AR247405A1 - Procedimiento de preparacion de polipeptidos inmunologicamente activos y juego de diagnostico que los comprende. - Google Patents
Procedimiento de preparacion de polipeptidos inmunologicamente activos y juego de diagnostico que los comprende.Info
- Publication number
- AR247405A1 AR247405A1 AR87309456A AR30945687A AR247405A1 AR 247405 A1 AR247405 A1 AR 247405A1 AR 87309456 A AR87309456 A AR 87309456A AR 30945687 A AR30945687 A AR 30945687A AR 247405 A1 AR247405 A1 AR 247405A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- amino acid
- preparation
- aminic
- polypeptide
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 238000009007 Diagnostic Kit Methods 0.000 title 1
- 230000000078 anti-malarial effect Effects 0.000 title 1
- 239000003430 antimalarial agent Substances 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 5
- -1 ASN AMINO ACID Chemical class 0.000 abstract 2
- 230000001012 protector Effects 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PREPARACION DE POLIPEPTIDOS IMNUNOLOGICAMENTE ACTIVOS DE FORMULA (I), QUE COMPRENDE LAS ETAPAS DE: (A) CONDENSAR EL PRIMER AMINOACIDO (ALA) PROTEGIDO AL GRUPO - AMINICO A UN SOPORTE INSOLUBLE POR UNA REACCION DE ESTERIFICACION ENTRE EL GRUPO CARBOXILICO ACTIVADO Y EL GANCHO DE CONEXION DEL SOPORTE SOLIDO; (B) REMOVER EL GRUPO PROTECTOR DEL GRUPO - AMINO; (C) CONDENSAR EL AMINOACIDO ALA LIGADO EN SOPORTE SOLIDO INSOLUBLE AL SEGUNDO AMINOACIDO ASN PROTEGIDO AL GRUPO - AMINICO POR MEDIO DE REACCION DE ACILACION ENTRE EL GRUPO AMINICO DESPROTEGIDO Y EL GRUPO CARBOXILICO ACTIVADO DEL SEGUNDO AMINOACIDO; (D) REMOVER EL GRUPO - AMINICO PROTECTOR DEL SEGUNDO AMINOACIDO; (E) CONDENSAR LOS SUCESIVOS AMINOACIDOS PROTEGIDOS A LAS FUNCIONALIDADES EN CADENA LATERAL, HASTA COMPLETAR EL POLIPEPTIDO (I); (F) DESBLOQUEAR EL POLIPEPTIDO (I) POR MEDIO DE HIDROLISIS ACIDA; (G) RECUPERAR Y PURIFICAR EL POLIPEPTIDO (I) POR MEDIO DE CROMATOGRAFIA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22560/86A IT1198225B (it) | 1986-12-04 | 1986-12-04 | Polipeptidi immunologicamente attivi utili per la preparazione di vaccini antimalaria e di kits diagnostici per la determinazione di anticorpi antisporozoita |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR247405A1 true AR247405A1 (es) | 1994-12-29 |
Family
ID=11197840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR87309456A AR247405A1 (es) | 1986-12-04 | 1987-12-01 | Procedimiento de preparacion de polipeptidos inmunologicamente activos y juego de diagnostico que los comprende. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4843146A (es) |
| AR (1) | AR247405A1 (es) |
| AT (1) | AT398426B (es) |
| BE (1) | BE1001692A5 (es) |
| CA (1) | CA1304888C (es) |
| CH (1) | CH672491A5 (es) |
| DE (1) | DE3741183A1 (es) |
| ES (1) | ES2005753A6 (es) |
| FR (1) | FR2607703B1 (es) |
| GB (1) | GB2199038B (es) |
| GR (1) | GR871850B (es) |
| IT (1) | IT1198225B (es) |
| NL (1) | NL8702921A (es) |
| OA (1) | OA08782A (es) |
| SE (1) | SE8704765L (es) |
| ZA (1) | ZA878903B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1198233B (it) * | 1986-12-23 | 1988-12-21 | Eniricerche Spa | Metodo per la determinazione di anticorpi antisporozoita di p. falciparum nel sangue umano |
| IT1223301B (it) * | 1987-09-11 | 1990-09-19 | Eniricerche Spa | Polipeptidi sequenziali immunologicamente attivi |
| IT1217582B (it) * | 1988-05-13 | 1990-03-30 | Eniricerche Spa | Metodo immunoenzimatico in fase omogenea per la determinazione di anticorpi antisporozoita di plasmodium falciparum nel sangue umano |
| US5028425A (en) * | 1988-07-07 | 1991-07-02 | The United States Of America As Represented By The Department Of Health And Human Services | Synthetic vaccine against P. falciparum malaria |
| CA2006700A1 (en) * | 1989-01-17 | 1990-07-17 | Antonello Pessi | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
| DE69014150T2 (de) * | 1989-05-19 | 1995-05-11 | Eniricerche Spa | Immunogen-Verbindungen und deren Benutzung in der Herstellung von genetisch unbeschränkten synthetischen Impfstoffen und bei der immunoenzymatischer Bestimmung von antisporozoiden Antikörpern von Plasmodium malariae. |
| IT1237764B (it) * | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| US6942866B2 (en) * | 2000-08-16 | 2005-09-13 | Apovia, Inc. | Malaria immunogen and vaccine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4707357A (en) * | 1984-06-26 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor |
| CN86100979A (zh) * | 1985-02-07 | 1986-12-17 | 史密丝克莱恩贝克曼公司 | 疟疾疫苗的制备方法 |
| AU4723999A (en) * | 1998-06-29 | 2000-01-17 | Sbc Technology Resources, Inc. | Emergency facility information system and methods |
-
1986
- 1986-12-04 IT IT22560/86A patent/IT1198225B/it active
-
1987
- 1987-11-26 ZA ZA878903A patent/ZA878903B/xx unknown
- 1987-11-27 CH CH4640/87A patent/CH672491A5/it not_active IP Right Cessation
- 1987-11-30 GB GB8728000A patent/GB2199038B/en not_active Expired - Lifetime
- 1987-11-30 SE SE8704765A patent/SE8704765L/ unknown
- 1987-12-01 AR AR87309456A patent/AR247405A1/es active
- 1987-12-02 BE BE8701373A patent/BE1001692A5/fr not_active IP Right Cessation
- 1987-12-03 AT AT0319087A patent/AT398426B/de not_active IP Right Cessation
- 1987-12-03 FR FR8716809A patent/FR2607703B1/fr not_active Expired - Fee Related
- 1987-12-03 NL NL8702921A patent/NL8702921A/nl not_active Application Discontinuation
- 1987-12-03 CA CA000553481A patent/CA1304888C/en not_active Expired - Lifetime
- 1987-12-03 US US07/128,082 patent/US4843146A/en not_active Expired - Fee Related
- 1987-12-04 ES ES8703801A patent/ES2005753A6/es not_active Expired
- 1987-12-04 DE DE19873741183 patent/DE3741183A1/de active Granted
- 1987-12-04 OA OA59237A patent/OA08782A/xx unknown
- 1987-12-04 GR GR871850A patent/GR871850B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE8704765D0 (sv) | 1987-11-30 |
| DE3741183C2 (es) | 1991-06-06 |
| NL8702921A (nl) | 1988-07-01 |
| AT398426B (de) | 1994-12-27 |
| FR2607703A1 (fr) | 1988-06-10 |
| GB8728000D0 (en) | 1988-01-06 |
| ES2005753A6 (es) | 1989-03-16 |
| SE8704765L (sv) | 1988-06-05 |
| GR871850B (en) | 1988-03-24 |
| IT8622560A0 (it) | 1986-12-04 |
| US4843146A (en) | 1989-06-27 |
| GB2199038A (en) | 1988-06-29 |
| IT1198225B (it) | 1988-12-21 |
| ZA878903B (en) | 1988-05-26 |
| CH672491A5 (es) | 1989-11-30 |
| GB2199038B (en) | 1991-03-20 |
| CA1304888C (en) | 1992-07-07 |
| ATA319087A (de) | 1994-04-15 |
| DE3741183A1 (de) | 1988-06-09 |
| FR2607703B1 (fr) | 1993-09-24 |
| BE1001692A5 (fr) | 1990-02-13 |
| OA08782A (en) | 1989-03-31 |
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