AT290528B - Verfahren zur Herstellung von neuen 5-NR<1>R<2>-6-Chlor-1H-imidazo[4,5-b]pyrazin-2-onen und ihren Salzen - Google Patents
Verfahren zur Herstellung von neuen 5-NR<1>R<2>-6-Chlor-1H-imidazo[4,5-b]pyrazin-2-onen und ihren SalzenInfo
- Publication number
- AT290528B AT290528B AT1082569A AT1082569A AT290528B AT 290528 B AT290528 B AT 290528B AT 1082569 A AT1082569 A AT 1082569A AT 1082569 A AT1082569 A AT 1082569A AT 290528 B AT290528 B AT 290528B
- Authority
- AT
- Austria
- Prior art keywords
- pyrazin
- imidazo
- chloro
- ones
- salts
- Prior art date
Links
- HUTNOYOBQPAKIA-UHFFFAOYSA-N 1h-pyrazin-2-one Chemical class OC1=CN=CC=N1 HUTNOYOBQPAKIA-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77747868A | 1968-11-20 | 1968-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT290528B true AT290528B (de) | 1971-06-11 |
Family
ID=25110370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT1082569A AT290528B (de) | 1968-11-20 | 1969-11-19 | Verfahren zur Herstellung von neuen 5-NR<1>R<2>-6-Chlor-1H-imidazo[4,5-b]pyrazin-2-onen und ihren Salzen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3567725A (de) |
| AT (1) | AT290528B (de) |
| BE (1) | BE741910A (de) |
| BR (1) | BR6914329D0 (de) |
| DE (2) | DE1957711A1 (de) |
| FR (1) | FR2035817B1 (de) |
| GB (1) | GB1246006A (de) |
| IL (1) | IL33336A0 (de) |
| NL (1) | NL6915957A (de) |
| ZA (1) | ZA698081B (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8810933D0 (en) * | 1987-05-26 | 1988-06-15 | Ici America Inc | Heterocyclic compounds |
| GB8810934D0 (en) * | 1987-05-26 | 1988-06-15 | Ici America Inc | Amides |
| US5705585A (en) | 1993-06-30 | 1998-01-06 | Arqule, Inc. | Aminimide-containing molecules and materials as molecular recognition agents |
| US7034110B2 (en) * | 1994-01-05 | 2006-04-25 | Arqule, Inc. | Method of identifying chemical compounds having selected properties for a particular application |
| EP0743857A4 (de) * | 1994-01-05 | 1998-07-15 | Arqule Inc | Methode zur herstellung von polymeren mit spezifischen eigenschaften |
| US5734082A (en) * | 1994-10-20 | 1998-03-31 | Arqule Inc. | Hydroxyethyl aminimides |
| US5712171A (en) * | 1995-01-20 | 1998-01-27 | Arqule, Inc. | Method of generating a plurality of chemical compounds in a spatially arranged array |
| WO1996031263A1 (en) * | 1995-04-06 | 1996-10-10 | Arqule, Inc. | Method for rapid purification, analysis and characterization of collections of chemical compounds |
| US5962412A (en) * | 1996-06-10 | 1999-10-05 | Arqule, Inc. | Method of making polymers having specific properties |
| KR20140104060A (ko) * | 2006-10-19 | 2014-08-27 | 시그날 파마소티칼 엘엘씨 | 헤테로아릴 화합물, 이들의 조성물 그리고 단백질 키나아제 억제제로서의 이들의 용도 |
| US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
| MY177695A (en) | 2009-10-26 | 2020-09-23 | Signal Pharm Llc | Methods of synthesis and purification of heteroaryl compounds |
| WO2013059396A2 (en) | 2011-10-19 | 2013-04-25 | Signal Pharmaceuticals, Llc | Treatment of cancer with tor kinase inhibitors |
| MX363034B (es) | 2011-12-02 | 2019-03-06 | Signal Pharm Llc | Composiciones farmaceuticas de 7-(6-(2-hidroxipropan-2-il)piridin- 3-il)-1-((trans)-4-metoxiciclohexil)-3,4-dihidropirazino[2,3-b]pi razin-2(1h)-ona, una forma solida de las mismas y metodos de su uso. |
| EA028462B1 (ru) | 2012-02-24 | 2017-11-30 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Способы лечения немелкоклеточного рака легких на поздних стадиях c применением комбинированного лечения с ингибитором киназы tor |
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| ES2638179T3 (es) | 2013-01-16 | 2017-10-19 | Signal Pharmaceuticals, Llc | Compuestos de pirrolopirimidina sustituidos, composiciones de los mismos, y métodos de tratamiento con los mismos |
| KR102221029B1 (ko) | 2013-04-17 | 2021-02-26 | 시그날 파마소티칼 엘엘씨 | 디하이드로피라지노-피라진을 사용한 암의 치료 |
| KR102459285B1 (ko) | 2013-04-17 | 2022-10-27 | 시그날 파마소티칼 엘엘씨 | 1-에틸-7-(2-메틸-6-(1H-1,2,4-트리아졸-3-일)피리딘-3-일)-3,4-디하이드로피라지노[2,3-b]피라진-2(1H)-온에 관한 약학 제제, 제조방법, 고체 형태 및 사용 방법 |
| CA2909579A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer |
| WO2014172431A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer |
| WO2014172432A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
| JP6382945B2 (ja) | 2013-04-17 | 2018-08-29 | シグナル ファーマシューティカルズ，エルエルシー | ジヒドロピラジノ−ピラジンによる癌治療 |
| TWI654979B (zh) | 2013-04-17 | 2019-04-01 | 美商標誌製藥公司 | 使用ｔｏｒ激酶抑制劑組合療法以治療癌症之方法 |
| GB201309508D0 (en) | 2013-05-28 | 2013-07-10 | Redx Pharma Ltd | Compounds |
| CN113831345A (zh) | 2013-05-29 | 2021-12-24 | 西格诺药品有限公司 | 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途 |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| EP3131551A4 (de) | 2014-04-16 | 2017-09-20 | Signal Pharmaceuticals, LLC | Feste formen mit 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-on und co-former, zusammensetzungen und verfahren zu deren verwendung |
| WO2015160868A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using tor kinase inhibitor combination therapy |
| WO2015160882A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 7-(6-(2-HYDROXYPROPAN-2YL) PYRIDIN-3-YL)-1-(TRANS)-4-METHOXYCYCLOHEXYL)-3, 4-DIHYDROPYRAZINO[2,3-b] PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
| NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
| JP2017520603A (ja) | 2014-07-14 | 2017-07-27 | シグナル ファーマシューティカルズ，エルエルシー | 置換ピロロピリミジン化合物を使用するがんの治療方法及びその組成物 |
| SG11201912403SA (en) | 2017-06-22 | 2020-01-30 | Celgene Corp | Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection |
-
1968
- 1968-11-20 US US777478A patent/US3567725A/en not_active Expired - Lifetime
-
1969
- 1969-10-22 NL NL6915957A patent/NL6915957A/xx unknown
- 1969-11-10 IL IL33336A patent/IL33336A0/xx unknown
- 1969-11-17 GB GB56181/69A patent/GB1246006A/en not_active Expired
- 1969-11-17 DE DE19691957711 patent/DE1957711A1/de active Pending
- 1969-11-17 DE DE19691965989 patent/DE1965989A1/de active Pending
- 1969-11-19 AT AT1082569A patent/AT290528B/de not_active IP Right Cessation
- 1969-11-19 BE BE741910D patent/BE741910A/xx unknown
- 1969-11-19 ZA ZA698081*A patent/ZA698081B/xx unknown
- 1969-11-19 BR BR214329/69A patent/BR6914329D0/pt unknown
- 1969-11-20 FR FR696939941A patent/FR2035817B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BR6914329D0 (pt) | 1973-02-22 |
| ZA698081B (en) | 1971-07-28 |
| US3567725A (en) | 1971-03-02 |
| DE1965989A1 (de) | 1971-02-18 |
| FR2035817B1 (de) | 1973-01-12 |
| GB1246006A (en) | 1971-09-15 |
| FR2035817A1 (de) | 1970-12-24 |
| NL6915957A (de) | 1970-05-22 |
| BE741910A (de) | 1970-05-19 |
| DE1957711A1 (de) | 1970-06-18 |
| IL33336A0 (en) | 1970-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AT290528B (de) | Verfahren zur Herstellung von neuen 5-NR<1>R<2>-6-Chlor-1H-imidazo[4,5-b]pyrazin-2-onen und ihren Salzen | |
| AT294113B (de) | Verfahren zur Herstellung von neuen 3,4-Dihydro-2H-1,2-benzothiazin-1,1-dioxyden und ihren Salzen | |
| AT295511B (de) | Verfahren zur Herstellung von neuen Phenoxyaminopropanolderivaten und ihren Salzen | |
| AT304535B (de) | Verfahren zur Herstellung von neuen 2-(Thienyl-3'-amino)-1,3-diazacycloalkenen-(2) und ihren Salzen | |
| AT321277B (de) | Verfahren zur Herstellung von neuen 1,3-Diphenyl-propan-1-onen und ihren Salzen | |
| AT288378B (de) | Verfahren zur Herstellung von neuen 1,2,5-Thiadiazolderivaten und ihren Salzen | |
| AT303053B (de) | Verfahren zur Herstellung von neuen 1,1,1-Trichloräthan-Derivaten und ihren Salzen | |
| AT291250B (de) | Verfahren zur Herstellung von neuen 5-NR<1>R<2> -6-Chlor-1H-imidazo[4,5-b]pyrazin-2-onen | |
| AT286290B (de) | Verfahren zur Herstellung von neuen Pyridoindolderivaten und ihren Salzen | |
| AT269166B (de) | Verfahren zur Herstellung von neuen p,p'-Dialkanoyldiphenylharnstoff-bis-guanylhydrazonen und ihren Salzen | |
| AT299193B (de) | Verfahren zur Herstellung von neuen Imidazolidinochinalinderivaten und ihren Salzen | |
| AT289789B (de) | Verfahren zur Herstellung von neuen 1,2,5-Thiadiazolderivaten und ihren Salzen | |
| AT315862B (de) | Verfahren zur Herstellung von neuen Diazepinderivaten und ihren Additionssalzen | |
| AT286289B (de) | Verfahren zur Herstellung von neuen Pyridoindolderivaten und ihren Salzen | |
| AT287694B (de) | Verfahren zur Herstellung von neuen Imidazolindinderivaten und ihren Salzen | |
| AT295756B (de) | Verfahren zur Herstellung von neuen Steroid-17&alpa;,21-orthocarbonaten | |
| AT288416B (de) | Verfahren zur Herstellung von neuen Benzoxazinderivaten und ihren Salzen | |
| AT307399B (de) | Verfahren zur Herstellung von neuen basischen Dithienylpropen-Derivaten und ihren Salzen | |
| AT315855B (de) | Verfahren zur Herstellung von neuen basisch substituierten 2,3,7,8-Tetrahydro-1H-chino[1,8-ab][1]benzazepinen und von ihren Salzen | |
| AT286299B (de) | Verfahren zur herstellung von neuen 1-substituierten 6,7-dimethoxy-isochinolinen und ihren salzen | |
| AT304488B (de) | Verfahren zur Herstellung von neuen 9-Aminoalkyl-9,10-dihydro-9,10-äthano-anthrazenen und ihren Salzen | |
| AT294112B (de) | Verfahren zur Herstellung von neuen 3-Aryl-benzazinen und ihren Salzen | |
| AT303749B (de) | Verfahren zur Herstellung von neuen 3,4-Dihydro-oxathiazin-4-on-2,2-dioxyden und ihren Salzen | |
| AT299196B (de) | Verfahren zur Herstellung von neuen 5-Aryl-3H-1,2,4-dithiazolen und ihren Salzen | |
| AT285620B (de) | Verfahren zur Herstellung von neuen 1,2-Oxazinderivaten und ihren Salzen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |