ATE116301T1 - Chinolinderivate, deren herstellung und verwendung. - Google Patents
Chinolinderivate, deren herstellung und verwendung.Info
- Publication number
- ATE116301T1 ATE116301T1 AT90119128T AT90119128T ATE116301T1 AT E116301 T1 ATE116301 T1 AT E116301T1 AT 90119128 T AT90119128 T AT 90119128T AT 90119128 T AT90119128 T AT 90119128T AT E116301 T1 ATE116301 T1 AT E116301T1
- Authority
- AT
- Austria
- Prior art keywords
- chem
- production
- quinoline derivatives
- alkyl group
- lower alkyl
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
- Measurement Of Radiation (AREA)
- Holo Graphy (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26278289 | 1989-10-06 | ||
| JP32229089 | 1989-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE116301T1 true ATE116301T1 (de) | 1995-01-15 |
Family
ID=26545706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90119128T ATE116301T1 (de) | 1989-10-06 | 1990-10-05 | Chinolinderivate, deren herstellung und verwendung. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5223513A (en:Method) |
| EP (1) | EP0421456B1 (en:Method) |
| KR (1) | KR910007883A (en:Method) |
| CN (1) | CN1050715A (en:Method) |
| AT (1) | ATE116301T1 (en:Method) |
| AU (1) | AU629048B2 (en:Method) |
| CA (1) | CA2026890C (en:Method) |
| DE (1) | DE69015541T2 (en:Method) |
| FI (1) | FI904915A7 (en:Method) |
| HU (1) | HUT55364A (en:Method) |
| IE (1) | IE903454A1 (en:Method) |
| IL (1) | IL95839A (en:Method) |
| NO (1) | NO904300L (en:Method) |
| NZ (1) | NZ235582A (en:Method) |
| PT (1) | PT95515A (en:Method) |
| RU (1) | RU2001910C1 (en:Method) |
| TW (1) | TW205037B (en:Method) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03181465A (ja) * | 1989-12-11 | 1991-08-07 | Takeda Chem Ind Ltd | キノリン誘導体 |
| FI934710A7 (fi) * | 1991-04-26 | 1993-10-25 | Pfizer | 4-aryyli-3-(heteroaryyliureido)kinoliinijohdannaisia |
| WO1993015058A1 (en) * | 1992-01-23 | 1993-08-05 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| TW241258B (en:Method) * | 1992-04-15 | 1995-02-21 | Takeda Pharm Industry Co Ltd | |
| US6001860A (en) * | 1992-05-28 | 1999-12-14 | Pfizer Inc. | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) |
| NO179904C (no) * | 1992-09-04 | 1997-01-08 | Takeda Chemical Industries Ltd | Kondenserte heterocykliske forbindelser og deres anvendelse |
| US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| TW263498B (en:Method) * | 1993-11-10 | 1995-11-21 | Takeda Pharm Industry Co Ltd | |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| US5843957A (en) * | 1995-05-19 | 1998-12-01 | Sumitomo Pharmaceuticals Company, Ltd. | Naphthyridine derivatives |
| US5972961A (en) * | 1997-08-28 | 1999-10-26 | Bristol-Myers Squibb Company | 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators |
| US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| AU2547399A (en) | 1998-02-25 | 1999-09-15 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for producing the same |
| AU755202B2 (en) * | 1998-12-04 | 2002-12-05 | Bristol-Myers Squibb Company | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators |
| UA75345C2 (en) | 2000-02-02 | 2006-04-17 | Warner Lambert Co | Pharmaceutical composition for topical use intended for treating sebaceous gland disorders and methods of treating acnes using this composition |
| CA2439663C (en) * | 2001-03-02 | 2012-04-03 | Sumika Fine Chemicals Co., Ltd. | Process for producing quinoline-3-carboxylic acid compound |
| CA2445693A1 (en) * | 2001-04-30 | 2002-11-07 | Pfizer Products Inc. | Compounds useful as intermediates for 4-aminoquinoline derivatives |
| JP4794445B2 (ja) | 2003-09-23 | 2011-10-19 | メルク・シャープ・エンド・ドーム・コーポレイション | キノリンカリウムチャネル阻害剤 |
| ES2609773T3 (es) * | 2011-11-04 | 2017-04-24 | F. Hoffmann-La Roche Ag | Nuevos derivados de arilquinolina |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1216878B (de) * | 1963-04-02 | 1966-05-18 | Cassella Farbwerke Mainkur Ag | Verfahren zur Herstellung von coronargefaesserweiternden Derivaten des 7-Hydroxy-2-oxo-1, 2-dihydrochinolins |
| NO133758C (en:Method) * | 1970-04-04 | 1976-06-23 | Takeda Chemical Industries Ltd | |
| JPS555502B1 (en:Method) * | 1971-07-31 | 1980-02-07 | ||
| US4530931A (en) * | 1983-01-03 | 1985-07-23 | Usv Pharmaceutical Corp. | 8-Quinoline carbanilates for the inhibition of lipolysis |
| EP0166354B1 (en) * | 1984-06-26 | 1992-08-05 | Merck & Co. Inc. | Benzofused lactam compounds and pharmaceutical compositions containing them |
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
-
1990
- 1990-09-20 TW TW079107912A patent/TW205037B/zh active
- 1990-09-25 US US07/587,795 patent/US5223513A/en not_active Expired - Fee Related
- 1990-09-25 IE IE345490A patent/IE903454A1/en unknown
- 1990-09-28 IL IL9583990A patent/IL95839A/en not_active IP Right Cessation
- 1990-09-28 AU AU63707/90A patent/AU629048B2/en not_active Ceased
- 1990-10-03 NO NO90904300A patent/NO904300L/no unknown
- 1990-10-04 CA CA002026890A patent/CA2026890C/en not_active Expired - Fee Related
- 1990-10-04 PT PT95515A patent/PT95515A/pt not_active Application Discontinuation
- 1990-10-05 NZ NZ235582A patent/NZ235582A/en unknown
- 1990-10-05 AT AT90119128T patent/ATE116301T1/de not_active IP Right Cessation
- 1990-10-05 RU SU904831426A patent/RU2001910C1/ru active
- 1990-10-05 CN CN90108222A patent/CN1050715A/zh active Pending
- 1990-10-05 DE DE69015541T patent/DE69015541T2/de not_active Expired - Fee Related
- 1990-10-05 FI FI904915A patent/FI904915A7/fi not_active Application Discontinuation
- 1990-10-05 EP EP90119128A patent/EP0421456B1/en not_active Expired - Lifetime
- 1990-10-05 HU HU906360A patent/HUT55364A/hu unknown
- 1990-10-06 KR KR1019900015908A patent/KR910007883A/ko not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IE903454A1 (en) | 1991-04-10 |
| HU906360D0 (en) | 1991-04-29 |
| NO904300L (no) | 1991-04-08 |
| KR910007883A (ko) | 1991-05-30 |
| CN1050715A (zh) | 1991-04-17 |
| FI904915A0 (fi) | 1990-10-05 |
| IL95839A0 (en) | 1991-06-30 |
| TW205037B (en:Method) | 1993-05-01 |
| IL95839A (en) | 1995-03-15 |
| EP0421456B1 (en) | 1994-12-28 |
| RU2001910C1 (ru) | 1993-10-30 |
| JPH03223254A (ja) | 1991-10-02 |
| PT95515A (pt) | 1991-08-14 |
| CA2026890C (en) | 2001-09-18 |
| AU6370790A (en) | 1991-04-11 |
| EP0421456A3 (en) | 1991-05-29 |
| DE69015541D1 (de) | 1995-02-09 |
| US5223513A (en) | 1993-06-29 |
| NZ235582A (en) | 1992-03-26 |
| AU629048B2 (en) | 1992-09-24 |
| CA2026890A1 (en) | 1991-04-07 |
| EP0421456A2 (en) | 1991-04-10 |
| NO904300D0 (no) | 1990-10-03 |
| DE69015541T2 (de) | 1995-06-01 |
| HUT55364A (en) | 1991-05-28 |
| FI904915A7 (fi) | 1991-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |