-17
IE881183L (en) 1988-10-23
EP0288273B1 (de) 1995-02-08
KR0126477B1 (ko) 1997-12-19
AU609798B2 (en) 1991-05-09
AR244242A1 (es) 1993-10-29
PH24261A (en) 1990-05-04
ES2068826T3 (es) 1995-05-01
GR3015662T3 (en) 1995-07-31
KR880012642A (ko) 1988-11-28
HUT46705A (en) 1988-11-28
DK210188A (da) 1989-01-03
IL86094A (en) 1993-06-10
CN1030988C (zh) 1996-02-14
DE3852963T2 (de) 1995-06-29
NZ224281A (en) 1990-06-26
PT87265B (pt) 1992-08-31
HU202555B (en) 1991-03-28
JP2602529B2 (ja) 1997-04-23

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee