AT347928B - Verfahren zur herstellung von neuen araliphatischen stickstoffverbindungen - Google Patents

Verfahren zur herstellung von neuen araliphatischen stickstoffverbindungen

Info

Publication number
AT347928B
AT347928B AT813575A AT813575A AT347928B AT 347928 B AT347928 B AT 347928B AT 813575 A AT813575 A AT 813575A AT 813575 A AT813575 A AT 813575A AT 347928 B AT347928 B AT 347928B
Authority
AT
Austria
Prior art keywords
araliphatic
new
production
nitrogen compounds
nitrogen
Prior art date
Application number
AT813575A
Other languages
English (en)
Other versions
ATA813575A (de
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19742450989 external-priority patent/DE2450989A1/de
Priority claimed from DE19752523565 external-priority patent/DE2523565A1/de
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Priority to AT76778A priority Critical patent/AT356660B/de
Priority to AT76578A priority patent/ATA76578A/de
Priority to AT76878A priority patent/ATA76878A/de
Priority to AT76678A priority patent/ATA76678A/de
Publication of ATA813575A publication Critical patent/ATA813575A/de
Application granted granted Critical
Publication of AT347928B publication Critical patent/AT347928B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
AT813575A 1974-10-26 1975-10-24 Verfahren zur herstellung von neuen araliphatischen stickstoffverbindungen AT347928B (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AT76778A AT356660B (de) 1975-05-28 1978-02-03 Verfahren zur herstellung von neuen arali- phatischen morpholinoverbindungen, deren saeureadditionssalzen und optisch aktiven ver- bindungen
AT76578A ATA76578A (de) 1974-10-26 1978-02-03 Verfahren zur herstellung von neuen arali- phatischen stickstoffverbindungen
AT76878A ATA76878A (de) 1975-05-28 1978-02-03 Verfahren zur herstellung von neuen arali- phatischen stickstoffverbindungen
AT76678A ATA76678A (de) 1974-10-26 1978-02-03 Verfahren zur herstellung von neuen arali- phatischen stickstoffverbindungen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19742450989 DE2450989A1 (de) 1974-10-26 1974-10-26 Biphenylyl-alkylamine und verfahren zu ihrer herstellung
DE19752523565 DE2523565A1 (de) 1975-05-28 1975-05-28 Araliphatische stickstoffverbindungen und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ATA813575A ATA813575A (de) 1978-06-15
AT347928B true AT347928B (de) 1979-01-25

Family

ID=25767882

Family Applications (1)

Application Number Title Priority Date Filing Date
AT813575A AT347928B (de) 1974-10-26 1975-10-24 Verfahren zur herstellung von neuen araliphatischen stickstoffverbindungen

Country Status (16)

Country Link
US (2) US4110447A (de)
JP (1) JPS51125231A (de)
AT (1) AT347928B (de)
AU (1) AU497803B2 (de)
CA (1) CA1073907A (de)
DD (1) DD122680A5 (de)
DK (1) DK479575A (de)
ES (4) ES442058A1 (de)
FR (1) FR2288518A1 (de)
GB (1) GB1476106A (de)
HU (1) HU175263B (de)
IE (1) IE43071B1 (de)
IL (1) IL48319A0 (de)
LU (1) LU73641A1 (de)
NL (1) NL7512485A (de)
SE (1) SE7511932L (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48319A0 (en) * 1974-10-26 1975-12-31 Merck Patent Gmbh Araliphatic nitrogen compounds and a process for their preparation
AT354187B (de) * 1976-11-22 1979-12-27 Hoffmann La Roche Fungizides mittel
DE2732750A1 (de) * 1977-07-20 1979-02-08 Merck Patent Gmbh Basische thioaether und verfahren zu ihrer herstellung
GB2010813B (en) * 1977-10-19 1982-07-28 Wellcome Found Imidazole derivatives and salts thereof their synthesis and intermediates and pharmaceutical formulations
US4396771A (en) * 1977-10-19 1983-08-02 Burroughs Wellcome Co. Imidazole derivatives and salts thereof
CA1151164A (en) * 1978-01-13 1983-08-02 Atsuyuki Kojima Conjugated ketone compounds and their production and use
IT1097314B (it) * 1978-07-26 1985-08-31 Recordati Chem Pharm Derivati dell'imidazolo ad attivita' anticonvulsivante
US4277471A (en) * 1979-03-12 1981-07-07 Eli Lilly And Company 1,1-Biphenyl-2-yl alkylamines, formulations and antiarrhythmic treatment
IL59557A (en) * 1979-03-12 1983-10-31 Lilly Co Eli 1,1-biphenyl-2-yl propyl butyl and pentyl amines,their preparation and pharmaceutical compositions comprising them
US4397855A (en) * 1981-06-26 1983-08-09 Warner-Lambert Company 4-(Substituted)-α, α-dimethyl-1-piperazine pentanoic acids and derivatives as anti-arteriosclerotic agents and method
IT1171605B (it) * 1981-10-22 1987-06-10 Roussel Maestretti Spa Derivati di acido 4-fenil-4-ossobuten-2-oico farmacologicamente attivi e procedimento per la loro preparazione
IT1213219B (it) * 1984-09-28 1989-12-14 Consiglio Nazionale Ricerche Derivati amminoalchilnaftalenici ad attivita' farmacologica.
EP0365064B1 (de) * 1988-10-10 1992-10-21 Akzo N.V. Substituierte aromatische Verbindungen mit zentraler Nervensystem-Wirkung
DK0539805T3 (da) * 1991-10-31 1998-03-23 Asta Medica Ag Phthalaziner indeholdende en ethergruppe i 1-stilling og fremgangsmåde til fremstilling deraf
US6297239B1 (en) 1997-10-08 2001-10-02 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
EP2027087A2 (de) 2006-05-18 2009-02-25 MannKind Corporation Intrazelluläre kinase-inhibitoren
EP2520561B1 (de) 2007-06-08 2016-02-10 MannKind Corporation IRE-1a-Inhibitoren

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2543271A (en) * 1951-02-27 Biphenyl compounds
US2441518A (en) * 1945-08-04 1948-05-11 Sharp & Dohme Inc Preparation of arylaliphatic amines
US2680115A (en) * 1949-01-28 1954-06-01 Maurice L Tainter Substituted tertiary-aminoalkyl carbinols
US2723269A (en) * 1949-11-03 1955-11-08 American Cyanamid Co Piperidino tertiary amino alcohols
US2771469A (en) * 1953-12-30 1956-11-20 Merck & Co Inc Quaternary ammonium salts of deltahydrocarbyoxyphenyl gamma-hydroxy amines
US3058987A (en) * 1959-09-21 1962-10-16 Hoffmann La Roche 3-amino-2-aminomethyl-1-phenyl-1-propanols
FR1504889A (fr) * 1966-07-14 1967-12-08 Labofina Sa Procédé de résolution des alpha-arylalkylamines en leurs antipodes optiques
US3532712A (en) * 1967-09-29 1970-10-06 Aldrich Chem Co Inc N'-cyclopropyl ethylenediamine derivatives
IL48319A0 (en) * 1974-10-26 1975-12-31 Merck Patent Gmbh Araliphatic nitrogen compounds and a process for their preparation
US4055664A (en) * 1975-02-10 1977-10-25 Armour Pharmaceutical Company Pharmaceutical preparations containing 4-(4-biphenylyl) butylamines and treatment of the animal organism therewith

Also Published As

Publication number Publication date
SE7511932L (sv) 1976-04-27
IL48319A0 (en) 1975-12-31
DD122680A5 (de) 1976-10-20
LU73641A1 (de) 1977-05-31
ES442058A1 (es) 1977-07-01
ATA813575A (de) 1978-06-15
CA1073907A (en) 1980-03-18
ES456348A1 (es) 1978-06-16
JPS51125231A (en) 1976-11-01
IE43071B1 (en) 1980-12-17
ES456347A1 (es) 1978-07-01
HU175263B (hu) 1980-06-28
NL7512485A (nl) 1976-04-28
ES456349A1 (es) 1978-07-01
IE43071L (en) 1976-04-26
AU8593775A (en) 1977-04-28
US4239759A (en) 1980-12-16
FR2288518B1 (de) 1980-05-30
AU497803B2 (en) 1979-01-11
GB1476106A (en) 1977-06-10
DK479575A (da) 1976-04-27
FR2288518A1 (fr) 1976-05-21
US4110447A (en) 1978-08-29

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