AT64972B - Process for the preparation of hexamethylenetetramine salts of α-phenylquinoline-γ-carboxylic acids. - Google Patents

Process for the preparation of hexamethylenetetramine salts of α-phenylquinoline-γ-carboxylic acids.

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Publication number
AT64972B
AT64972B AT64972DA AT64972B AT 64972 B AT64972 B AT 64972B AT 64972D A AT64972D A AT 64972DA AT 64972 B AT64972 B AT 64972B
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Austria
Prior art keywords
phenylquinoline
preparation
carboxylic acids
hexamethylenetetramine
salts
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German (de)
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Hoechst Ag
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Publication of AT64972B publication Critical patent/AT64972B/en

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Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur Darstellung von Hexamethylentetraminsalzen der   a-Phenylchinolin-     - r -karbon8äuren.   



   Es wurde gefunden, dass man durch Vereinigung von Hexamethylentetramin mit   N-Phenylchinolin-Y-karbonsäuro   oder deren Derivaten zu Verbindungen gelangt, die für medizinische Zwecke wertvoll sind. Um die neuen Verbindungen darzustellen, bringt man die genannten   Karbonsäuren   mit der äquimolekularen Menge Hexamethylentetramin in einem geeigneten Lösungsmittel zusammen und kann dann die neue Verbindung entweder durch Kristallisation oder Fällung aus der Lösung abscheiden. 



   Beispiel : 70 Teile Hexamethylentetramin werden mit der 15fachen Menge absoluten Alkohols gekocht und 125 Teile   &alpha;-Phenylchinolin-&gamma;-karbonsäure hinzugegeben.   Es entsteht dann eine Lösung, aus welcher die neue Verbindung    < x-phenylchinolin-Y-karbon-   saures Hexamothylentetramin beim Erkalten kristallisiert. Sie bildet kleine Kristalle, die in Wasser und heissem Alkohol löslich, in Äther unlöslich sind und deren Schmelz- und Zersetzungspunkt bei etwa 1850 liegt. In gleicher Weise kann z. B.   &alpha;-Phenylchininsäure   zur Darstellung einer analogen Verbindung verwendet werden. 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 



  Process for the preparation of hexamethylenetetramine salts of a-phenylquinoline - r -carboxylic acids.



   It has been found that the combination of hexamethylenetetramine with N-phenylquinoline-Y-carboxylic acid or derivatives thereof leads to compounds which are valuable for medical purposes. To produce the new compounds, the carboxylic acids mentioned are combined with the equimolecular amount of hexamethylenetetramine in a suitable solvent and the new compound can then be separated out from the solution either by crystallization or precipitation.



   Example: 70 parts of hexamethylenetetramine are boiled with 15 times the amount of absolute alcohol and 125 parts of α-phenylquinoline-γ-carboxylic acid are added. A solution is then formed from which the new compound <x-phenylquinoline-Y-carbonic acid hexamothylenetetramine crystallizes on cooling. It forms small crystals that are soluble in water and hot alcohol, insoluble in ether and whose melting and decomposition point is around 1850. In the same way, for. B. α-phenylquinic acid can be used to prepare an analogous compound.

** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

PATENT-ANSPRUCH: Verfahren zur Darstellung von Verbindungen des Hexamethylentetramins mit ex-Phenyl- chinolin-#039-karbonsäure oder deren Derivaten, darin bestehend, dass man äquivalente Mengen derselben in geeigneten Lösungsmitteln zusammenbringt. **WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. PATENT CLAIM: Process for the preparation of compounds of hexamethylenetetramine with ex-phenylquinoline- # 039-carboxylic acid or derivatives thereof, consisting in bringing together equivalent amounts of the same in suitable solvents. ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT64972D 1911-11-08 1912-10-19 Process for the preparation of hexamethylenetetramine salts of α-phenylquinoline-γ-carboxylic acids. AT64972B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE64972X 1911-11-08

Publications (1)

Publication Number Publication Date
AT64972B true AT64972B (en) 1914-05-25

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ID=5632649

Family Applications (1)

Application Number Title Priority Date Filing Date
AT64972D AT64972B (en) 1911-11-08 1912-10-19 Process for the preparation of hexamethylenetetramine salts of α-phenylquinoline-γ-carboxylic acids.

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AT (1) AT64972B (en)

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