ATE106075T1 - Diäthylentriaminpentaessigsäure-derivate. - Google Patents
Diäthylentriaminpentaessigsäure-derivate.Info
- Publication number
- ATE106075T1 ATE106075T1 AT89110208T AT89110208T ATE106075T1 AT E106075 T1 ATE106075 T1 AT E106075T1 AT 89110208 T AT89110208 T AT 89110208T AT 89110208 T AT89110208 T AT 89110208T AT E106075 T1 ATE106075 T1 AT E106075T1
- Authority
- AT
- Austria
- Prior art keywords
- acid derivatives
- pentaacetic acid
- compound
- diethylenetriamine pentaacetic
- radioactive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13988688 | 1988-06-07 | ||
JP13988588 | 1988-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE106075T1 true ATE106075T1 (de) | 1994-06-15 |
Family
ID=26472565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89110208T ATE106075T1 (de) | 1988-06-07 | 1989-06-06 | Diäthylentriaminpentaessigsäure-derivate. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5094950A (de) |
EP (1) | EP0345723B1 (de) |
KR (1) | KR0126238B1 (de) |
AT (1) | ATE106075T1 (de) |
AU (1) | AU617816B2 (de) |
CA (1) | CA1331450C (de) |
DE (1) | DE68915476T2 (de) |
DK (1) | DK276789A (de) |
ES (1) | ES2056150T3 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE107276T1 (de) * | 1988-02-03 | 1994-07-15 | Hybritech Inc | Modifizierte haptene, nützlich als bildformendes agens und als arzneimittel. |
US5776894A (en) * | 1988-12-05 | 1998-07-07 | Novartis Ag | Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors |
US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
US5274082A (en) * | 1990-04-10 | 1993-12-28 | Nihon Medi-Physics Co., Ltd. | Paramagnetic complexes of chelating compounds |
JP2901787B2 (ja) * | 1991-07-15 | 1999-06-07 | 日本メジフィジックス株式会社 | 核磁気共鳴造影剤 |
US5562894A (en) * | 1991-08-09 | 1996-10-08 | Regents Of The University Of California | Amino-acyl-type and catecholamine-type contrast agents for MRI |
JP2894879B2 (ja) * | 1991-10-04 | 1999-05-24 | 日本メジフィジックス株式会社 | 診断用造影剤 |
PT590766E (pt) * | 1992-07-31 | 2000-07-31 | Australian Nuclear Science Tec | Complexos metalicos de hidroxiarilo contendo agentes quelantes de acido aminocarboxilico |
AU5360994A (en) * | 1992-10-13 | 1994-05-09 | Mallinckrodt Medical, Inc. | Novel compositions for magnetic resonance imaging |
DE69421698T2 (de) * | 1993-05-14 | 2000-03-09 | Mallinckrodt, Inc. | Die vorstufe eines liganden zum einbau in peptide |
DE19505960A1 (de) * | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Konjugat zur individuellen Dosierung von Arzneimitteln |
AU2001234478A1 (en) * | 2000-01-21 | 2001-07-31 | Mallinckrodt, Inc. | Chelating agents and method for their use as tandem metal chelators and hydrophilic spacers for medical diagnosis and therapy |
WO2001052900A2 (en) * | 2000-01-21 | 2001-07-26 | Mallinckrodt Inc. | Novel orthogonally protected amino acid chelators for biomedical applications |
AU2001232845A1 (en) * | 2000-01-21 | 2001-07-31 | Mallinckrodt, Inc. | Methods for incorporating metal chelators at carboxyl-terminal site of peptides |
TW200505934A (en) * | 2003-03-26 | 2005-02-16 | Nihon Mediphysics Co Ltd | Compound having affinity with calcified tissue |
EP1771440A4 (de) * | 2004-07-23 | 2009-09-02 | Amgen Inc | Generische proben zur detektion phosphorylierter sequenzen |
CN100382847C (zh) * | 2005-02-05 | 2008-04-23 | 四川大学 | 用于影像诊断的配合体化合物及制备方法和影像诊断用化合物及其制备中间体 |
IL280308B2 (en) * | 2018-07-23 | 2024-09-01 | Centurion Biopharma Corp | Imaging factors for radiolabeling of exogenous and endogenous albumin |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4622420A (en) * | 1980-03-18 | 1986-11-11 | The Regents Of The University Of California | Chelating agents and method |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
US4668503A (en) * | 1982-07-26 | 1987-05-26 | Trustees Of University Of Massachusetts | Process for labeling amines with 99m Tc |
US4479930A (en) * | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
US4741900A (en) * | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
CA1260827A (en) * | 1984-08-31 | 1989-09-26 | Richard C. Siegel | Antibody-metal ion complexes |
US4837003A (en) * | 1984-09-13 | 1989-06-06 | Mallinckrodt, Inc. | Radiolabeled antibody fragments |
US4678667A (en) * | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
AU593611B2 (en) * | 1986-02-14 | 1990-02-15 | Nihon Medi-Physics Co., Ltd. | High molecular compounds having amino groups, and their utilization |
EP0250358A3 (de) * | 1986-06-20 | 1988-10-05 | Schering Aktiengesellschaft | Komplexe Verbindungen |
IL83966A (en) * | 1986-09-26 | 1992-03-29 | Schering Ag | Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them |
EP0282057A3 (de) * | 1987-03-11 | 1990-03-07 | The Board Of Regents Of The University Of Michigan | Chemo-Radio-Immunkonjugate |
-
1989
- 1989-06-05 US US07/362,370 patent/US5094950A/en not_active Expired - Fee Related
- 1989-06-06 AT AT89110208T patent/ATE106075T1/de not_active IP Right Cessation
- 1989-06-06 DK DK276789A patent/DK276789A/da not_active Application Discontinuation
- 1989-06-06 ES ES89110208T patent/ES2056150T3/es not_active Expired - Lifetime
- 1989-06-06 EP EP89110208A patent/EP0345723B1/de not_active Expired - Lifetime
- 1989-06-06 DE DE68915476T patent/DE68915476T2/de not_active Expired - Fee Related
- 1989-06-06 CA CA000601896A patent/CA1331450C/en not_active Expired - Fee Related
- 1989-06-06 AU AU36039/89A patent/AU617816B2/en not_active Ceased
- 1989-06-07 KR KR1019890007823A patent/KR0126238B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK276789D0 (da) | 1989-06-06 |
DK276789A (da) | 1989-12-08 |
KR910000604A (ko) | 1991-01-29 |
ES2056150T3 (es) | 1994-10-01 |
CA1331450C (en) | 1994-08-16 |
KR0126238B1 (ko) | 1997-12-26 |
EP0345723A2 (de) | 1989-12-13 |
US5094950A (en) | 1992-03-10 |
AU3603989A (en) | 1989-12-14 |
EP0345723B1 (de) | 1994-05-25 |
DE68915476T2 (de) | 1994-09-29 |
EP0345723A3 (de) | 1991-01-09 |
DE68915476D1 (de) | 1994-06-30 |
AU617816B2 (en) | 1991-12-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |