AT291250B - Verfahren zur Herstellung von neuen 5-NR<1>R<2> -6-Chlor-1H-imidazo[4,5-b]pyrazin-2-onen - Google Patents
Verfahren zur Herstellung von neuen 5-NR<1>R<2> -6-Chlor-1H-imidazo[4,5-b]pyrazin-2-onenInfo
- Publication number
- AT291250B AT291250B AT1082669A AT1082669A AT291250B AT 291250 B AT291250 B AT 291250B AT 1082669 A AT1082669 A AT 1082669A AT 1082669 A AT1082669 A AT 1082669A AT 291250 B AT291250 B AT 291250B
- Authority
- AT
- Austria
- Prior art keywords
- pyrazin
- imidazo
- chloro
- ones
- preparation
- Prior art date
Links
- HUTNOYOBQPAKIA-UHFFFAOYSA-N 1h-pyrazin-2-one Chemical class OC1=CN=CC=N1 HUTNOYOBQPAKIA-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77747968A | 1968-11-20 | 1968-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT291250B true AT291250B (de) | 1971-07-12 |
Family
ID=25110373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT1082669A AT291250B (de) | 1968-11-20 | 1969-11-19 | Verfahren zur Herstellung von neuen 5-NR<1>R<2> -6-Chlor-1H-imidazo[4,5-b]pyrazin-2-onen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3549633A (de) |
| AT (1) | AT291250B (de) |
| BR (1) | BR6914169D0 (de) |
| CH (1) | CH518957A (de) |
| ES (1) | ES373698A1 (de) |
| FR (1) | FR2070653A1 (de) |
| GB (1) | GB1242625A (de) |
| NL (1) | NL6915958A (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053577A (en) * | 1972-02-18 | 1977-10-11 | Tioxide Group Limited | Process for the gaseous phase production of metal oxide particles |
| GR74944B (de) * | 1980-07-02 | 1984-07-12 | Merck & Co Inc | |
| EA025345B1 (ru) * | 2010-11-16 | 2016-12-30 | Эситайлон Фармасьютикалз, Инк. | Гидроксиамидные соединения пиримидина в качестве ингибиторов деацетилаз белков и фармацевтические композиции для лечения заболевания, обусловленного hdac6, включающие эти соединения |
| ES2929576T3 (es) | 2013-10-08 | 2022-11-30 | Acetylon Pharmaceuticals Inc | Combinaciones de inhibidores de histona deacetilasa 6 y el inhibidor de Her2 lapatinib para el uso en el tratamiento del cáncer de mama |
| US9278963B2 (en) | 2013-10-10 | 2016-03-08 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors |
| ES2918673T3 (es) | 2013-10-24 | 2022-07-19 | Mayo Found Medical Education & Res | Tratamiento de enfermedades poliquísticas con un inhibidor de HDAC6 |
| JP6535670B2 (ja) | 2013-12-03 | 2019-06-26 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | ヒストンデアセチラーゼ阻害剤と免疫調節薬の組合せ |
| US9464073B2 (en) | 2014-02-26 | 2016-10-11 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors |
| US9833466B2 (en) | 2014-07-07 | 2017-12-05 | Acetylon Pharmaceuticals, Inc. | Treatment of leukemia with histone deacetylase inhibitors |
| CN107438436A (zh) | 2014-12-05 | 2017-12-05 | 摩德纳和雷焦艾米利亚大学 | 用于治疗淋巴瘤的组蛋白脱乙酰酶抑制剂和苯达莫司汀的组合 |
| US10272084B2 (en) | 2015-06-01 | 2019-04-30 | Regenacy Pharmaceuticals, Llc | Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy |
| WO2017184774A1 (en) | 2016-04-19 | 2017-10-26 | Acetylon Pharmaceuticals, Inc. | Hdac inhibitors, alone or in combination with btk inhibitors, for treating chronic lymphocytic leukemia |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE651730A (de) * | 1962-10-30 | 1965-02-12 | ||
| US3361748A (en) * | 1965-11-22 | 1968-01-02 | Merck & Co Inc | Process for the preparation of pteridinones |
-
1968
- 1968-11-20 US US777479A patent/US3549633A/en not_active Expired - Lifetime
-
1969
- 1969-10-22 NL NL6915958A patent/NL6915958A/xx unknown
- 1969-11-13 BR BR214169/69A patent/BR6914169D0/pt unknown
- 1969-11-13 CH CH1690669A patent/CH518957A/de not_active IP Right Cessation
- 1969-11-17 GB GB56182/69A patent/GB1242625A/en not_active Expired
- 1969-11-19 AT AT1082669A patent/AT291250B/de not_active IP Right Cessation
- 1969-11-19 ES ES373698A patent/ES373698A1/es not_active Expired
- 1969-11-20 FR FR6939940A patent/FR2070653A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US3549633A (en) | 1970-12-22 |
| BR6914169D0 (pt) | 1973-02-22 |
| GB1242625A (en) | 1971-08-11 |
| FR2070653A1 (de) | 1971-09-17 |
| ES373698A1 (es) | 1972-02-01 |
| CH518957A (de) | 1972-02-15 |
| NL6915958A (de) | 1970-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |