AT50290B - Method for the preparation of a sleeping pill using chloral. - Google Patents
Method for the preparation of a sleeping pill using chloral.Info
- Publication number
- AT50290B AT50290B AT50290DA AT50290B AT 50290 B AT50290 B AT 50290B AT 50290D A AT50290D A AT 50290DA AT 50290 B AT50290 B AT 50290B
- Authority
- AT
- Austria
- Prior art keywords
- chloral
- preparation
- sleeping pill
- sleeping
- pill
- Prior art date
Links
- HFFLGKNGCAIQMO-UHFFFAOYSA-N trichloroacetaldehyde Chemical compound ClC(Cl)(Cl)C=O HFFLGKNGCAIQMO-UHFFFAOYSA-N 0.000 title description 5
- 238000002360 preparation method Methods 0.000 title description 2
- 239000006187 pill Substances 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000007795 chemical reaction product Substances 0.000 claims description 2
- 239000000155 melt Substances 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
- 230000000147 hypnotic effect Effects 0.000 description 3
- YVOXCIJEBFMIKI-UHFFFAOYSA-N C(CC(C)C)(=O)NBr Chemical compound C(CC(C)C)(=O)NBr YVOXCIJEBFMIKI-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- UEBARDWJXBGYEJ-UHFFFAOYSA-N 2-bromo-3-methylbutanoic acid Chemical compound CC(C)C(Br)C(O)=O UEBARDWJXBGYEJ-UHFFFAOYSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
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Nachdem, wie bereits ausgeführt, eine grosse Anzahl vergeblicher Versuche zur Beseitigung der schädlichen Eigenschaften des Chlorals gemacht wurden und nachdem auch die Vereinigung von Chloral mit anderen hypnotisch wirkenden Komponenten meistens nur eine Abschwächung, der hypnotischen Wirkung bewirkte, ohne sonstige Vorteile zu bieten, war es durchaus nicht vorauszusehen, dass gerade die Verbindung mit dem Amid der Bromisovaleriansäure zu einem Körper führen würde, in welchem die hypnotische Wirkung des Chorals noch verstärkt erscheint,
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Verbindung bedeutet also einen unerwarteten Effekt und einen erheblichen technischen und therapeutischen Fortschritt.
Die Darstellung geschieht in der Weise, dass man äquimolekulare Mengen von Chloral und Bromisovalerylamid auf dem Wasserbad einige Zeit erwärmt und die erhaltene Schmelze aus heissem Benzol oder Alkohol umkristallisiert.
Bei s piel: 10 kg Bromisovalerylamid und 8 kg Chloral werden auf dem Wasserbad 1/2 Stunde erwärmt. Das Reaktionsprodukt wird in etwa 20 bis 30 kg heissem Benzol gelöst, beim Erkalten kristallisiert der grösste Teil aus. Der noch in der Mutterlauge befindliche Anteil kann durch Zusatz von Petroläther ausgefällt werden.
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After a large number of unsuccessful attempts had been made to eliminate the harmful properties of chloral, as already stated, and after the combination of chloral with other hypnotic components usually only weakened the hypnotic effect without offering any other advantages, it was It cannot be foreseen at all that the connection with the amide of bromoisovaleric acid would lead to a body in which the hypnotic effect of the chorale appears to be even stronger,
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So connection means an unexpected effect and a considerable technical and therapeutic advance.
The preparation takes place in such a way that equimolecular amounts of chloral and bromoisovalerylamide are heated for some time on a water bath and the resulting melt is recrystallized from hot benzene or alcohol.
For example: 10 kg of bromoisovalerylamide and 8 kg of chloral are heated on the water bath for 1/2 hour. The reaction product is dissolved in about 20 to 30 kg of hot benzene; most of it crystallizes out on cooling. The portion still in the mother liquor can be precipitated by adding petroleum ether.
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Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT50290T | 1910-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT50290B true AT50290B (en) | 1911-10-25 |
Family
ID=3571129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT50290D AT50290B (en) | 1910-10-04 | 1910-10-04 | Method for the preparation of a sleeping pill using chloral. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT50290B (en) |
-
1910
- 1910-10-04 AT AT50290D patent/AT50290B/en active
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