ATA508977A - Verfahren zur herstellung von neuen in stellung 5 substituierten 1,2-dihydro-3h-pyrrolo-(1,2-a) -pyrrol-1-carbonsaeureestern und -salzen - Google Patents

Verfahren zur herstellung von neuen in stellung 5 substituierten 1,2-dihydro-3h-pyrrolo-(1,2-a) -pyrrol-1-carbonsaeureestern und -salzen

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Publication number
ATA508977A
ATA508977A AT508977A AT508977A ATA508977A AT A508977 A ATA508977 A AT A508977A AT 508977 A AT508977 A AT 508977A AT 508977 A AT508977 A AT 508977A AT A508977 A ATA508977 A AT A508977A
Authority
AT
Austria
Prior art keywords
pyrrol
pyrrolo
dihydro
acid esters
carbonic acid
Prior art date
Application number
AT508977A
Other languages
English (en)
Other versions
AT363464B (de
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Priority to AT413279A priority Critical patent/AT364845B/de
Priority to AT69680A priority patent/AT364846B/de
Publication of ATA508977A publication Critical patent/ATA508977A/de
Application granted granted Critical
Publication of AT363464B publication Critical patent/AT363464B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT0508977A 1976-07-14 1977-07-14 Verfahren zur herstellung von neuen in stellung 5 substituierten 1,2-dihydro-3h-pyrrolo-(1,2-a) -pyrrol-1-carbonsaeureestern und -salzen AT363464B (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT413279A AT364845B (de) 1976-07-14 1979-06-08 Verfahren zur herstellung von neuen in stellung 5 substituierten 1,2-dihydro-3h-pyrrolo-(1,2-a) -pyrrol-1-carbonsaeuren, von deren einzelnen 1-saeureisomeren und d-saeureisomeren und von deren pharmazeutisch unbedenklichen salzen
AT69680A AT364846B (de) 1976-07-14 1980-02-08 Verfahren zur herstellung von neuen in stellung 5 substituierten 1,2-dihydro-3h-pyrrolo-(1,2-a) -pyrrol-1-carbonsaeuren und von deren einzelnen 1-saeureisomeren und d-saeureisomeren

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70485776A 1976-07-14 1976-07-14

Publications (2)

Publication Number Publication Date
ATA508977A true ATA508977A (de) 1981-01-15
AT363464B AT363464B (de) 1981-08-10

Family

ID=24831134

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0508977A AT363464B (de) 1976-07-14 1977-07-14 Verfahren zur herstellung von neuen in stellung 5 substituierten 1,2-dihydro-3h-pyrrolo-(1,2-a) -pyrrol-1-carbonsaeureestern und -salzen

Country Status (4)

Country Link
US (1) US4087539A (de)
AT (1) AT363464B (de)
BE (1) BE856682A (de)
ZA (1) ZA774239B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
US4410534A (en) * 1979-12-26 1983-10-18 Syntex (U.S.A.) Inc. 3-Substituted-5,6,7,8-tetrahydropyrrolo[1,2-a]-pyridine-and 6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]-azepine carboxylic acid derivatives useful as blood platelet aggregation inhibitors
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4347185A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Processes for preparing 5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4454326A (en) * 1981-06-11 1984-06-12 Syntex (U.S.A.) Inc. 5-Aroyl 6-chloro or 6-bromo 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-di-carboxylates
US4434175A (en) 1981-08-10 1984-02-28 Merck & Co., Inc. Nonsteroidal compounds as anti-inflammatory and analgesic agents
WO1983001382A1 (en) * 1981-10-13 1983-04-28 Mroszczak, Edward Gastrointestinal sparing thioester pro-drugs
US4454151A (en) * 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
US4457941A (en) * 1982-03-22 1984-07-03 Syntex (U.S.A.) Inc. Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes
US4536512A (en) * 1982-10-08 1985-08-20 Merck & Co., Inc. 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents
US4533671A (en) * 1982-10-08 1985-08-06 Merck & Co., Inc. 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2-alkanoic or carboxylic acids and analogs as anti-inflammatory and analgesic agents
EP0117675B1 (de) * 1983-02-19 1986-07-23 Beecham Group Plc Benzofuran- und Benzothiophencarbonsäurederivate
US4988822A (en) * 1986-05-29 1991-01-29 Syntex (U.S.A.) Inc. Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates
US4873340A (en) * 1986-05-29 1989-10-10 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates
US4937368A (en) * 1987-01-14 1990-06-26 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4835288A (en) * 1987-01-14 1989-05-30 Syntex Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates
US4874872A (en) * 1987-01-14 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
US5414011A (en) * 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations
US5110493A (en) * 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
JPH09503997A (ja) * 1993-07-08 1997-04-22 シグナス，インコーポレイテッド モノリシックなマトリックス経皮送達システム
US5621115A (en) * 1996-02-21 1997-04-15 Ohmeda Pharmaceutical Products Division Inc. Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids
US6191285B1 (en) 1997-07-03 2001-02-20 Abbott Laboratories Process for the preparation of ketorolac tromethamine
MX2008012734A (es) 2006-04-04 2009-01-29 Fibrogen Inc Compuestos pirrolo- y tiazolo-piridina como moduladores del factor inducible de hipoxia (hif).
US8163195B2 (en) 2006-06-30 2012-04-24 Otsuka Chemical Co., Ltd. Additives for electrolyte solution and electrolyte solution

Also Published As

Publication number Publication date
BE856682A (fr) 1978-01-11
ZA774239B (en) 1979-02-28
US4087539A (en) 1978-05-02
AT363464B (de) 1981-08-10

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