CH518957A - Verfahren zur Herstellung von 5-Amino (oder substituierten Amino)-6-chlor-1H-imidazo(4,5-b)pyrazin-2-onen - Google Patents

Verfahren zur Herstellung von 5-Amino (oder substituierten Amino)-6-chlor-1H-imidazo(4,5-b)pyrazin-2-onen

Info

Publication number
CH518957A
CH518957A CH1690669A CH1690669A CH518957A CH 518957 A CH518957 A CH 518957A CH 1690669 A CH1690669 A CH 1690669A CH 1690669 A CH1690669 A CH 1690669A CH 518957 A CH518957 A CH 518957A
Authority
CH
Switzerland
Prior art keywords
amino
pyrazin
imidazo
chloro
ones
Prior art date
Application number
CH1690669A
Other languages
English (en)
Inventor
John Grabowski Edward Joseph
Welis Tristram Edward
James Tull Roger
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH518957A publication Critical patent/CH518957A/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH1690669A 1968-11-20 1969-11-13 Verfahren zur Herstellung von 5-Amino (oder substituierten Amino)-6-chlor-1H-imidazo(4,5-b)pyrazin-2-onen CH518957A (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77747968A 1968-11-20 1968-11-20

Publications (1)

Publication Number Publication Date
CH518957A true CH518957A (de) 1972-02-15

Family

ID=25110373

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1690669A CH518957A (de) 1968-11-20 1969-11-13 Verfahren zur Herstellung von 5-Amino (oder substituierten Amino)-6-chlor-1H-imidazo(4,5-b)pyrazin-2-onen

Country Status (8)

Country Link
US (1) US3549633A (de)
AT (1) AT291250B (de)
BR (1) BR6914169D0 (de)
CH (1) CH518957A (de)
ES (1) ES373698A1 (de)
FR (1) FR2070653A1 (de)
GB (1) GB1242625A (de)
NL (1) NL6915958A (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053577A (en) * 1972-02-18 1977-10-11 Tioxide Group Limited Process for the gaseous phase production of metal oxide particles
GR74944B (de) * 1980-07-02 1984-07-12 Merck & Co Inc
NZ710405A (en) * 2010-11-16 2017-04-28 Acetylon Pharmaceuticals Inc Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
WO2015054099A1 (en) 2013-10-08 2015-04-16 Acetylon Pharmaceuticals, Inc. Combinations of histone deacetylase inhibitors and either her2 inhibitors or pi3k inhibitors
EP3055299B1 (de) 2013-10-10 2021-01-06 Acetylon Pharmaceuticals, Inc. Pyrimidinhydroxyamidverbindungen als histondeacetylaseinhibitoren
US10660890B2 (en) 2013-10-24 2020-05-26 National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government Nih Division Of Extramural Inventions And Technology Resources (Deitr) Treatment of polycystic diseases with an HDAC6 inhibitor
US9949972B2 (en) 2013-12-03 2018-04-24 Acetylon Pharmaceuticals, Inc Combinations of histone deacetylase inhibitors and immunomodulatory drugs
US9464073B2 (en) 2014-02-26 2016-10-11 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
CN107205988A (zh) 2014-07-07 2017-09-26 埃斯泰隆制药公司 利用组蛋白脱乙酰酶抑制剂治疗白血病
WO2016087950A1 (en) 2014-12-05 2016-06-09 University of Modena and Reggio Emilia Combinations of histone deacetylase inhibitors and bendamustine for use in the treatment of lymphoma
US10272084B2 (en) 2015-06-01 2019-04-30 Regenacy Pharmaceuticals, Llc Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy
WO2017184774A1 (en) 2016-04-19 2017-10-26 Acetylon Pharmaceuticals, Inc. Hdac inhibitors, alone or in combination with btk inhibitors, for treating chronic lymphocytic leukemia

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE651729A (de) * 1962-10-30 1965-02-12
US3361748A (en) * 1965-11-22 1968-01-02 Merck & Co Inc Process for the preparation of pteridinones

Also Published As

Publication number Publication date
GB1242625A (en) 1971-08-11
ES373698A1 (es) 1972-02-01
NL6915958A (de) 1970-05-22
FR2070653A1 (de) 1971-09-17
AT291250B (de) 1971-07-12
US3549633A (en) 1970-12-22
BR6914169D0 (pt) 1973-02-22

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Legal Events

Date Code Title Description
PL Patent ceased