AT290032B - Verfahren zur Herstellung von neuem N<α><(A1)>,Nγ<(B29)>-Di-tert.Butyloxycarbonyl-insulin - Google Patents
Verfahren zur Herstellung von neuem N<α><(A1)>,Nγ<(B29)>-Di-tert.Butyloxycarbonyl-insulinInfo
- Publication number
- AT290032B AT290032B AT913469A AT913469A AT290032B AT 290032 B AT290032 B AT 290032B AT 913469 A AT913469 A AT 913469A AT 913469 A AT913469 A AT 913469A AT 290032 B AT290032 B AT 290032B
- Authority
- AT
- Austria
- Prior art keywords
- butyloxycarbonyl
- insulin
- tert
- new
- production
- Prior art date
Links
- 229940125396 insulin Drugs 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Substances N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1793517A DE1793517C3 (de) | 1968-09-28 | 1968-09-28 | N(Al),N(B29>Bis-(tert.-butyloxycarbonyl)-insulin und Verfahren zu seiner Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT290032B true AT290032B (de) | 1971-05-10 |
Family
ID=5707736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT913469A AT290032B (de) | 1968-09-28 | 1969-09-26 | Verfahren zur Herstellung von neuem N<α><(A1)>,Nγ<(B29)>-Di-tert.Butyloxycarbonyl-insulin |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3684791A (de) |
| AT (1) | AT290032B (de) |
| BE (1) | BE739511A (de) |
| CH (1) | CH530207A (de) |
| DE (1) | DE1793517C3 (de) |
| DK (1) | DK123094B (de) |
| FR (1) | FR2019135A1 (de) |
| GB (1) | GB1223350A (de) |
| NL (1) | NL159089B (de) |
| SE (1) | SE362872B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3934008A (en) * | 1968-08-23 | 1976-01-20 | Ciba-Geigy Corporation | N-acyl and desamino human calcitonin and analogs thereof |
| GB1381273A (en) * | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
| GB1381274A (en) * | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
| US3864325A (en) * | 1971-11-18 | 1975-02-04 | Nat Res Dev | (N{HU Al{b , N{HU Bl{b , N{HU B29{B , carbamoyl)-(O{HU A14{B , O{HU B16{B , O{HU B26{B aryl) insulin derivatives |
| AR020047A1 (es) | 1997-10-24 | 2002-04-10 | Lilly Co Eli | Composiciones insolubles de insulina, formulaciones en suspension que incluyen dicha composicion insoluble de insulina; y el uso de dicha composicionpara preparar medicamentos y procedimiento para preparar dichas composiciones insolubles. |
| CO4970787A1 (es) | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
| US7040519B2 (en) * | 2003-06-12 | 2006-05-09 | Jere F. Irwin | Thermoformable web support apparatus and support device for a heated plastic sheet |
| JP2012516339A (ja) | 2009-01-28 | 2012-07-19 | スマートセルズ・インコーポレイテツド | 外因的刺激型制御放出物質体およびその使用 |
| US8906850B2 (en) | 2009-01-28 | 2014-12-09 | Smartcells, Inc. | Crystalline insulin-conjugates |
| AU2010208305A1 (en) | 2009-01-28 | 2011-09-08 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
| CA2750262C (en) | 2009-01-28 | 2016-08-09 | Smartcells, Inc. | Conjugate based systems for controlled drug delivery |
| US8623345B2 (en) | 2009-03-20 | 2014-01-07 | Smartcells | Terminally-functionalized conjugates and uses thereof |
| WO2010107520A1 (en) | 2009-03-20 | 2010-09-23 | Smartcells, Inc. | Soluble non-depot insulin conjugates and uses thereof |
| JP2013541500A (ja) | 2010-07-28 | 2013-11-14 | スマートセルズ・インコーポレイテツド | 組換えレクチン、結合部位修飾レクチンおよびそれらの用途 |
| CA2806399A1 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
| CA2805739A1 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Drug-ligand conjugates, synthesis thereof, and intermediates thereto |
| CN105792852B (zh) | 2013-10-04 | 2019-12-10 | 默沙东公司 | 葡萄糖响应性的胰岛素缀合物 |
| FR3120445B1 (fr) | 2021-03-08 | 2023-02-10 | Aryballe | Procédé de caractérisation d’un analyte présent dans un échantillon gazeux contenant au moins une espèce chimique parasite |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3528960A (en) * | 1968-10-07 | 1970-09-15 | Lilly Co Eli | N-carboxyaroyl insulins |
-
1968
- 1968-09-28 DE DE1793517A patent/DE1793517C3/de not_active Expired
-
1969
- 1969-09-22 US US859688A patent/US3684791A/en not_active Expired - Lifetime
- 1969-09-23 NL NL6914400.A patent/NL159089B/xx not_active IP Right Cessation
- 1969-09-25 DK DK511369AA patent/DK123094B/da not_active IP Right Cessation
- 1969-09-25 CH CH1449569A patent/CH530207A/de not_active IP Right Cessation
- 1969-09-26 SE SE13247/69A patent/SE362872B/xx unknown
- 1969-09-26 AT AT913469A patent/AT290032B/de not_active IP Right Cessation
- 1969-09-29 GB GB47799/69A patent/GB1223350A/en not_active Expired
- 1969-09-29 FR FR6933086A patent/FR2019135A1/fr not_active Withdrawn
- 1969-09-29 BE BE739511D patent/BE739511A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL159089B (nl) | 1979-01-15 |
| DE1793517B2 (de) | 1974-05-09 |
| DE1793517C3 (de) | 1974-12-05 |
| GB1223350A (en) | 1971-02-24 |
| BE739511A (de) | 1970-03-31 |
| NL6914400A (de) | 1970-04-01 |
| DK123094B (da) | 1972-05-15 |
| FR2019135A1 (de) | 1970-06-26 |
| SE362872B (de) | 1973-12-27 |
| CH530207A (de) | 1972-11-15 |
| US3684791A (en) | 1972-08-15 |
| DE1793517A1 (de) | 1972-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |