AT64972B - Process for the preparation of hexamethylenetetramine salts of α-phenylquinoline-γ-carboxylic acids. - Google Patents
Process for the preparation of hexamethylenetetramine salts of α-phenylquinoline-γ-carboxylic acids.Info
- Publication number
- AT64972B AT64972B AT64972DA AT64972B AT 64972 B AT64972 B AT 64972B AT 64972D A AT64972D A AT 64972DA AT 64972 B AT64972 B AT 64972B
- Authority
- AT
- Austria
- Prior art keywords
- phenylquinoline
- preparation
- carboxylic acids
- hexamethylenetetramine
- salts
- Prior art date
Links
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical class C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 title claims description 10
- 238000000034 method Methods 0.000 title claims description 3
- 238000002360 preparation method Methods 0.000 title claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 6
- 235000010299 hexamethylene tetramine Nutrition 0.000 claims description 4
- 239000004312 hexamethylene tetramine Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- FSEXLNMNADBYJU-UHFFFAOYSA-N 2-phenylquinoline Chemical class C1=CC=CC=C1C1=CC=C(C=CC=C2)C2=N1 FSEXLNMNADBYJU-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Darstellung von Hexamethylentetraminsalzen der a-Phenylchinolin- - r -karbon8äuren.
Es wurde gefunden, dass man durch Vereinigung von Hexamethylentetramin mit N-Phenylchinolin-Y-karbonsäuro oder deren Derivaten zu Verbindungen gelangt, die für medizinische Zwecke wertvoll sind. Um die neuen Verbindungen darzustellen, bringt man die genannten Karbonsäuren mit der äquimolekularen Menge Hexamethylentetramin in einem geeigneten Lösungsmittel zusammen und kann dann die neue Verbindung entweder durch Kristallisation oder Fällung aus der Lösung abscheiden.
Beispiel : 70 Teile Hexamethylentetramin werden mit der 15fachen Menge absoluten Alkohols gekocht und 125 Teile α-Phenylchinolin-γ-karbonsäure hinzugegeben. Es entsteht dann eine Lösung, aus welcher die neue Verbindung < x-phenylchinolin-Y-karbon- saures Hexamothylentetramin beim Erkalten kristallisiert. Sie bildet kleine Kristalle, die in Wasser und heissem Alkohol löslich, in Äther unlöslich sind und deren Schmelz- und Zersetzungspunkt bei etwa 1850 liegt. In gleicher Weise kann z. B. α-Phenylchininsäure zur Darstellung einer analogen Verbindung verwendet werden.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Process for the preparation of hexamethylenetetramine salts of a-phenylquinoline - r -carboxylic acids.
It has been found that the combination of hexamethylenetetramine with N-phenylquinoline-Y-carboxylic acid or derivatives thereof leads to compounds which are valuable for medical purposes. To produce the new compounds, the carboxylic acids mentioned are combined with the equimolecular amount of hexamethylenetetramine in a suitable solvent and the new compound can then be separated out from the solution either by crystallization or precipitation.
Example: 70 parts of hexamethylenetetramine are boiled with 15 times the amount of absolute alcohol and 125 parts of α-phenylquinoline-γ-carboxylic acid are added. A solution is then formed from which the new compound <x-phenylquinoline-Y-carbonic acid hexamothylenetetramine crystallizes on cooling. It forms small crystals that are soluble in water and hot alcohol, insoluble in ether and whose melting and decomposition point is around 1850. In the same way, for. B. α-phenylquinic acid can be used to prepare an analogous compound.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE64972X | 1911-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT64972B true AT64972B (en) | 1914-05-25 |
Family
ID=5632649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT64972D AT64972B (en) | 1911-11-08 | 1912-10-19 | Process for the preparation of hexamethylenetetramine salts of α-phenylquinoline-γ-carboxylic acids. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT64972B (en) |
-
1912
- 1912-10-19 AT AT64972D patent/AT64972B/en active
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