DE2534391C2
(de)
*
|
1975-08-01 |
1983-01-13 |
Henkel KGaA, 4000 Düsseldorf |
1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
|
DE2553963A1
(de)
*
|
1975-12-01 |
1977-06-08 |
Henkel & Cie Gmbh |
Pharmazeutische praeparate zur behandlung von stoerungen des calciumstoffwechsels
|
DE2745083C2
(de)
|
1977-10-07 |
1985-05-02 |
Henkel KGaA, 4000 Düsseldorf |
Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
|
FR2489334A1
(fr)
*
|
1980-09-04 |
1982-03-05 |
Vysoka Skola Chem Tech |
Acide 6-amino-1-hydroxyhexilidene-diphosphonique, ses sels, et procede pour l'obtention de ces produits
|
IT1194748B
(it)
*
|
1981-02-12 |
1988-09-28 |
Gentili Ist Spa |
Composizioni farmaceutiche per il trattamento di osteopatie
|
DE3313049A1
(de)
*
|
1982-04-15 |
1983-11-17 |
Istituto Gentili S.p.A., 56100 Pisa |
Pharmakologisch wirksame biphosphonate, verfahren fuer ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen
|
IT1201087B
(it)
*
|
1982-04-15 |
1989-01-27 |
Gentili Ist Spa |
Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
|
US4446052A
(en)
*
|
1982-05-17 |
1984-05-01 |
The Procter & Gamble Company |
Aqueous gel containing tricalcium di(1-hydroxy-3-aminopropane-1,1-diphosphonate
|
DE3225469A1
(de)
*
|
1982-07-05 |
1984-01-05 |
Schering AG, 1000 Berlin und 4709 Bergkamen |
Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
|
WO1985002770A1
(en)
*
|
1983-12-21 |
1985-07-04 |
Institut Organicheskoi I Fizicheskoi Khimii Imeni |
Antiacidotic medicinal agent
|
IT1195993B
(it)
*
|
1984-01-12 |
1988-11-03 |
Gentili Ist Spa |
Forme farmaceutiche a base di difosfonati
|
FR2558837B1
(fr)
*
|
1984-01-26 |
1986-06-27 |
Sanofi Sa |
Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
|
DE3425812A1
(de)
*
|
1984-07-13 |
1986-01-16 |
Deutsches Krebsforschungszentrum, 6900 Heidelberg |
Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
|
US4639338A
(en)
*
|
1984-08-06 |
1987-01-27 |
Ciba-Geigy Corporation |
Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
|
DE3434667A1
(de)
*
|
1984-09-21 |
1986-04-03 |
Henkel KGaA, 4000 Düsseldorf |
4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
|
US4575456A
(en)
*
|
1984-11-30 |
1986-03-11 |
Colgate-Palmolive Company |
Gel dentifrice of desirable consistency
|
IT1187828B
(it)
*
|
1985-05-24 |
1987-12-23 |
Gentili Ist Spa |
Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
|
DE3540150A1
(de)
*
|
1985-11-13 |
1987-05-14 |
Boehringer Mannheim Gmbh |
Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
|
DE3623397A1
(de)
*
|
1986-07-11 |
1988-01-14 |
Boehringer Mannheim Gmbh |
Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
|
DE3724654A1
(de)
*
|
1987-07-25 |
1989-02-02 |
Henkel Kgaa |
Hydroxyacetonitrildiphosphonsaeure, verfahren zu ihrer herstellung und ihre verwendung
|
FR2629716B1
(fr)
*
|
1988-04-07 |
1991-07-19 |
Sanofi Sa |
Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
|
US5139786A
(en)
*
|
1989-07-07 |
1992-08-18 |
Ciba-Geigy Corporation |
Topical formulations
|
MX21452A
(es)
*
|
1989-07-07 |
1994-01-31 |
Ciba Geigy Ag |
Preparaciones farmaceuticas que se administran en forma topica.
|
MX21453A
(es)
*
|
1989-07-07 |
1994-01-31 |
Ciba Geigy Ag |
Preparaciones farmaceuticas que se administran en forma topica.
|
US5227506A
(en)
*
|
1989-09-06 |
1993-07-13 |
Merck & Co., Inc. |
Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
|
US5356887A
(en)
*
|
1990-01-31 |
1994-10-18 |
Merck & Co., Inc. |
Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
|
US5270365A
(en)
*
|
1991-12-17 |
1993-12-14 |
Merck & Co., Inc. |
Prevention and treatment of periodontal disease with alendronate
|
EP0550385A1
(de)
*
|
1991-12-19 |
1993-07-07 |
Ciba-Geigy Ag |
Peroral zu verabreichende pharmazeutische Zusammensetzungen, die Methandiphosphonsäure-Derivate und 18-Krone-6 Ether enthalten
|
TW237386B
(de)
|
1992-04-15 |
1995-01-01 |
Ciba Geigy |
|
US6406714B1
(en)
|
1992-12-02 |
2002-06-18 |
Merck & Co., Inc. |
Dry mix formulation for bisphosphonic acids
|
US20010007863A1
(en)
*
|
1998-06-18 |
2001-07-12 |
Merck & Co., Inc. |
Wet granulation formulation for bisphosphonic acids
|
TW390813B
(en)
*
|
1994-04-29 |
2000-05-21 |
Merck & Co Inc |
Wet granulation formulation for bisphosphonic acids
|
GB9408775D0
(en)
*
|
1994-05-04 |
1994-06-22 |
Ciba Geigy Ag |
Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration
|
EP0753523A1
(de)
|
1995-07-10 |
1997-01-15 |
Gador S.A. |
Amino-substuierte bisphosphonsäure
|
AU7213196A
(en)
*
|
1995-09-29 |
1997-04-28 |
Ciba-Geigy Ag |
Method of treating the navicular disease in horses
|
US6794536B1
(en)
|
1998-12-10 |
2004-09-21 |
Aesqen, Inc. |
Method for preparation of disodium pamidronate
|
ATE238315T1
(de)
|
1998-12-10 |
2003-05-15 |
Aesgen Inc |
Verfahren zur herstellung von dinatriumpamidronat
|
US6160165A
(en)
*
|
1998-12-10 |
2000-12-12 |
Aesgen, Inc. |
Method for preparation of disodium pamidronate
|
AR021347A1
(es)
*
|
1999-10-20 |
2002-07-17 |
Cipla Ltd |
Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
|
US6677320B2
(en)
|
2000-01-20 |
2004-01-13 |
Hoffmann-La Roches Inc. |
Parenteral bisphosphonate composition with improved local tolerance
|
US6638920B2
(en)
*
|
2000-07-21 |
2003-10-28 |
Merck & Co., Inc. |
Compositions and methods of preventing or reducing the risk or incidence of skeletal injuries in horses
|
BRPI0116865B8
(pt)
*
|
2001-01-23 |
2021-05-25 |
Gador Sa |
composição compreendendo bisfosfonatos para prevenção e/ou tratamento de doenças metabólicas dos ossos, processo para preparar tal composição e uso desta
|
BR0209361A
(pt)
*
|
2001-05-02 |
2004-06-08 |
Sicor Inc |
Dissódio de pamidronato injetável
|
CA2372450A1
(en)
*
|
2001-05-10 |
2001-09-19 |
Pharmaceutical Partners Of Canada Inc. |
Liquid injectable formulation of disodium pamidronate
|
TWI315982B
(en)
|
2001-07-19 |
2009-10-21 |
Novartis Ag |
Combinations comprising epothilones and pharmaceutical uses thereof
|
CN100479823C
(zh)
*
|
2001-12-21 |
2009-04-22 |
宝洁公司 |
双膦酸盐在制造药物套盒中的用途以及用于增加骨质的套盒
|
ES2532393T3
(es)
*
|
2002-05-10 |
2015-03-26 |
F. Hoffmann-La Roche Ag |
Acidos bisfosfónicos para tratamiento y prevención de osteoporosis
|
US20040138180A1
(en)
*
|
2002-10-03 |
2004-07-15 |
Barr Laboratories, Inc. |
Bisphosphonate composition and process for the preparation thereof
|
NZ536273A
(en)
|
2002-12-20 |
2007-08-31 |
Hoffmann La Roche |
High dose ibandronate formulation
|
US20050119230A1
(en)
*
|
2003-09-18 |
2005-06-02 |
Alexandra Glausch |
Pharmaceutical products comprising bisphosphonated
|
US20100144679A1
(en)
*
|
2007-03-21 |
2010-06-10 |
Duke University |
Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture
|
HUE025737T2
(en)
|
2009-09-01 |
2016-05-30 |
Univ Duke |
Bisphosphonate compositions and methods for treating heart failure
|
CA2795886A1
(en)
|
2010-04-16 |
2011-10-20 |
Novartis Ag |
Methods and compositions for improving implant osseointegration
|
CN104010647A
(zh)
|
2011-11-16 |
2014-08-27 |
杜克大学 |
用于治疗和/或减轻心功能障碍的双膦酸盐组合物及方法
|
PL407922A1
(pl)
|
2014-04-16 |
2015-10-26 |
Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością |
Nowe bisfosfoniany i ich zastosowanie
|