ATE115954T1 - Substituierte zyklobutendion-verbindungen. - Google Patents

Substituierte zyklobutendion-verbindungen.

Info

Publication number
ATE115954T1
ATE115954T1 AT90311721T AT90311721T ATE115954T1 AT E115954 T1 ATE115954 T1 AT E115954T1 AT 90311721 T AT90311721 T AT 90311721T AT 90311721 T AT90311721 T AT 90311721T AT E115954 T1 ATE115954 T1 AT E115954T1
Authority
AT
Austria
Prior art keywords
alkyl
hydrogen
group
cyano
nitro
Prior art date
Application number
AT90311721T
Other languages
English (en)
Inventor
Geoffrey Smith Kline Bee Stemp
Pinnacles
Gordon Burrell
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Application granted granted Critical
Publication of ATE115954T1 publication Critical patent/ATE115954T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fuel-Injection Apparatus (AREA)
  • Cosmetics (AREA)
  • Silicon Polymers (AREA)
  • Optical Head (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
AT90311721T 1989-10-30 1990-10-25 Substituierte zyklobutendion-verbindungen. ATE115954T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898924373A GB8924373D0 (en) 1989-10-30 1989-10-30 Novel compounds

Publications (1)

Publication Number Publication Date
ATE115954T1 true ATE115954T1 (de) 1995-01-15

Family

ID=10665385

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90311721T ATE115954T1 (de) 1989-10-30 1990-10-25 Substituierte zyklobutendion-verbindungen.

Country Status (12)

Country Link
US (1) US5147866A (de)
EP (1) EP0426379B1 (de)
JP (1) JPH03151374A (de)
KR (1) KR910007908A (de)
AT (1) ATE115954T1 (de)
AU (1) AU625427B2 (de)
CA (1) CA2028668A1 (de)
DE (1) DE69015322T2 (de)
GB (1) GB8924373D0 (de)
IE (1) IE903868A1 (de)
PT (1) PT95730A (de)
ZA (1) ZA908594B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0430621A3 (en) * 1989-11-29 1992-03-04 Beecham Group P.L.C. Process for the preparation of chiral 3,4-epoxy benzopyrans
US5206252A (en) * 1992-05-08 1993-04-27 American Home Products Corporation Thiadiazolyl-amino derivatives of benzopyrans and indanes
CA2139930A1 (en) * 1992-07-10 1994-01-20 Alan Martin Birch Dioxycyclobutene derivatives as angiotensin ii antagonists
CA2130078A1 (en) * 1993-09-16 1995-03-17 Jonas A. Gylys Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5521188A (en) * 1993-09-16 1996-05-28 Bristol-Myers Squibb Company Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5382592A (en) * 1993-09-16 1995-01-17 Bristol-Myers Squibb Company Antimigraine cyclobutenedione derivatives of tryptamines
US5354763A (en) * 1993-11-17 1994-10-11 American Home Products Corporation Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
US5506252A (en) * 1993-11-17 1996-04-09 American Home Products Corporation Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
US5500442A (en) * 1994-06-10 1996-03-19 American Home Products Corporation Cyclobut-3-ene-1,2-dione derivatives as smooth muscle relaxants
US5482942A (en) * 1994-06-28 1996-01-09 American Home Products Corporation (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants
US5466712A (en) * 1994-11-04 1995-11-14 American Home Products Corporation Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones
AU686896B2 (en) * 1994-11-16 1998-02-12 American Home Products Corporation Diaminocyclobutene-3,4-diones
US5464867A (en) * 1994-11-16 1995-11-07 American Home Products Corporation Diaminocyclobutene-3,4-diones
US5872139A (en) * 1996-06-17 1999-02-16 American Home Products Corporation Heterocyclymethylamino derivatives of cyclobutene-3,4-diones
US5750574A (en) * 1996-07-17 1998-05-12 American Home Products Corporation Fluorinated N-arylmethylamino derivatives of cyclobutene-3,4-diones
US5846999A (en) * 1996-07-17 1998-12-08 American Home Products Corporation Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones
US5780505A (en) * 1996-07-17 1998-07-14 American Home Products Corporation Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones
US5763474A (en) * 1996-07-17 1998-06-09 American Home Products Corporation Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones
US5840764A (en) * 1997-01-30 1998-11-24 American Home Products Corporation Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones
HUP9701865A3 (en) * 1997-11-06 2000-01-28 Egyt Gyogyszervegyeszeti Gyar Pyrano[3,2-c]pyridine derivatives and pharmaceutical compositons containing them, process for the preparation and use thereof
MX2007007103A (es) * 2004-12-13 2008-03-10 Lilly Co Eli Derivados espiro como inhibidores de lipoxigenasa.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
US4391815A (en) * 1976-04-02 1983-07-05 Beecham Group Limited Cyanobenzano[b]pyrans
EP0028064B1 (de) * 1979-09-28 1983-07-20 Beecham Group Plc Chromanol-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzung
DE3064285D1 (en) * 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
EP0076075B1 (de) * 1981-09-25 1986-11-20 Beecham Group Plc Benzopyran-Verbindungen mit pharmazeutischer Wirkung
EP0091748B1 (de) * 1982-04-08 1986-06-18 Beecham Group Plc Blutdrucksenkende Benzopyranole
EP0107423B1 (de) * 1982-10-19 1986-07-23 Beecham Group Plc Chromanen und Chromenen
DE3475786D1 (de) * 1983-09-01 1989-02-02 Beecham Group Plc Chromanol derivatives
GB8414987D0 (en) * 1984-06-12 1984-07-18 Beecham Group Plc Active compounds
US4612309A (en) * 1984-10-23 1986-09-16 William H. Rorer, Inc. Antisecretory bicyclic benzo-oxy heterocyclic ethers and thioethers
DE3682331D1 (de) * 1985-06-08 1991-12-12 Beecham Group Plc Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
GB8521857D0 (en) * 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
DE3835011A1 (de) * 1988-10-14 1990-04-19 Merck Patent Gmbh Chromanderivate
DE3703227A1 (de) * 1987-02-04 1988-08-18 Hoechst Ag Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
DE3881714D1 (de) * 1987-02-04 1993-07-22 Hoechst Ag Alkylsubstituierte n-benzopyranyllactame, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen.
CH674984A5 (de) * 1987-05-16 1990-08-15 Sandoz Ag
IL88035A0 (en) * 1987-10-27 1989-06-30 American Home Prod Benzopyran derivatives,their preparation and pharmaceutical compositions containing them
CA1308108C (en) * 1987-10-27 1992-09-29 Dominick A. Quagliato Antihypertensive benzopyran derivatives
DK691488A (da) * 1987-12-14 1989-06-15 Beecham Group Plc Hidtil ukendte forbindelser
JPH0699439B2 (ja) * 1988-02-03 1994-12-07 日産化学工業株式会社 ピラノベンゾオキサジアゾール誘導体
US5021432A (en) * 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use

Also Published As

Publication number Publication date
CA2028668A1 (en) 1991-05-01
ZA908594B (en) 1992-02-26
JPH03151374A (ja) 1991-06-27
KR910007908A (ko) 1991-05-30
DE69015322T2 (de) 1995-05-18
GB8924373D0 (en) 1989-12-20
EP0426379B1 (de) 1994-12-21
DE69015322D1 (de) 1995-02-02
US5147866A (en) 1992-09-15
EP0426379A2 (de) 1991-05-08
AU625427B2 (en) 1992-07-09
PT95730A (pt) 1991-09-13
AU6554490A (en) 1991-05-02
EP0426379A3 (en) 1991-11-06
IE903868A1 (en) 1991-05-08

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties