AT362869B - Verfahren zur herstellung von arzneipraeparaten zur topischen behandlung von entzuendlichen zustaenden der haut - Google Patents
Verfahren zur herstellung von arzneipraeparaten zur topischen behandlung von entzuendlichen zustaenden der hautInfo
- Publication number
- AT362869B AT362869B AT0341277A AT341277A AT362869B AT 362869 B AT362869 B AT 362869B AT 0341277 A AT0341277 A AT 0341277A AT 341277 A AT341277 A AT 341277A AT 362869 B AT362869 B AT 362869B
- Authority
- AT
- Austria
- Prior art keywords
- inflammable
- skin
- states
- medicinal products
- producing medicinal
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
- A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68594276A | 1976-05-13 | 1976-05-13 | |
| US05/788,453 US4185100A (en) | 1976-05-13 | 1977-04-20 | Topical anti-inflammatory drug therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA341277A ATA341277A (de) | 1980-11-15 |
| AT362869B true AT362869B (de) | 1981-06-25 |
Family
ID=27103704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0341277A AT362869B (de) | 1976-05-13 | 1977-05-12 | Verfahren zur herstellung von arzneipraeparaten zur topischen behandlung von entzuendlichen zustaenden der haut |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4185100A (de) |
| JP (1) | JPS52145525A (de) |
| AT (1) | AT362869B (de) |
| AU (1) | AU512371B2 (de) |
| CA (1) | CA1101334A (de) |
| DE (1) | DE2721831A1 (de) |
| FR (1) | FR2394293A1 (de) |
| GB (1) | GB1544351A (de) |
| LU (1) | LU77312A1 (de) |
| NL (1) | NL190049C (de) |
| NZ (1) | NZ184064A (de) |
| PH (1) | PH14140A (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5794680A (en) * | 1979-05-31 | 1980-12-04 | E.R. Squibb & Sons, Inc. | Corticosteroid stick formulations |
| JPS5636411A (en) * | 1979-08-31 | 1981-04-09 | Sumitomo Chem Co Ltd | Liquid agent for external use |
| JPS574919A (en) * | 1980-06-09 | 1982-01-11 | Sankyo Co Ltd | Anti-inflammatory for external use |
| JPS57203011A (en) * | 1981-06-05 | 1982-12-13 | Taiyo Yakuhin Kogyo Kk | Anti-inflammatory external agent |
| US5635497A (en) * | 1982-06-23 | 1997-06-03 | Yamanouchi Europe B.V. | Topical application compositions |
| CH655656B (de) * | 1982-10-07 | 1986-05-15 | ||
| CA1229554A (en) * | 1983-04-18 | 1987-11-24 | Warner-Lambert Company | Meclofenamic acid topical pharmaceutical composition |
| US4602040A (en) * | 1983-04-18 | 1986-07-22 | Warner-Lambert Company | Meclofenamic acid topical pharmaceutical composition |
| US4472431A (en) * | 1983-08-18 | 1984-09-18 | Methodist Hospital Of Indiana, Inc. | Method for treatment of shock |
| CA1316827C (en) * | 1987-03-25 | 1993-04-27 | Peter M. Ross | Prevention and treatment of the deleterious effects of exposing skin to the sun, and compositions therefor |
| US4775529A (en) * | 1987-05-21 | 1988-10-04 | Schering Corporation | Steroid lotion |
| US4897260A (en) * | 1987-05-22 | 1990-01-30 | The Rockefeller University | Compositions that affect suppression of cutaneous delayed hypersensitivity and products including same |
| US4843099A (en) * | 1987-07-20 | 1989-06-27 | Colgate-Palmolive Company | Device and composition for treatment of the gums |
| US4869897A (en) * | 1987-10-22 | 1989-09-26 | The Procter & Gamble Company | Photoprotection compositions comprising sorbohydroxamic acid |
| US5039513A (en) * | 1987-10-22 | 1991-08-13 | The Procter & Gamble Company | Photoprotection compositions and methods comprising sorbohydroxamic acid |
| US4847071A (en) * | 1987-10-22 | 1989-07-11 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent |
| US4946671A (en) * | 1987-10-22 | 1990-08-07 | The Procter & Gamble Company | Photoprotection compositions comprising sorbohydroxamic acid and an anti-inflammatory agent |
| US4954332A (en) * | 1987-10-22 | 1990-09-04 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent |
| US4847069A (en) * | 1987-10-22 | 1989-07-11 | The Procter & Gamble Company | Photoprotection compositions comprising sorbohydroxamic acid and an anti-inflammatory agent |
| DE3856315T2 (de) * | 1987-10-22 | 1999-10-14 | The Procter & Gamble Co. | Chelatbildner enthaltende Lichtschutzmittel |
| US4959205A (en) * | 1989-03-23 | 1990-09-25 | Collagen Corporation | Composition and method for treatment of dermal inflammation |
| US5093133A (en) * | 1990-01-24 | 1992-03-03 | Mcneil-Ppc, Inc. | Method for percutaneous delivery of ibuprofen using hydroalcoholic gel |
| DE4119170C2 (de) * | 1991-06-11 | 2002-04-25 | Geb Herber Miltner | Mittel gegen Neurodermitis |
| US5324746A (en) * | 1993-02-12 | 1994-06-28 | Mckee Rex N | Method of treating damaged mucosal and epithelial tissues with misoprostol |
| US6703009B1 (en) | 1993-03-30 | 2004-03-09 | Tendskin International Inc. | Topical compositions and methods for treating pseudofolliculitis barbae and ingrown hair |
| US6001340A (en) * | 1993-03-30 | 1999-12-14 | Steven E. Rosen | Topical compositions and methods for treating Pseudofolliculitis barbae and ingrown hair |
| US5807568A (en) * | 1994-12-27 | 1998-09-15 | Mcneil-Ppc, Inc. | Enhanced delivery of topical compositions containing flurbiprofen |
| US5702720A (en) * | 1995-12-22 | 1997-12-30 | Minnesota Mining And Manufacturing Company | Transdermal device for the delivery of flurbiprofen |
| US5994399A (en) * | 1997-03-27 | 1999-11-30 | Mckee; Rex N. | Method of regenerating collagen-containing tissues with misoprostol |
| US20010031244A1 (en) * | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
| US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
| US7629384B2 (en) * | 1997-09-17 | 2009-12-08 | Strategic Science & Technologies, Llc | Topical delivery of L-arginine to cause beneficial effects |
| US7914814B2 (en) * | 1997-09-17 | 2011-03-29 | Strategic Science & Technologies, Llc | Topical delivery of arginine of cause beneficial effects |
| US6617488B1 (en) | 1997-10-14 | 2003-09-09 | Indicator Technologies, Inc. | Method and apparatus for indicating the conditions in an absorbent article |
| AUPP583198A0 (en) * | 1998-09-11 | 1998-10-01 | Soltec Research Pty Ltd | Mousse composition |
| US8263580B2 (en) * | 1998-09-11 | 2012-09-11 | Stiefel Research Australia Pty Ltd | Vitamin formulation |
| US6503488B1 (en) | 1998-11-17 | 2003-01-07 | Tend Skin International, Inc. | Topical compositions including deodorant compositions |
| DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| PT1031347E (pt) | 1999-01-27 | 2002-09-30 | Idea Ag | Transporte/imunizacao transnasal com veiculos muitissimo adaptaveis |
| SI1031346T1 (en) | 1999-01-27 | 2002-08-31 | Idea Ag | Noninvasive vaccination through the skin |
| US6315985B1 (en) * | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
| IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
| IT1317720B1 (it) * | 2000-01-07 | 2003-07-15 | Chiesi Farma Spa | Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani. |
| IT1317846B1 (it) | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva. |
| IT1318514B1 (it) * | 2000-05-12 | 2003-08-27 | Chiesi Farma Spa | Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari. |
| EE05167B1 (et) * | 2000-05-22 | 2009-06-15 | Chiesi Farmaceutici S.P.A. | Stabiilsed farmatseutilised lahuspreparaadid survestatud doseerivatele inhalaatoritele |
| FR2823670B1 (fr) * | 2001-04-23 | 2004-12-17 | Oreal | Procede pour diminuer partiellement ou totalement les symptomes associes a la liberation d'histamine dans l'organisme |
| WO2002098404A1 (en) * | 2001-06-01 | 2002-12-12 | Tendskin Company | Topical compositions for veterinary uses |
| DK1273292T3 (da) * | 2001-07-02 | 2004-10-04 | Chiesi Farma Spa | Optimeret tobramycinformulering til aerosoldannelse |
| DK3384931T3 (da) * | 2002-03-01 | 2019-09-16 | Chiesi Farm Spa | Superfin formoterolformulering |
| TR200201556A2 (tr) * | 2002-06-12 | 2004-01-21 | Orva İlaç Sanayi̇ Ve Ti̇caret A. Ş. | Kortikosteroid ve nonsteroidal antienflamatuar içeren farmasötik bileşim |
| CN100464741C (zh) * | 2002-12-12 | 2009-03-04 | 盖尔德马研究及发展公司 | 含有酚衍生物和类维生素a的含水醇脱色素凝胶 |
| US7241746B2 (en) * | 2003-08-06 | 2007-07-10 | Regena Therapeutics, Lc | Method and composition for treating periodontal disease |
| EP1732577B1 (de) * | 2004-02-23 | 2013-04-10 | Strategic Science & Technologies, LLC | Topische verabreichung von l-arginin zur verbesserung des aussehens von körper und haut |
| EP1595531A1 (de) | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stabile Arzneimittellösung für Druckdosierinhalatoren |
| ES2429443T3 (es) * | 2004-04-19 | 2013-11-14 | Strategic Science & Technologies, Llc | Suministro transdérmico de sustancias beneficiosas efectuado mediante un entorno de fuerza iónica elevada |
| US20110028548A1 (en) * | 2004-04-19 | 2011-02-03 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| US9226909B2 (en) | 2004-04-19 | 2016-01-05 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| EP1811961A2 (de) * | 2004-11-12 | 2007-08-01 | Idea Ag | Erweiterte oberflächen-aggregate bei der behandlung von hauterkrankungen |
| US20070053984A1 (en) * | 2005-03-03 | 2007-03-08 | Monique Spann-Wade | Topical gels compositions |
| US20070027217A1 (en) * | 2005-05-27 | 2007-02-01 | Ehrlich H Paul | Composition and Method for Preventing Secondary Burn Ischemia |
| ES2447301T3 (es) * | 2005-06-01 | 2014-03-11 | Glaxosmithkline Intellectual Property Development Limited | Formulación vitamínica |
| MX2008011236A (es) * | 2006-03-01 | 2009-02-10 | Tristrata Inc | Composicion y metodo para tratamiento topico de trastornos dermatologicos que responden a alquitran. |
| US20080317684A1 (en) * | 2006-09-06 | 2008-12-25 | Isw Group, Inc. | Topical Compositions |
| GB0622920D0 (en) * | 2006-11-17 | 2006-12-27 | Providence Capital Mangement | Topical treatment |
| JP5509090B2 (ja) * | 2007-11-21 | 2014-06-04 | テイコク ファーマ ユーエスエー インコーポレーテッド | ピラゾロン誘導体のエマルジョン製剤 |
| EP3574921A1 (de) * | 2008-09-10 | 2019-12-04 | BioChemics, Inc. | Ibuprofen zur topischen verabreichung |
| WO2010151241A1 (en) | 2009-06-24 | 2010-12-29 | Strategic Science & Technologies, Llc | Topical composition containing naproxen |
| US11684624B2 (en) | 2009-06-24 | 2023-06-27 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| RU2505291C2 (ru) * | 2009-06-24 | 2014-01-27 | СТРАТЕДЖИК САЙЕНС ЭНД ТЕКНОЛОДЖИЗ, ЭлЭлСи | Топическая композиция, содержащая ибупрофен |
| US12138268B2 (en) | 2009-06-24 | 2024-11-12 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| GB0915319D0 (en) * | 2009-09-03 | 2009-10-07 | Sharma Anant | Combination medicament |
| US20130059019A1 (en) * | 2009-12-18 | 2013-03-07 | Exodus Life Sciences Limited Partnership | Methods and compositions for treating inflammation of skin |
| WO2011076401A1 (de) | 2009-12-23 | 2011-06-30 | Holger Schankin | Acetylsalicylsäure-haltige, im wesentlichen wasserfreie pharmazeutische zusammensetzungen |
| WO2012092523A1 (en) | 2010-12-29 | 2012-07-05 | Strategic Science & Technologies, Llc | Systems and methods for treatment of allergies and other indications |
| DK2658551T3 (da) | 2010-12-29 | 2020-09-21 | Strategic Science & Tech Llc | Behandling af erektil dysfunktion og andre indikationer |
| PT2704703T (pt) | 2011-05-03 | 2019-10-25 | Aponia Laboratories Inc | Composições transdermais de ibuprofeno e seus métodos de utilização. |
| CA2834710A1 (en) * | 2011-05-16 | 2012-11-22 | Dale L. Pearlman | Compositions and methods for the treatment of skin diseases |
| US8580286B2 (en) * | 2012-03-16 | 2013-11-12 | Dale L. Pearlman | Compositions and methods for the treatment of skin diseases |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3243344A (en) * | 1966-03-29 | Anti-inflammatory barbituric acid derivatives | ||
| FR124F (de) | 1964-04-29 | |||
| NL6406688A (de) * | 1964-06-05 | 1965-12-06 | ||
| US3374145A (en) * | 1965-03-11 | 1968-03-19 | Armour Pharma | Preparations and method for treating inflammatory conditions |
| US3461208A (en) * | 1966-11-01 | 1969-08-12 | Merck & Co Inc | Indomethacin compositions |
| GB1268523A (en) * | 1969-10-29 | 1972-03-29 | Ici Ltd | Dihydrofuran derivatives, the preparation thereof, and compositions containing the same |
| US3752826A (en) * | 1970-01-26 | 1973-08-14 | Mcneilab Inc | Aroyl substituted pyrroles |
| US3721680A (en) * | 1970-06-15 | 1973-03-20 | Mc Neil Labor Inc | 5-aroyl-2-(beta-hydroxyethyl)-1-loweralkylpyrroles |
| GB1335269A (en) * | 1971-04-20 | 1973-10-24 | Ici Ltd | Dihydrofuran derivatives |
| DE2302005A1 (de) | 1973-01-16 | 1974-07-18 | Lege Artis Pharma Gmbh & Co Kg | Mittel zum entfernen von warzen |
| US4012508A (en) * | 1975-02-03 | 1977-03-15 | Burton Verna M | Topical composition and method |
-
1977
- 1977-04-20 US US05/788,453 patent/US4185100A/en not_active Expired - Lifetime
- 1977-05-04 CA CA277,688A patent/CA1101334A/en not_active Expired
- 1977-05-05 FR FR7713724A patent/FR2394293A1/fr active Granted
- 1977-05-10 GB GB19637/77A patent/GB1544351A/en not_active Expired
- 1977-05-11 PH PH19763A patent/PH14140A/en unknown
- 1977-05-11 NZ NZ184064A patent/NZ184064A/xx unknown
- 1977-05-11 LU LU77312A patent/LU77312A1/xx unknown
- 1977-05-11 AU AU25073/77A patent/AU512371B2/en not_active Expired
- 1977-05-12 NL NLAANVRAGE7705276,A patent/NL190049C/xx not_active IP Right Cessation
- 1977-05-12 JP JP5378377A patent/JPS52145525A/ja active Pending
- 1977-05-12 AT AT0341277A patent/AT362869B/de not_active IP Right Cessation
- 1977-05-13 DE DE19772721831 patent/DE2721831A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| PH14140A (en) | 1981-03-05 |
| LU77312A1 (de) | 1977-08-24 |
| NL190049C (nl) | 1993-10-18 |
| CA1101334A (en) | 1981-05-19 |
| GB1544351A (en) | 1979-04-19 |
| NL190049B (nl) | 1993-05-17 |
| NZ184064A (en) | 1979-03-16 |
| FR2394293B1 (de) | 1980-06-20 |
| AU2507377A (en) | 1978-11-16 |
| DE2721831A1 (de) | 1977-11-24 |
| ATA341277A (de) | 1980-11-15 |
| US4185100A (en) | 1980-01-22 |
| NL7705276A (nl) | 1977-11-15 |
| AU512371B2 (en) | 1980-10-09 |
| FR2394293A1 (fr) | 1979-01-12 |
| JPS52145525A (en) | 1977-12-03 |
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