ATE100331T1 - Verfahren zur behandlung von septischem schock. - Google Patents

Verfahren zur behandlung von septischem schock.

Info

Publication number
ATE100331T1
ATE100331T1 AT91902317T AT91902317T ATE100331T1 AT E100331 T1 ATE100331 T1 AT E100331T1 AT 91902317 T AT91902317 T AT 91902317T AT 91902317 T AT91902317 T AT 91902317T AT E100331 T1 ATE100331 T1 AT E100331T1
Authority
AT
Austria
Prior art keywords
septic shock
treatment
methods
antagonist
human
Prior art date
Application number
AT91902317T
Other languages
English (en)
Inventor
H Fletcher Starnes
John S Abrams
Original Assignee
Schering Corp
H Fletcher Starnes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, H Fletcher Starnes filed Critical Schering Corp
Application granted granted Critical
Publication of ATE100331T1 publication Critical patent/ATE100331T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Treatment Of Sludge (AREA)
  • Fertilizers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compression-Type Refrigeration Machines With Reversible Cycles (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT91902317T 1989-12-04 1991-06-28 Verfahren zur behandlung von septischem schock. ATE100331T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44519289A 1989-12-04 1989-12-04
PCT/US1990/006872 WO1991007986A1 (en) 1989-12-04 1990-11-30 Method of treating septic shock
EP91902317A EP0504307B1 (de) 1989-12-04 1991-06-28 Verfahren zur behandlung von septischem schock

Publications (1)

Publication Number Publication Date
ATE100331T1 true ATE100331T1 (de) 1994-02-15

Family

ID=23767939

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91902317T ATE100331T1 (de) 1989-12-04 1991-06-28 Verfahren zur behandlung von septischem schock.

Country Status (11)

Country Link
EP (1) EP0504307B1 (de)
JP (1) JPH0747547B2 (de)
AT (1) ATE100331T1 (de)
AU (1) AU648777B2 (de)
CA (1) CA2070424A1 (de)
DE (1) DE69006221T2 (de)
DK (1) DK0504307T3 (de)
ES (1) ES2062762T3 (de)
FI (1) FI922551A7 (de)
HU (1) HUT64481A (de)
WO (1) WO1991007986A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0672144A1 (de) * 1992-10-20 1995-09-20 Chiron Corporation Interleukin-6-receptor-antagonisten
JP3525221B2 (ja) * 1993-02-17 2004-05-10 味の素株式会社 免疫抑制剤
ATE183513T1 (de) * 1993-06-03 1999-09-15 Therapeutic Antibodies Inc Herstellung von antikörperfragmenten
DE4409513C1 (de) * 1994-02-07 1995-10-19 Knoll Ag Verwendung von anti-TNF-Antikörpern als Arzneimittel zur Behandlung von Erkrankungen mit einem erhöhten Interleukin-6 Serumspiegel
US8017121B2 (en) 1994-06-30 2011-09-13 Chugai Seiyaku Kabushika Kaisha Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
CN101601861A (zh) * 1994-10-07 2009-12-16 中外制药株式会社 以il-6拮抗剂作为有效成分治疗慢性类风湿性关节炎
CA2295440A1 (en) * 1997-06-18 1998-12-23 The Rockefeller University Methods for identifying antibodies and peptides useful in the treatment of septic shock and experimental arthritis and uses thereof
CA2724279C (en) 2008-05-13 2017-03-07 Novimmune S.A. Anti-il-6/il-6r antibodies and methods of use thereof
US8188235B2 (en) 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
EP4692802A1 (de) 2023-03-31 2026-02-11 The University of Osaka Biomarker zur prognose bei septischem patienten und verwendung davon
CN119667163B (zh) * 2024-10-18 2025-12-09 中国科学技术大学 Il-1r2在鉴定对象免疫状态中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2598666B2 (ja) * 1987-10-19 1997-04-09 忠三 岸本 抗ヒトｂｃｄｆモノクローナル抗体
CA1341588C (en) * 1988-01-26 2009-01-06 Michel Revel Human ifn-beta2/i1-6, its purification and use
HU211059B (en) * 1988-02-02 1995-10-30 Schering Biotech Corp Method for producing pharmaceutical compositions usable for reducing immunglobulin e responses, containing human il-4 antibodies
EP0399429A1 (de) * 1989-05-22 1990-11-28 Toray Industries, Inc. Monoklonaler Antikörper gegen menschliches Interleukin-6

Also Published As

Publication number Publication date
HUT64481A (en) 1994-01-28
WO1991007986A1 (en) 1991-06-13
AU648777B2 (en) 1994-05-05
CA2070424A1 (en) 1991-06-05
JPH05504058A (ja) 1993-07-01
DK0504307T3 (da) 1994-03-21
JPH0747547B2 (ja) 1995-05-24
FI922551A0 (fi) 1992-06-03
FI922551L (fi) 1992-06-03
DE69006221T2 (de) 1994-05-05
ES2062762T3 (es) 1994-12-16
EP0504307A1 (de) 1992-09-23
EP0504307B1 (de) 1994-01-19
AU7179491A (en) 1991-06-26
WO1991007986A8 (en) 2004-04-22
HU9201859D0 (en) 1992-09-28
FI922551A7 (fi) 1992-06-03
DE69006221D1 (de) 1994-03-03

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee